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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cytisine
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Accession:CHEBI:4055 term browser browse the term
Definition:An organic heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family. An acetylcholine agonist, it is widely used throughout Eastern Europe as an aid to giving up smoking.
Synonyms:exact_synonym: (1R,5S)-1,2,3,4,5,6-hexahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one
 related_synonym: Formula=C11H14N2O;   InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8-,9+/m0/s1;   InChIKey=ANJTVLIZGCUXLD-DTWKUNHWSA-N;   SMILES=O=c1cccc2[C@H]3CNC[C@H](C3)Cn12;   baptitoxin;   baptitoxine;   laburnin;   sophorin;   sophorine
 xref: CAS:485-35-8;   KEGG:C10763;   KEGG:D07770;   KNApSAcK:C00002218;   LINCS:LSM-25650
 xref_mesh: MESH:C004712
 xref: PDBeChem:C5E;   PMID:21217866;   PMID:21991893;   PMID:22090039;   PMID:22250168;   PMID:22367109;   PMID:23022271;   PMID:23404838;   PMID:23563038;   PMID:23601929;   PMID:23876236;   PMID:23966067;   PMID:23974638;   PMID:24117010;   PMID:24550234;   PMID:24831822;   PMID:24885253;   PMID:25117409;   PMID:25231024;   PMID:25288485;   PMID:25517706;   PMID:25517710;   Reaxys:83882;   Wikipedia:Cytisine


show annotations for term's descendants           Sort by:
cytisine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions ISO
EXP		 cytisine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]
cytisine affects binding to Chrna2 protein; cytisine inhibits the reaction [epibatidine affects binding to Chrna2 protein] in rat retina		 CTD
RGD		 PMID:9454827 PMID:16129735 RGD:2303195 NCBI chr15:44,517,862...44,534,144
Ensembl chr15:40,342,317...40,358,601 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions ISO
EXP		 cytisine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]
cytisine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]
cytisine affects binding [Epibatidine binds to Chrna3 protein]		 CTD
RGD		 PMID:9454827 PMID:11600638 PMID:16129735 RGD:2303195 NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
affects binding
affects expression		 ISO
EXP		 cytisine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; cytisine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; cytisine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; cytisine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]; Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]; pozanicline inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]
cytisine affects the expression of CHRNA4 protein
cytisine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]
cytisine affects binding to Chrna4 protein; cytisine competes with [Epibatidine binds to Chrna4 protein]
cytisine affects binding to Chrna4 protein; cytisine inhibits the reaction [epibatidine affects binding to Chrna4 protein] in rat retina		 CTD
RGD		 PMID:7756618 PMID:9336329 PMID:9454827 PMID:14645658 PMID:20331614 More... RGD:2303194, RGD:2303195 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions ISO
EXP		 cytisine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]
cytisine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]		 CTD PMID:10216184 PMID:19448648 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit affects binding
multiple interactions
affects expression		 ISO
EXP		 cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]
cytisine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; cytisine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; cytisine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]; pozanicline inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]
cytisine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]
cytisine affects the expression of CHRNB2 protein
cytisine affects binding to Chrnb2 protein; cytisine competes with [Epibatidine binds to Chrnb2 protein]
cytisine affects binding to Chrnb2 protein; cytisine inhibits the reaction [epibatidine affects binding to Chrnb2 protein] in rat retina		 CTD
RGD		 PMID:7756618 PMID:9336329 PMID:14645658 PMID:20331614 PMID:15016836 More... RGD:2303194, RGD:2303195 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit multiple interactions EXP cytisine affects binding to Chrnb3 protein; cytisine inhibits the reaction [epibatidine affects binding to Chrnb3 protein] in rat retina RGD PMID:16129735 RGD:2303195 NCBI chr16:71,411,847...71,454,225
Ensembl chr16:64,714,169...64,751,360 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO
EXP		 cytisine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; cytisine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; cytisine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]
cytisine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]		 CTD PMID:9454827 PMID:11600638 NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Ifng interferon gamma decreases secretion ISO cytisine analog results in decreased secretion of IFNG protein CTD PMID:17630191 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Tbx21 T-box transcription factor 21 decreases expression ISO cytisine analog results in decreased expression of TBX21 mRNA CTD PMID:17630191 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO cytisine analog results in decreased secretion of TNF protein CTD PMID:17630191 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        biochemical role 19566
          metabolite 19554
            alkaloid 8030
              cytisine 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            heteroorganic entity 19521
                              organochalcogen compound 19282
                                organooxygen compound 19197
                                  carbon oxoacid 18676
                                    carboxylic acid 18673
                                      carboacyl group 17700
                                        univalent carboacyl group 17700
                                          carbamoyl group 17545
                                            carboxamide 17545
                                              lactam 8392
                                                cytisine 10
paths to the root