Gad2 (glutamate decarboxylase 2) - Rat Genome Database

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Gene: Gad2 (glutamate decarboxylase 2) Rattus norvegicus
Symbol: Gad2
Name: glutamate decarboxylase 2
RGD ID: 2653
Description: Enables glutamate binding activity; glutamate decarboxylase activity; and pyridoxal phosphate binding activity. Involved in glutamate decarboxylation to succinate; neurotransmitter biosynthetic process; and response to xenobiotic stimulus. Located in inhibitory synapse; perinuclear region of cytoplasm; and synaptic vesicle membrane. Is active in GABA-ergic synapse and presynapse. Human ortholog(s) of this gene implicated in gestational diabetes; schizophrenia; and type 1 diabetes mellitus. Orthologous to human GAD2 (glutamate decarboxylase 2); PARTICIPATES IN alanine, aspartate and glutamate metabolic pathway; beta-alanine metabolic pathway; butanoate metabolic pathway; INTERACTS WITH (+)-pilocarpine; (aminooxy)acetic acid; (S)-nicotine.
Type: protein-coding
Previously known as: 65 kDa glutamic acid decarboxylase; GAD-65; GAD65; Glutamate decarboxylase 2 (islet); glutamate decarboxylase 65 kDa isoform; glutamic acid decarboxylase 2; glutamic acid decarboxylase 65
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Gad2em24Yyan  
Genetic Models: LE-Gad2em24Yyan
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21784,763,630 - 84,826,155 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1784,763,628 - 84,826,155 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1788,243,822 - 88,306,313 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01792,079,214 - 92,141,706 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01786,096,016 - 86,158,509 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01789,171,576 - 89,234,770 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1789,171,250 - 89,238,040 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01790,851,699 - 90,914,893 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41796,259,430 - 96,321,857 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11796,270,262 - 96,332,686 (+)NCBI
Celera1784,065,137 - 84,127,559 (-)NCBICelera
RH 3.4 Map17841.1RGD
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(aminooxy)acetic acid  (EXP)
(S)-nicotine  (EXP)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-mercaptopropanoic acid  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-aminopyridine  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitraz  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
bromobenzene  (EXP)
chlorpyrifos  (EXP,ISO)
clozapine  (EXP,ISO)
Cyclopamine  (ISO)
dexamethasone  (EXP)
diazepam  (EXP)
diazinon  (ISO)
dichloroacetic acid  (ISO)
diisopropyl fluorophosphate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fluoxetine  (EXP)
gamma-aminobutyric acid  (EXP)
glyphosate  (ISO)
haloperidol  (EXP)
hydrazine  (EXP)
idazoxan  (EXP)
kainic acid  (EXP)
L-glutamic acid  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
malathion  (ISO)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
Mipafox  (ISO)
monosodium L-glutamate  (EXP)
morphine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethylmaleimide  (ISO)
nicotine  (EXP)
Nonylphenol  (EXP)
olanzapine  (EXP)
oxidopamine  (EXP)
panobinostat  (ISO)
paraoxon  (ISO)
paraquat  (EXP)
pentetrazol  (ISO)
phencyclidine  (ISO)
phenylmercury acetate  (ISO)
picrotoxin  (EXP,ISO)
pyridoxal 5'-phosphate  (ISO)
sarin  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
tamoxifen  (ISO)
tributylstannane  (EXP)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
VX nerve agent  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures. Asada H, etal., Biochem Biophys Res Commun 1996 Dec 24;229(3):891-5.
2. Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene. Bu DF, etal., Proc Natl Acad Sci U S A 1992 Mar 15;89(6):2115-9.
3. Targeting of the 67-kDa isoform of glutamic acid decarboxylase to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase. Dirkx R Jr, etal., J Biol Chem. 1995 Feb 3;270(5):2241-6.
4. Two genes encode distinct glutamate decarboxylases. Erlander MG, etal., Neuron 1991 Jul;7(1):91-100.
5. Chronic psychotropic drug treatment causes differential expression of Reelin signaling system in frontal cortex of rats. Fatemi SH, etal., Schizophr Res. 2009 Jun;111(1-3):138-52. Epub 2009 Apr 9.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Modulation of diabetes in NOD mice by GAD65-specific monoclonal antibodies is epitope specific and accompanied by anti-idiotypic antibodies. Hall TR, etal., Immunology. 2008 Apr;123(4):547-54. Epub 2007 Nov 14.
9. Induction of anti-whole GAD65 reactivity in vivo results in disease suppression in type 1 diabetes. Kanazawa Y, etal., J Autoimmun. 2009 Mar;32(2):104-9. Epub 2009 Feb 1.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Characterization of hydroxyl radical modified GAD65: a potential autoantigen in type 1 diabetes. Khan MW, etal., Autoimmunity. 2009 Feb;42(2):150-8.
12. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
13. Ionotropic glutamate receptors are expressed in GABAergic terminals in the rat superficial dorsal horn. Lu CR, etal., J Comp Neurol. 2005 May 30;486(2):169-78.
14. Regulatory properties of brain glutamate decarboxylase (GAD): the apoenzyme of GAD is present principally as the smaller of two molecular forms of GAD in brain. Martin DL, etal., J Neurosci. 1991 Sep;11(9):2725-31.
15. Structural features and regulatory properties of the brain glutamate decarboxylases. Martin DL, etal., Neurochem Int. 2000 Aug-Sep;37(2-3):111-9.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Autoimmunity in gestational diabetes mellitus in Sardinia: a preliminary case-control report. Murgia C, etal., Reprod Biol Endocrinol. 2008 Jun 29;6:24.
18. Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alpha. Namchuk M, etal., J Biol Chem. 1997 Jan 17;272(3):1548-57.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. The components required for amino acid neurotransmitter signaling are present in adipose tissues. Nicolaysen A, etal., J Lipid Res. 2007 Oct;48(10):2123-32. Epub 2007 Jun 28.
21. Pancreatic Islet Autoantibodies as Predictors of Type 1 Diabetes in the Diabetes Prevention Trial-Type 1 (DPT-1). Orban T, etal., Diabetes Care. 2009 Sep 9.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Rat-1 fibroblasts engineered with GAD65 and GAD67 cDNAs in retroviral vectors produce and release GABA. Ruppert C, etal., J Neurochem. 1993 Aug;61(2):768-71. doi: 10.1111/j.1471-4159.1993.tb02186.x.
27. Increased density of GAD65/67 immunoreactive neurons in the posterior subiculum and parahippocampal gyrus in treated patients with chronic schizophrenia. Schreiber S, etal., World J Biol Psychiatry. 2011 Feb;12(1):57-65. Epub 2011 Jan 20.
28. Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65. Shi Y, etal., J Cell Biol. 1994 Mar;124(6):927-34.
29. DGKiota regulates presynaptic release during mGluR-dependent LTD. Yang J, etal., EMBO J. 2011 Jan 5;30(1):165-80. doi: 10.1038/emboj.2010.286. Epub 2010 Nov 30.
Additional References at PubMed
PMID:1321158   PMID:3385490   PMID:10452943   PMID:15479642   PMID:15686475   PMID:15947074   PMID:18230651   PMID:19190758   PMID:19578718   PMID:20232399   PMID:20405034   PMID:21907636  
PMID:21983856   PMID:22194107   PMID:22291989   PMID:22332935   PMID:22427928   PMID:22750123   PMID:23376695   PMID:23500099   PMID:23904086   PMID:23973096   PMID:24275587   PMID:25189404  
PMID:25701657   PMID:27284108   PMID:27702572   PMID:33236473   PMID:34972242   PMID:36587827  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21784,763,630 - 84,826,155 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1784,763,628 - 84,826,155 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1788,243,822 - 88,306,313 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01792,079,214 - 92,141,706 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01786,096,016 - 86,158,509 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01789,171,576 - 89,234,770 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1789,171,250 - 89,238,040 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01790,851,699 - 90,914,893 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41796,259,430 - 96,321,857 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11796,270,262 - 96,332,686 (+)NCBI
Celera1784,065,137 - 84,127,559 (-)NCBICelera
RH 3.4 Map17841.1RGD
Cytogenetic Map17q12.3NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381026,216,372 - 26,304,558 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1026,216,665 - 26,304,558 (+)EnsemblGRCh38hg38GRCh38
GRCh371026,505,301 - 26,593,487 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361026,545,600 - 26,633,493 (+)NCBINCBI36Build 36hg18NCBI36
Build 341026,545,599 - 26,633,493NCBI
Celera1026,216,982 - 26,305,252 (+)NCBICelera
Cytogenetic Map10p12.1NCBI
HuRef1026,164,647 - 26,252,919 (+)NCBIHuRef
CHM1_11026,506,137 - 26,594,390 (+)NCBICHM1_1
T2T-CHM13v2.01026,240,884 - 26,329,300 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39222,512,262 - 22,583,889 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl222,512,217 - 22,583,886 (+)EnsemblGRCm39 Ensembl
GRCm38222,621,015 - 22,693,877 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl222,622,205 - 22,693,874 (+)EnsemblGRCm38mm10GRCm38
MGSCv37222,477,847 - 22,549,397 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36222,473,967 - 22,542,641 (+)NCBIMGSCv36mm8
Celera222,352,193 - 22,424,544 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map215.15NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554293,096,453 - 3,169,259 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554293,092,977 - 3,170,128 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11038,919,890 - 39,007,209 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01026,392,877 - 26,481,859 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11026,757,877 - 26,843,647 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1026,759,243 - 26,843,197 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.127,365,708 - 7,450,893 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl27,365,283 - 7,450,893 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha26,118,684 - 6,180,324 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.025,562,197 - 5,647,420 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl25,558,766 - 5,648,257 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.124,932,241 - 5,017,384 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.025,011,639 - 5,096,787 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.025,177,275 - 5,262,494 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934425,572,699 - 25,645,221 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364841,737,520 - 1,810,398 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364841,737,806 - 1,810,378 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1049,313,647 - 49,390,926 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11049,316,682 - 49,391,013 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21054,614,739 - 54,689,368 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1925,906,047 - 25,993,715 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl925,906,103 - 25,995,489 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605131,891,428 - 31,980,135 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247962,703,614 - 2,771,555 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247962,700,443 - 2,771,757 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Gad2
183 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:16
Interacting mature miRNAs:17
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21784,826,021 - 84,826,148 (+)MAPPERmRatBN7.2
Rnor_6.01789,234,637 - 89,234,763NCBIRnor6.0
Rnor_5.01790,914,760 - 90,914,886UniSTSRnor5.0
RGSC_v3.41796,321,724 - 96,321,850UniSTSRGSC3.4
Celera1784,065,144 - 84,065,270UniSTS
RH 3.4 Map17841.1UniSTS
Cytogenetic Map17q12.3UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21784,801,020 - 84,801,140 (+)MAPPERmRatBN7.2
Rnor_6.01789,209,638 - 89,209,757NCBIRnor6.0
Rnor_5.01790,889,761 - 90,889,880UniSTSRnor5.0
RGSC_v3.41796,296,724 - 96,296,843UniSTSRGSC3.4
Celera1784,090,167 - 84,090,286UniSTS
RH 3.4 Map17842.8UniSTS
Cytogenetic Map17q12.3UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21784,826,027 - 84,826,152 (+)MAPPERmRatBN7.2
Rnor_6.01789,234,643 - 89,234,767NCBIRnor6.0
Rnor_5.01790,914,766 - 90,914,890UniSTSRnor5.0
RGSC_v3.41796,321,730 - 96,321,854UniSTSRGSC3.4
Celera1784,065,140 - 84,065,264UniSTS
Cytogenetic Map17q12.3UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21784,825,894 - 84,826,023 (+)MAPPERmRatBN7.2
Rnor_6.01789,234,510 - 89,234,638NCBIRnor6.0
Rnor_5.01790,914,633 - 90,914,761UniSTSRnor5.0
RGSC_v3.41796,321,597 - 96,321,725UniSTSRGSC3.4
Celera1784,065,269 - 84,065,397UniSTS
Cytogenetic Map17q12.3UniSTS

Genetic Models
This gene Gad2 is modified in the following models/strains


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 68 3
Low 2 2 6 8 19 8
Below cutoff 2 13 28 14 16 14 8 8 18 19 2 8


RefSeq Acc Id: ENSRNOT00000024901   ⟹   ENSRNOP00000024901
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1784,763,628 - 84,826,155 (+)Ensembl
Rnor_6.0 Ensembl1789,171,250 - 89,238,040 (+)Ensembl
RefSeq Acc Id: NM_012563   ⟹   NP_036695
Rat AssemblyChrPosition (strand)Source
mRatBN7.21784,763,630 - 84,826,155 (+)NCBI
Rnor_6.01789,171,576 - 89,234,770 (+)NCBI
Rnor_5.01790,851,699 - 90,914,893 (+)NCBI
RGSC_v3.41796,259,430 - 96,321,857 (+)RGD
Celera1784,065,137 - 84,127,559 (-)RGD
Protein Sequences
Protein RefSeqs NP_036695 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA63488 (Get FASTA)   NCBI Sequence Viewer  
  AAC64947 (Get FASTA)   NCBI Sequence Viewer  
  EDL83940 (Get FASTA)   NCBI Sequence Viewer  
  EDL83941 (Get FASTA)   NCBI Sequence Viewer  
  Q05683 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036695   ⟸   NM_012563
- UniProtKB: Q05683 (UniProtKB/Swiss-Prot),   A6KS02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024901   ⟸   ENSRNOT00000024901

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q05683-F1-model_v2 AlphaFold Q05683 1-585 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2653 AgrOrtholog
BioCyc Gene G2FUF-8486 BioCyc
BioCyc Pathway GLUDEG-I-PWY [GABA shunt] BioCyc
  PWY0-1305 [L-glutamate degradation IX (via 4-aminobutanoate)] BioCyc
Ensembl Genes ENSRNOG00000018200 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000024901 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024901 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot
  3.90.1150.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Type I PLP-dependent aspartate aminotransferase-like (Major domain) UniProtKB/TrEMBL
InterPro PyrdxlP-dep_de-COase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyridoxal-P_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24380 UniProtKB/Swiss-Prot
Pfam Pyridoxal_deC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gad2 PhenoGen
Superfamily-SCOP PLP-dependent transferases UniProtKB/TrEMBL, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-12-08 Gad2  glutamate decarboxylase 2   Gad2  glutamic acid decarboxylase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Gad2  glutamic acid decarboxylase 2    glutamate decarboxylase 2  Name updated 1299863 APPROVED
2002-06-10 Gad2  Glutamate decarboxylase 2 (islet)      Symbol and Name status set to approved 70586 APPROVED