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Gene: Ccn2 (cellular communication network factor 2) Rattus norvegicus
Symbol: Ccn2
Name: cellular communication network factor 2
Description: Exhibits fibronectin binding activity and growth factor activity. Involved in several processes, including positive regulation of G0 to G1 transition; positive regulation of collagen biosynthetic process; and positive regulation of macromolecule metabolic process. Localizes to several cellular components, including cell cortex; cis-Golgi network; and perinuclear region of cytoplasm. Used to study endomyocardial fibrosis. Biomarker of several diseases, including artery disease (multiple); lung disease (multiple); membranoproliferative glomerulonephritis; primary biliary cirrhosis; and restrictive cardiomyopathy (multiple). Orthologous to human CCN2 (cellular communication network factor 2); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH (R)-carnitine; (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CCN family member 2; connective tissue growth factor; connective tissue growth-related protein; Ctgf; CTGRP
Homo sapiens (human) : CCN2 (cellular communication network factor 2)  HGNC  Alliance
Mus musculus (house mouse) : Ccn2 (cellular communication network factor 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ccn2 (cellular communication network factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CCN2 (cellular communication network factor 2)
Canis lupus familiaris (dog) : CCN2 (cellular communication network factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ccn2 (cellular communication network factor 2)
Sus scrofa (pig) : CCN2 (cellular communication network factor 2)
Chlorocebus sabaeus (African green monkey) : CCN2 (cellular communication network factor 2)
Heterocephalus glaber (naked mole-rat) : Ccn2 (cellular communication network factor 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0121,851,657 - 21,854,773 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,851,660 - 21,854,773 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,331,544 - 23,334,660 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,327,099 - 21,330,215 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1121,328,460 - 21,331,568 (-)NCBI
Celera119,554,327 - 19,557,443 (-)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ccn2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621392
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-07-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.