Casp12 (caspase 12) - Rat Genome Database

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Gene: Casp12 (caspase 12) Rattus norvegicus
Symbol: Casp12
Name: caspase 12
RGD ID: 621758
Description: Enables cysteine-type peptidase activity; endopeptidase activity; and protease binding activity. Involved in several processes, including cellular response to hydrogen peroxide; positive regulation of striated muscle cell apoptotic process; and protein autoprocessing. Predicted to be located in endoplasmic reticulum. Predicted to be part of NLRP1 inflammasome complex. Predicted to be active in cytoplasm. Used to study sciatic neuropathy. Biomarker of several diseases, including diabetes mellitus (multiple); heart disease (multiple); neurodegenerative disease (multiple); post-traumatic stress disorder; and ureteral obstruction. Orthologous to human CASP12 (caspase 12 (gene/pseudogene)); PARTICIPATES IN Alzheimer's disease pathway; amyotrophic lateral sclerosis pathway; apoptotic cell death pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CASP-12; caspase-12
RGD Orthologs
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8810,927,188 - 10,954,442 (+)NCBIGRCr8
mRatBN7.282,642,296 - 2,669,549 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl82,642,434 - 2,674,037 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx86,605,520 - 6,632,760 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.084,903,288 - 4,930,529 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.082,893,978 - 2,921,241 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.082,658,892 - 2,686,160 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl82,659,865 - 2,686,160 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.082,680,961 - 2,711,365 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.482,082,933 - 2,110,511 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.182,082,932 - 2,110,511 (+)NCBI
Celera84,241,433 - 4,268,684 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-pilocarpine  (EXP)
(+)-Tetrandrine  (ISO)
(R)-noradrenaline  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-aminoethoxydiphenylborane  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4,5,3',4',5'-Hexachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-aminophenol  (EXP)
4-phenylbutyric acid  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
acrylonitrile  (ISO)
aflatoxin B1  (ISO)
agomelatine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (EXP)
alpha-naphthoflavone  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimony trichloride  (ISO)
apigenin  (ISO)
arsenic acid  (EXP)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
brefeldin A  (ISO)
C.I. Natural Red 20  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
Chikusetsusaponin-V  (ISO)
chloroacetic acid  (ISO)
chlorogenic acid  (EXP)
chlorohydrocarbon  (EXP)
chloroquine  (EXP)
chlorpyrifos  (EXP)
choline  (ISO)
chromium(6+)  (EXP)
cimetidine  (ISO)
cisplatin  (EXP,ISO)
citric acid  (ISO)
clofibric acid  (EXP)
clotrimazole  (EXP)
cobalt dichloride  (EXP)
cordycepin  (ISO)
corticosterone  (EXP)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
D-glucose  (EXP,ISO)
demethoxycurcumin  (ISO)
desferrioxamine B  (ISO)
Diacetoxyscirpenol  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (EXP,ISO)
edaravone  (EXP)
elemental selenium  (EXP)
emodin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
excitatory amino acid agonist  (ISO)
fisetin  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fomepizole  (ISO)
furan  (EXP,ISO)
furosemide  (EXP)
galactose  (EXP)
geneticin  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
GW 4064  (ISO)
heparin  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxamic acid  (EXP)
icosanoid  (EXP)
iron(III) nitrilotriacetate  (EXP)
isoflurane  (EXP)
ketoconazole  (ISO)
KN-93  (EXP)
L-glutamic acid  (EXP)
L-methionine  (ISO)
lead(0)  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
manganese(II) chloride  (EXP,ISO)
meglumine amidotrizoate  (EXP)
melatonin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
minocycline  (EXP)
Mitotane  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nickel sulfate  (EXP)
nicotine  (EXP,ISO)
ochratoxin A  (EXP)
oxidopamine  (EXP)
paclitaxel  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pifithrin-?  (EXP)
poly(guanylic acid)  (EXP)
potassium dichromate  (EXP)
procaine  (ISO)
procymidone  (ISO)
quartz  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
rubimaillin  (ISO)
ruthenium red  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
Salidroside  (ISO)
salubrinal  (EXP,ISO)
selenium atom  (EXP)
senecionine  (EXP)
Shikonin  (EXP)
silicon dioxide  (EXP)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
T-2 toxin  (EXP,ISO)
tauroursodeoxycholic acid  (EXP,ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
trichlorfon  (ISO)
trichloroethene  (EXP)
trichostatin A  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
tropisetron  (EXP)
tunicamycin  (EXP,ISO)
urethane  (ISO)
verapamil  (ISO)
vildagliptin  (EXP)
vorinostat  (ISO)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc oxide  (EXP,ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component


References - curated
# Reference Title Reference Citation
1. Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1. Atkin JD, etal., J Biol Chem. 2006 Oct 6;281(40):30152-65. Epub 2006 Jul 17.
2. Involvement of glucose related energy crisis and endoplasmic reticulum stress: Insinuation of streptozotocin induced Alzheimer's like pathology. Biswas J, etal., Cell Signal. 2018 Jan;42:211-226. doi: 10.1016/j.cellsig.2017.10.018. Epub 2017 Nov 7.
3. Hypothyroidism minimizes the effects of acute hepatic failure caused by endoplasmic reticulum stress and redox environment alterations in rats. Blas-Valdivia V, etal., Acta Histochem. 2015 Oct;117(8):811-9. doi: 10.1016/j.acthis.2015.07.003. Epub 2015 Jul 31.
4. Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Cai J, etal., Neurosci Lett. 2008 Aug 22;441(2):167-72. Epub 2008 May 24.
5. Nitric oxide-mediated neuronal apoptosis in rats with recurrent febrile seizures through endoplasmic reticulum stress pathway. Chen J, etal., Neurosci Lett. 2008 Oct 10;443(3):134-9. Epub 2008 Jul 26.
6. Age-related alterations in expression of apoptosis regulatory proteins and heat shock proteins in rat skeletal muscle. Chung L and Ng YC, Biochim Biophys Acta. 2006 Jan;1762(1):103-9. Epub 2005 Aug 24.
7. Estrogen limits ischemic cell death by modulating caspase-12-mediated apoptotic pathways following middle cerebral artery occlusion. Crosby KM, etal., Neuroscience. 2007 Jun 8;146(4):1524-35. Epub 2007 Apr 12.
8. Na/Ca exchanger overexpression induces endoplasmic reticulum-related apoptosis and caspase-12 activation in insulin-releasing BRIN-BD11 cells. Diaz-Horta O, etal., Diabetes 2002 Jun;51(6):1815-24.
9. Neuroprotective effects and impact on caspase-12 expression of tauroursodeoxycholic acid after acute spinal cord injury in rats. Dong Y, etal., Int J Clin Exp Pathol. 2015 Dec 1;8(12):15871-8. eCollection 2015.
10. Roles of autophagy and endoplasmic reticulum stress in intracerebral hemorrhage-induced secondary brain injury in rats. Duan XC, etal., CNS Neurosci Ther. 2017 Jul;23(7):554-566. doi: 10.1111/cns.12703. Epub 2017 May 19.
11. Long-term hypothermia reduces infarct volume in aged rats after focal ischemia. Florian B, etal., Neurosci Lett. 2008 Jun 20;438(2):180-5. Epub 2008 Apr 10.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Implication of caspases and subcellular compartments in tert-butylhydroperoxide induced apoptosis. Haidara K, etal., Toxicol Appl Pharmacol. 2008 May 15;229(1):65-76. Epub 2008 Jan 29.
14. A SnoN-Ccd1 pathway promotes axonal morphogenesis in the mammalian brain. Ikeuchi Y, etal., J Neurosci. 2009 Apr 1;29(13):4312-21.
15. Early activation of endoplasmic reticulum stress is associated with arginine-induced acute pancreatitis. Kubisch CH, etal., Am J Physiol Gastrointest Liver Physiol. 2006 Aug;291(2):G238-45. Epub 2006 Mar 30.
16. Ischemic acidosis causes apoptosis in coronary endothelial cells through activation of caspase-12. Kumar S, etal., Cardiovasc Res. 2007 Jan 1;73(1):172-80. Epub 2006 Sep 29.
17. The hyperglycemia stimulated myocardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic non-obese type 2 diabetic rats: a differential role of unfolded protein response (UPR) signaling proteins. Lakshmanan AP, etal., Int J Biochem Cell Biol. 2013 Feb;45(2):438-47. doi: 10.1016/j.biocel.2012.09.017. Epub 2012 Sep 29.
18. Increased expression and processing of caspase-12 after traumatic brain injury in rats. Larner SF, etal., J Neurochem. 2004 Jan;88(1):78-90.
19. Optimized postconditioning algorithm protects liver graft after liver transplantation in rats. Li JH, etal., Hepatobiliary Pancreat Dis Int. 2018 Feb;17(1):32-38. doi: 10.1016/j.hbpd.2018.01.006. Epub 2018 Feb 2.
20. Ginsenoside-Rg1 inhibits endoplasmic reticulum stress-induced apoptosis after unilateral ureteral obstruction in rats. Li SS, etal., Ren Fail. 2015 Jun;37(5):890-5. doi: 10.3109/0886022X.2015.1015427. Epub 2015 Feb 24.
21. [Resveratrol attenuates endoplasmic reticulum stress and alveolar epithelial apoptosis in a rat model of chronic obstructive pulmonary disease]. Li Y, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2014 Jan;37(1):30-5.
22. Dexmedetomidine attenuates H2O2-induced neonatal rat cardiomyocytes apoptosis through mitochondria- and ER-medicated oxidative stress pathways. Liu XR, etal., Mol Med Rep. 2018 May;17(5):7258-7264. doi: 10.3892/mmr.2018.8751. Epub 2018 Mar 15.
23. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology Liu Y, etal., Zhonghua Gan Zang Bing Za Zhi. 2005 Aug;13(8):563-6.
24. [Salubrinal improves cardiac function in rats with heart failure post myocardial infarction through reducing endoplasmic reticulum stress-associated apoptosis]. Liu Y, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2016 Jun 24;44(6):494-500.
25. Endoplasmic reticulum stress involved in heart and liver injury in iron-loaded rats. Lou LX, etal., Clin Exp Pharmacol Physiol. 2009 Jul;36(7):612-8.
26. Role of HMGB1 in Post-traumatic Endoplasmic Reticulum Stress in Rat Lung Tissues. Lu JF, etal., Fa Yi Xue Za Zhi. 2018 Aug;34(4):347-351. doi: 10.12116/j.issn.1004-5619.2018.04.001. Epub 2018 Aug 25.
27. Clofibrate-induced apoptosis is mediated by Ca2+-dependent caspase-12 activation. Matzno S, etal., Life Sci. 2006 Mar 13;78(16):1892-9. Epub 2005 Oct 19.
28. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
29. Activation of caspase-12, an endoplasmic reticulum resident caspase, after permanent focal ischemia in rat. Mouw G, etal., Neuroreport 2003 Feb 10;14(2):183-6.
30. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nakagawa T, etal., Nature. 2000 Jan 6;403(6765):98-103.
31. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Confinement of caspase-12 proteolytic activity to autoprocessing. Roy S, etal., Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4133-8. Epub 2008 Mar 10.
37. Nicotine suppresses tunicamycin-induced, but not thapsigargin-induced, expression of GRP78 during ER stress-mediated apoptosis in PC12 cells. Sasaya H, etal., J Biochem. 2008 Aug;144(2):251-7. Epub 2008 May 13.
38. The effect of C-peptide on cognitive dysfunction and hippocampal apoptosis in type 1 diabetic rats. Sima AA and Li ZG, Diabetes. 2005 May;54(5):1497-505.
39. Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain. Sokka AL, etal., J Neurosci. 2007 Jan 24;27(4):901-8.
40. ACE-inhibitor suppresses the apoptosis induced by endoplasmic reticulum stress in renal tubular in experimental diabetic rats. Sun HL, etal., Exp Clin Endocrinol Diabetes. 2009 Jul;117(7):336-44. Epub 2009 Mar 19.
41. Upregulation of GRP78 and caspase-12 in diastolic failing heart. Sun Y, etal., Acta Biochim Pol. 2008;55(3):511-6. Epub 2008 Sep 12.
42. Valsartan Protects Against Contrast-Induced Acute Kidney Injury in Rats by Inhibiting Endoplasmic Reticulum Stress-Induced Apoptosis. Sun Y, etal., Curr Vasc Pharmacol. 2017;15(2):174-183. doi: 10.2174/1570161114666161025100656.
43. ER stress contributes to ischemia-induced cardiomyocyte apoptosis. Szegezdi E, etal., Biochem Biophys Res Commun. 2006 Nov 3;349(4):1406-11. Epub 2006 Sep 12.
44. Stronger expression of CHOP and caspase 12 in diabetic spinal cord injury rats. Wan S, etal., Neurol Res. 2009 Feb 11.
45. Endoplasmic reticulum stress is involved in apoptosis of detrusor muscle in streptozocin-induced diabetic rats. Wang D, etal., Neurourol Urodyn. 2017 Jan;36(1):65-72. doi: 10.1002/nau.22886. Epub 2015 Sep 14.
46. Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. Wang P, etal., Nat Immunol. 2010 Oct;11(10):912-9. doi: 10.1038/ni.1933. Epub 2010 Sep 5.
47. Evaluation of apoptotic pathways in dorsal root ganglion neurons following peripheral nerve injury. Wiberg R, etal., Neuroreport. 2018 Jun 13;29(9):779-785. doi: 10.1097/WNR.0000000000001031.
48. alpha-Synuclein is involved in manganese-induced ER stress via PERK signal pathway in organotypic brain slice cultures. Xu B, etal., Mol Neurobiol. 2014 Feb;49(1):399-412. doi: 10.1007/s12035-013-8527-2. Epub 2013 Aug 10.
49. Activation of caspase-12 at early stage contributes to cardiomyocyte apoptosis in trauma-induced secondary cardiac injury. Yan Z, etal., Sheng Li Xue Bao. 2017 Aug 25;69(4):367-377.
50. MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint. Yang H, etal., Autophagy. 2020 Feb;16(2):271-288. doi: 10.1080/15548627.2019.1606647. Epub 2019 Apr 21.
51. Endoplasmic reticulum stress-mediated apoptotic pathway is involved in corpus luteum regression in rats. Yang Y, etal., Reprod Sci. 2015 May;22(5):572-84. doi: 10.1177/1933719114553445. Epub 2014 Oct 20.
52. Single Prolonged Stress induces ATF6 alpha-dependent Endoplasmic reticulum stress and the apoptotic process in medial Frontal Cortex neurons. Yu B, etal., BMC Neurosci. 2014 Oct 21;15:115. doi: 10.1186/s12868-014-0115-5.
53. Ginsenoside Rg1 ameliorates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress-induced apoptosis in a streptozotocin-induced diabetes rat model. Yu H, etal., J Cell Mol Med. 2016 Apr;20(4):623-31. doi: 10.1111/jcmm.12739. Epub 2016 Feb 12.
54. Inhibition of endoplasm reticulum stress by ghrelin protects against ischemia/reperfusion injury in rat heart. Zhang GG, etal., Peptides. 2009 Jun;30(6):1109-16. Epub 2009 May 3.
55. Effects of ATP sensitive potassium channel opener on the mRNA and protein expressions of caspase-12 after cerebral ischemia-reperfusion in rats. Zhang H, etal., Neurosci Bull. 2008 Feb;24(1):7-12.
56. Caspase-12 is involved in stretch-induced apoptosis mediated endoplasmic reticulum stress. Zhang Q, etal., Apoptosis. 2016 Apr;21(4):432-42. doi: 10.1007/s10495-016-1217-6.
57. [Effects of hydrogen-rich saline on endoplasmic reticulum stress during myocardial ischemia-reperfusion in rats]. Zhao Y, etal., Zhonghua Yi Xue Za Zhi. 2014 Oct 21;94(38):3024-8.
Additional References at PubMed
PMID:10882126   PMID:12097332   PMID:12847083   PMID:14732288   PMID:15113843   PMID:15556633   PMID:15843901   PMID:16955111   PMID:18280615   PMID:19769458   PMID:20444431   PMID:20871144  
PMID:21429313   PMID:21476018   PMID:21525936   PMID:21784110   PMID:21845883   PMID:22099262   PMID:24129401   PMID:24185830   PMID:24961950   PMID:24976582   PMID:25219918   PMID:25839043  
PMID:26261584   PMID:28078280  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8810,927,188 - 10,954,442 (+)NCBIGRCr8
mRatBN7.282,642,296 - 2,669,549 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl82,642,434 - 2,674,037 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx86,605,520 - 6,632,760 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.084,903,288 - 4,930,529 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.082,893,978 - 2,921,241 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.082,658,892 - 2,686,160 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl82,659,865 - 2,686,160 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.082,680,961 - 2,711,365 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.482,082,933 - 2,110,511 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.182,082,932 - 2,110,511 (+)NCBI
Celera84,241,433 - 4,268,684 (+)NCBICelera
Cytogenetic Map8q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3811104,883,286 - 104,898,460 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11104,885,718 - 104,898,670 (-)EnsemblGRCh38hg38GRCh38
GRCh3711104,756,445 - 104,769,187 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611104,262,627 - 104,274,607 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411104,262,626 - 104,274,607NCBI
Cytogenetic Map11q22.3NCBI
HuRef11100,688,549 - 100,700,548 (-)NCBIHuRef
CHM1_111104,639,398 - 104,652,341 (-)NCBICHM1_1
T2T-CHM13v2.011104,887,413 - 104,902,580 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3995,345,419 - 5,373,034 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl95,345,430 - 5,373,032 (+)EnsemblGRCm39 Ensembl
GRCm3895,345,442 - 5,373,034 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl95,345,430 - 5,373,032 (+)EnsemblGRCm38mm10GRCm38
MGSCv3795,345,476 - 5,373,034 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3695,345,502 - 5,373,034 (+)NCBIMGSCv36mm8
Celera3117,331,063 - 117,358,628 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1527,162,840 - 27,176,964 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl527,161,700 - 27,177,683 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha527,093,663 - 27,107,789 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0527,199,590 - 27,213,717 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl527,197,878 - 27,214,431 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1527,241,103 - 27,255,223 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0527,127,410 - 27,141,630 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0527,286,329 - 27,300,448 (+)NCBIUU_Cfam_GSD_1.0


Variants in Casp12
130 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:23
Interacting mature miRNAs:24
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)813402289Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1 20 12 12 1 7 11
Low 3 38 25 17 19 17 8 11 62 34 31 8
Below cutoff 4 12 12 12 12 3


RefSeq Acc Id: ENSRNOT00000010243   ⟹   ENSRNOP00000010244
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl82,642,883 - 2,672,278 (+)Ensembl
Rnor_6.0 Ensembl82,659,871 - 2,686,160 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088553   ⟹   ENSRNOP00000071294
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl82,642,434 - 2,669,525 (+)Ensembl
Rnor_6.0 Ensembl82,659,865 - 2,686,136 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109244   ⟹   ENSRNOP00000088120
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl82,642,883 - 2,674,037 (+)Ensembl
RefSeq Acc Id: NM_130422   ⟹   NP_569106
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr8810,927,188 - 10,954,442 (+)NCBI
mRatBN7.282,642,296 - 2,669,549 (+)NCBI
Rnor_6.082,658,892 - 2,686,160 (+)NCBI
Rnor_5.082,680,961 - 2,711,365 (+)NCBI
RGSC_v3.482,082,933 - 2,110,511 (+)RGD
Celera84,241,433 - 4,268,684 (+)RGD
RefSeq Acc Id: NP_569106   ⟸   NM_130422
- UniProtKB: Q920D5 (UniProtKB/Swiss-Prot),   F1LNW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010244   ⟸   ENSRNOT00000010243
RefSeq Acc Id: ENSRNOP00000071294   ⟸   ENSRNOT00000088553
RefSeq Acc Id: ENSRNOP00000088120   ⟸   ENSRNOT00000109244
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q920D5-F1-model_v2 AlphaFold Q920D5 1-420 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621758 AgrOrtholog
BioCyc Gene G2FUF-31817 BioCyc
Ensembl Genes ENSRNOG00000033434 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055006095 UniProtKB/Swiss-Prot
  ENSRNOG00060015916 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010243.6 UniProtKB/TrEMBL
  ENSRNOT00000088553.2 UniProtKB/TrEMBL
  ENSRNOT00000109244.1 UniProtKB/TrEMBL
  ENSRNOT00055009897 UniProtKB/Swiss-Prot
  ENSRNOT00060027358 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Caspase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Caspase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Caspase_his_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C14_caspase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C14_p20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C14A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:156117 UniProtKB/Swiss-Prot
  CASPASE-12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Casp12 PhenoGen
PIRSF Caspase_ICE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASPASE_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASPASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASPASE_P20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033434 RatGTEx
  ENSRNOG00055006095 RatGTEx
  ENSRNOG00060015916 RatGTEx
SMART CASc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52129 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K041_RAT UniProtKB/TrEMBL
  CASPC_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Casp12  caspase 12      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Casp12  caspase 12      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the endoplasmic reticulum 1299333
gene_regulation activity is induced by overexpression of plasma membrane Na/Ca exchanger (NCX1.7 isoform) 632460