Ccn2 (cellular communication network factor 2) - Rat Genome Database

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Gene: Ccn2 (cellular communication network factor 2) Rattus norvegicus
Analyze
Symbol: Ccn2
Name: cellular communication network factor 2
RGD ID: 621392
Description: Enables fibronectin binding activity and growth factor activity. Involved in several processes, including positive regulation of G0 to G1 transition; positive regulation of collagen biosynthetic process; and positive regulation of macromolecule metabolic process. Located in several cellular components, including cell cortex; cis-Golgi network; and perinuclear region of cytoplasm. Used to study endomyocardial fibrosis. Biomarker of several diseases, including artery disease (multiple); lung disease (multiple); membranoproliferative glomerulonephritis; primary biliary cholangitis; and restrictive cardiomyopathy (multiple). Orthologous to human CCN2 (cellular communication network factor 2); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH (R)-carnitine; (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CCN family member 2; connective tissue growth factor; connective tissue growth-related protein; Ctgf; CTGRP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2120,802,199 - 20,805,315 (-)NCBI
Rnor_6.0 Ensembl121,851,660 - 21,854,773 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0121,851,657 - 21,854,773 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0123,331,544 - 23,334,660 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,327,099 - 21,330,215 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1121,328,460 - 21,331,568 (-)NCBI
Celera119,554,327 - 19,557,443 (-)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-carnitine  (EXP)
(S)-nicotine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-butoxyethanol  (ISO)
2-methoxyethanol  (EXP)
2-tert-butylhydroquinone  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-phenylprop-2-enal  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (ISO)
adenine  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-D-galactose  (EXP)
ammonium chloride  (EXP)
andrographolide  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
bazedoxifene  (ISO)
belinostat  (ISO)
benazepril  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP,ISO)
Betanin  (EXP)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bromobenzene  (EXP)
bucladesine  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
camostat  (EXP)
candesartan  (EXP)
Candesartan cilexetil  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
cefaloridine  (EXP)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
coenzyme Q10  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
dexamethasone  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP,ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP)
enalapril  (EXP,ISO)
endosulfan  (EXP)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
etoposide  (ISO)
fisetin  (ISO)
folic acid  (ISO)
fomepizole  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
furan  (EXP)
galactose  (EXP)
genistein  (ISO)
glucose  (EXP,ISO)
Honokiol  (EXP,ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
idebenone  (EXP)
iloprost  (EXP)
indole-3-methanol  (EXP)
indometacin  (EXP)
irinotecan  (ISO)
isobutanol  (ISO)
isoprenaline  (EXP,ISO)
jaspamide  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
letrozole  (EXP)
Licochalcone B  (ISO)
limonin  (ISO)
lipopolysaccharide  (EXP,ISO)
lovastatin  (ISO)
LY 364947  (ISO)
LY294002  (ISO)
manganese(II) chloride  (EXP,ISO)
mechlorethamine  (EXP)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
metoprolol  (EXP,ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nicotine  (EXP)
nitric oxide  (ISO)
nitrofen  (EXP)
NSC 23766  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
olaparib  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
Paeonol  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
pentane-2,3-dione  (EXP)
Pentoxifylline  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (EXP,ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
platycodin D  (EXP)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
prostaglandin E2  (ISO)
puerarin  (ISO)
quercetin  (EXP,ISO)
ramipril  (EXP)
resveratrol  (EXP,ISO)
rofecoxib  (ISO)
rosmarinic acid  (EXP)
rotenone  (EXP)
rutin  (EXP)
saralasin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium tungstate  (ISO)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
spironolactone  (EXP)
stattic  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sunitinib  (EXP)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetramethylpyrazine  (ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
triamcinolone acetonide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vanillin  (ISO)
verteporfin  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin D  (ISO)
vorinostat  (ISO)
Y-27632  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
angiogenesis  (ISO,TAS)
cartilage condensation  (ISO)
cell adhesion  (IBA,TAS)
cell differentiation  (ISO)
cell migration  (ISO)
cell-matrix adhesion  (ISO)
chondrocyte proliferation  (ISO)
connective tissue development  (ISO)
cytosolic calcium ion transport  (IMP)
DNA biosynthetic process  (IEA)
extracellular matrix constituent secretion  (IMP)
fibroblast growth factor receptor signaling pathway  (ISO)
integrin-mediated signaling pathway  (ISO)
intracellular signal transduction  (IDA)
lung development  (IEP,ISO)
negative regulation of cell death  (IBA,IMP)
negative regulation of gene expression  (ISO)
ossification  (ISO)
positive regulation of cardiac muscle contraction  (IMP)
positive regulation of cell activation  (IMP)
positive regulation of cell death  (IMP)
positive regulation of cell differentiation  (ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of collagen biosynthetic process  (IMP)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IMP)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of G0 to G1 transition  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of JNK cascade  (ISO)
positive regulation of protein phosphorylation  (IMP)
positive regulation of stress fiber assembly  (ISO)
reactive oxygen species metabolic process  (ISO)
regulation of chondrocyte differentiation  (ISO)
response to amino acid  (IEP)
response to anoxia  (IEP)
response to estradiol  (IEP)
response to fatty acid  (IEP)
response to glucose  (IEP)
response to mineralocorticoid  (IEP)
response to organic cyclic compound  (IEP)
response to peptide hormone  (IEP)
signal transduction  (IBA,IEA)
tissue homeostasis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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2. Ares-Carrasco S, etal., Am J Physiol Heart Circ Physiol. 2009 Oct 9.
3. Barbolina MV, etal., Int J Cancer. 2009 Aug 15;125(4):816-25.
4. Bu YH, etal., J Endocrinol Invest. 2009 May 26.
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6. Champetier S, etal., Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H669-77. Epub 2008 Dec 26.
7. Chen L, etal., Exp Ther Med. 2018 May;15(5):4318-4324. doi: 10.3892/etm.2018.5952. Epub 2018 Mar 13.
8. Chen Y, etal., Exp Cell Res. 2001 Nov 15;271(1):109-17.
9. Chen Y, etal., Kidney Int 2002 Oct;62(4):1149-59.
10. Cortijo J, etal., Br J Pharmacol. 2009 Feb;156(3):534-44.
11. Fan WH and Karnovsky MJ, J Biol Chem 2002 Mar 22;277(12):9800-5.
12. Fedorczyk JM, etal., J Orthop Res. 2009 Sep 9.
13. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. GOA data from the GO Consortium
15. Harlow CR, etal., Endocrinology 2002 Sep;143(9):3316-25.
16. Ihm SH, etal., Basic Res Cardiol. 2009 Oct 23.
17. Kajikawa S, etal., Dig Dis Sci. 2009 Oct 24.
18. Kim KH, etal., Biochem Biophys Res Commun. 2004 Jun 11;318(4):819-25.
19. Kundi R, etal., Cardiovasc Res. 2009 Nov 1;84(2):326-35. Epub 2009 Jul 1.
20. Lempinen M, etal., Eur Surg Res 2002 May-Jun;34(3):232-8.
21. Li G, etal., J Gene Med. 2008 Sep;10(9):1039-47.
22. Li H, etal., Eur J Pharmacol. 2009 Nov 4.
23. Li X, etal., Exp Biol Med (Maywood). 2009 May;234(5):504-12. Epub 2009 Feb 20.
24. Li Y, etal., Clin Invest Med. 2009 Jun 1;32(3):229-238.
25. Liu DG and Wang TM, Chin Med J (Engl). 2008 Oct 5;121(19):1925-31.
26. Liu N, etal., Am J Physiol Renal Physiol. 2004 Oct;287(4):F612-20. Epub 2004 Jun 1.
27. Louhelainen M, etal., J Hypertens. 2009 Oct;27(10):2094-107.
28. Lubel JS, etal., Clin Sci (Lond). 2009 Sep 14;117(11):375-86.
29. Luo GH, etal., Transplant Proc. 2008 Oct;40(8):2800-3.
30. Luo GH, etal., Transplant Proc. 2008 Sep;40(7):2365-9.
31. Ma FY, etal., Am J Physiol Renal Physiol. 2009 Jan;296(1):F177-85. Epub 2008 Nov 5.
32. McClain JA, etal., Neurosci Lett. 2009 Aug 21;460(1):27-31. Epub 2009 May 20.
33. Mesas-Burgos C, etal., J Pediatr Surg. 2009 Apr;44(4):720-8.
34. MGD data from the GO Consortium
35. Morrison JP, etal., Toxicol Pathol. 2009;37(4):502-11. Epub 2009 Apr 24.
36. Murphy M, etal., J Biol Chem 1999 Feb 26;274(9):5830-4.
37. Nakanishi T, etal., Biochem Biophys Res Commun 2001 Mar 2;281(3):678-81.
38. NCBI rat LocusLink and RefSeq merged data July 26, 2002
39. Ou XM, etal., Respirology. 2009 Jul;14(5):734-45.
40. Panek AN, etal., PLoS One. 2009 Aug 25;4(8):e6743.
41. Pi L, etal., Hepatology. 2008 Mar;47(3):996-1004.
42. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
43. Ren X, etal., Pharmacology. 2009;83(2):80-7. Epub 2008 Dec 9.
44. RGD automated data pipeline
45. RGD automated import pipeline for gene-chemical interactions
46. Riser BL, etal., Am J Pathol. 2009 May;174(5):1725-34. Epub 2009 Apr 9.
47. Shi Y, etal., Scand J Urol Nephrol. 2009 Aug 9:1-10.
48. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
49. Tang Y, etal., J Nutr Biochem. 2009 Apr 13.
50. Thomas M, etal., Synapse. 2009 Oct;63(10):881-94.
51. Twigg SM, etal., Endocrinology 2002 Dec;143(12):4907-15.
52. Varma H, etal., J Biol Chem. 2010 Nov 26;285(48):37445-57. doi: 10.1074/jbc.M110.125542. Epub 2010 Sep 21.
53. Wang XY, etal., Am J Physiol Cell Physiol. 2009 Jul 22.
54. Xi S, etal., Exp Mol Med. 2009 Aug 31;41(8):538-47.
55. Xia Z, etal., Cardiovasc Res. 2007 Mar 1;73(4):770-82. Epub 2006 Nov 30.
56. Xu J, etal., J Cell Biochem 2000 Feb;77(1):103-15.
57. Yamahara H, etal., Kidney Blood Press Res. 2009;32(3):185-93. Epub 2009 Jun 12.
58. Yang F, etal., Hypertension. 2009 Oct;54(4):877-84. Epub 2009 Aug 10.
59. Yang F, etal., Parasitol Int. 2016 Aug;65(4):308-15. doi: 10.1016/j.parint.2016.03.001. Epub 2016 Mar 2.
60. Ying L, etal., J Cell Sci. 2009 May 1;122(Pt 9):1441-51. Epub 2009 Apr 14.
61. Yokoi H, etal., Am J Physiol Renal Physiol 2002 May;282(5):F933-42.
62. Yuan YC, etal., J Formos Med Assoc. 2009 Mar;108(3):240-6.
63. Zagorski J, etal., Physiol Genomics. 2009 Sep 9;39(1):61-71. Epub 2009 Jul 14.
Additional References at PubMed
PMID:1888698   PMID:9184077   PMID:9927660   PMID:10082563   PMID:10393331   PMID:10446209   PMID:11988308   PMID:12199527   PMID:12217894   PMID:12736220   PMID:12763067   PMID:12767040  
PMID:12819040   PMID:12952842   PMID:14586741   PMID:14592956   PMID:15153554   PMID:15221486   PMID:15305294   PMID:15345671   PMID:15389880   PMID:15662226   PMID:15780081   PMID:16143139  
PMID:16294326   PMID:16306131   PMID:16374037   PMID:16463662   PMID:16636587   PMID:16707502   PMID:16914537   PMID:16926534   PMID:17133352   PMID:17229371   PMID:17278980   PMID:17318787  
PMID:17407709   PMID:17597657   PMID:17606220   PMID:17629588   PMID:17944991   PMID:17989112   PMID:18030501   PMID:18187544   PMID:18213577   PMID:18266973   PMID:18287961   PMID:18314002  
PMID:18364077   PMID:18375200   PMID:18397232   PMID:18401334   PMID:18597638   PMID:18639630   PMID:18644231   PMID:18782537   PMID:18790235   PMID:18846337   PMID:18846344   PMID:19032869  
PMID:19096030   PMID:19099753   PMID:19111553   PMID:19349682   PMID:19364818   PMID:19468237   PMID:19620052   PMID:19662997   PMID:19921985   PMID:19959709   PMID:20008146   PMID:20039536  
PMID:20039857   PMID:20369462   PMID:20432467   PMID:20534773   PMID:20576680   PMID:20684283   PMID:20689330   PMID:20809981   PMID:20936727   PMID:20979869   PMID:21092636   PMID:21126421  
PMID:21138629   PMID:21144460   PMID:21170500   PMID:21209863   PMID:21215756   PMID:21245987   PMID:21258935   PMID:21295007   PMID:21382976   PMID:21576830   PMID:21659659   PMID:21762408  
PMID:21804025   PMID:21814837   PMID:21914267   PMID:21928352   PMID:22097728   PMID:22334618   PMID:22363806   PMID:22899499   PMID:23099153   PMID:23207149   PMID:23383241   PMID:23456538  
PMID:23530034   PMID:23839921   PMID:23848567   PMID:24006456   PMID:24083993   PMID:24613393   PMID:24839947   PMID:25003484   PMID:25012526   PMID:25177951   PMID:25815693   PMID:25833297  
PMID:26340021   PMID:26392029   PMID:26600407   PMID:26894526   PMID:26945889   PMID:27049870   PMID:27126736   PMID:27322082   PMID:27427487   PMID:27597128   PMID:28816418   PMID:29058957  
PMID:29175126   PMID:29179208   PMID:29187583   PMID:29198711   PMID:29861095   PMID:30268161   PMID:30965128   PMID:31041999   PMID:31127659   PMID:31183597   PMID:31267533   PMID:31830619  
PMID:33065236   PMID:33604679  


Genomics

Comparative Map Data
Ccn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2120,802,199 - 20,805,315 (-)NCBI
Rnor_6.0 Ensembl121,851,660 - 21,854,773 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0121,851,657 - 21,854,773 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0123,331,544 - 23,334,660 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,327,099 - 21,330,215 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1121,328,460 - 21,331,568 (-)NCBI
Celera119,554,327 - 19,557,443 (-)NCBICelera
Cytogenetic Map1p12NCBI
CCN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6131,948,176 - 131,951,372 (-)EnsemblGRCh38hg38GRCh38
GRCh386131,948,176 - 131,951,372 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376132,269,316 - 132,272,512 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366132,311,009 - 132,314,211 (-)NCBINCBI36hg18NCBI36
Build 346132,311,017 - 132,314,147NCBI
Celera6133,016,448 - 133,019,647 (-)NCBI
Cytogenetic Map6q23.2NCBI
HuRef6129,844,775 - 129,847,974 (-)NCBIHuRef
CHM1_16132,533,071 - 132,536,270 (-)NCBICHM1_1
Ccn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391024,471,340 - 24,474,581 (+)NCBIGRCm39mm39
GRCm39 Ensembl1024,471,340 - 24,474,581 (+)Ensembl
GRCm381024,595,442 - 24,598,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1024,595,442 - 24,598,683 (+)EnsemblGRCm38mm10GRCm38
MGSCv371024,315,248 - 24,318,489 (+)NCBIGRCm37mm9NCBIm37
MGSCv361024,284,923 - 24,288,096 (+)NCBImm8
Celera1025,537,033 - 25,540,272 (+)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1011.84NCBI
Ccn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543612,522,944 - 12,526,480 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543612,523,602 - 12,526,986 (-)NCBIChiLan1.0ChiLan1.0
CCN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16133,836,319 - 133,839,017 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6133,836,319 - 133,842,077 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06129,729,572 - 129,733,113 (-)NCBIMhudiblu_PPA_v0panPan3
CCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1125,508,082 - 25,511,058 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl125,507,662 - 25,510,145 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha126,004,899 - 26,007,816 (-)NCBI
ROS_Cfam_1.0124,930,014 - 24,932,944 (-)NCBI
UMICH_Zoey_3.1124,975,729 - 24,978,649 (-)NCBI
UNSW_CanFamBas_1.0124,865,809 - 24,868,736 (-)NCBI
UU_Cfam_GSD_1.0125,137,679 - 25,140,601 (-)NCBI
Ccn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946120,263,340 - 120,266,574 (-)NCBI
SpeTri2.0NW_00493656042,561 - 45,748 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl131,673,798 - 31,677,696 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1131,674,398 - 31,677,697 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2135,134,660 - 35,137,098 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11341,613,838 - 41,617,010 (+)NCBI
ChlSab1.1 Ensembl1341,613,798 - 41,617,651 (+)Ensembl
Vero_WHO_p1.0NW_02366604013,786,737 - 13,789,973 (+)NCBI
Ccn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247536,022,033 - 6,024,866 (-)NCBI

Position Markers
RH134556  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2120,802,376 - 20,802,566 (+)MAPPER
Rnor_6.0121,851,835 - 21,852,024NCBIRnor6.0
Rnor_5.0123,331,722 - 23,331,911UniSTSRnor5.0
RGSC_v3.4121,327,277 - 21,327,466UniSTSRGSC3.4
Celera119,554,505 - 19,554,694UniSTS
RH 3.4 Map1194.0UniSTS
Cytogenetic Map1p12UniSTS
AI555745  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2120,802,274 - 20,802,365 (+)MAPPER
Rnor_6.0121,851,733 - 21,851,823NCBIRnor6.0
Rnor_5.0123,331,620 - 23,331,710UniSTSRnor5.0
RGSC_v3.4121,327,175 - 21,327,265UniSTSRGSC3.4
Celera119,554,403 - 19,554,493UniSTS
RH 3.4 Map1195.1UniSTS
Cytogenetic Map1p12UniSTS
Ctgf  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2120,802,710 - 20,803,267 (+)MAPPER
Rnor_6.0121,852,169 - 21,852,725NCBIRnor6.0
Rnor_5.0123,332,056 - 23,332,612UniSTSRnor5.0
Celera119,554,839 - 19,555,395UniSTS
Cytogenetic Map1p12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124368159Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128468970Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1134993530Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1134993530Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)1134993530Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1164407321Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)125439343579402Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)125439343579402Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)125439343579402Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)125439386904217Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1186804543724576Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1457869349578693Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15655769122614963Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1565577285706974Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11131448975844121Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11131448983657083Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11131448983657083Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11131448983657083Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11131448983657083Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11131465834993348Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11249343957493439Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11362925158629251Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11614314349547474Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11614314349547474Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12034156058000154Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12107930566079305Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12130082249454378Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12181262344409802Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:637
Count of miRNA genes:301
Interacting mature miRNAs:387
Transcripts:ENSRNOT00000020528
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 42 7 1 2 17 34 30 11 1
Low 1 1 57 41 12 41 7 9 57 1 11 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020528   ⟹   ENSRNOP00000020528
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl121,851,660 - 21,854,773 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089196   ⟹   ENSRNOP00000074740
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl121,851,660 - 21,854,763 (-)Ensembl
RefSeq Acc Id: NM_022266   ⟹   NP_071602
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2120,802,199 - 20,805,315 (-)NCBI
Rnor_6.0121,851,657 - 21,854,773 (-)NCBI
Rnor_5.0123,331,544 - 23,334,660 (-)NCBI
RGSC_v3.4121,327,099 - 21,330,215 (-)RGD
Celera119,554,327 - 19,557,443 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_071602   ⟸   NM_022266
- Peptide Label: precursor
- UniProtKB: Q9R1E9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074740   ⟸   ENSRNOT00000089196
RefSeq Acc Id: ENSRNOP00000020528   ⟸   ENSRNOT00000020528
Protein Domains
CTCK   IGFBP N-terminal   TSP type-1   VWFC

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689528
Promoter ID:EPDNEW_R52
Type:multiple initiation site
Name:Ctgf_1
Description:connective tissue growth factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0121,854,774 - 21,854,834EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621392 AgrOrtholog
Ensembl Genes ENSRNOG00000015036 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020528 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000074740 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020528 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000089196 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7098774 IMAGE-MGC_LOAD
InterPro Cys_knot_C UniProtKB/Swiss-Prot
  Glyco_hormone_CN UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_CNN UniProtKB/Swiss-Prot
  Insulin_GF-bd_Cys-rich_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_CCN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64032 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91697 IMAGE-MGC_LOAD
NCBI Gene 64032 ENTREZGENE
Pfam Cys_knot UniProtKB/Swiss-Prot
  IGFBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_CCN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ccn2 PhenoGen
PIRSF IGFBP_rP_CNN UniProtKB/Swiss-Prot
PROSITE CTCK_1 UniProtKB/Swiss-Prot
  CTCK_2 UniProtKB/Swiss-Prot
  IGFBP_N_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00041 UniProtKB/Swiss-Prot
  SM00121 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CTGF_RAT UniProtKB/Swiss-Prot
  Q6IN11_RAT UniProtKB/TrEMBL
  Q9R1E9 ENTREZGENE
UniProt Secondary Q53YJ0 UniProtKB/Swiss-Prot
  Q9WVS1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-10-22 Ccn2  cellular communication network factor 2  Ctgf  connective tissue growth factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Ctgf  connective tissue growth factor      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Ctgf  connective tissue growth factor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in granulosa cells of preantral and early antral follicles, in granulosa and theca of the porcine ovary 628364
gene_expression expression is inversely related to the stage of granulosa cell differentiation 628364
gene_function a novel ligand for integrin receptors 628364
gene_function heparin binding protein 628364
gene_process mediates mitosis, angiogenesis, cellular chemotaxis and remodeling of the extracellular matrix of the epithelial cells types 628364
gene_process a novel ligand for integrin receptors  
gene_product member of the CTGF/cysteine-rich 61/nephroblastoma overexpressed gene family 628364
gene_regulation mRNA in nondifferentiated granulosa cells increased in vitro by TGFb1, growth/differentiation factor-9, and activin 628364
gene_regulation expression is directly inhibited by FSH via cAMP-mediated signaling 628364
gene_regulation expression is upregulated in osteopetrosis 632527