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Gene: Casp12 (caspase 12) Rattus norvegicus
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Symbol: Casp12
Name: caspase 12
Description: Exhibits cysteine-type peptidase activity; endopeptidase activity; and protease binding activity. Involved in several processes, including aging; positive regulation of apoptotic process; and protein autoprocessing. Localizes to the cytosol and nucleus. Used to study sciatic neuropathy. Biomarker of several diseases, including diabetes mellitus (multiple); heart disease (multiple); neurodegenerative disease (multiple); post-traumatic stress disorder; and ureteral obstruction. Orthologous to human CASP12 (caspase 12 (gene/pseudogene)); PARTICIPATES IN Alzheimer's disease pathway; amyotrophic lateral sclerosis pathway; apoptotic cell death pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CASP-12; caspase-12
Orthologs:
Homo sapiens (human) : CASP12 (caspase 12 (gene/pseudogene))  HGNC  Alliance
Mus musculus (house mouse) : Casp12 (caspase 12)  MGI  Alliance
Canis lupus familiaris (dog) : CASP12 (caspase 12)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.082,658,892 - 2,686,160 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.082,680,961 - 2,711,365 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.482,082,933 - 2,110,511 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.182,082,932 - 2,110,511 (+)NCBI
Celera84,241,433 - 4,268,684 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Casp12
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621758
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.