Cyp4f1 (cytochrome P450, family 4, subfamily f, polypeptide 1) - Rat Genome Database

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Gene: Cyp4f1 (cytochrome P450, family 4, subfamily f, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp4f1
Name: cytochrome P450, family 4, subfamily f, polypeptide 1
RGD ID: 70926
Description: Enables several functions, including arachidonic acid binding activity; heme binding activity; and leukotriene-B4 20-monooxygenase activity. Involved in leukotriene B4 catabolic process; omega-hydroxylase P450 pathway; and response to toxic substance. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Biomarker of hypertension. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to several human genes including CYP4F2 (cytochrome P450 family 4 subfamily F member 2); PARTICIPATES IN cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism; arachidonic acid metabolic pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; amiodarone; amitriptyline.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cyp4f14; Cyp4f2; CYPIVF1; cytochrome P450 4F1; cytochrome P450, family 4, subfamily F, polypeptide 2; cytochrome P450, subfamily IVF, polypeptide 14 (leukotriene B4 omega hydroxylase); cytochrome P450-A3; leukotriene-B4 20-monooxygenase; MGC93476; P450-A3
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2712,010,850 - 12,022,497 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl712,010,852 - 12,022,046 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx714,812,767 - 14,823,988 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0716,690,173 - 16,701,390 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0714,561,760 - 14,572,976 (-)NCBIRnor_WKY
Rnor_6.0715,179,472 - 15,191,113 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl715,179,467 - 15,190,796 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0715,338,346 - 15,349,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4713,589,662 - 13,600,856 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1713,589,661 - 13,600,856 (-)NCBI
Celera710,104,934 - 10,116,152 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
4,4'-sulfonyldiphenol  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
azoxystrobin  (EXP)
barium sulfate  (EXP)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
chlorpyrifos  (EXP)
choline  (ISO)
ciprofibrate  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clomipramine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
doxorubicin  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fipronil  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (EXP,ISO)
glafenine  (EXP)
glyphosate  (EXP)
imidacloprid  (EXP)
imipramine  (EXP)
indometacin  (EXP)
inulin  (ISO)
irinotecan  (EXP)
ketoconazole  (EXP,ISO)
kojic acid  (EXP)
L-methionine  (ISO)
lithocholic acid  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
obeticholic acid  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phlorizin  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
rotenone  (EXP)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
streptozocin  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
Triptolide  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors. Chen L and Hardwick JP, Arch Biochem Biophys 1993 Jan;300(1):18-23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Identification of differentially expressed genes in aflatoxin B1-treated cultured primary rat hepatocytes and Fischer 344 rats. Harris AJ, etal., Carcinogenesis. 1998 Aug;19(8):1451-8.
4. Localization of rat cytochrome P450 in various tissues and comparison of arachidonic acid metabolism by rat P450 with that by human P450 orthologs. Imaoka S, etal., Drug Metab Pharmacokinet. 2005 Dec;20(6):478-84.
5. Renal localization, expression, and developmental regulation of P450 4F cytochromes in three substrains of spontaneously hypertensive rats. Kalsotra A, etal., Biochem Biophys Res Commun. 2005 Dec 9;338(1):423-31. Epub 2005 Aug 25.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Purification and characterization of recombinant rat hepatic CYP4F1. Kikuta Y, etal., Arch Biochem Biophys. 1999 Sep 15;369(2):193-6.
8. Covalent attachment of the heme prosthetic group in the CYP4F cytochrome P450 family. LeBrun LA, etal., Biochemistry. 2002 May 7;41(18):5931-7.
9. Gene Data Set MGD Curation, June 12, 2002
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. CYP4Fs Expression in Rat Brain Correlates with Changes in LTB(4) Levels after Traumatic Brain Injury. Wang Y, etal., J Neurotrauma. 2008 Oct 11.
16. Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes. Xu F, etal., J Pharmacol Exp Ther. 2004 Mar;308(3):887-95. Epub 2003 Nov 21.
Additional References at PubMed
PMID:12477932   PMID:18262487   PMID:25866300  


Genomics

Comparative Map Data
Cyp4f1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2712,010,850 - 12,022,497 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl712,010,852 - 12,022,046 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx714,812,767 - 14,823,988 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0716,690,173 - 16,701,390 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0714,561,760 - 14,572,976 (-)NCBIRnor_WKY
Rnor_6.0715,179,472 - 15,191,113 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl715,179,467 - 15,190,796 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0715,338,346 - 15,349,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4713,589,662 - 13,600,856 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1713,589,661 - 13,600,856 (-)NCBI
Celera710,104,934 - 10,116,152 (-)NCBICelera
Cytogenetic Map7q11NCBI
CYP4F12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381915,673,087 - 15,697,174 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1915,673,018 - 15,697,174 (+)EnsemblGRCh38hg38GRCh38
GRCh371915,783,897 - 15,807,984 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361915,644,886 - 15,668,984 (+)NCBINCBI36Build 36hg18NCBI36
Build 341915,644,917 - 15,668,984NCBI
Celera1915,680,803 - 15,704,255 (+)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1915,352,410 - 15,376,054 (+)NCBIHuRef
CHM1_11915,783,320 - 15,806,476 (+)NCBICHM1_1
T2T-CHM13v2.01915,798,486 - 15,822,059 (+)NCBIT2T-CHM13v2.0
Cyp4f14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391733,122,331 - 33,136,353 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1733,124,044 - 33,136,316 (-)EnsemblGRCm39 Ensembl
GRCm381732,903,357 - 32,917,376 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1732,905,070 - 32,917,342 (-)EnsemblGRCm38mm10GRCm38
MGSCv371733,042,015 - 33,054,023 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361732,643,488 - 32,655,496 (-)NCBIMGSCv36mm8
Celera1733,817,222 - 33,829,231 (-)NCBICelera
Cytogenetic Map17B1NCBI

Variants

.
Variants in Cyp4f1
43 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:110
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000006533
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat

Markers in Region
D7Rat217  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2712,015,193 - 12,015,434 (+)MAPPERmRatBN7.2
Rnor_6.0715,183,870 - 15,184,110NCBIRnor6.0
Rnor_5.0715,342,690 - 15,342,930UniSTSRnor5.0
RGSC_v3.4713,594,005 - 13,594,246RGDRGSC3.4
RGSC_v3.4713,594,006 - 13,594,246UniSTSRGSC3.4
RGSC_v3.1713,594,005 - 13,594,246RGD
Celera710,109,278 - 10,109,534UniSTS
SHRSP x BN Map74.58RGD
SHRSP x BN Map74.58UniSTS
Cytogenetic Map7q11UniSTS
D7Uia4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,731,803 - 68,732,645 (+)MAPPERmRatBN7.2
mRatBN7.2712,015,443 - 12,015,645 (+)MAPPERmRatBN7.2
Rnor_6.0715,184,120 - 15,184,321NCBIRnor6.0
Rnor_6.01071,155,773 - 71,156,614NCBIRnor6.0
Rnor_5.01070,774,281 - 70,775,122UniSTSRnor5.0
Rnor_5.0715,342,940 - 15,343,141UniSTSRnor5.0
RGSC_v3.4713,594,256 - 13,594,457UniSTSRGSC3.4
RGSC_v3.4713,594,255 - 13,594,457RGDRGSC3.4
RGSC_v3.41072,076,880 - 72,077,721UniSTSRGSC3.4
RGSC_v3.1713,594,255 - 13,594,457RGD
Celera1067,664,758 - 67,665,599UniSTS
Celera710,109,544 - 10,109,753UniSTS
Cytogenetic Map7q11UniSTS
D7Wox50  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2712,023,533 - 12,023,731 (+)MAPPERmRatBN7.2
Rnor_6.0715,192,208 - 15,192,405NCBIRnor6.0
Rnor_5.0715,351,028 - 15,351,225UniSTSRnor5.0
RGSC_v3.4713,602,344 - 13,602,541UniSTSRGSC3.4
Cytogenetic Map7q11UniSTS
D7Wox54  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2712,022,879 - 12,023,453 (+)MAPPERmRatBN7.2
Rnor_6.0715,191,554 - 15,192,127NCBIRnor6.0
Rnor_5.0715,350,374 - 15,350,947UniSTSRnor5.0
RGSC_v3.4713,601,690 - 13,602,263UniSTSRGSC3.4
Cytogenetic Map7q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 25 25 25 25
Low 17 13 10 1 10 1 1 35 6 26 3 1
Below cutoff 12 19 6 15 6 6 7 19 2 11 5 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006533   ⟹   ENSRNOP00000006533
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl712,010,852 - 12,022,046 (-)Ensembl
Rnor_6.0 Ensembl715,179,467 - 15,190,796 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090844   ⟹   ENSRNOP00000072675
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl712,011,196 - 12,022,046 (-)Ensembl
RefSeq Acc Id: NM_019623   ⟹   NP_062569
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2712,010,850 - 12,022,046 (-)NCBI
Rnor_6.0715,179,526 - 15,190,720 (-)NCBI
Rnor_5.0715,338,346 - 15,349,540 (-)NCBI
RGSC_v3.4713,589,662 - 13,600,856 (-)RGD
Celera710,104,934 - 10,116,152 (-)RGD
Sequence:
RefSeq Acc Id: XM_008765180   ⟹   XP_008763402
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2712,010,859 - 12,022,497 (-)NCBI
Rnor_6.0715,179,472 - 15,191,113 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765181   ⟹   XP_008763403
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2712,011,238 - 12,022,356 (-)NCBI
Rnor_6.0715,179,472 - 15,191,032 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079791   ⟹   XP_038935719
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2712,011,238 - 12,022,121 (-)NCBI
RefSeq Acc Id: XM_039079792   ⟹   XP_038935720
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2712,010,859 - 12,022,357 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_062569   ⟸   NM_019623
- UniProtKB: Q66HK8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763402   ⟸   XM_008765180
- Peptide Label: isoform X1
- UniProtKB: Q66HK8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763403   ⟸   XM_008765181
- Peptide Label: isoform X1
- UniProtKB: Q66HK8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006533   ⟸   ENSRNOT00000006533
RefSeq Acc Id: XP_038935720   ⟸   XM_039079792
- Peptide Label: isoform X1
- UniProtKB: Q66HK8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935719   ⟸   XM_039079791
- Peptide Label: isoform X1
- UniProtKB: Q66HK8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000072675   ⟸   ENSRNOT00000090844

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P33274-F1-model_v2 AlphaFold P33274 1-524 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695075
Promoter ID:EPDNEW_R5599
Type:initiation region
Name:Cyp4f1_1
Description:cytochrome P450, family 4, subfamily f, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0715,190,796 - 15,190,856EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70926 AgrOrtholog
BioCyc Gene G2FUF-34799 BioCyc
Ensembl Genes ENSRNOG00000004786 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000006533 ENTREZGENE
  ENSRNOP00000006533.3 UniProtKB/TrEMBL
  ENSRNOP00000072675.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006533 ENTREZGENE
  ENSRNOT00000006533.6 UniProtKB/TrEMBL
  ENSRNOT00000090844.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109036 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:56266 UniProtKB/TrEMBL
MGC_CLONE MGC:93476 IMAGE-MGC_LOAD
NCBI Gene 56266 ENTREZGENE
PANTHER CYTOCHROME P450 FAMILY 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LEUKOTRIENE-B4 OMEGA-HYDROXYLASE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp4f1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K3K4_RAT UniProtKB/TrEMBL
  CP4F1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q66HK8 ENTREZGENE, UniProtKB/TrEMBL
  Q9ESF5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-07-06 Cyp4f1  cytochrome P450, family 4, subfamily f, polypeptide 1  Cyp4f2  cytochrome P450, family 4, subfamily F, polypeptide 2  Name updated 1299863 APPROVED
2004-09-10 Cyp4f2  cytochrome P450, family 4, subfamily F, polypeptide 2  Cyp4f14  cytochrome P450, subfamily IVF, polypeptide 14 (leukotriene B4 omega hydroxylase)  Symbol and Name updated 1299863 APPROVED
2002-07-09 Cyp4f14  cytochrome P450, subfamily IVF, polypeptide 14 (leukotriene B4 omega hydroxylase)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in hepatic tumors; expression levels are higher than those detected in parental liver tissue 70707
gene_regulation Cyp4 genes differentially regulated during hepatic carcinogenesis 70707