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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cytisine
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Accession:CHEBI:4055 term browser browse the term
Definition:An organic heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family. An acetylcholine agonist, it is widely used throughout Eastern Europe as an aid to giving up smoking.
Synonyms:exact_synonym: (1R,5S)-1,2,3,4,5,6-hexahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one
 related_synonym: Formula=C11H14N2O;   InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8-,9+/m0/s1;   InChIKey=ANJTVLIZGCUXLD-DTWKUNHWSA-N;   SMILES=O=c1cccc2[C@H]3CNC[C@H](C3)Cn12;   baptitoxin;   baptitoxine;   laburnin;   sophorin;   sophorine
 xref: CAS:485-35-8;   KEGG:C10763;   KEGG:D07770;   KNApSAcK:C00002218;   LINCS:LSM-25650
 xref_mesh: MESH:C004712
 xref: PDBeChem:C5E;   PMID:21217866;   PMID:21991893;   PMID:22090039;   PMID:22250168;   PMID:22367109;   PMID:23022271;   PMID:23404838;   PMID:23563038;   PMID:23601929;   PMID:23876236;   PMID:23966067;   PMID:23974638;   PMID:24117010;   PMID:24550234;   PMID:24831822;   PMID:24885253;   PMID:25117409;   PMID:25231024;   PMID:25288485;   PMID:25517706;   PMID:25517710;   Reaxys:83882;   Wikipedia:Cytisine



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cytisine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions ISO
EXP
cytisine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]
cytisine affects binding to Chrna2 protein; cytisine inhibits the reaction [epibatidine affects binding to Chrna2 protein] in rat retina
CTD
RGD
PMID:9454827 PMID:16129735 RGD:2303195 NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions ISO
EXP
cytisine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]
cytisine affects binding [Epibatidine binds to Chrna3 protein]
cytisine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]
CTD
RGD
PMID:9454827 PMID:11600638 PMID:16129735 RGD:2303195 NCBI chr 8:55,401,981...55,415,012
Ensembl chr 8:55,401,702...55,415,165
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
affects expression
affects binding
ISO
EXP
cytisine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; cytisine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; cytisine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; cytisine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]; Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]; pozanicline inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]
cytisine affects binding to Chrna4 protein; cytisine inhibits the reaction [epibatidine affects binding to Chrna4 protein] in rat retina
cytisine affects binding to Chrna4 protein; cytisine competes with [Epibatidine binds to Chrna4 protein]
cytisine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]
cytisine affects the expression of CHRNA4 protein
CTD
RGD
PMID:7756618 PMID:9336329 PMID:9454827 PMID:14645658 PMID:20331614 More... RGD:2303195, RGD:2303194 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions ISO
EXP
cytisine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]
cytisine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]
CTD PMID:10216184 PMID:19448648 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit affects binding
multiple interactions
affects expression
ISO
EXP
cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]
cytisine affects binding to Chrnb2 protein; cytisine inhibits the reaction [epibatidine affects binding to Chrnb2 protein] in rat retina
cytisine affects binding to Chrnb2 protein; cytisine competes with [Epibatidine binds to Chrnb2 protein]
cytisine affects the expression of CHRNB2 protein
cytisine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]
cytisine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; cytisine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; cytisine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]; pozanicline inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]
CTD
RGD
PMID:7756618 PMID:9336329 PMID:14645658 PMID:20331614 PMID:16129735 More... RGD:2303195, RGD:2303194 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit multiple interactions EXP cytisine affects binding to Chrnb3 protein; cytisine inhibits the reaction [epibatidine affects binding to Chrnb3 protein] in rat retina RGD PMID:16129735 RGD:2303195 NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO
EXP
cytisine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; cytisine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; cytisine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]
cytisine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]
CTD PMID:9454827 PMID:11600638 NCBI chr 8:55,418,379...55,436,967
Ensembl chr 8:55,418,313...55,437,027
JBrowse link
G Ifng interferon gamma decreases secretion ISO cytisine analog results in decreased secretion of IFNG protein CTD PMID:17630191 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Tbx21 T-box transcription factor 21 decreases expression ISO cytisine analog results in decreased expression of TBX21 mRNA CTD PMID:17630191 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO cytisine analog results in decreased secretion of TNF protein CTD PMID:17630191 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        biochemical role 19671
          metabolite 19631
            alkaloid 5702
              cytisine 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic acid 18597
                                        carboacyl group 17730
                                          univalent carboacyl group 17710
                                            carbamoyl group 17550
                                              carboxamide 17570
                                                lactam 8349
                                                  cytisine 10
paths to the root