Cyp4f1 (cytochrome P450, family 4, subfamily f, polypeptide 1) - Rat Genome Database

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Gene: Cyp4f1 (cytochrome P450, family 4, subfamily f, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp4f1
Name: cytochrome P450, family 4, subfamily f, polypeptide 1
RGD ID: 70926
Description: Enables several functions, including arachidonic acid binding activity; heme binding activity; and leukotriene-B4 20-monooxygenase activity. Involved in leukotriene B4 catabolic process; omega-hydroxylase P450 pathway; and response to toxic substance. Located in intracellular membrane-bounded organelle. Biomarker of hypertension. Orthologous to several human genes including CYP4F2 (cytochrome P450 family 4 subfamily F member 2); PARTICIPATES IN cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism; arachidonic acid metabolic pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; ammonium chloride; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cyp4f14; Cyp4f2; CYPIVF1; cytochrome P450 4F1; cytochrome P450, family 4, subfamily F, polypeptide 2; cytochrome P450, subfamily IVF, polypeptide 14 (leukotriene B4 omega hydroxylase); cytochrome P450-A3; leukotriene-B4 20-monooxygenase; MGC93476; P450-A3
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2712,010,850 - 12,022,497 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl712,010,852 - 12,022,046 (-)Ensembl
Rnor_6.0715,179,472 - 15,191,113 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl715,179,467 - 15,190,796 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0715,338,346 - 15,349,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4713,589,662 - 13,600,856 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1713,589,661 - 13,600,856 (-)NCBI
Celera710,104,934 - 10,116,152 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
4,4'-sulfonyldiphenol  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
azoxystrobin  (EXP)
barium sulfate  (EXP)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
chlorpyrifos  (EXP)
choline  (ISO)
ciprofibrate  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
doxorubicin  (EXP)
ethanol  (ISO)
fipronil  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (EXP,ISO)
glafenine  (EXP)
glyphosate  (EXP)
imidacloprid  (EXP)
indometacin  (EXP)
irinotecan  (EXP)
ketoconazole  (ISO)
L-methionine  (ISO)
lithocholic acid  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
obeticholic acid  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phlorizin  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
rotenone  (EXP)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium dodecyl sulfate  (ISO)
streptozocin  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
Triptolide  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:12477932   PMID:18262487   PMID:25866300  


Genomics

Comparative Map Data
Cyp4f1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2712,010,850 - 12,022,497 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl712,010,852 - 12,022,046 (-)Ensembl
Rnor_6.0715,179,472 - 15,191,113 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl715,179,467 - 15,190,796 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0715,338,346 - 15,349,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4713,589,662 - 13,600,856 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1713,589,661 - 13,600,856 (-)NCBI
Celera710,104,934 - 10,116,152 (-)NCBICelera
Cytogenetic Map7q11NCBI
CYP4F12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381915,673,087 - 15,697,174 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1915,673,018 - 15,697,174 (+)EnsemblGRCh38hg38GRCh38
GRCh371915,783,897 - 15,807,984 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361915,644,886 - 15,668,984 (+)NCBINCBI36hg18NCBI36
Build 341915,644,917 - 15,668,984NCBI
Celera1915,680,803 - 15,704,255 (+)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1915,352,410 - 15,376,054 (+)NCBIHuRef
CHM1_11915,783,320 - 15,806,476 (+)NCBICHM1_1
Cyp4f14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391733,122,331 - 33,136,353 (-)NCBIGRCm39mm39
GRCm39 Ensembl1733,124,044 - 33,136,316 (-)Ensembl
GRCm381732,903,357 - 32,917,376 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1732,905,070 - 32,917,342 (-)EnsemblGRCm38mm10GRCm38
MGSCv371733,042,015 - 33,054,023 (-)NCBIGRCm37mm9NCBIm37
MGSCv361732,643,488 - 32,655,496 (-)NCBImm8
Celera1733,817,222 - 33,829,231 (-)NCBICelera
Cytogenetic Map17B1NCBI

Position Markers
D7Rat217  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2712,015,193 - 12,015,434 (+)MAPPERmRatBN7.2
Rnor_6.0715,183,870 - 15,184,110NCBIRnor6.0
Rnor_5.0715,342,690 - 15,342,930UniSTSRnor5.0
RGSC_v3.4713,594,005 - 13,594,246RGDRGSC3.4
RGSC_v3.4713,594,006 - 13,594,246UniSTSRGSC3.4
RGSC_v3.1713,594,005 - 13,594,246RGD
Celera710,109,278 - 10,109,534UniSTS
SHRSP x BN Map74.58RGD
SHRSP x BN Map74.58UniSTS
Cytogenetic Map7q11UniSTS
D7Uia4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2712,015,443 - 12,015,645 (+)MAPPERmRatBN7.2
mRatBN7.21068,731,803 - 68,732,645 (+)MAPPERmRatBN7.2
Rnor_6.0715,184,120 - 15,184,321NCBIRnor6.0
Rnor_6.01071,155,773 - 71,156,614NCBIRnor6.0
Rnor_5.01070,774,281 - 70,775,122UniSTSRnor5.0
Rnor_5.0715,342,940 - 15,343,141UniSTSRnor5.0
RGSC_v3.4713,594,256 - 13,594,457UniSTSRGSC3.4
RGSC_v3.41072,076,880 - 72,077,721UniSTSRGSC3.4
RGSC_v3.4713,594,255 - 13,594,457RGDRGSC3.4
RGSC_v3.1713,594,255 - 13,594,457RGD
Celera710,109,544 - 10,109,753UniSTS
Celera1067,664,758 - 67,665,599UniSTS
Cytogenetic Map7q11UniSTS
D7Wox50  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2712,023,533 - 12,023,731 (+)MAPPERmRatBN7.2
Rnor_6.0715,192,208 - 15,192,405NCBIRnor6.0
Rnor_5.0715,351,028 - 15,351,225UniSTSRnor5.0
RGSC_v3.4713,602,344 - 13,602,541UniSTSRGSC3.4
Cytogenetic Map7q11UniSTS
D7Wox54  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2712,022,879 - 12,023,453 (+)MAPPERmRatBN7.2
Rnor_6.0715,191,554 - 15,192,127NCBIRnor6.0
Rnor_5.0715,350,374 - 15,350,947UniSTSRnor5.0
RGSC_v3.4713,601,690 - 13,602,263UniSTSRGSC3.4
Cytogenetic Map7q11UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:110
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000006533
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 25 25 25 25
Low 17 13 10 1 10 1 1 35 6 26 3 1
Below cutoff 12 19 6 15 6 6 7 19 2 11 5 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006533   ⟹   ENSRNOP00000006533
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl712,010,852 - 12,022,046 (-)Ensembl
Rnor_6.0 Ensembl715,179,467 - 15,190,796 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090844   ⟹   ENSRNOP00000072675
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl712,011,196 - 12,022,046 (-)Ensembl
RefSeq Acc Id: NM_019623   ⟹   NP_062569
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2712,010,850 - 12,022,046 (-)NCBI
Rnor_6.0715,179,526 - 15,190,720 (-)NCBI
Rnor_5.0715,338,346 - 15,349,540 (-)NCBI
RGSC_v3.4713,589,662 - 13,600,856 (-)RGD
Celera710,104,934 - 10,116,152 (-)RGD
Sequence:
RefSeq Acc Id: XM_008765180   ⟹   XP_008763402
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2712,010,859 - 12,022,497 (-)NCBI
Rnor_6.0715,179,472 - 15,191,113 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765181   ⟹   XP_008763403
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2712,011,238 - 12,022,356 (-)NCBI
Rnor_6.0715,179,472 - 15,191,032 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079791   ⟹   XP_038935719
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2712,011,238 - 12,022,121 (-)NCBI
RefSeq Acc Id: XM_039079792   ⟹   XP_038935720
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2712,010,859 - 12,022,357 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_062569   ⟸   NM_019623
- UniProtKB: Q66HK8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763402   ⟸   XM_008765180
- Peptide Label: isoform X1
- UniProtKB: Q66HK8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763403   ⟸   XM_008765181
- Peptide Label: isoform X1
- UniProtKB: Q66HK8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006533   ⟸   ENSRNOT00000006533
RefSeq Acc Id: XP_038935720   ⟸   XM_039079792
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038935719   ⟸   XM_039079791
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000072675   ⟸   ENSRNOT00000090844

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P33274-F1-model_v2 AlphaFold P33274 1-524 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695075
Promoter ID:EPDNEW_R5599
Type:initiation region
Name:Cyp4f1_1
Description:cytochrome P450, family 4, subfamily f, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0715,190,796 - 15,190,856EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
7 15180939 15180940 G A snv CDR, MWF/Hsd (2019), FHL/EurMcwi (MCW), GH/OmrMcwi (MCW), BBDP/Wor (RGD), FHH/EurMcwi (RGD), LEW/NCrlBR (RGD), MHS/Gib (RGD), MNS/Gib (RGD), FHH/EurMcwi (2019), FXLE18/Stm (2020), LEW/Crl (2019), LEXF11/Stm (2020), LEXF1A/Stm (2019), LEXF1C/Stm (2019), LEXF2B/Stm (2019), LEXF3/Stm (2020), LE/Stm (2019), LEXF10A/StmMcwi (2020), FHH/EurMcwi (MCW)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
7 15339759 15339760 G A snv FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), GH/OmrMcwi (MCW), MHS/Gib (KNAW), BBDP/WorN (KNAW), FHH/EurMcwi (KNAW), LE/OrlBarth (UDEL), LE/Stm (Illumina) (KNAW), LE/Stm (SOLiD) (KNAW), LEW/Crl (KNAW), LEW/NCrl (KNAW), MNS/Gib (KNAW), FHL/EurMcwi (KNAW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
7 13591075 13591076 G A snv FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), FHH/EurMcwi (MDC), LE/Stm (KNAW), GH/OmrMcwi (MCW), BBDP/WorN (ICL), MNS/Gib (ICL), FHL/EurMcwi (ICL), LE/Stm (ICL), LEW/Crl (ICL), LEW/NCrl (ICL), MHS/Gib (ICL), FHH/EurMcwi (ICL)


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
7 12012263 12012264 G A snv FHH/EurMcwi (2019), FXLE18/Stm (2020), LEW/Crl (2019), LEXF11/Stm (2020), LEXF1A/Stm (2019), MWF/Hsd (2019), LEXF2B/Stm (2019), LEXF3/Stm (2020), LE/Stm (2019), LEXF10A/StmMcwi (2020), LEXF1C/Stm (2019)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70926 AgrOrtholog
BioCyc Gene G2FUF-34799 BioCyc
Ensembl Genes ENSRNOG00000004786 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000006533 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006533 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109036 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:56266 UniProtKB/TrEMBL
MGC_CLONE MGC:93476 IMAGE-MGC_LOAD
NCBI Gene 56266 ENTREZGENE
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp4f1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CP4F1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q66HK8 ENTREZGENE, UniProtKB/TrEMBL
  Q9ESF5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-07-06 Cyp4f1  cytochrome P450, family 4, subfamily f, polypeptide 1  Cyp4f2  cytochrome P450, family 4, subfamily F, polypeptide 2  Name updated 1299863 APPROVED
2004-09-10 Cyp4f2  cytochrome P450, family 4, subfamily F, polypeptide 2  Cyp4f14  cytochrome P450, subfamily IVF, polypeptide 14 (leukotriene B4 omega hydroxylase)  Symbol and Name updated 1299863 APPROVED
2002-07-09 Cyp4f14  cytochrome P450, subfamily IVF, polypeptide 14 (leukotriene B4 omega hydroxylase)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in hepatic tumors; expression levels are higher than those detected in parental liver tissue 70707
gene_regulation Cyp4 genes differentially regulated during hepatic carcinogenesis 70707