Gene: Nts (neurotensin) Rattus norvegicus
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Symbol:
Nts
Name:
neurotensin
Description:
Predicted to have neuropeptide hormone activity. Involved in several processes, including cellular response to lithium ion; response to glucocorticoid; and visual learning. Localizes to the axon terminus and neuronal cell body. Biomarker of sciatic neuropathy. Orthologous to human NTS (neurotensin); INTERACTS WITH (S)-colchicine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
LOC299757; neuromedin N; neurotensin/neuromedin N; neurotensin/neuromedin N gene
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
NTS (neurotensin) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Nts (neurotensin) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Nts (neurotensin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
NTS (neurotensin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
NTS (neurotensin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Nts (neurotensin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
NTS (neurotensin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
NTS (neurotensin)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Nts (neurotensin)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
nts (neurotensin)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 7 44,111,594 - 44,120,998 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 7 44,111,151 - 44,121,130 (-) Ensembl Rnor_5.0 7 44,140,647 - 44,150,051 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 7 40,474,654 - 40,484,058 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 7 40,494,497 - 40,495,295 (-) NCBI Celera 7 34,527,468 - 34,536,872 (-) NCBI Celera Cytogenetic Map 7 q21 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
breast ductal carcinoma ISO RGD:1319092 8554872 ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar
Imported Annotations - CTD
Bradycardia ISO RGD:1319092 11554173 CTD Direct Evidence: therapeutic CTD PMID:2326505 Catalepsy ISO RGD:1319092 11554173 CTD Direct Evidence: therapeutic CTD PMID:20882060 Hyperkinesis ISO RGD:1319092 11554173 CTD Direct Evidence: therapeutic CTD PMID:3748325 , PMID:6682440 Muscle Rigidity ISO RGD:1319092 11554173 CTD Direct Evidence: therapeutic CTD PMID:8036282
(S)-amphetamine increases expression ISO RGD:1319093 6480464 Dextroamphetamine results in increased expression of NTS mRNA CTD PMID:11120399 (S)-colchicine increases expression EXP 6480464 Colchicine results in increased expression of NTS mRNA CTD PMID:1850078 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of NTS mRNA CTD PMID:20068009 17beta-estradiol increases expression ISO RGD:1319092 6480464 Estradiol results in increased expression of NTS mRNA CTD PMID:21795739 17beta-estradiol multiple interactions ISO RGD:1319092 6480464 [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of NTS mRNA, Progesterone inhibits the reaction [Estradiol results in increased expression of NTS mRNA] CTD PMID:20823114 , PMID:21795739 17beta-hydroxy-5alpha-androstan-3-one affects expression ISO RGD:1319092 6480464 Dihydrotestosterone affects the expression of NTS mRNA CTD PMID:17094431 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of NTS mRNA CTD PMID:15977195 2,4,6-trinitrobenzenesulfonic acid multiple interactions ISO RGD:1319093 6480464 NTS protein promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VWF protein] CTD PMID:25307345 3,4-methylenedioxymethamphetamine increases expression EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of NTS mRNA CTD PMID:15661373 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione multiple interactions ISO RGD:1319092 6480464 bisindolylmaleimide I affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates] more ... CTD PMID:18313772 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione increases activity ISO RGD:1319092 6480464 bisindolylmaleimide I results in increased activity of NTS protein CTD PMID:18313772 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione increases activity EXP 6480464 bisindolylmaleimide I results in increased activity of NTS protein CTD PMID:18313772 5-azacytidine decreases expression ISO RGD:1319092 6480464 Azacitidine results in decreased expression of NTS mRNA CTD PMID:20823114 5-fluorouracil affects response to substance ISO RGD:1319092 6480464 NTS protein affects the susceptibility to Fluorouracil CTD PMID:16217747 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of NTS mRNA CTD PMID:24780913 , PMID:25825206 8-(3-chlorostyryl)caffeine multiple interactions EXP 6480464 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of NTS mRNA] CTD PMID:10199625 aflatoxin B1 increases expression ISO RGD:1319093 6480464 Aflatoxin B1 results in increased expression of NTS mRNA CTD PMID:19770486 aflatoxin B1 increases expression ISO RGD:1319092 6480464 Aflatoxin B1 results in increased expression of NTS mRNA CTD PMID:21641981 aldehydo-D-glucose increases transport EXP 6480464 NTS protein results in increased transport of Glucose CTD PMID:11208724 aldrin increases expression ISO RGD:1319093 6480464 Aldrin results in increased expression of NTS mRNA CTD PMID:18579281 alpha-hexylcinnamaldehyde affects expression ISO RGD:1319093 6480464 hexyl cinnamic aldehyde affects the expression of NTS mRNA CTD PMID:22302311 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of NTS mRNA CTD PMID:16483693 amphetamine increases expression ISO RGD:1319093 6480464 Amphetamine results in increased expression of NTS mRNA CTD PMID:14698760 arsenite(3-) decreases expression ISO RGD:1319093 6480464 arsenite results in decreased expression of NTS mRNA CTD PMID:18929588 arsenite(3-) multiple interactions ISO RGD:1319093 6480464 TRP53 protein affects the reaction [arsenite results in decreased expression of NTS mRNA] CTD PMID:18929588 arsenous acid decreases expression ISO RGD:1319092 6480464 Arsenic Trioxide results in decreased expression of NTS mRNA CTD PMID:26705709 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of NTS mRNA CTD PMID:21839799 benzo[a]pyrene increases expression ISO RGD:1319093 6480464 Benzo(a)pyrene results in increased expression of NTS mRNA CTD PMID:19770486 , PMID:23735875 bicalutamide decreases response to substance ISO RGD:1319092 6480464 NTS protein results in decreased susceptibility to bicalutamide CTD PMID:17044078 bis(2-ethylhexyl) phthalate increases expression ISO RGD:1319092 6480464 Diethylhexyl Phthalate results in increased expression of NTS mRNA CTD PMID:31163220 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of NTS mRNA CTD PMID:25181051 bucladesine multiple interactions ISO RGD:1319092 6480464 [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of NTS mRNA CTD PMID:20823114 chelerythrine increases activity ISO RGD:1319092 6480464 chelerythrine results in increased activity of NTS protein CTD PMID:18313772 chlorpyrifos increases expression EXP 6480464 Chlorpyrifos results in increased expression of NTS mRNA CTD PMID:20682304 chromium atom increases transport EXP 6480464 NTS protein results in increased transport of Chromium CTD PMID:11208724 clozapine increases expression EXP 6480464 Clozapine results in increased expression of NTS mRNA CTD PMID:12887421 cocaine increases expression ISO RGD:1319093 6480464 Cocaine results in increased expression of NTS mRNA CTD PMID:11120399 cocaine increases expression EXP 6480464 Cocaine results in increased expression of NTS mRNA CTD PMID:27899881 cocaine multiple interactions EXP 6480464 NTS protein inhibits the reaction [Cocaine results in decreased secretion of gamma-Aminobutyric Acid] CTD PMID:18252810 cocaine multiple interactions ISO RGD:1319093 6480464 DRD3 protein affects the reaction [Cocaine results in increased expression of NTS mRNA] CTD PMID:11120399 copper atom multiple interactions ISO RGD:1319092 6480464 [NSC 689534 binds to Copper] which results in decreased expression of NTS mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:1319092 6480464 [NSC 689534 binds to Copper] which results in decreased expression of NTS mRNA CTD PMID:20971185 cyclosporin A increases expression ISO RGD:1319092 6480464 Cyclosporine results in increased expression of NTS mRNA CTD PMID:20106945 D-glucose increases transport EXP 6480464 NTS protein results in increased transport of Glucose CTD PMID:11208724 D-mannitol increases transport EXP 6480464 NTS protein results in increased transport of Mannitol CTD PMID:11208724 dehydroepiandrosterone affects expression ISO RGD:1319092 6480464 Dehydroepiandrosterone affects the expression of NTS mRNA CTD PMID:17094431 dexloxiglumide multiple interactions ISO RGD:1319092 6480464 dexloxiglumide inhibits the reaction [osteum results in increased secretion of NTS protein] CTD PMID:18303078 dextran sulfate multiple interactions ISO RGD:1319093 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of NTS mRNA CTD PMID:29950665 diarsenic trioxide decreases expression ISO RGD:1319092 6480464 Arsenic Trioxide results in decreased expression of NTS mRNA CTD PMID:26705709 diazinon increases expression EXP 6480464 Diazinon results in increased expression of NTS mRNA CTD PMID:20682304 diazinon decreases expression EXP 6480464 Diazinon results in decreased expression of NTS mRNA CTD PMID:29108742 dieldrin increases expression EXP 6480464 Dieldrin results in increased expression of NTS mRNA CTD PMID:20682304 dioxygen decreases expression ISO RGD:1319092 6480464 Oxygen deficiency results in decreased expression of NTS mRNA CTD PMID:24236059 dorsomorphin multiple interactions ISO RGD:1319092 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 emamectin benzoate affects activity ISO RGD:1319092 6480464 emamectin benzoate affects the activity of NTS protein CTD PMID:23611293 ethanol increases response to substance EXP 6480464 NTS protein results in increased susceptibility to Ethanol CTD PMID:11602683 fragrance increases expression ISO RGD:1319092 6480464 Perfume results in increased expression of NTS mRNA CTD PMID:24768652 gamma-aminobutyric acid multiple interactions EXP 6480464 NTS protein inhibits the reaction [Cocaine results in decreased secretion of gamma-Aminobutyric Acid] CTD PMID:18252810 gamma-aminobutyric acid increases secretion EXP 6480464 NTS protein results in increased secretion of gamma-Aminobutyric Acid CTD PMID:18252810 glucose increases transport EXP 6480464 NTS protein results in increased transport of Glucose CTD PMID:11208724 Goe 6976 increases activity ISO RGD:1319092 6480464 Go 6976 results in increased activity of NTS protein CTD PMID:18313772 Goe 6976 multiple interactions ISO RGD:1319092 6480464 Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein] more ... CTD PMID:18313772 haloperidol multiple interactions ISO RGD:1319093 6480464 SLC6A3 protein promotes the reaction [Haloperidol results in increased expression of NTS mRNA] CTD PMID:14698760 haloperidol increases expression ISO RGD:1319093 6480464 Haloperidol results in increased expression of NTS mRNA CTD PMID:11120399 more ... haloperidol increases expression EXP 6480464 Haloperidol results in increased expression of NTS mRNA, Haloperidol results in increased expression of NTS protein CTD PMID:10199625 more ... haloperidol multiple interactions EXP 6480464 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of NTS mRNA], Theophylline inhibits the reaction [Haloperidol results in increased expression of NTS mRNA] CTD PMID:10199625 LY294002 multiple interactions ISO RGD:1319092 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] more ... CTD PMID:15177934 medroxyprogesterone acetate multiple interactions ISO RGD:1319092 6480464 [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of NTS mRNA CTD PMID:20823114 mercury dibromide increases expression ISO RGD:1319092 6480464 mercuric bromide results in increased expression of NTS mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO RGD:1319092 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTS mRNA CTD PMID:27188386 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of NTS mRNA CTD PMID:19564919 methylmercury chloride increases expression ISO RGD:1319092 6480464 methylmercuric chloride results in increased expression of NTS mRNA CTD PMID:28001369 N-ethyl-N-nitrosourea increases mutagenesis EXP 6480464 Ethylnitrosourea results in increased mutagenesis of NTS gene CTD PMID:16495775 nickel atom increases expression EXP 6480464 Nickel results in increased expression of NTS mRNA CTD PMID:20682304 okadaic acid decreases activity ISO RGD:1319092 6480464 Okadaic Acid results in decreased activity of NTS protein CTD PMID:18313772 okadaic acid multiple interactions ISO RGD:1319092 6480464 Okadaic Acid promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein] CTD PMID:18313772 orlistat multiple interactions ISO RGD:1319092 6480464 Orlistat inhibits the reaction [Fats results in increased secretion of NTS protein], Orlistat inhibits the reaction [Olive Oil results in increased secretion of NTS protein] CTD PMID:18303078 paracetamol affects expression ISO RGD:1319093 6480464 Acetaminophen affects the expression of NTS mRNA CTD PMID:17562736 phenylephrine decreases response to substance EXP 6480464 NTS protein results in decreased susceptibility to Phenylephrine CTD PMID:2326505 phenylmercury acetate multiple interactions ISO RGD:1319092 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTS mRNA CTD PMID:27188386 phorbol 13-acetate 12-myristate decreases activity ISO RGD:1319092 6480464 Tetradecanoylphorbol Acetate results in decreased activity of NTS protein CTD PMID:18313772 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:1319092 6480464 2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein] more ... CTD PMID:18313772 phosphoramidon multiple interactions ISO RGD:1319092 6480464 phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] more ... CTD PMID:15177934 phthalaldehyde affects expression ISO RGD:1319093 6480464 o-Phthalaldehyde affects the expression of NTS mRNA CTD PMID:22302311 pirinixic acid multiple interactions ISO RGD:1319092 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NTS mRNA CTD PMID:19710929 progesterone multiple interactions ISO RGD:1319092 6480464 Progesterone inhibits the reaction [Estradiol results in increased expression of NTS mRNA] CTD PMID:21795739 quercetin increases activity ISO RGD:1319092 6480464 Quercetin results in increased activity of NTS protein CTD PMID:18313772 reserpine increases expression EXP 6480464 Reserpine results in increased expression of NTS mRNA CTD PMID:1850078 Ro 31-8220 increases activity ISO RGD:1319092 6480464 Ro 31-8220 results in increased activity of NTS protein CTD PMID:18313772 Ro 31-8220 multiple interactions ISO RGD:1319092 6480464 Ro 31-8220 affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates], Tetradecanoylphorbol Acetate inhibits the reaction [Ro 31-8220 results in increased activity of NTS protein] CTD PMID:18313772 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of NTS mRNA CTD PMID:19013527 rottlerin multiple interactions ISO RGD:1319092 6480464 rottlerin affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates] more ... CTD PMID:15177934 , PMID:18313772 rottlerin increases activity ISO RGD:1319092 6480464 rottlerin results in increased activity of NTS protein CTD PMID:18313772 SB 431542 multiple interactions ISO RGD:1319092 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide decreases expression ISO RGD:1319092 6480464 Silicon Dioxide analog results in decreased expression of NTS mRNA CTD PMID:25895662 silicon dioxide increases expression ISO RGD:1319093 6480464 Silicon Dioxide results in increased expression of NTS mRNA CTD PMID:23221170 sodium arsenate increases expression ISO RGD:1319093 6480464 sodium arsenate results in increased expression of NTS mRNA CTD PMID:30953684 sodium arsenite decreases expression ISO RGD:1319092 6480464 sodium arsenite results in decreased expression of NTS mRNA CTD PMID:29301061 Sodium oleate multiple interactions ISO RGD:1319092 6480464 dexloxiglumide inhibits the reaction [osteum results in increased secretion of NTS protein] CTD PMID:18303078 Sodium oleate increases secretion ISO RGD:1319092 6480464 osteum results in increased secretion of NTS protein CTD PMID:18303078 staurosporine multiple interactions ISO RGD:1319092 6480464 Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] more ... CTD PMID:15177934 , PMID:18313772 staurosporine increases activity ISO RGD:1319092 6480464 Staurosporine results in increased activity of NTS protein CTD PMID:18313772 sucrose decreases activity ISO RGD:1319092 6480464 Sucrose results in decreased activity of NTS protein CTD PMID:18313772 sucrose multiple interactions ISO RGD:1319092 6480464 Sucrose promotes the reaction [bisindolylmaleimide I results in increased activity of NTS protein], Sucrose promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein] CTD PMID:18313772 theophylline multiple interactions EXP 6480464 Theophylline inhibits the reaction [Haloperidol results in increased expression of NTS mRNA] CTD PMID:10199625 titanium dioxide multiple interactions ISO RGD:1319093 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of NTS mRNA CTD PMID:29950665 trichostatin A increases expression ISO RGD:1319092 6480464 trichostatin A results in increased expression of NTS mRNA CTD PMID:24935251 trimellitic anhydride increases expression ISO RGD:1319093 6480464 trimellitic anhydride results in increased expression of NTS mRNA CTD PMID:19042947 trimellitic anhydride affects expression ISO RGD:1319093 6480464 trimellitic anhydride affects the expression of NTS mRNA CTD PMID:22302311 tyrphostin AG 1478 multiple interactions ISO RGD:1319092 6480464 RTKI cpd inhibits the reaction [NTS protein results in increased expression of CXCL8 mRNA] more ... CTD PMID:15177934 , PMID:15247267 U-73122 multiple interactions ISO RGD:1319092 6480464 1-(6-((3-methoxyestra-1 more ... CTD PMID:15177934 valproic acid affects expression ISO RGD:1319093 6480464 Valproic Acid affects the expression of NTS mRNA CTD PMID:17292431 valproic acid multiple interactions ISO RGD:1319092 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTS mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:1319092 6480464 Valproic Acid results in increased expression of NTS mRNA CTD PMID:19101580 more ... wortmannin multiple interactions ISO RGD:1319092 6480464 wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] more ... CTD PMID:15177934
Gene-Chemical Interaction Annotations
