Reln (reelin) - Rat Genome Database

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Gene: Reln (reelin) Rattus norvegicus
Symbol: Reln
Name: reelin
RGD ID: 3553
Description: Predicted to enable very-low-density lipoprotein particle receptor binding activity. Involved in several processes, including nervous system development; response to steroid hormone; and social behavior. Located in several cellular components, including axon; dendrite; and perikaryon. Biomarker of hypothyroidism and status epilepticus. Human ortholog(s) of this gene implicated in Norman-Roberts syndrome; autistic disorder; familial temporal lobe epilepsy 7; and schizophrenia. Orthologous to human RELN (reelin); PARTICIPATES IN Reelin signaling pathway; altered Reelin signaling pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH (R)-lipoic acid; (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Previously known as: Reelen; reeler; Rl
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   KZC/Tky  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8413,628,440 - 14,055,201 (+)NCBIGRCr8
mRatBN7.2412,736,177 - 13,162,956 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl412,736,130 - 13,162,211 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx417,880,111 - 18,309,565 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0413,705,793 - 14,126,350 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0412,061,189 - 12,495,212 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.049,347,533 - 9,774,257 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl49,347,528 - 9,773,670 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.049,349,408 - 9,775,894 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.448,150,873 - 8,609,141 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.148,150,872 - 8,609,141 (+)NCBI
Celera48,330,632 - 8,754,202 (+)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (EXP)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chaetocin  (EXP)
chlordecone  (ISO)
chlorpyrifos  (EXP)
cisplatin  (EXP)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
diallyl trisulfide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzacamene  (EXP)
epoxiconazole  (EXP,ISO)
ethanol  (EXP,ISO)
fluoxetine  (EXP)
flutamide  (EXP)
fulvestrant  (ISO)
genistein  (ISO)
glutathione  (EXP)
glyphosate  (EXP)
graphite  (EXP)
haloperidol  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
linuron  (EXP)
lipoic acid  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
LY294002  (ISO)
malathion  (ISO)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
morphine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodimethylamine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nicotine  (EXP)
nimesulide  (EXP)
olanzapine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PD 0325901  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phencyclidine  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
propiconazole  (ISO)
pyrimidifen  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sterigmatocystin  (EXP)
sulfadimethoxine  (EXP)
sulpiride  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vigabatrin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
associative learning  (IEA,ISO)
axon guidance  (IEA,ISO,ISS)
brain development  (ISO,ISS)
cell adhesion  (IEA)
cell migration  (ISO)
cell morphogenesis  (ISO,ISS)
cellular response to dexamethasone stimulus  (IEP)
central nervous system development  (IBA,IEA,ISO,ISS)
cerebral cortex development  (IEP,ISO)
cerebral cortex tangential migration  (IEA,ISO,ISS)
dendrite development  (IEA,ISO)
dentate gyrus development  (IMP)
forebrain development  (ISO)
glial cell differentiation  (IEA,ISO,ISS)
hippocampus development  (IEA,ISO)
hypothalamus development  (IEP)
interneuron migration  (IEA,ISO)
lateral motor column neuron migration  (IEA,ISO)
layer formation in cerebral cortex  (IEA,ISO)
learning  (ISO)
locomotory behavior  (IEA,IMP,ISO)
long-term memory  (IEA,ISO)
long-term synaptic potentiation  (IEA,ISO)
memory  (IEP)
midgut development  (IEP)
modulation of chemical synaptic transmission  (ISO)
motor neuron migration  (ISO)
neuron migration  (IBA,IEA,IMP,ISO,ISS)
NMDA glutamate receptor clustering  (IEA,ISO)
orbitofrontal cortex development  (IEP)
positive regulation of dendritic spine morphogenesis  (IEA,ISO)
positive regulation of excitatory postsynaptic potential  (IEA,ISO)
positive regulation of lateral motor column neuron migration  (IEA,ISO)
positive regulation of long-term synaptic potentiation  (IEA,ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of small GTPase mediated signal transduction  (IEA,ISO,ISS)
positive regulation of synapse maturation  (IEA,ISO)
positive regulation of synaptic transmission, glutamatergic  (IEA,ISO)
positive regulation of TOR signaling  (IEA,ISO)
postsynaptic density protein 95 clustering  (IEA,ISO)
protein localization to synapse  (IEA,ISO)
proteolysis  (IEA)
receptor localization to synapse  (IEA,ISO)
reelin-mediated signaling pathway  (IEA,ISO)
regulation of behavior  (IEA,ISO)
regulation of gene expression  (IEA,ISO)
regulation of synapse maturation  (ISO)
response to amino acid  (IEP)
response to axon injury  (IEP)
response to corticosterone  (IEP)
response to electrical stimulus  (IEP)
response to ethanol  (IEP)
response to fatty acid  (IEP)
response to hormone  (IEP)
response to insecticide  (IEP)
response to mechanical stimulus  (IEP)
response to organic cyclic compound  (IEP)
response to pain  (IEA,ISO,ISS)
response to progesterone  (IEP)
response to toxic substance  (IEP)
response to xenobiotic stimulus  (IEP)
social behavior  (IEP)
spinal cord patterning  (IEA,IEP,ISO,ISS)
thyroid hormone metabolic process  (ISO)
ventral spinal cord development  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Thyroid hormone regulates reelin and dab1 expression during brain development. Alvarez-Dolado M, etal., J Neurosci 1999 Aug 15;19(16):6979-93.
2. Three autism candidate genes: a synthesis of human genetic analysis with other disciplines. Bartlett CW, etal., Int J Dev Neurosci 2005 Apr-May;23(2-3):221-34.
3. Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta. Beffert U, etal., J Biol Chem 2002 Dec 20;277(51):49958-64.
4. Effect of developmental exposure to chlorpyrifos on the expression of neurotrophin growth factors and cell-specific markers in neonatal rat brain. Betancourt AM, etal., Toxicol Sci. 2006 Aug;92(2):500-6. Epub 2006 May 4.
5. Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination. Bock HH, etal., J Biol Chem 2003 Oct 3;278(40):38772-9. Epub 2003 Jul 25.
6. Reelin is overexpressed in the liver and plasma of bile duct ligated rats and its levels and glycosylation are altered in plasma of humans with cirrhosis. Botella-Lopez A, etal., Int J Biochem Cell Biol. 2008;40(4):766-75.
7. Beta-amyloid controls altered Reelin expression and processing in Alzheimer's disease. Botella-López A, etal., Neurobiol Dis. 2010 Mar;37(3):682-91. doi: 10.1016/j.nbd.2009.12.006. Epub 2009 Dec 16.
8. Developmental emergence of reelin deficits in the prefrontal cortex of Wistar rats reared in social isolation. Cassidy AW, etal., Neuroscience. 2010 Mar 17;166(2):377-85. Epub 2009 Dec 24.
9. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. D'Arcangelo G, etal., Nature. 1995 Apr 20;374(6524):719-23.
10. Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network. Devlin B, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126B(1):46-50.
11. Reelin signaling is impaired in autism. Fatemi SH, etal., Biol Psychiatry. 2005 Apr 1;57(7):777-87.
12. Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression. Fatemi SH, etal., Mol Psychiatry. 2000 Nov;5(6):654-63, 571.
13. Chronic psychotropic drug treatment causes differential expression of Reelin signaling system in frontal cortex of rats. Fatemi SH, etal., Schizophr Res. 2009 Jun;111(1-3):138-52. Epub 2009 Apr 9.
14. The effect of amygdala kindling on hippocampal neurogenesis coincides with decreased reelin and DISC1 expression in the adult dentate gyrus. Fournier NM, etal., Hippocampus. 2009 Jun 4.
15. Rat small intestine expresses the reelin-Disabled-1 signalling pathway. Garcia-Miranda P, etal., Exp Physiol. 2010 Apr;95(4):498-507. Epub 2009 Nov 27.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. Reelin regulates neuronal progenitor migration in intact and epileptic hippocampus. Gong C, etal., J Neurosci. 2007 Feb 21;27(8):1803-11.
19. Reelin promoter hypermethylation in schizophrenia. Grayson DR, etal., Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9341-6. Epub 2005 Jun 16.
20. C-Terminal Region Truncation of RELN Disrupts an Interaction with VLDLR, Causing Abnormal Development of the Cerebral Cortex and Hippocampus. Ha S, etal., J Neurosci. 2017 Jan 25;37(4):960-971. doi: 10.1523/JNEUROSCI.1826-16.2016.
21. Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy. Haas CA, etal., J Neurosci. 2002 Jul 15;22(14):5797-802.
22. Reelin signaling directly affects radial glia morphology and biochemical maturation. Hartfuss E, etal., Development 2003 Oct;130(19):4597-609.
23. Postnatal effect of embryonic neurogenesis disturbance on reelin level in organotypic cultures of rat hippocampus. Hoareau C, etal., Brain Res. 2006 Jun 30;1097(1):43-51. Epub 2006 May 30.
24. Interaction of reelin with amyloid precursor protein promotes neurite outgrowth. Hoe HS, etal., J Neurosci. 2009 Jun 10;29(23):7459-73.
25. Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations. Hong SE, etal., Nat Genet 2000 Sep;26(1):93-6.
26. A decrease of reelin expression as a putative vulnerability factor in schizophrenia. Impagnatiello F, etal., Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15718-23.
27. Creeping: a new mutant rat with neurological disease. Ishibashi K, etal., Lab Anim Sci 1989 Mar;39(2):132-6.
28. Polymorphisms of candidate genes in Slovak autistic patients. Kelemenova S, etal., Psychiatr Genet. 2010 Aug;20(4):137-9. doi: 10.1097/YPG.0b013e32833a1eb3.
29. Missplicing resulting from a short deletion in the reelin gene causes reeler-like neuronal disorders in the mutant shaking rat Kawasaki. Kikkawa S, etal., J Comp Neurol 2003 Aug 25;463(3):303-15.
30. Expression of reelin in hepatic stellate cells and during hepatic tissue repair: a novel marker for the differentiation of HSC from other liver myofibroblasts. Kobold D, etal., J Hepatol. 2002 May;36(5):607-13.
31. Increased reelin promoter methylation is associated with granule cell dispersion in human temporal lobe epilepsy. Kobow K, etal., J Neuropathol Exp Neurol. 2009 Apr;68(4):356-64. doi: 10.1097/NEN.0b013e31819ba737.
32. Developmental distribution of reelin-positive cells and their secreted product in the rodent spinal cord. Kubasak MD, etal., J Comp Neurol. 2004 Jan 6;468(2):165-78.
33. Repeated exposure to corticosterone, but not restraint, decreases the number of reelin-positive cells in the adult rat hippocampus. Lussier AL, etal., Neurosci Lett. 2009 Aug 28;460(2):170-4. Epub 2009 May 27.
34. Reelin immunoreactivity in the adult neocortex: a comparative study in rodents, carnivores, and non-human primates. Martinez-Cerdeno V and Clasca F, Brain Res Bull. 2002 Feb-Mar 1;57(3-4):485-8.
35. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
36. Covalent modification of DNA regulates memory formation. Miller CA and Sweatt JD, Neuron. 2007 Mar 15;53(6):857-69.
37. Reelin-expressing neurons in the anterior commissure and corpus callosum of the rat. Misaki K, etal., Brain Res Dev Brain Res. 2004 Jan 31;148(1):89-96.
38. Ethanol induces heterotopias in organotypic cultures of rat cerebral cortex. Mooney SM, etal., Cereb Cortex. 2004 Oct;14(10):1071-80. Epub 2004 May 27.
39. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
40. Lack of Reelin causes malpositioning of nigral dopaminergic neurons: evidence from comparison of normal and Reln(rl) mutant mice. Nishikawa S, etal., J Comp Neurol 2003 Jun 23;461(2):166-73.
41. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
42. Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder. Persico AM, etal., Mol Psychiatry. 2001 Mar;6(2):150-9.
43. Cortical bitufted, horizontal, and Martinotti cells preferentially express and secrete reelin into perineuronal nets, nonsynaptically modulating gene expression. Pesold C, etal., Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3217-22.
44. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
45. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
46. Reelin promotes peripheral synapse elimination and maturation. Quattrocchi CC, etal., Science 2003 Aug 1;301(5633):649-53.
47. Extracellular matrix molecules and synaptic plasticity: immunomapping of intracellular and secreted Reelin in the adult rat brain. Ramos-Moreno T, etal., Eur J Neurosci. 2006 Jan;23(2):401-22.
48. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
49. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
50. Comprehensive gene review and curation RGD comprehensive gene curation
51. Neuroprotective effects of dihydroprogesterone and progesterone in an experimental model of nerve crush injury. Roglio I, etal., Neuroscience. 2008 Aug 26;155(3):673-85. Epub 2008 Jun 19.
52. Altered levels of cerebrospinal fluid reelin in frontotemporal dementia and Alzheimer's disease. Saez-Valero J, etal., J Neurosci Res 2003 Apr 1;72(1):132-6.
53. Lifelong impact of variations in maternal care on dendritic structure and function of cortical layer 2/3 pyramidal neurons in rat offspring. Smit-Rigter LA, etal., PLoS One. 2009;4(4):e5167. Epub 2009 Apr 9.
54. Administration of thyroid hormone increases reelin and brain-derived neurotrophic factor expression in rat hippocampus in vivo. Sui L, etal., Brain Res. 2010 Feb 8;1313:9-24. Epub 2009 Dec 16.
55. Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. Weaver IC, etal., Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3480-5. Epub 2006 Feb 16.
56. Reelin-deficient mice show impaired neurogenesis and increased stroke size. Won SJ, etal., Exp Neurol. 2006 Mar;198(1):250-9. Epub 2006 Jan 24.
57. Delayed cell migration in the developing rat brain following maternal omega 3 alpha linolenic acid dietary deficiency. Yavin E, etal., Neuroscience. 2009 Sep 15;162(4):1011-22. Epub 2009 May 14.
58. Rat neurological disease creeping is caused by a mutation in the reelin gene. Yokoi N, etal., Brain Res Mol Brain Res 2003 Apr 10;112(1-2):1-7.
59. Reelin is a positional signal for the lamination of dentate granule cells. Zhao S, etal., Development. 2004 Oct;131(20):5117-25.
Additional References at PubMed
PMID:10328932   PMID:10571240   PMID:11226314   PMID:11900467   PMID:12223565   PMID:12526740   PMID:14715136   PMID:14980731   PMID:15062102   PMID:15255972   PMID:15525772   PMID:15677725  
PMID:15703280   PMID:16207762   PMID:16324103   PMID:16580148   PMID:16901480   PMID:17229826   PMID:17694053   PMID:18778775   PMID:19409883   PMID:20347957   PMID:20357114   PMID:20368265  
PMID:20421250   PMID:20438765   PMID:20538740   PMID:20600205   PMID:20711475   PMID:20847152   PMID:21148112   PMID:21491433   PMID:21492744   PMID:21664258   PMID:21784155   PMID:21814183  
PMID:21852430   PMID:21858819   PMID:22469747   PMID:22595232   PMID:22665518   PMID:22871113   PMID:22990595   PMID:23385810   PMID:23478644   PMID:23493620   PMID:23608736   PMID:23803971  
PMID:24134921   PMID:24210904   PMID:24539699   PMID:25679528   PMID:25790952   PMID:25887698   PMID:27168410   PMID:27653801   PMID:28385118   PMID:28602919   PMID:29880879   PMID:30169690  
PMID:30433855   PMID:32115961   PMID:35797964  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8413,628,440 - 14,055,201 (+)NCBIGRCr8
mRatBN7.2412,736,177 - 13,162,956 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl412,736,130 - 13,162,211 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx417,880,111 - 18,309,565 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0413,705,793 - 14,126,350 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0412,061,189 - 12,495,212 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.049,347,533 - 9,774,257 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl49,347,528 - 9,773,670 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.049,349,408 - 9,775,894 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.448,150,873 - 8,609,141 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.148,150,872 - 8,609,141 (+)NCBI
Celera48,330,632 - 8,754,202 (+)NCBICelera
Cytogenetic Map4q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh387103,471,789 - 103,989,658 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7103,471,381 - 103,989,658 (-)EnsemblGRCh38hg38GRCh38
GRCh377103,112,236 - 103,630,105 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367102,899,473 - 103,417,198 (-)NCBINCBI36Build 36hg18NCBI36
Build 347102,706,187 - 103,223,913NCBI
Celera797,918,553 - 98,435,889 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef797,472,665 - 97,989,692 (-)NCBIHuRef
CHM1_17103,045,544 - 103,563,285 (-)NCBICHM1_1
T2T-CHM13v2.07104,786,230 - 105,303,683 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27102,473,053 - 102,990,385 (-)NCBI
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39522,089,452 - 22,549,703 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl522,089,452 - 22,549,700 (-)EnsemblGRCm39 Ensembl
GRCm38521,884,454 - 22,344,705 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl521,884,454 - 22,344,702 (-)EnsemblGRCm38mm10GRCm38
MGSCv37521,390,272 - 21,850,523 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36521,396,293 - 21,856,514 (-)NCBIMGSCv36mm8
Celera518,857,999 - 19,307,447 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map59.98NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554108,424,394 - 8,863,969 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554108,424,439 - 8,863,966 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v26140,332,563 - 140,853,083 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17188,602,533 - 189,123,051 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0795,464,285 - 95,984,813 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17108,208,344 - 108,728,037 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7108,208,344 - 108,728,037 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11816,275,822 - 16,773,875 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1816,275,837 - 16,773,875 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1815,920,416 - 16,416,804 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01816,579,791 - 17,064,382 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1816,579,785 - 17,064,382 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11816,349,469 - 16,829,572 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01816,282,254 - 16,767,463 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01816,555,196 - 17,036,210 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440511858,504,719 - 58,964,509 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647919,628,940 - 20,087,250 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647919,628,488 - 20,088,278 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl9103,460,863 - 103,963,883 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19103,460,855 - 103,963,728 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29114,069,880 - 114,180,603 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12172,440,988 - 72,951,173 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2172,440,160 - 72,950,747 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604231,044,210 - 31,561,114 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473925,472,561 - 25,918,167 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473925,472,626 - 25,918,064 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Reln
3044 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:426
Count of miRNA genes:220
Interacting mature miRNAs:265
Transcripts:ENSRNOT00000010521, ENSRNOT00000061858
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2413,045,402 - 13,045,633 (+)MAPPERmRatBN7.2
Rnor_6.049,657,095 - 9,657,325NCBIRnor6.0
Rnor_5.049,658,484 - 9,658,714UniSTSRnor5.0
RGSC_v3.448,490,768 - 8,490,998UniSTSRGSC3.4
RGSC_v3.448,490,767 - 8,490,998RGDRGSC3.4
RGSC_v3.148,490,768 - 8,490,998RGD
Celera48,637,529 - 8,637,759UniSTS
RH 3.4 Map439.9RGD
RH 3.4 Map439.9UniSTS
RH 2.0 Map465.7RGD
Cytogenetic Map4q11.2UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2413,162,841 - 13,162,927 (+)MAPPERmRatBN7.2
Rnor_6.049,774,143 - 9,774,228NCBIRnor6.0
Rnor_5.049,775,780 - 9,775,865UniSTSRnor5.0
RGSC_v3.448,609,169 - 8,609,254UniSTSRGSC3.4
Celera48,754,230 - 8,754,315UniSTS
Cytogenetic Map4q11.2UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2413,162,714 - 13,162,894 (+)MAPPERmRatBN7.2
Rnor_6.049,774,016 - 9,774,195NCBIRnor6.0
Rnor_5.049,775,653 - 9,775,832UniSTSRnor5.0
RGSC_v3.448,609,042 - 8,609,221UniSTSRGSC3.4
Celera48,754,103 - 8,754,282UniSTS
Cytogenetic Map4q11.2UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2413,055,115 - 13,055,266 (+)MAPPERmRatBN7.2
Rnor_6.049,666,429 - 9,666,579NCBIRnor6.0
Rnor_5.049,667,818 - 9,667,968UniSTSRnor5.0
RGSC_v3.448,501,582 - 8,501,732UniSTSRGSC3.4
Celera48,646,654 - 8,646,804UniSTS
RH 3.4 Map441.7UniSTS
Cytogenetic Map4q11.2UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2413,068,522 - 13,068,659 (+)MAPPERmRatBN7.2
Rnor_6.049,679,836 - 9,679,972NCBIRnor6.0
Rnor_5.049,681,225 - 9,681,361UniSTSRnor5.0
RGSC_v3.448,514,989 - 8,515,125UniSTSRGSC3.4
Celera48,660,061 - 8,660,197UniSTS
RH 3.4 Map439.9UniSTS
Cytogenetic Map4q11.2UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2413,162,625 - 13,162,852 (+)MAPPERmRatBN7.2
Rnor_6.049,773,927 - 9,774,153NCBIRnor6.0
Rnor_5.049,775,564 - 9,775,790UniSTSRnor5.0
RGSC_v3.448,608,953 - 8,609,179UniSTSRGSC3.4
Celera48,754,014 - 8,754,240UniSTS
RH 3.4 Map441.4UniSTS
Cytogenetic Map4q11.2UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2412,823,106 - 12,823,329 (+)MAPPERmRatBN7.2
Rnor_6.049,435,815 - 9,436,037NCBIRnor6.0
Rnor_5.049,436,037 - 9,436,259UniSTSRnor5.0
RGSC_v3.448,257,094 - 8,257,316UniSTSRGSC3.4
Celera48,415,973 - 8,416,195UniSTS
RH 3.4 Map441.4UniSTS
Cytogenetic Map4q11.2UniSTS

Related Rat Strains
The following Strains have been annotated to Reln


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 41 32 1 32 68 2 4
Low 3 39 16 9 18 9 8 8 6 29 34 11 8
Below cutoff 2 3 4 3


RefSeq Acc Id: ENSRNOT00000010521   ⟹   ENSRNOP00000010521
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl412,736,130 - 13,162,211 (+)Ensembl
Rnor_6.0 Ensembl49,347,528 - 9,773,670 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000061858   ⟹   ENSRNOP00000058574
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl412,736,130 - 13,162,211 (+)Ensembl
Rnor_6.0 Ensembl49,347,779 - 9,773,217 (+)Ensembl
RefSeq Acc Id: NM_080394   ⟹   NP_536319
Rat AssemblyChrPosition (strand)Source
GRCr8413,628,568 - 14,055,059 (+)NCBI
mRatBN7.2412,736,299 - 13,162,814 (+)NCBI
Rnor_6.049,347,607 - 9,774,115 (+)NCBI
Rnor_5.049,349,408 - 9,775,894 (+)NCBI
RGSC_v3.448,150,873 - 8,609,141 (+)RGD
Celera48,330,632 - 8,754,202 (+)RGD
RefSeq Acc Id: XM_006235873   ⟹   XP_006235935
Rat AssemblyChrPosition (strand)Source
GRCr8413,628,451 - 14,055,201 (+)NCBI
mRatBN7.2412,736,177 - 13,162,956 (+)NCBI
Rnor_6.049,347,533 - 9,774,257 (+)NCBI
Rnor_5.049,349,408 - 9,775,894 (+)NCBI
RefSeq Acc Id: XM_039107060   ⟹   XP_038962988
Rat AssemblyChrPosition (strand)Source
GRCr8413,628,440 - 14,054,075 (+)NCBI
mRatBN7.2412,736,177 - 13,156,893 (+)NCBI
RefSeq Acc Id: XM_039107062   ⟹   XP_038962990
Rat AssemblyChrPosition (strand)Source
GRCr8413,628,451 - 14,054,075 (+)NCBI
mRatBN7.2412,736,177 - 13,156,893 (+)NCBI
RefSeq Acc Id: NP_536319   ⟸   NM_080394
- Peptide Label: precursor
- UniProtKB: Q80T65 (UniProtKB/Swiss-Prot),   P58751 (UniProtKB/Swiss-Prot),   F1LM29 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235935   ⟸   XM_006235873
- Peptide Label: isoform X3
- UniProtKB: Q80T65 (UniProtKB/Swiss-Prot),   P58751 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010521   ⟸   ENSRNOT00000010521
RefSeq Acc Id: ENSRNOP00000058574   ⟸   ENSRNOT00000061858
RefSeq Acc Id: XP_038962988   ⟸   XM_039107060
- Peptide Label: isoform X1
- UniProtKB: A6K598 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962990   ⟸   XM_039107062
- Peptide Label: isoform X2
- UniProtKB: A6K598 (UniProtKB/TrEMBL)
Protein Domains
EGF-like   Reelin


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692804
Promoter ID:EPDNEW_R3328
Type:single initiation site
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.049,347,781 - 9,347,841EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3553 AgrOrtholog
BioCyc Gene G2FUF-45993 BioCyc
Ensembl Genes ENSRNOG00000021441 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010521 ENTREZGENE
  ENSRNOT00000010521.9 UniProtKB/TrEMBL
  ENSRNOT00000061858.5 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Tenascin UniProtKB/TrEMBL
  Reeler_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reeler_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reelin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reelin_subrepeat-B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sialidase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24718 UniProtKB/Swiss-Prot
PANTHER PTHR11841 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REELIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF_Tenascin UniProtKB/TrEMBL
  Reeler UniProtKB/TrEMBL
  Reelin_subrepeat-B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Reln PhenoGen
PROSITE EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REELIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021441 RatGTEx
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50939 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RELN_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q80T65 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2001-05-08 Reln  Reelin      Name changed to reflect Human and Mouse nomenclature 62408 APPROVED
2001-05-08 Reln  Reeler      Name withdrawn, does not match Human and Mouse nomenclature 62408 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_disease mutation causes the autosomal recessive mutant creeping (cre) in the Komeda Zucker creeping (KZC) rat strain 727518
gene_disease mutation causes the autosomal recessive reeler-like abnormal locomoter phenotype in the shaking rat Kawasaki (SRK) 729917