Aldh1a1 (aldehyde dehydrogenase 1 family, member A1) - Rat Genome Database

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Gene: Aldh1a1 (aldehyde dehydrogenase 1 family, member A1) Rattus norvegicus
Analyze
Symbol: Aldh1a1
Name: aldehyde dehydrogenase 1 family, member A1
RGD ID: 2087
Description: Enables benzaldehyde dehydrogenase (NAD+) activity; identical protein binding activity; and retinal dehydrogenase activity. Involved in several processes, including estrous cycle; response to estradiol; and retinoic acid metabolic process. Predicted to be located in axon; cytosol; and synapse. Orthologous to human ALDH1A1 (aldehyde dehydrogenase 1 family member A1); PARTICIPATES IN retinoic acid metabolic pathway; cyclophosphamide pharmacodynamics pathway; cyclophosphamide pharmacokinetics pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3-deoxyglucosone dehydrogenase; Ahd2; Aldehyde dehydrogenase 1; Aldehyde dehydrogenase 1 subfamily A1; Aldehyde dehydrogenase 1, subfamily A1; aldehyde dehydrogenase 1A1; aldehyde dehydrogenase 2; aldehyde dehydrogenase family 1 member A1; aldehyde dehydrogenase family 1, member A1; aldehyde dehydrogenase family 1, subfamily A1; aldehyde dehydrogenase, cytosolic; ALDH-E1; Aldh1; Aldh2; ALHDII; LOC103695056; RALDH 1; ralDH1; retinal dehydrogenase 1; uncharacterized LOC103695056
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21218,000,470 - 218,152,962 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1218,042,127 - 218,152,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1226,448,507 - 226,490,531 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,385,074 - 233,427,098 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01226,203,095 - 226,245,121 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01238,222,689 - 238,264,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1238,222,521 - 238,264,330 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01245,340,587 - 245,562,970 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,731,675 - 223,773,285 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11223,895,697 - 223,937,307 (+)NCBI
Celera1215,379,207 - 215,421,068 (+)NCBICelera
Cytogenetic Map1q51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrotoluene  (EXP)
2,4-diaminotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (EXP)
2-acetamidofluorene  (EXP)
2-amino-4,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-hexenal  (ISO)
2-nitro-p-phenylenediamine  (EXP)
2-nitroanisole  (EXP)
2-nitrofluorene  (EXP)
2-nitropropane  (EXP)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4'-hydroxyacetophenone  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(diethylamino)benzaldehyde  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-acetylaminofluorene  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-Amino-2-nitrophenol  (EXP)
4-dimethylaminocinnamaldehyde  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
4-nitrophenol  (ISO)
4-nitrophenyl acetate  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-Hydroxythalidomide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP,ISO)
7H-xanthine  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinal  (EXP,ISO)
9H-xanthine  (ISO)
acetaldehyde  (EXP,ISO)
acetamide  (EXP)
acetic acid  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
adenosine 5'-monophosphate  (ISO)
aflatoxin B1  (EXP,ISO)
Aldophosphamide  (ISO)
all-trans-retinal  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (EXP)
alpha-hexachlorocyclohexane  (EXP)
amiodarone  (EXP)
amitriptyline  (EXP)
amphetamine  (ISO)
anthracen-2-amine  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
auramine O  (ISO)
azathioprine  (EXP)
bacitracin  (EXP)
benzaldehyde  (EXP,ISO)
benzbromarone  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzophenone  (EXP)
benzyl isothiocyanate  (ISO)
beta-naphthoflavone  (EXP)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
captan  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carboplatin  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chloroform  (EXP)
chlorohydrocarbon  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
ciglitazone  (EXP)
cimetidine  (ISO)
ciprofibrate  (EXP,ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP,ISO)
clomipramine  (EXP)
clothianidin  (EXP)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corn oil  (EXP)
coumarin  (EXP)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cyproconazole  (EXP,ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (ISO)
diamminedichloroplatinum  (ISO)
diarsenic trioxide  (ISO)
dibenzofurans  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dichlorvos  (EXP)
dicrotophos  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diheptyl phthalate  (EXP)
diiodine  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
diquat  (ISO)
disulfiram  (EXP,ISO)
diuron  (EXP)
doxorubicin  (ISO)
Echimidine  (EXP)
endosulfan  (EXP)
enilconazole  (EXP,ISO)
epoxiconazole  (EXP)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
ethoxyquin  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
felbamate  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
furosemide  (EXP)
gadodiamide hydrate  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glutathione  (EXP)
graphene oxide  (ISO)
Heliotrine  (EXP)
hexanal  (ISO)
hydrogen peroxide  (ISO)
imipramine  (EXP)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (EXP,ISO)
inulin  (ISO)
irinotecan  (ISO)
ketoconazole  (EXP)
L-ethionine  (EXP)
lapatinib  (ISO)
Lasiocarpine  (EXP)
lead diacetate  (ISO)
Licochalcone B  (ISO)
limonin  (ISO)
lipopolysaccharide  (ISO)
magnesium atom  (EXP)
magnesium dichloride  (EXP)
malonaldehyde  (ISO)
manganese(II) chloride  (EXP)
menadione  (ISO)
metformin  (EXP)
methamphetamine  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
miconazole  (EXP)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (ISO)
monuron  (EXP)
Muraglitazar  (EXP)
N,N-bis(2-hydroxypropyl)nitrosamine  (EXP)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
naphthalene  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
nitroglycerin  (EXP)
non-2-enal  (ISO)
ochratoxin A  (EXP)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
oltipraz  (ISO)
omeprazole  (EXP)
orphenadrine  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paclitaxel  (ISO)
para-Cresidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phencyclidine  (ISO)
phenethyl isothiocyanate  (EXP)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prochloraz  (EXP)
progesterone  (ISO)
propanal  (EXP,ISO)
propiconazole  (EXP,ISO)
pyrazinecarboxamide  (EXP)
pyrogallol  (ISO)
quartz  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
Salinomycin  (ISO)
senecionine  (EXP)
Senkirkine  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP)
Soman  (EXP)
spironolactone  (ISO)
streptozocin  (EXP)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulindac  (EXP)
T-2 toxin  (EXP)
tacrolimus hydrate  (ISO)
tanespimycin  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thapsigargin  (EXP)
thiacloprid  (EXP,ISO)
thioacetamide  (EXP)
Thiotepa  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
transplatin  (ISO)
triadimefon  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
trimethylarsine oxide  (EXP)
triphenyl phosphate  (EXP)
troglitazone  (EXP)
trovafloxacin  (EXP)
Tungsten carbide  (ISO)
ubiquinone-0  (ISO)
uracil  (EXP)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vinclozolin  (EXP)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IEA,ISO,ISS)
cytosol  (ISO,ISS)
synapse  (IEA,ISO,ISS)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Crystal structure of eta-crystallin: adaptation of a class 1 aldehyde dehydrogenase for a new role in the eye lens. Bateman OA, etal., Biochemistry. 2003 Apr 22;42(15):4349-56.
2. Cloning of a cDNA encoding rat aldehyde dehydrogenase with high activity for retinal oxidation. Bhat PV, etal., Gene 1995 Dec 12;166(2):303-6.
3. Kinetic properties of chimeric class I aldehyde dehydrogenases for retinal isomers. Brodeur H, etal., Biochem Cell Biol. 2006 Oct;84(5):799-804.
4. Role of aldehyde dehydrogenase isozymes in the defense of rat lens and human lens epithelial cells against oxidative stress. Choudhary S, etal., Invest Ophthalmol Vis Sci. 2005 Jan;46(1):259-67.
5. Estrogen suppresses retinaldehyde dehydrogenase 1 expression in the anterior pituitary glands of female rats. Fujiwara K, etal., Endocr J. 2008 Mar;55(1):91-6. Epub 2008 Jan 17.
6. Reduction of retinaldehyde dehydrogenase 1 expression and production in estrogen-induced prolactinoma of rat. Fujiwara K, etal., Med Mol Morphol. 2008 Sep;41(3):126-31. Epub 2008 Sep 20.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Characterization of the rat RALDH1 promoter. A functional CCAAT and octamer motif are critical for basal promoter activity. Guimond J, etal., Biochim Biophys Acta 2002 Dec 12;1579(2-3):81-91.
10. A preliminary report on the cloning of a constitutively expressed rat liver cytosolic ALDH cDNA by PCR. Kathmann EC and Lipsky JJ, Adv Exp Med Biol 1997;414:69-72.
11. Cloning of a cDNA encoding a constitutively expressed rat liver cytosolic aldehyde dehydrogenase. Kathmann EC and Lipsky JJ, Biochem Biophys Res Commun 1997 Jul 18;236(2):527-31.
12. Rat liver constitutive and phenobarbital-inducible cytosolic aldehyde dehydrogenases are highly homologous proteins that function as distinct isozymes. Kathmann EC, etal., Biochemistry. 2000 Sep 12;39(36):11170-6.
13. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
14. Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue. Kiefer FW, etal., Nat Med. 2012 Jun;18(6):918-25. doi: 10.1038/nm.2757.
15. A novel isoenzyme of aldehyde dehydrogenase specifically involved in the biosynthesis of 9-cis and all-trans retinoic acid. Labrecque J, etal., Biochem J. 1995 Jan 15;305 ( Pt 2):681-4.
16. Expression of retinoic acid-synthesizing and -metabolizing enzymes during nephrogenesis in the rat. Marlier A and Gilbert T, Gene Expr Patterns. 2004 Dec;5(2):179-85.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Inactivation of cytosolic aldehyde dehydrogenase via S-nitrosylation in ethanol-exposed rat liver. Moon KH, etal., FEBS Lett. 2007 Aug 21;581(21):3967-72. Epub 2007 Jul 25.
19. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Different blood acetaldehyde concentration following ethanol administration in a newly developed high alcohol preference and low alcohol preference rat model system. Nishiguchi M, etal., Alcohol Alcohol. 2002 Jan-Feb;37(1):9-12.
22. Postnatal changes in gene expression of retinal dehydrogenase and retinoid receptors in liver of rats. Ogura Y, etal., Life Sci. 2004 Feb 6;74(12):1519-28.
23. Developmental changes of the expression of the genes regulated by retinoic acid in the small intestine of rats. Ogura Y, etal., Life Sci. 2005 Oct 14;77(22):2804-13.
24. Zoxazolamine-induced paralysis in two rat substrains: differences in hepatic drug metabolism. Pappas P, etal., Eur J Drug Metab Pharmacokinet. 1998 Oct-Dec;23(4):461-7.
25. Cloning of a rat cDNA encoding retinal dehydrogenase isozyme type I and its expression in E. coli. Penzes P, etal., Gene 1997 Jun 3;191(2):167-72.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
28. GOA pipeline RGD automated data pipeline
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
31. Identification of pancreatic cancer invasion-related proteins by proteomic analysis. Walsh N, etal., Proteome Sci. 2009 Feb 14;7:3.
32. Multiple retinol and retinal dehydrogenases catalyze all-trans-retinoic acid biosynthesis in astrocytes. Wang C, etal., J Biol Chem. 2011 Feb 25;286(8):6542-53. Epub 2010 Dec 7.
33. Developmental expression of aldehyde dehydrogenase in rat: a comparison of liver and lung development. Yoon M, etal., Toxicol Sci. 2006 Feb;89(2):386-98. Epub 2005 Nov 16.
34. Cellular expression of retinal dehydrogenase types 1 and 2: effects of vitamin A status on testis mRNA. Zhai Y, etal., J Cell Physiol. 2001 Feb;186(2):220-32.
Additional References at PubMed
PMID:224930   PMID:4015840   PMID:10191271   PMID:11876656   PMID:12610736   PMID:12808103   PMID:12851412   PMID:15489334   PMID:15682487   PMID:16207763   PMID:16611695   PMID:17180597  
PMID:17257171   PMID:17497177   PMID:18971422   PMID:19056867   PMID:19199708   PMID:19671997   PMID:22170038   PMID:23028851   PMID:23376485   PMID:23533145   PMID:25450233   PMID:27618414  
PMID:28392548   PMID:33400378   PMID:35909581   PMID:36535138   PMID:36587924  


Genomics

Comparative Map Data
Aldh1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21218,000,470 - 218,152,962 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1218,042,127 - 218,152,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1226,448,507 - 226,490,531 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,385,074 - 233,427,098 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01226,203,095 - 226,245,121 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01238,222,689 - 238,264,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1238,222,521 - 238,264,330 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01245,340,587 - 245,562,970 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,731,675 - 223,773,285 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11223,895,697 - 223,937,307 (+)NCBI
Celera1215,379,207 - 215,421,068 (+)NCBICelera
Cytogenetic Map1q51NCBI
ALDH1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38972,900,671 - 72,953,053 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl972,900,671 - 73,080,442 (-)EnsemblGRCh38hg38GRCh38
GRCh37975,515,587 - 75,567,969 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36974,705,407 - 74,757,789 (-)NCBINCBI36Build 36hg18NCBI36
Build 34972,745,141 - 72,797,523NCBI
Celera946,088,447 - 46,140,830 (-)NCBICelera
Cytogenetic Map9q21.13NCBI
HuRef945,338,144 - 45,390,773 (-)NCBIHuRef
CHM1_1975,662,616 - 75,715,255 (-)NCBICHM1_1
T2T-CHM13v2.0985,051,589 - 85,103,957 (-)NCBIT2T-CHM13v2.0
Aldh1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391920,469,947 - 20,620,827 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1920,470,079 - 20,620,829 (+)EnsemblGRCm39 Ensembl
GRCm381920,492,583 - 20,643,463 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1920,492,715 - 20,643,465 (+)EnsemblGRCm38mm10GRCm38
MGSCv371920,676,472 - 20,717,952 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361920,669,079 - 20,710,559 (+)NCBIMGSCv36mm8
Celera1921,323,202 - 21,366,435 (+)NCBICelera
Cytogenetic Map19BNCBI
cM Map1913.91NCBI
ALDH1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1972,091,914 - 72,271,273 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0951,737,305 - 51,916,648 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1971,680,352 - 71,859,144 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl971,680,890 - 71,814,085 (-)Ensemblpanpan1.1panPan2
ALDH1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1184,940,411 - 84,994,789 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl184,940,411 - 84,994,789 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha185,406,217 - 85,460,597 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0185,390,369 - 85,444,756 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl185,390,360 - 85,444,756 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1185,159,477 - 85,213,817 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0184,862,384 - 84,917,606 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0185,621,439 - 85,676,732 (+)NCBIUU_Cfam_GSD_1.0
Aldh1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947132,159,211 - 132,303,931 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365038,868,961 - 8,918,532 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365038,869,073 - 8,953,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,161,299 - 226,217,308 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,163,347 - 226,217,342 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,778,605 - 252,808,516 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11283,949,529 - 84,092,452 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1283,949,399 - 84,009,003 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603872,378,038 - 72,569,020 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldh1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624811505,101 - 563,855 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624811505,297 - 563,795 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aldh1a1
1148 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:208
Count of miRNA genes:139
Interacting mature miRNAs:162
Transcripts:ENSRNOT00000024000
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1199368955224569684Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1206329708222745518Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1207702246228581766Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210702053240947965Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
634340Hcar5Hepatocarcinoma resistance QTL 58liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1214537555226660468Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1214537555238757011Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
5508828Leukc3Leukocyte quantity QTL 3eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)1218108584224054420Rat

Markers in Region
RH94633  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21218,152,697 - 218,152,876 (+)MAPPERmRatBN7.2
Rnor_6.01238,264,117 - 238,264,295NCBIRnor6.0
Rnor_5.01245,562,706 - 245,562,884UniSTSRnor5.0
RGSC_v3.41223,773,021 - 223,773,199UniSTSRGSC3.4
Celera1215,420,804 - 215,420,982UniSTS
Cytogenetic Map1q51UniSTS
D1Bda57  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21218,152,592 - 218,152,800 (+)MAPPERmRatBN7.2
Rnor_6.01238,264,012 - 238,264,219NCBIRnor6.0
Rnor_5.01245,562,601 - 245,562,808UniSTSRnor5.0
RGSC_v3.41223,772,916 - 223,773,123UniSTSRGSC3.4
Celera1215,420,699 - 215,420,906UniSTS
Cytogenetic Map1q51UniSTS
RH137275  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21218,152,663 - 218,152,850 (+)MAPPERmRatBN7.2
Rnor_6.01238,264,083 - 238,264,269NCBIRnor6.0
Rnor_5.01245,562,672 - 245,562,858UniSTSRnor5.0
RGSC_v3.41223,772,987 - 223,773,173UniSTSRGSC3.4
Celera1215,420,770 - 215,420,956UniSTS
Cytogenetic Map1q51UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 4 2
Medium 3 14 26 23 3 23 8 11 31 31 38 11 8
Low 29 27 14 13 14 43 1
Below cutoff 4 4 3 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024000   ⟹   ENSRNOP00000024000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1218,110,834 - 218,152,961 (+)Ensembl
Rnor_6.0 Ensembl1238,222,521 - 238,264,330 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112107   ⟹   ENSRNOP00000090793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1218,042,127 - 218,152,961 (+)Ensembl
RefSeq Acc Id: NM_022407   ⟹   NP_071852
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21218,111,085 - 218,152,962 (+)NCBI
Rnor_6.01238,222,689 - 238,264,381 (+)NCBI
Rnor_5.01245,340,587 - 245,562,970 (+)NCBI
RGSC_v3.41223,731,675 - 223,773,285 (+)RGD
Celera1215,379,207 - 215,421,068 (+)RGD
Sequence:
RefSeq Acc Id: XM_039093858   ⟹   XP_038949786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21218,000,471 - 218,152,901 (+)NCBI
RefSeq Acc Id: XM_039093900   ⟹   XP_038949828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21218,000,477 - 218,152,901 (+)NCBI
RefSeq Acc Id: XM_039093931   ⟹   XP_038949859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21218,000,470 - 218,152,901 (+)NCBI
RefSeq Acc Id: XM_039093955   ⟹   XP_038949883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21218,043,987 - 218,152,901 (+)NCBI
RefSeq Acc Id: XM_039093967   ⟹   XP_038949895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21218,000,574 - 218,152,901 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_071852   ⟸   NM_022407
- UniProtKB: O09184 (UniProtKB/Swiss-Prot),   P51647 (UniProtKB/Swiss-Prot),   A6I0L3 (UniProtKB/TrEMBL),   A0A0H2UHP1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024000   ⟸   ENSRNOT00000024000
RefSeq Acc Id: XP_038949859   ⟸   XM_039093931
- Peptide Label: isoform X2
- UniProtKB: P51647 (UniProtKB/Swiss-Prot),   O09184 (UniProtKB/Swiss-Prot),   A6I0L3 (UniProtKB/TrEMBL),   A0A0H2UHP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949786   ⟸   XM_039093858
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AP49 (UniProtKB/TrEMBL),   A0A0H2UHP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949828   ⟸   XM_039093900
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AP49 (UniProtKB/TrEMBL),   A0A0H2UHP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949895   ⟸   XM_039093967
- Peptide Label: isoform X2
- UniProtKB: P51647 (UniProtKB/Swiss-Prot),   O09184 (UniProtKB/Swiss-Prot),   A6I0L3 (UniProtKB/TrEMBL),   A0A0H2UHP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949883   ⟸   XM_039093955
- Peptide Label: isoform X2
- UniProtKB: P51647 (UniProtKB/Swiss-Prot),   O09184 (UniProtKB/Swiss-Prot),   A6I0L3 (UniProtKB/TrEMBL),   A0A0H2UHP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000090793   ⟸   ENSRNOT00000112107
Protein Domains
Aldehyde dehydrogenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51647-F1-model_v2 AlphaFold P51647 1-501 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2087 AgrOrtholog
BioCyc Gene G2FUF-56179 BioCyc
BioCyc Pathway PWY-6872 [retinoate biosynthesis I] BioCyc
Ensembl Genes ENSRNOG00000017619 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024000 ENTREZGENE
  ENSRNOT00000024000.7 UniProtKB/TrEMBL
  ENSRNOT00000112107 ENTREZGENE
  ENSRNOT00000112107.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6921926 IMAGE-MGC_LOAD
InterPro Ald_DH/histidinol_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_CS_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_CS_GLU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde_DH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24188 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72648 IMAGE-MGC_LOAD
NCBI Gene 24188 ENTREZGENE
PANTHER ALDEHYDE DEHYDROGENASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RETINAL DEHYDROGENASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldedh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ALDH1A1 RGD
PhenoGen Aldh1a1 PhenoGen
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDEHYDE_DEHYDR_GLU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017619 RatGTEx
Superfamily-SCOP SSF53720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHP1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AP49 ENTREZGENE, UniProtKB/TrEMBL
  A6I0L3 ENTREZGENE, UniProtKB/TrEMBL
  AL1A1_RAT UniProtKB/Swiss-Prot
  O09184 ENTREZGENE
  P51647 ENTREZGENE
UniProt Secondary O09184 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Aldh1a1  aldehyde dehydrogenase 1 family, member A1  LOC103695056  uncharacterized LOC103695056  Data merged from RGD:9330766 737654 PROVISIONAL
2014-08-25 LOC103695056  uncharacterized LOC103695056      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-26 Aldh1a1  aldehyde dehydrogenase 1 family, member A1  Aldh1a1  aldehyde dehydrogenase family 1, subfamily A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Aldh1a1  aldehyde dehydrogenase family 1, subfamily A1  Aldh1a1  aldehyde dehydrogenase 1 family, member A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-12 Aldh1a1  aldehyde dehydrogenase 1 family, member A1  Aldh1a1  aldehyde dehydrogenase family 1, member A1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Aldh1a1  aldehyde dehydrogenase family 1, member A1     Aldehyde dehydrogenase 1, subfamily A1  Name updated 629478 APPROVED
2001-06-12 Aldh1a1  Aldehyde dehydrogenase 1, subfamily A1      Symbol and Name updated to reflect Human and Mouse nomenclature 62408 APPROVED
2001-06-12 Aldh1  Aldehyde dehydrogenase 2      Symbol and Name withdrawn 62408 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_domains high luciferase activity is seen in the cloned 1360-bp promoter, mutation in the CCAAT box (-72 to -68) abolished the luciferase activity, octamer (Oct)-binding site (-56 to -49) and the CCAAT-binding proteins help in the regulation of the gene 628383
gene_domains high luciferase activity is seen in the cloned 1360-bp promoter, mutation in the CCAAT box (-72 to -68) abolished the luciferase activity, octamer (Oct)-binding site (-56 to -49) and the CCAAT-binding proteins help in the regulation of the gene 628400
gene_expression high levels are observed in developing kidneys and in stomach and intestine but weakly expressed in the liver 628383
gene_expression high levels are observed in developing kidneys and in stomach and intestine but weakly expressed in the liver 628400
gene_function catalyzes the oxidation of retinal to retinoic acid 628383
gene_function catalyzes the oxidation of retinal to retinoic acid 628400
gene_process involved in the prduction of RA required for proper differentiation of the epithelia 628383
gene_process involved in the prduction of RA required for proper differentiation of the epithelia 628400