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Gene: Rad50 (RAD50 double strand break repair protein) Rattus norvegicus
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Symbol: Rad50
Name: RAD50 double strand break repair protein
RGD ID: 621542
Description: Exhibits double-stranded DNA binding activity. Predicted to contribute to 3'-5' exonuclease activity; DNA helicase activity; and single-stranded DNA endodeoxyribonuclease activity. Involved in several processes, including cellular response to DNA damage stimulus; negative regulation of viral entry into host cell; and response to human chorionic gonadotropin. Localizes to inclusion body; nuclear lumen; and perinuclear region of cytoplasm. Used to study liver cirrhosis and myocardial infarction. Human ortholog(s) of this gene implicated in transitional cell carcinoma. Orthologous to human RAD50 (RAD50 double strand break repair protein); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; non-homologous end joining pathway of double-strand break repair; INTERACTS WITH 1,3-dinitrobenzene; 4-hydroperoxycyclophosphamide; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: DNA repair protein RAD50; RAD50 homolog; RAD50 homolog (S. cerevisiae); RAD50 homolog, double strand break repair protein
Orthologs:
Homo sapiens (human) : RAD50 (RAD50 double strand break repair protein)  HGNC  Alliance
Mus musculus (house mouse) : Rad50 (RAD50 double strand break repair protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rad50 (RAD50 double strand break repair protein)
Pan paniscus (bonobo/pygmy chimpanzee) : RAD50 (RAD50 double strand break repair protein)
Canis lupus familiaris (dog) : RAD50 (RAD50 double strand break repair protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rad50 (RAD50 double strand break repair protein)
Sus scrofa (pig) : RAD50 (RAD50 double strand break repair protein)
Chlorocebus sabaeus (African green monkey) : RAD50 (RAD50 double strand break repair protein)
Heterocephalus glaber (naked mole-rat) : Rad50 (RAD50 double strand break repair protein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01039,002,130 - 39,054,042 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,001,498 - 39,054,142 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,783,860 - 38,835,810 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,112,733 - 39,164,694 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11039,121,979 - 39,173,935 (-)NCBI
Celera1037,153,558 - 37,205,520 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Rad50
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621542
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.