Ccn2 (cellular communication network factor 2) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ccn2 (cellular communication network factor 2) Rattus norvegicus
Symbol: Ccn2
Name: cellular communication network factor 2
RGD ID: 621392
Description: Enables fibronectin binding activity and growth factor activity. Involved in several processes, including positive regulation of G0 to G1 transition; positive regulation of collagen biosynthetic process; and positive regulation of macromolecule metabolic process. Located in cell cortex; extracellular space; and perinuclear region of cytoplasm. Used to study endomyocardial fibrosis. Biomarker of several diseases, including artery disease (multiple); lung disease (multiple); membranoproliferative glomerulonephritis; restrictive cardiomyopathy (multiple); and ureteral obstruction. Orthologous to human CCN2 (cellular communication network factor 2); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH (R)-carnitine; (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CCN family member 2; connective tissue growth factor; connective tissue growth-related protein; Ctgf; CTGRP
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2120,802,199 - 20,805,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl120,802,199 - 20,805,734 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx120,578,855 - 20,581,971 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0126,578,869 - 26,581,985 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0120,778,746 - 20,781,863 (-)NCBIRnor_WKY
Rnor_6.0121,851,657 - 21,854,773 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,851,660 - 21,854,773 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,331,544 - 23,334,660 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,327,099 - 21,330,215 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1121,328,460 - 21,331,568 (-)NCBI
Celera119,554,327 - 19,557,443 (-)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
Aggressive Fibromatosis  (ISO)
aortic valve insufficiency  (IEP,ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
bone disease  (IEP)
Carotid Artery Injuries  (IEP)
Chronic Allograft Nephropathy  (IEP)
Chronic Hepatitis B  (ISO)
chronic obstructive pulmonary disease  (IEP)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (ISO)
contact dermatitis  (ISO)
Diabetic Nephropathies  (IEP)
diabetic retinopathy  (IEP)
Dwarfism  (ISO)
endomyocardial fibrosis  (IDA,IEP)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (IEP,ISO)
Experimental Radiation Injuries  (IEP)
extrahepatic cholestasis  (ISO)
Female Infertility  (ISO)
Fever  (IEP)
Fibrosis  (IMP)
focal segmental glomerulosclerosis  (ISO)
Generalized Arterial Calcification of Infancy, 1  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
hypertension  (ISO)
Left Ventricular Hypertrophy  (IDA)
liver cirrhosis  (IMP,ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
membranoproliferative glomerulonephritis  (IEP)
myocardial infarction  (IEP)
Necrosis  (IEP)
ovarian cancer  (ISO)
ovarian carcinoma  (ISO)
Parkinson's disease  (IEP)
Prenatal Exposure Delayed Effects  (ISO)
primary biliary cholangitis  (IEP)
Primary Graft Dysfunction  (IEP)
pulmonary embolism  (IEP)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (IEP)
restrictive cardiomyopathy  (IEP)
rheumatoid arthritis  (ISO)
systemic scleroderma  (ISO)
tendinitis  (IEP)
type 2 diabetes mellitus  (IEP)
ureteral obstruction  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-carnitine  (EXP)
(S)-nicotine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-butoxyethanol  (ISO)
2-methoxyethanol  (EXP)
2-tert-butylhydroquinone  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-phenylprop-2-enal  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (ISO)
adenine  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-D-galactose  (EXP)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
andrographolide  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
bazedoxifene  (ISO)
belinostat  (ISO)
benazepril  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP,ISO)
Betanin  (EXP)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bromobenzene  (EXP)
bucladesine  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
camostat  (EXP)
candesartan  (EXP)
Candesartan cilexetil  (EXP)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
cefaloridine  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
coenzyme Q10  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP,ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
EC (peptidyl-dipeptidase A) inhibitor  (EXP)
enalapril  (EXP,ISO)
endosulfan  (EXP)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
etoposide  (ISO)
ferulic acid  (ISO)
fipronil  (EXP)
fisetin  (ISO)
folic acid  (ISO)
fomepizole  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
galactose  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
hexadecanoic acid  (EXP)
Honokiol  (EXP,ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
idebenone  (EXP)
iloprost  (EXP)
indole-3-methanol  (EXP)
indometacin  (EXP)
irinotecan  (ISO)
isobutanol  (ISO)
isoprenaline  (EXP,ISO)
jaspamide  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
letrozole  (EXP)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
limonin  (ISO)
lipopolysaccharide  (EXP,ISO)
lovastatin  (ISO)
LY294002  (ISO)
manganese(II) chloride  (EXP,ISO)
mechlorethamine  (EXP)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
metoprolol  (EXP,ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nicotine  (EXP)
nitric oxide  (ISO)
nitrofen  (EXP)
NSC 23766  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
olaparib  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
Paeonol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
pentane-2,3-dione  (EXP)
Pentoxifylline  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphane  (EXP)
pioglitazone  (EXP,ISO)
pirfenidone  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
platycodin D  (EXP)
potassium cyanide  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
prostaglandin E2  (ISO)
puerarin  (ISO)
quercetin  (EXP,ISO)
ramipril  (EXP)
resveratrol  (EXP,ISO)
rofecoxib  (ISO)
rosmarinic acid  (EXP)
rotenone  (EXP)
rutin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
saralasin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium tungstate  (ISO)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
spironolactone  (EXP)
stattic  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sunitinib  (EXP)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
tebufenpyrad  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetramethylpyrazine  (ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
triamcinolone acetonide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vanillin  (ISO)
verteporfin  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin D  (ISO)
vorinostat  (ISO)
Y-27632  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO,TAS)
calcium ion transmembrane import into cytosol  (IMP)
cartilage condensation  (ISO)
cell adhesion  (IBA,TAS)
cell migration  (ISO)
cell-matrix adhesion  (ISO)
cellular response to fatty acid  (IEP)
cellular response to glucose stimulus  (IEP)
chondrocyte differentiation  (ISO)
chondrocyte proliferation  (ISO)
connective tissue development  (ISO)
DNA biosynthetic process  (IEA)
extracellular matrix constituent secretion  (IMP)
fibroblast growth factor receptor signaling pathway  (ISO)
integrin-mediated signaling pathway  (ISO)
intracellular signal transduction  (IDA)
lung development  (IEP,ISO)
microtubule depolymerization  (IMP)
negative regulation of gene expression  (ISO)
obsolete negative regulation of cell death  (IBA)
ossification  (ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of cardiac muscle contraction  (IMP)
positive regulation of cell activation  (IMP)
positive regulation of cell differentiation  (ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of collagen biosynthetic process  (IMP)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IMP)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of G0 to G1 transition  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of JNK cascade  (ISO)
positive regulation of protein phosphorylation  (IMP)
positive regulation of stress fiber assembly  (ISO)
reactive oxygen species metabolic process  (ISO)
regulation of chondrocyte differentiation  (ISO)
response to amino acid  (IEP)
response to anoxia  (IEP)
response to estradiol  (IEP)
response to fatty acid  (IEP)
response to mineralocorticoid  (IEP)
response to organic cyclic compound  (IEP)
response to peptide hormone  (IEP)
signal transduction  (IBA,IEA)
tissue homeostasis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Omega-3 fatty acid supplementation attenuates oxidative stress, inflammation, and tubulointerstitial fibrosis in the remnant kidney. An WS, etal., Am J Physiol Renal Physiol. 2009 Oct;297(4):F895-903. Epub 2009 Aug 5.
2. Myocardial fibrosis and apoptosis, but not inflammation, are present in long-term experimental diabetes. Ares-Carrasco S, etal., Am J Physiol Heart Circ Physiol. 2009 Oct 9.
3. Downregulation of connective tissue growth factor by three-dimensional matrix enhances ovarian carcinoma cell invasion. Barbolina MV, etal., Int J Cancer. 2009 Aug 15;125(4):816-25.
4. Insulin Receptor Substrate 2 plays Important Roles in 17betaEstradiol Induced Bone Formation. Bu YH, etal., J Endocrinol Invest. 2009 May 26.
5. Investigating structural and biochemical correlates of ganglion cell dysfunction in streptozotocin-induced diabetic rats. Bui BV, etal., Exp Eye Res. 2009 Jun;88(6):1076-83. Epub 2009 Feb 7.
6. Gene profiling of left ventricle eccentric hypertrophy in aortic regurgitation in rats: rationale for targeting the beta-adrenergic and renin-angiotensin systems. Champetier S, etal., Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H669-77. Epub 2008 Dec 26.
7. miR-30a attenuates cardiac fibrosis in rats with myocardial infarction by inhibiting CTGF. Chen L, etal., Exp Ther Med. 2018 May;15(5):4318-4324. doi: 10.3892/etm.2018.5952. Epub 2018 Mar 13.
8. Connective tissue growth factor is secreted through the Golgi and is degraded in the endosome. Chen Y, etal., Exp Cell Res. 2001 Nov 15;271(1):109-17.
9. CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC. Chen Y, etal., Kidney Int 2002 Oct;62(4):1149-59.
10. Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury. Cortijo J, etal., Br J Pharmacol. 2009 Feb;156(3):534-44.
11. Increased MMP-2 expression in connective tissue growth factor over-expression vascular smooth muscle cells. Fan WH and Karnovsky MJ, J Biol Chem 2002 Mar 22;277(12):9800-5.
12. Exposure-dependent increases in IL-1beta, substance P, CTGF, and tendinosis in flexor digitorum tendons with upper extremity repetitive strain injury. Fedorczyk JM, etal., J Orthop Res. 2009 Sep 9.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. FSH and TGF-beta superfamily members regulate granulosa cell connective tissue growth factor gene expression in vitro and in vivo. Harlow CR, etal., Endocrinology 2002 Sep;143(9):3316-25.
16. Peroxisome proliferator-activated receptor-gamma activation attenuates cardiac fibrosis in type 2 diabetic rats: the effect of rosiglitazone on myocardial expression of receptor for advanced glycation end products and of connective tissue growth factor. Ihm SH, etal., Basic Res Cardiol. 2009 Oct 23.
17. Highly Purified Eicosapentaenoic Acid Ethyl Ester Prevents Development of Steatosis and Hepatic Fibrosis in Rats. Kajikawa S, etal., Dig Dis Sci. 2009 Oct 24.
18. Expression of connective tissue growth factor, a biomarker in senescence of human diploid fibroblasts, is up-regulated by a transforming growth factor-beta-mediated signaling pathway. Kim KH, etal., Biochem Biophys Res Commun. 2004 Jun 11;318(4):819-25.
19. Arterial gene transfer of the TGF-beta signalling protein Smad3 induces adaptive remodelling following angioplasty: a role for CTGF. Kundi R, etal., Cardiovasc Res. 2009 Nov 1;84(2):326-35. Epub 2009 Jul 1.
20. Connective tissue growth factor in indomethacin-induced rat gastric ulcer. Lempinen M, etal., Eur Surg Res 2002 May-Jun;34(3):232-8.
21. RNA interfering connective tissue growth factor prevents rat hepatic stellate cell activation and extracellular matrix production. Li G, etal., J Gene Med. 2008 Sep;10(9):1039-47.
22. XLF-III-43, a novel coumarin-aspirin compound, prevents diabetic nephropathy in rats via inhibiting advanced glycation end products. Li H, etal., Eur J Pharmacol. 2009 Nov 4.
23. Endogenous hydrogen sulfide regulates pulmonary artery collagen remodeling in rats with high pulmonary blood flow. Li X, etal., Exp Biol Med (Maywood). 2009 May;234(5):504-12. Epub 2009 Feb 20.
24. Protective effect of glycyrrhizin on nephrotic syndrome induced by adriamycin in rats. Li Y, etal., Clin Invest Med. 2009 Jun 1;32(3):229-238.
25. Role of connective tissue growth factor in experimental radiation nephropathy in rats. Liu DG and Wang TM, Chin Med J (Engl). 2008 Oct 5;121(19):1925-31.
26. Coagulation in the mesangial area promotes ECM accumulation through factor V expression in MsPGN in rats. Liu N, etal., Am J Physiol Renal Physiol. 2004 Oct;287(4):F612-20. Epub 2004 Jun 1.
27. Oral levosimendan prevents postinfarct heart failure and cardiac remodeling in diabetic Goto-Kakizaki rats. Louhelainen M, etal., J Hypertens. 2009 Oct;27(10):2094-107.
28. Angiotensin-(1-7), an alternative metabolite of the renin-angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat. Lubel JS, etal., Clin Sci (Lond). 2009 Sep 14;117(11):375-86.
29. Epithelial to mesenchymal transformation in tubular epithelial cells undergoing anoxia. Luo GH, etal., Transplant Proc. 2008 Oct;40(8):2800-3.
30. Inhibition of connective tissue growth factor by small interfering RNA prevents renal fibrosis in rats undergoing chronic allograft nephropathy. Luo GH, etal., Transplant Proc. 2008 Sep;40(7):2365-9.
31. Targeting renal macrophage accumulation via c-fms kinase reduces tubular apoptosis but fails to modify progressive fibrosis in the obstructed rat kidney. Ma FY, etal., Am J Physiol Renal Physiol. 2009 Jan;296(1):F177-85. Epub 2008 Nov 5.
32. Increased MMP-3 and CTGF expression during lipopolysaccharide-induced dopaminergic neurodegeneration. McClain JA, etal., Neurosci Lett. 2009 Aug 21;460(1):27-31. Epub 2009 May 20.
33. Gene expression analysis after prenatal tracheal ligation in fetal rat as a model of stimulated lung growth. Mesas-Burgos C, etal., J Pediatr Surg. 2009 Apr;44(4):720-8.
34. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
35. Gene expression studies reveal that DNA damage, vascular perturbation, and inflammation contribute to the pathogenesis of carbonyl sulfide neurotoxicity. Morrison JP, etal., Toxicol Pathol. 2009;37(4):502-11. Epub 2009 Apr 24.
36. Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells. Murphy M, etal., J Biol Chem 1999 Feb 26;274(9):5830-4.
37. Overexpression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 decreases bone density in adult mice and induces dwarfism. Nakanishi T, etal., Biochem Biophys Res Commun 2001 Mar 2;281(3):678-81.
38. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
39. Simvastatin attenuates experimental small airway remodelling in rats. Ou XM, etal., Respirology. 2009 Jul;14(5):734-45.
40. Connective tissue growth factor overexpression in cardiomyocytes promotes cardiac hypertrophy and protection against pressure overload. Panek AN, etal., PLoS One. 2009 Aug 25;4(8):e6743.
41. Connective tissue growth factor with a novel fibronectin binding site promotes cell adhesion and migration during rat oval cell activation. Pi L, etal., Hepatology. 2008 Mar;47(3):996-1004.
42. CCN2/CTGF promotes liver fibrosis through crosstalk with the Slit2/Robo signaling. Pi L, etal., J Cell Commun Signal. 2023 Mar;17(1):137-150. doi: 10.1007/s12079-022-00713-y. Epub 2022 Dec 5.
43. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
44. Irbesartan ameliorates diabetic nephropathy by reducing the expression of connective tissue growth factor and alpha-smooth-muscle actin in the tubulointerstitium of diabetic rats. Ren X, etal., Pharmacology. 2009;83(2):80-7. Epub 2008 Dec 9.
45. GOA pipeline RGD automated data pipeline
46. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
47. CCN3 (NOV) is a negative regulator of CCN2 (CTGF) and a novel endogenous inhibitor of the fibrotic pathway in an in vitro model of renal disease. Riser BL, etal., Am J Pathol. 2009 May;174(5):1725-34. Epub 2009 Apr 9.
48. Urinary connective tissue growth factor increases far earlier than histopathological damage and functional deterioration in early chronic renal allograft injury. Shi Y, etal., Scand J Urol Nephrol. 2009;43(5):390-9. doi: 10.3109/00365520903142244.
49. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
50. Zinc supplementation partially prevents renal pathological changes in diabetic rats. Tang Y, etal., J Nutr Biochem. 2009 Apr 13.
51. Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature. Thomas M, etal., Synapse. 2009 Oct;63(10):881-94.
52. Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine. Twigg SM, etal., Endocrinology 2002 Dec;143(12):4907-15.
53. Mutant huntingtin alters cell fate in response to microtubule depolymerization via the GEF-H1-RhoA-ERK pathway. Varma H, etal., J Biol Chem. 2010 Nov 26;285(48):37445-57. doi: 10.1074/jbc.M110.125542. Epub 2010 Sep 21.
55. Protective effect of total aralosides of Aralia elata (Miq) Seem (TASAES) against diabetic cardiomyopathy in rats during the early stage, and possible mechanisms. Xi S, etal., Exp Mol Med. 2009 Aug 31;41(8):538-47.
56. N-acetylcysteine attenuates PKCbeta2 overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats. Xia Z, etal., Cardiovasc Res. 2007 Mar 1;73(4):770-82. Epub 2006 Nov 30.
57. Cloning the full-length cDNA for rat connective tissue growth factor: implications for skeletal development. Xu J, etal., J Cell Biochem 2000 Feb;77(1):103-15.
58. Direct aldosterone action as a profibrotic factor via ROS-mediated SGK1 in peritoneal fibroblasts. Yamahara H, etal., Kidney Blood Press Res. 2009;32(3):185-93. Epub 2009 Jun 12.
59. Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-beta-dependent and -independent Smad pathways: the role of Smad3. Yang F, etal., Hypertension. 2009 Oct;54(4):877-84. Epub 2009 Aug 10.
60. Effect of Corilagin on the miR-21/smad7/ERK signaling pathway in a schistosomiasis-induced hepatic fibrosis mouse model. Yang F, etal., Parasitol Int. 2016 Aug;65(4):308-15. doi: 10.1016/j.parint.2016.03.001. Epub 2016 Mar 2.
61. LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor. Ying L, etal., J Cell Sci. 2009 May 1;122(Pt 9):1441-51. Epub 2009 Apr 14.
62. Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis. Yokoi H, etal., Am J Physiol Renal Physiol 2002 May;282(5):F933-42.
63. Increased connective tissue growth factor expression in a rat model of chronic heart allograft rejection. Yuan YC, etal., J Formos Med Assoc. 2009 Mar;108(3):240-6.
64. Transcriptional changes in right ventricular tissues are enriched in the outflow tract compared with the apex during chronic pulmonary embolism in rats. Zagorski J, etal., Physiol Genomics. 2009 Sep 9;39(1):61-71. Epub 2009 Jul 14.
Additional References at PubMed
PMID:1888698   PMID:9184077   PMID:9927660   PMID:10082563   PMID:10393331   PMID:10446209   PMID:11988308   PMID:12199527   PMID:12217894   PMID:12736220   PMID:12763067   PMID:12767040  
PMID:12819040   PMID:12952842   PMID:14586741   PMID:14592956   PMID:15153554   PMID:15221486   PMID:15305294   PMID:15345671   PMID:15389880   PMID:15662226   PMID:15780081   PMID:16143139  
PMID:16294326   PMID:16306131   PMID:16374037   PMID:16463662   PMID:16636587   PMID:16707502   PMID:16914537   PMID:16926534   PMID:17133352   PMID:17229371   PMID:17278980   PMID:17318787  
PMID:17407709   PMID:17597657   PMID:17606220   PMID:17629588   PMID:17944991   PMID:17989112   PMID:18030501   PMID:18187544   PMID:18213577   PMID:18266973   PMID:18287961   PMID:18314002  
PMID:18364077   PMID:18375200   PMID:18397232   PMID:18401334   PMID:18597638   PMID:18639630   PMID:18644231   PMID:18782537   PMID:18790235   PMID:18846337   PMID:18846344   PMID:19032869  
PMID:19096030   PMID:19099753   PMID:19111553   PMID:19349682   PMID:19364818   PMID:19468237   PMID:19620052   PMID:19662997   PMID:19959709   PMID:20008146   PMID:20039536   PMID:20039857  
PMID:20369462   PMID:20432467   PMID:20534773   PMID:20576680   PMID:20684283   PMID:20689330   PMID:20809981   PMID:20936727   PMID:20979869   PMID:21092636   PMID:21126421   PMID:21138629  
PMID:21144460   PMID:21170500   PMID:21209863   PMID:21215756   PMID:21245987   PMID:21258935   PMID:21295007   PMID:21382976   PMID:21576830   PMID:21659659   PMID:21762408   PMID:21804025  
PMID:21814837   PMID:21914267   PMID:21928352   PMID:22097728   PMID:22334618   PMID:22363806   PMID:22899499   PMID:23099153   PMID:23207149   PMID:23383241   PMID:23456538   PMID:23530034  
PMID:23839921   PMID:23848567   PMID:24006456   PMID:24083993   PMID:24613393   PMID:24839947   PMID:25003484   PMID:25012526   PMID:25177951   PMID:25815693   PMID:25833297   PMID:26340021  
PMID:26392029   PMID:26600407   PMID:26894526   PMID:26945889   PMID:27049870   PMID:27126736   PMID:27322082   PMID:27427487   PMID:27597128   PMID:28816418   PMID:29058957   PMID:29175126  
PMID:29179208   PMID:29187583   PMID:29198711   PMID:29861095   PMID:30268161   PMID:30965128   PMID:31041999   PMID:31127659   PMID:31183597   PMID:31267533   PMID:33065236   PMID:33594198  
PMID:33604679   PMID:34553456   PMID:34797990   PMID:36539014  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2120,802,199 - 20,805,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl120,802,199 - 20,805,734 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx120,578,855 - 20,581,971 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0126,578,869 - 26,581,985 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0120,778,746 - 20,781,863 (-)NCBIRnor_WKY
Rnor_6.0121,851,657 - 21,854,773 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,851,660 - 21,854,773 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,331,544 - 23,334,660 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,327,099 - 21,330,215 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1121,328,460 - 21,331,568 (-)NCBI
Celera119,554,327 - 19,557,443 (-)NCBICelera
Cytogenetic Map1p12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh386131,948,176 - 131,951,372 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl6131,948,176 - 131,951,372 (-)EnsemblGRCh38hg38GRCh38
GRCh376132,269,316 - 132,272,512 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366132,311,009 - 132,314,211 (-)NCBINCBI36Build 36hg18NCBI36
Build 346132,311,017 - 132,314,147NCBI
Celera6133,016,448 - 133,019,647 (-)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6129,844,775 - 129,847,974 (-)NCBIHuRef
CHM1_16132,533,071 - 132,536,270 (-)NCBICHM1_1
T2T-CHM13v2.06133,143,212 - 133,146,410 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391024,471,340 - 24,474,581 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1024,471,340 - 24,474,581 (+)EnsemblGRCm39 Ensembl
GRCm381024,595,442 - 24,598,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1024,595,442 - 24,598,683 (+)EnsemblGRCm38mm10GRCm38
MGSCv371024,315,248 - 24,318,489 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361024,284,923 - 24,288,096 (+)NCBIMGSCv36mm8
Celera1025,537,033 - 25,540,272 (+)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1011.84NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495543612,522,944 - 12,526,480 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543612,523,602 - 12,526,986 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan16149,842,461 - 149,845,654 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06129,729,572 - 129,733,113 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16133,836,319 - 133,839,017 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6133,836,319 - 133,842,077 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1125,508,082 - 25,511,058 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl125,507,662 - 25,510,145 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha126,004,899 - 26,007,816 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0124,930,014 - 24,932,944 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl124,930,014 - 24,933,489 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1124,975,729 - 24,978,649 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0124,865,809 - 24,868,736 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0125,137,679 - 25,140,601 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404946120,263,340 - 120,266,574 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493656042,537 - 45,807 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493656042,561 - 45,748 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl131,674,394 - 31,677,691 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1131,674,398 - 31,677,697 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2135,134,660 - 35,137,098 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11341,613,838 - 41,617,010 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1341,613,798 - 41,617,651 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604013,786,737 - 13,789,973 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247536,023,069 - 6,024,833 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247536,022,033 - 6,024,866 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ccn2
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:637
Count of miRNA genes:301
Interacting mature miRNAs:387
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1592587724697545Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2120,802,376 - 20,802,566 (+)MAPPERmRatBN7.2
Rnor_6.0121,851,835 - 21,852,024NCBIRnor6.0
Rnor_5.0123,331,722 - 23,331,911UniSTSRnor5.0
RGSC_v3.4121,327,277 - 21,327,466UniSTSRGSC3.4
Celera119,554,505 - 19,554,694UniSTS
RH 3.4 Map1194.0UniSTS
Cytogenetic Map1p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2120,802,274 - 20,802,365 (+)MAPPERmRatBN7.2
Rnor_6.0121,851,733 - 21,851,823NCBIRnor6.0
Rnor_5.0123,331,620 - 23,331,710UniSTSRnor5.0
RGSC_v3.4121,327,175 - 21,327,265UniSTSRGSC3.4
Celera119,554,403 - 19,554,493UniSTS
RH 3.4 Map1195.1UniSTS
Cytogenetic Map1p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2120,802,710 - 20,803,267 (+)MAPPERmRatBN7.2
Rnor_6.0121,852,169 - 21,852,725NCBIRnor6.0
Rnor_5.0123,332,056 - 23,332,612UniSTSRnor5.0
Celera119,554,839 - 19,555,395UniSTS
Cytogenetic Map1p12UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 42 7 1 2 17 34 30 11 1
Low 1 1 57 41 12 41 7 9 57 1 11 7
Below cutoff


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020528   ⟹   ENSRNOP00000020528
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl120,802,199 - 20,805,734 (-)Ensembl
Rnor_6.0 Ensembl121,851,660 - 21,854,773 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089196   ⟹   ENSRNOP00000074740
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl121,851,660 - 21,854,763 (-)Ensembl
RefSeq Acc Id: NM_022266   ⟹   NP_071602
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2120,802,199 - 20,805,315 (-)NCBI
Rnor_6.0121,851,657 - 21,854,773 (-)NCBI
Rnor_5.0123,331,544 - 23,334,660 (-)NCBI
RGSC_v3.4121,327,099 - 21,330,215 (-)RGD
Celera119,554,327 - 19,557,443 (-)RGD
Reference Sequences
RefSeq Acc Id: NP_071602   ⟸   NM_022266
- Peptide Label: precursor
- UniProtKB: Q9WVS1 (UniProtKB/Swiss-Prot),   Q9R1E9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074740   ⟸   ENSRNOT00000089196
RefSeq Acc Id: ENSRNOP00000020528   ⟸   ENSRNOT00000020528
Protein Domains
CTCK   IGFBP N-terminal   TSP type-1   VWFC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R1E9-F1-model_v2 AlphaFold Q9R1E9 1-347 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13689528
Promoter ID:EPDNEW_R52
Type:multiple initiation site
Description:connective tissue growth factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0121,854,774 - 21,854,834EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621392 AgrOrtholog
BioCyc Gene G2FUF-62111 BioCyc
Ensembl Genes ENSRNOG00000015036 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020528.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020528.6 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cys_knot_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hormone_CN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_CNN UniProtKB/Swiss-Prot
  Insulin_GF-bd_Cys-rich_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_CCN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64032 UniProtKB/Swiss-Prot
Pfam Cys_knot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_CCN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ccn2 PhenoGen
PROSITE CTCK_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTCK_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_N_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00041 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00121 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP FnI-like domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTGF_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q53YJ0 UniProtKB/Swiss-Prot
  Q9WVS1 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-10-22 Ccn2  cellular communication network factor 2  Ctgf  connective tissue growth factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Ctgf  connective tissue growth factor      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Ctgf  connective tissue growth factor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in granulosa cells of preantral and early antral follicles, in granulosa and theca of the porcine ovary 628364
gene_expression expression is inversely related to the stage of granulosa cell differentiation 628364
gene_function a novel ligand for integrin receptors 628364
gene_function heparin binding protein 628364
gene_process mediates mitosis, angiogenesis, cellular chemotaxis and remodeling of the extracellular matrix of the epithelial cells types 628364
gene_process a novel ligand for integrin receptors  
gene_product member of the CTGF/cysteine-rich 61/nephroblastoma overexpressed gene family 628364
gene_regulation mRNA in nondifferentiated granulosa cells increased in vitro by TGFb1, growth/differentiation factor-9, and activin 628364
gene_regulation expression is directly inhibited by FSH via cAMP-mediated signaling 628364
gene_regulation expression is upregulated in osteopetrosis 632527