Hsd17b3 (hydroxysteroid (17-beta) dehydrogenase 3) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Hsd17b3 (hydroxysteroid (17-beta) dehydrogenase 3) Rattus norvegicus
Symbol: Hsd17b3
Name: hydroxysteroid (17-beta) dehydrogenase 3
RGD ID: 621805
Description: Enables estradiol 17-beta-dehydrogenase [NAD(P)] activity and testosterone dehydrogenase (NAD+) activity. Involved in several processes, including Leydig cell differentiation; response to fungicide; and response to vitamin. Predicted to be active in endoplasmic reticulum. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and disorder of sexual development. Orthologous to human HSD17B3 (hydroxysteroid 17-beta dehydrogenase 3); PARTICIPATES IN estradiol biosynthetic pathway; testosterone biosynthetic pathway; steroid hormone biosynthetic pathway; INTERACTS WITH (+)-taxifolin; (R,R,R)-alpha-tocopherol; (S)-nicotine.
Type: protein-coding
Previously known as: 17-beta-HSD 3; 17-beta-hydroxysteroid dehydrogenase type 3; 17beta-HSD; estradiol 17 beta-dehydrogenase 3; estradiol 17-beta-dehydrogenase 2; hydroxysteroid 17-beta dehydrogenase 3; testicular 17-beta-hydroxysteroid dehydrogenase; testosterone 17-beta-dehydrogenase 3
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2171,027,229 - 1,058,554 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl171,027,229 - 1,058,554 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx171,045,909 - 1,077,225 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0172,588,485 - 2,619,812 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0171,043,327 - 1,074,653 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0171,579,319 - 1,610,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl171,579,319 - 1,610,745 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0171,570,077 - 1,600,357 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,554,164 - 6,585,525 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1176,554,163 - 6,585,525 (+)NCBI
Celera171,458,596 - 1,490,020 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-nicotine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-tert-butylhydroquinone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
aconitine  (EXP)
aflatoxin B1  (EXP,ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
androst-4-ene-3,17-dione  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
Aroclor 1254  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (ISO)
butylated hydroxyanisole  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (EXP)
clofibrate  (EXP)
colforsin daropate hydrochloride  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (EXP)
dibutyl phthalate  (EXP,ISO)
Dicyclohexyl phthalate  (EXP)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
Diisodecyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethoate  (EXP)
dipentyl phthalate  (EXP)
diuron  (EXP)
doxorubicin  (EXP)
dutasteride  (ISO)
fenitrothion  (EXP)
fenvalerate  (EXP)
fipronil  (ISO)
flavonoids  (EXP)
flufenoxuron  (ISO)
fonofos  (ISO)
fulvestrant  (EXP)
herbicide  (EXP)
iprodione  (EXP)
L-ascorbic acid  (EXP)
linuron  (EXP)
malathion  (EXP,ISO)
mercury dichloride  (EXP)
methoxychlor  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (EXP)
N-Nitrosopyrrolidine  (ISO)
NADP zwitterion  (EXP,ISO)
nickel sulfate  (EXP)
nicotine  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorododecanoic acid  (EXP)
perfluoroheptanoic acid  (EXP)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP)
potassium dichromate  (EXP)
propanal  (ISO)
pyrethrins  (EXP)
quercetin  (EXP)
rivaroxaban  (EXP)
SB 203580  (EXP)
sodium arsenite  (ISO)
sulfasalazine  (EXP)
tamoxifen  (ISO)
taurine  (EXP)
terbufos  (ISO)
terbutylazine  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
triclosan  (EXP)
trimethyltin  (EXP)
triphenylstannane  (EXP)
vitamin E  (EXP)
zearalenone  (EXP,ISO)
zinc oxide  (EXP)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
endoplasmic reticulum  (IBA,IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Chromium induced testicular impairment in relation to adrenocortical activities in adult albino rats. Chandra AK, etal., Reprod Toxicol. 2007 Nov-Dec;24(3-4):388-96. Epub 2007 Aug 1.
2. Modulatory effects of lipoic acid and selenium against cadmium-induced biochemical alterations in testicular steroidogenesis. El-Maraghy SA and Nassar NN, J Biochem Mol Toxicol. 2010 Oct 18.
3. Inhibitory effect of valproic acid on ovarian androgen biosynthesis in rat theca-interstitial cells. Fisseha S, etal., Endocrine. 2010 Feb;37(1):187-93. Epub 2009 Dec 15.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Male pseudohermaphroditism caused by mutations of testicular 17 beta-hydroxysteroid dehydrogenase 3. Geissler WM, etal., Nat Genet. 1994 May;7(1):34-9.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Inhibitory effects of melatonin on sulfatase and 17beta-hydroxysteroid dehydrogenase activity and expression in glioma cells. Gonzalez A, etal., Oncol Rep. 2010 Apr;23(4):1173-8.
8. The (+)- and (-)-gossypols potently inhibit both 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 in human and rat testes. Hu GX, etal., J Steroid Biochem Mol Biol. 2009 May;115(1-2):14-9. Epub 2009 Feb 14.
9. Influence of commercial dietary oils on lipid composition and testosterone production in interstitial cells isolated from rat testis. Hurtado de Catalfo GE, etal., Lipids. 2009 Apr;44(4):345-57. Epub 2009 Jan 8.
10. Protective effect of sodium selenite and zinc sulfate on intensive swimming-induced testicular gamatogenic and steroidogenic disorders in mature male rats. Jana K, etal., Appl Physiol Nutr Metab. 2008 Oct;33(5):903-14.
11. Effects of chronic exposure to sodium arsenite on hypothalamo-pituitary-testicular activities in adult rats: possible an estrogenic mode of action. Jana K, etal., Reprod Biol Endocrinol. 2006 Feb 16;4:9.
12. Semicomprehensive Analysis of the Postnatal Age-Related Changes in the mRNA Expression of Sex Steroidogenic Enzymes and Sex Steroid Receptors in the Male Rat Hippocampus. Kimoto T, etal., Endocrinology. 2010 Nov 3.
13. Androgenic endocrine disruptors in wastewater treatment plant effluents in India: their influence on reproductive processes and systemic toxicity in male rats. Kumar V, etal., Toxicol Appl Pharmacol. 2008 Jan 1;226(1):60-73. Epub 2007 Sep 5.
14. Disruption of LH-induced testosterone biosynthesis in testicular Leydig cells by triclosan: probable mechanism of action. Kumar V, etal., Toxicology. 2008 Sep 4;250(2-3):124-31. Epub 2008 Jul 9.
15. The transcription of steroidogenic genes in the human cerebellum and hippocampus: a comparative survey of normal and Alzheimer's tissue. MacKenzie SM, etal., J Endocrinol. 2008 Jan;196(1):123-30.
16. Effects of dietary fats and proteins on rat testicular steroidogenic enzymes and serum testosterone levels. McVey MJ, etal., Food Chem Toxicol. 2008 Jan;46(1):259-69. Epub 2007 Sep 11.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Androgen synthesis in adrenarche. Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17.
19. Polychlorinated biphenyl (Aroclor 1254) inhibits testosterone biosynthesis and antioxidant enzymes in cultured rat Leydig cells. Murugesan P, etal., Reprod Toxicol. 2008 Aug;25(4):447-54. Epub 2008 Apr 18.
20. Effects of vitamins C and E on steroidogenic enzymes mRNA expression in polychlorinated biphenyl (Aroclor 1254) exposed adult rat Leydig cells. Murugesan P, etal., Toxicology. 2007 Apr 11;232(3):170-82. Epub 2007 Jan 16.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Leydig cell re-generation and expression of cell signaling molecules in the germ cell-free testis. O'Shaughnessy PJ, etal., Reproduction. 2008 Jun;135(6):851-8.
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Lead and cadmium co-exposure mediated toxic insults on hepatic steroid metabolism and antioxidant system of adult male rats. Pandya CD, etal., Biol Trace Elem Res. 2010 Jun;134(3):307-17. Epub 2009 Aug 4.
25. Effects of corticosterone deficiency and its replacement on Leydig cell steroidogenesis. Parthasarathy C and Balasubramanian K, J Cell Biochem. 2008 Aug 1;104(5):1671-83.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. Upregulation of peripubertal rat Leydig cell steroidogenesis following 24 h in vitro and in vivo exposure to atrazine. Pogrmic-Majkic K, etal., Toxicol Sci. 2010 Nov;118(1):52-60. Epub 2010 Jul 28.
28. Modulation of antioxidant defense system by the environmental fungicide carbendazim in Leydig cells of rats. Rajeswary S, etal., Reprod Toxicol. 2007 Nov-Dec;24(3-4):371-80. Epub 2007 Apr 5.
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Comprehensive gene review and curation RGD comprehensive gene curation
33. Influence of oleoyl-estrone treatment on circulating testosterone. Role of 17beta-hydroxysteroid dehydrogenase isoenzymes. Romero MM, etal., J Physiol Pharmacol. 2009 Mar;60(1):181-90.
34. Alterations in gene expression and testosterone synthesis in the testes of male rats exposed to perfluorododecanoic acid. Shi Z, etal., Toxicol Sci. 2007 Jul;98(1):206-15. Epub 2007 Mar 30.
35. The expression of serum steroid sex hormones and steroidogenic enzymes following intraperitoneal administration of dehydroepiandrosterone (DHEA) in male rats. Song L, etal., Steroids. 2010 Mar;75(3):213-8. Epub 2009 Dec 2.
36. Effect of exogenous selenium on the testicular toxicity induced by ethanol in rats. Swathy SS, etal., Indian J Physiol Pharmacol. 2006 Jul-Sep;50(3):215-24.
37. The rat 17beta-hydroxysteroid dehydrogenase type III: molecular cloning and gonadotropin regulation. Tsai-Morris CH, etal., Endocrinology 1999 Aug;140(8):3534-42.
38. Transient inhibitory effect of methoxychlor on testicular steroidogenesis in rat: an in vivo study. Vaithinathan S, etal., Arch Toxicol. 2008 Nov;82(11):833-9. Epub 2008 Apr 10.
39. Anti-androgenic endocrine disrupting activities of chlorpyrifos and piperophos. Viswanath G, etal., J Steroid Biochem Mol Biol. 2010 May;120(1):22-9. Epub 2010 Mar 6.
40. Zhonghua nan ke xue = National journal of andrology Wu XY, etal., Zhonghua Nan Ke Xue. 2008 Apr;14(4):371-6.
41. Inhibition of 3beta- and 17beta-hydroxysteroid dehydrogenase activities in rat Leydig cells by perfluorooctane acid. Zhao B, etal., J Steroid Biochem Mol Biol. 2010 Jan;118(1-2):13-7. Epub 2009 Oct 7.
Additional References at PubMed
PMID:21440566   PMID:26545797   PMID:32438512   PMID:33586219  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2171,027,229 - 1,058,554 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl171,027,229 - 1,058,554 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx171,045,909 - 1,077,225 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0172,588,485 - 2,619,812 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0171,043,327 - 1,074,653 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0171,579,319 - 1,610,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl171,579,319 - 1,610,745 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0171,570,077 - 1,600,357 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,554,164 - 6,585,525 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1176,554,163 - 6,585,525 (+)NCBI
Celera171,458,596 - 1,490,020 (-)NCBICelera
Cytogenetic Map17p14NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38996,235,306 - 96,302,176 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl996,235,306 - 96,302,176 (-)EnsemblGRCh38hg38GRCh38
GRCh37998,997,588 - 99,064,458 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36998,037,410 - 98,104,255 (-)NCBINCBI36Build 36hg18NCBI36
Build 34996,077,143 - 96,143,989NCBI
Celera969,439,150 - 69,506,013 (-)NCBICelera
Cytogenetic Map9q22.32NCBI
HuRef968,608,833 - 68,675,720 (-)NCBIHuRef
CHM1_1999,144,095 - 99,210,909 (-)NCBICHM1_1
T2T-CHM13v2.09108,406,656 - 108,473,885 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391364,206,088 - 64,237,076 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1364,206,080 - 64,237,044 (-)EnsemblGRCm39 Ensembl
GRCm381364,058,274 - 64,089,262 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1364,058,266 - 64,089,230 (-)EnsemblGRCm38mm10GRCm38
MGSCv371364,159,582 - 64,190,509 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361364,067,496 - 64,098,408 (-)NCBIMGSCv36mm8
Celera1365,722,306 - 65,753,080 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1333.26NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542223,101,795 - 23,148,999 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542223,104,752 - 23,251,250 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1943,150,475 - 43,223,335 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0967,327,047 - 67,411,754 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1995,451,031 - 95,531,578 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl995,451,031 - 95,522,739 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1170,551,013 - 70,586,364 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl170,487,334 - 70,586,368 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha171,314,005 - 71,349,356 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0170,851,728 - 70,887,109 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl170,788,086 - 70,886,492 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1170,663,395 - 70,698,690 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0170,426,654 - 70,461,997 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0171,137,784 - 71,173,174 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244049446,011,845 - 6,041,225 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936487228,557 - 245,295 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936487228,301 - 282,495 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1025,822,913 - 25,866,871 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11025,822,913 - 25,866,871 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21029,949,458 - 29,993,351 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.112106,831,807 - 106,885,543 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12106,832,034 - 106,886,385 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603895,260,015 - 95,282,321 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462475317,789,789 - 17,832,747 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475317,770,326 - 17,832,560 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Hsd17b3
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:55
Interacting mature miRNAs:62
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2171,030,618 - 1,030,731 (-)MAPPERmRatBN7.2
mRatBN7.23154,440,566 - 154,441,900 (+)MAPPERmRatBN7.2
Rnor_6.03162,387,094 - 162,388,427NCBIRnor6.0
Rnor_6.0171,607,243 - 1,607,355NCBIRnor6.0
Rnor_5.0171,596,799 - 1,596,911UniSTSRnor5.0
Rnor_5.03168,566,785 - 168,568,118UniSTSRnor5.0
RGSC_v3.43156,762,172 - 156,763,505UniSTSRGSC3.4
RGSC_v3.4176,557,554 - 6,557,666UniSTSRGSC3.4
Celera171,486,353 - 1,486,465UniSTS
Celera3153,029,202 - 153,030,535UniSTS
Cytogenetic Map3q42UniSTS
Cytogenetic Map17p14UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 9
Low 8 3 22 21 6
Below cutoff 3 27 35 27 16 27 7 9 26 25 7 5 7


RefSeq Acc Id: ENSRNOT00000025850   ⟹   ENSRNOP00000025850
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl171,027,229 - 1,058,554 (+)Ensembl
Rnor_6.0 Ensembl171,579,319 - 1,610,745 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116377   ⟹   ENSRNOP00000094524
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl171,027,250 - 1,058,554 (+)Ensembl
RefSeq Acc Id: NM_054007   ⟹   NP_446459
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,027,229 - 1,058,554 (+)NCBI
Rnor_6.0171,579,319 - 1,610,745 (-)NCBI
Rnor_5.0171,570,077 - 1,600,357 (-)NCBI
RGSC_v3.4176,554,164 - 6,585,525 (+)RGD
Celera171,458,596 - 1,490,020 (-)RGD
Protein Sequences
Protein RefSeqs NP_446459 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB99739 (Get FASTA)   NCBI Sequence Viewer  
  EDL84424 (Get FASTA)   NCBI Sequence Viewer  
  EDL84425 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025850
GenBank Protein O54939 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446459   ⟸   NM_054007
- UniProtKB: O54939 (UniProtKB/Swiss-Prot),   F1LMA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025850   ⟸   ENSRNOT00000025850
RefSeq Acc Id: ENSRNOP00000094524   ⟸   ENSRNOT00000116377

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54939-F1-model_v2 AlphaFold O54939 1-306 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700259
Promoter ID:EPDNEW_R10782
Type:multiple initiation site
Description:hydroxysteroid (17-beta) dehydrogenase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0171,610,760 - 1,610,820EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621805 AgrOrtholog
BioCyc Gene G2FUF-10535 BioCyc
Ensembl Genes ENSRNOG00000019096 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025850 ENTREZGENE
  ENSRNOT00000025850.4 UniProtKB/TrEMBL
  ENSRNOT00000116377.1 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117182 UniProtKB/Swiss-Prot
PANTHER PTHR43899:SF7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RH59310P UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam adh_short UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hsd17b3 PhenoGen
PIRSF 11-beta-HSD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019096 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DHB3_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Hsd17b3  hydroxysteroid (17-beta) dehydrogenase 3    hydroxysteroid 17-beta dehydrogenase 3  Name updated 1299863 APPROVED
2002-08-07 Hsd17b3  hydroxysteroid 17-beta dehydrogenase 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 306 amino acids; 33.7 kDa 727276