Gad2 (glutamate decarboxylase 2) - Rat Genome Database

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Gene: Gad2 (glutamate decarboxylase 2) Rattus norvegicus
Analyze
Symbol: Gad2
Name: glutamate decarboxylase 2
RGD ID: 2653
Description: Enables glutamate binding activity; glutamate decarboxylase activity; and pyridoxal phosphate binding activity. Involved in glutamate decarboxylation to succinate and response to xenobiotic stimulus. Located in several cellular components, including inhibitory synapse; perinuclear region of cytoplasm; and synaptic vesicle membrane. Is anchored component of membrane. Human ortholog(s) of this gene implicated in gestational diabetes; schizophrenia; and type 1 diabetes mellitus. Orthologous to human GAD2 (glutamate decarboxylase 2); PARTICIPATES IN alanine, aspartate and glutamate metabolic pathway; beta-alanine metabolic pathway; butanoate metabolic pathway; INTERACTS WITH (+)-pilocarpine; (aminooxy)acetic acid; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 65 kDa glutamic acid decarboxylase; GAD-65; GAD65; Glutamate decarboxylase 2 (islet); glutamate decarboxylase 65 kDa isoform; glutamic acid decarboxylase 2; glutamic acid decarboxylase 65
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Gad2em24Yyan  
Genetic Models: LE-Gad2em24Yyan
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21784,763,630 - 84,826,155 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1784,763,628 - 84,826,155 (+)Ensembl
Rnor_6.01789,171,576 - 89,234,770 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1789,171,250 - 89,238,040 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01790,851,699 - 90,914,893 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41796,259,430 - 96,321,857 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11796,270,262 - 96,332,686 (+)NCBI
Celera1784,065,137 - 84,127,559 (-)NCBICelera
RH 3.4 Map17841.1RGD
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(aminooxy)acetic acid  (EXP)
(S)-nicotine  (EXP)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-mercaptopropanoic acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-aminopyridine  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitraz  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
bisphenol F  (ISO)
Brodifacoum  (EXP)
bromobenzene  (EXP)
chlorpyrifos  (EXP)
clozapine  (EXP,ISO)
Cyclopamine  (ISO)
dexamethasone  (EXP)
diazepam  (EXP)
dichloroacetic acid  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fluoxetine  (EXP)
gamma-aminobutyric acid  (EXP)
haloperidol  (EXP)
hydrazine  (EXP)
idazoxan  (EXP)
kainic acid  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
monosodium L-glutamate  (EXP)
morphine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethylmaleimide  (ISO)
nicotine  (EXP)
Nonylphenol  (EXP)
olanzapine  (EXP)
oxidopamine  (EXP)
panobinostat  (ISO)
paraquat  (EXP)
pentetrazol  (ISO)
phencyclidine  (ISO)
phenylmercury acetate  (ISO)
picrotoxin  (EXP,ISO)
pyridoxal 5'-phosphate  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
sodium arsenite  (EXP)
tamoxifen  (ISO)
tributylstannane  (EXP)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. Asada H, etal., Biochem Biophys Res Commun 1996 Dec 24;229(3):891-5.
2. Bu DF, etal., Proc Natl Acad Sci U S A 1992 Mar 15;89(6):2115-9.
3. Dirkx R Jr, etal., J Biol Chem. 1995 Feb 3;270(5):2241-6.
4. Erlander MG, etal., Neuron 1991 Jul;7(1):91-100.
5. Fatemi SH, etal., Schizophr Res. 2009 Jun;111(1-3):138-52. Epub 2009 Apr 9.
6. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. GOA data from the GO Consortium
8. Hall TR, etal., Immunology. 2008 Apr;123(4):547-54. Epub 2007 Nov 14.
9. Kanazawa Y, etal., J Autoimmun. 2009 Mar;32(2):104-9. Epub 2009 Feb 1.
10. KEGG
11. Khan MW, etal., Autoimmunity. 2009 Feb;42(2):150-8.
12. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
13. Martin DL, etal., J Neurosci. 1991 Sep;11(9):2725-31.
14. Martin DL, etal., Neurochem Int. 2000 Aug-Sep;37(2-3):111-9.
15. MGD data from the GO Consortium
16. Murgia C, etal., Reprod Biol Endocrinol. 2008 Jun 29;6:24.
17. Namchuk M, etal., J Biol Chem. 1997 Jan 17;272(3):1548-57.
18. NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Nicolaysen A, etal., J Lipid Res. 2007 Oct;48(10):2123-32. Epub 2007 Jun 28.
20. Orban T, etal., Diabetes Care. 2009 Sep 9.
21. Pipeline to import KEGG annotations from KEGG into RGD
22. RGD automated data pipeline
23. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. RGD automated import pipeline for gene-chemical interactions
25. Schreiber S, etal., World J Biol Psychiatry. 2011 Feb;12(1):57-65. Epub 2011 Jan 20.
26. Shi Y, etal., J Cell Biol. 1994 Mar;124(6):927-34.
27. Yang J, etal., EMBO J. 2011 Jan 5;30(1):165-80. doi: 10.1038/emboj.2010.286. Epub 2010 Nov 30.
Additional References at PubMed
PMID:1321158   PMID:3385490   PMID:10452943   PMID:15479642   PMID:15686475   PMID:15947074   PMID:18230651   PMID:19190758   PMID:19578718   PMID:20232399   PMID:20405034   PMID:21907636  
PMID:21983856   PMID:22194107   PMID:22291989   PMID:22332935   PMID:22427928   PMID:22750123   PMID:23376695   PMID:23500099   PMID:23904086   PMID:23973096   PMID:24275587   PMID:25189404  
PMID:25701657   PMID:27284108   PMID:27702572   PMID:33236473   PMID:34972242  


Genomics

Comparative Map Data
Gad2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21784,763,630 - 84,826,155 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1784,763,628 - 84,826,155 (+)Ensembl
Rnor_6.01789,171,576 - 89,234,770 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1789,171,250 - 89,238,040 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01790,851,699 - 90,914,893 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41796,259,430 - 96,321,857 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11796,270,262 - 96,332,686 (+)NCBI
Celera1784,065,137 - 84,127,559 (-)NCBICelera
RH 3.4 Map17841.1RGD
Cytogenetic Map17q12.3NCBI
GAD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381026,216,372 - 26,304,558 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1026,216,665 - 26,304,558 (+)EnsemblGRCh38hg38GRCh38
GRCh371026,505,301 - 26,593,487 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361026,545,600 - 26,633,493 (+)NCBINCBI36hg18NCBI36
Build 341026,545,599 - 26,633,493NCBI
Celera1026,216,982 - 26,305,252 (+)NCBI
Cytogenetic Map10p12.1NCBI
HuRef1026,164,647 - 26,252,919 (+)NCBIHuRef
CHM1_11026,506,137 - 26,594,390 (+)NCBICHM1_1
Gad2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39222,512,262 - 22,583,889 (+)NCBIGRCm39mm39
GRCm39 Ensembl222,512,217 - 22,583,886 (+)Ensembl
GRCm38222,621,015 - 22,693,877 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl222,622,205 - 22,693,874 (+)EnsemblGRCm38mm10GRCm38
MGSCv37222,477,847 - 22,549,397 (+)NCBIGRCm37mm9NCBIm37
MGSCv36222,473,967 - 22,542,641 (+)NCBImm8
Celera222,352,193 - 22,424,544 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map215.15NCBI
Gad2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554293,096,453 - 3,169,259 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554293,092,977 - 3,170,128 (-)NCBIChiLan1.0ChiLan1.0
GAD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11026,757,877 - 26,843,647 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1026,759,243 - 26,843,197 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01026,392,877 - 26,481,859 (+)NCBIMhudiblu_PPA_v0panPan3
GAD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.127,365,708 - 7,450,893 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl27,365,283 - 7,450,893 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha26,118,684 - 6,180,324 (-)NCBI
ROS_Cfam_1.025,562,197 - 5,647,420 (-)NCBI
ROS_Cfam_1.0 Ensembl25,558,766 - 5,648,257 (-)Ensembl
UMICH_Zoey_3.124,932,241 - 5,017,384 (-)NCBI
UNSW_CanFamBas_1.025,011,639 - 5,096,787 (-)NCBI
UU_Cfam_GSD_1.025,177,275 - 5,262,494 (-)NCBI
Gad2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934425,572,699 - 25,645,221 (+)NCBI
SpeTri2.0NW_0049364841,737,806 - 1,810,378 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1049,313,641 - 49,390,926 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11049,316,682 - 49,391,013 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21054,614,739 - 54,689,368 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GAD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1925,906,047 - 25,993,715 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl925,906,103 - 25,995,489 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605131,891,428 - 31,980,135 (+)NCBIVero_WHO_p1.0
Gad2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247962,700,443 - 2,771,757 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH142194  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21784,826,021 - 84,826,148 (+)MAPPERmRatBN7.2
Rnor_6.01789,234,637 - 89,234,763NCBIRnor6.0
Rnor_5.01790,914,760 - 90,914,886UniSTSRnor5.0
RGSC_v3.41796,321,724 - 96,321,850UniSTSRGSC3.4
Celera1784,065,144 - 84,065,270UniSTS
RH 3.4 Map17841.1UniSTS
Cytogenetic Map17q12.3UniSTS
RH138172  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21784,801,020 - 84,801,140 (+)MAPPERmRatBN7.2
Rnor_6.01789,209,638 - 89,209,757NCBIRnor6.0
Rnor_5.01790,889,761 - 90,889,880UniSTSRnor5.0
RGSC_v3.41796,296,724 - 96,296,843UniSTSRGSC3.4
Celera1784,090,167 - 84,090,286UniSTS
RH 3.4 Map17842.8UniSTS
Cytogenetic Map17q12.3UniSTS
RH94411  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21784,826,027 - 84,826,152 (+)MAPPERmRatBN7.2
Rnor_6.01789,234,643 - 89,234,767NCBIRnor6.0
Rnor_5.01790,914,766 - 90,914,890UniSTSRnor5.0
RGSC_v3.41796,321,730 - 96,321,854UniSTSRGSC3.4
Celera1784,065,140 - 84,065,264UniSTS
Cytogenetic Map17q12.3UniSTS
Gad2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21784,825,894 - 84,826,023 (+)MAPPERmRatBN7.2
Rnor_6.01789,234,510 - 89,234,638NCBIRnor6.0
Rnor_5.01790,914,633 - 90,914,761UniSTSRnor5.0
RGSC_v3.41796,321,597 - 96,321,725UniSTSRGSC3.4
Celera1784,065,269 - 84,065,397UniSTS
Cytogenetic Map17q12.3UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat


Genetic Models
This gene Gad2 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:16
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000024901
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 68 3
Low 2 2 6 8 19 8
Below cutoff 2 13 28 14 16 14 8 8 18 19 2 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024901   ⟹   ENSRNOP00000024901
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1784,763,628 - 84,826,155 (+)Ensembl
Rnor_6.0 Ensembl1789,171,250 - 89,238,040 (+)Ensembl
RefSeq Acc Id: NM_012563   ⟹   NP_036695
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21784,763,630 - 84,826,155 (+)NCBI
Rnor_6.01789,171,576 - 89,234,770 (+)NCBI
Rnor_5.01790,851,699 - 90,914,893 (+)NCBI
RGSC_v3.41796,259,430 - 96,321,857 (+)RGD
Celera1784,065,137 - 84,127,559 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036695 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA63488 (Get FASTA)   NCBI Sequence Viewer  
  AAC64947 (Get FASTA)   NCBI Sequence Viewer  
  EDL83940 (Get FASTA)   NCBI Sequence Viewer  
  EDL83941 (Get FASTA)   NCBI Sequence Viewer  
  Q05683 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036695   ⟸   NM_012563
- UniProtKB: Q05683 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024901   ⟸   ENSRNOT00000024901

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q05683-F1-model_v2 AlphaFold Q05683 1-585 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
17 96307512 96307513 C A snv SS/JrHsdMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2653 AgrOrtholog
BioCyc Gene G2FUF-8486 BioCyc
BioCyc Pathway GLUDEG-I-PWY [GABA shunt] BioCyc
  PWY0-1305 [L-glutamate degradation IX (via 4-aminobutanoate)] BioCyc
Ensembl Genes ENSRNOG00000018200 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000024901 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024901 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot
InterPro PyrdxlP-dep_de-COase UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot
  Pyridoxal-P_BS UniProtKB/Swiss-Prot
KEGG Report rno:24380 UniProtKB/Swiss-Prot
NCBI Gene 24380 ENTREZGENE
Pfam Pyridoxal_deC UniProtKB/Swiss-Prot
PhenoGen Gad2 PhenoGen
PROSITE DDC_GAD_HDC_YDC UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot
UniProt DCE2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-12-08 Gad2  glutamate decarboxylase 2   Gad2  glutamic acid decarboxylase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Gad2  glutamic acid decarboxylase 2    glutamate decarboxylase 2  Name updated 1299863 APPROVED
2002-06-10 Gad2  Glutamate decarboxylase 2 (islet)      Symbol and Name status set to approved 70586 APPROVED