Slc22a2 (solute carrier family 22 member 2) - Rat Genome Database

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Gene: Slc22a2 (solute carrier family 22 member 2) Rattus norvegicus
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Symbol: Slc22a2
Name: solute carrier family 22 member 2
RGD ID: 61936
Description: Enables several functions, including monoamine transmembrane transporter activity; organic cation transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in several processes, including acetylcholine transport; histamine transport; and monoamine transport. Acts upstream of or within positive regulation of gene expression. Located in apical plasma membrane and basolateral plasma membrane. Is active in cholinergic synapse; presynaptic membrane; and synaptic vesicle membrane. Used to study acute kidney failure. Biomarker of cholestasis (multiple); hyperuricemia; and kidney failure (multiple). Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to human SLC22A2 (solute carrier family 22 member 2); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH (R)-carnitine; 11-deoxycorticosterone; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: OCT2; OCT2r; organic cation transporter 2; rOCT2; solute carrier family 22 (organic cation transporter), member 2; solute carrier family 22, member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SD-Slc22a2em1Sage  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,668,817 - 50,711,019 (-)NCBIGRCr8
mRatBN7.2148,121,061 - 48,163,268 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,121,061 - 48,163,268 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,812,678 - 48,854,865 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,798,480 - 54,840,630 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,888,183 - 48,930,374 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,318,025 - 48,360,219 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,317,995 - 48,360,261 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,394,014 - 51,435,104 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,395,676 - 42,442,847 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,398,620 - 42,445,782 (-)NCBI
Celera143,920,665 - 43,963,268 (-)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-pilocarpine  (ISO)
(-)-noscapine  (ISO)
(-)-selegiline  (ISO)
(E)-thiamethoxam  (ISO)
(R)-carnitine  (EXP)
(S)-atropine  (ISO)
(S)-fenfluramine  (ISO)
(S)-nicotine  (ISO)
1,1'-diethyl-2,2'-cyanine  (ISO)
1,1-dichloroethene  (ISO)
1,3-diphenylguanidine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methyl-1,4-diazepane  (ISO)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-methylnicotinamide  (ISO)
1-naphthyl isothiocyanate  (ISO)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (EXP)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP)
2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (ISO)
2-Amino-3-methyl-9H-pyrido[2,3-b]indole  (ISO)
2-Amino-9H-pyrido[2,3-b]indole  (ISO)
2-hydroxy-2,2-diphenylacetic acid (1,1-dimethyl-3-piperidin-1-iumyl) ester  (ISO)
2-hydroxy-2,2-diphenylacetic acid (1-methyl-1-azoniabicyclo[2.2.2]octan-3-yl) ester  (ISO)
2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4',5-tetrachlorosalicylanilide  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3,4-dimethoxybenzoic acid 4-[ethyl-[1-(4-methoxyphenyl)propan-2-yl]amino]butyl ester  (ISO)
3-[2-(ethylamino)-1-hydroxyethyl]phenol  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone  (ISO)
4-[1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl]phenol  (ISO)
4-[6-(diaminomethylideneamino)-1-oxohexoxy]benzoic acid ethyl ester  (ISO)
4-amino-5-chloro-2-methoxy-N-[1-(phenylmethyl)-4-piperidinyl]benzamide  (ISO)
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide  (ISO)
5-azaorotic acid  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (EXP)
9-aminoacridine  (ISO)
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol  (ISO)
AB-Fubinaca  (ISO)
acetamiprid  (ISO)
acetylsalicylic acid  (ISO)
aclacinomycin A  (ISO)
aconitine  (ISO)
adapalene  (ISO)
adrenosterone  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP,ISO)
alprazolam  (ISO)
alprenolol  (ISO)
amiloride  (ISO)
amitraz  (ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
anastrozole  (ISO)
androsterone  (ISO)
angelicin  (ISO)
antazoline  (ISO)
apomorphine  (ISO)
aristolochic acids  (EXP)
atrazine  (EXP)
atropine  (ISO)
auranofin  (ISO)
azelastine  (ISO)
azithromycin  (ISO)
bazedoxifene  (ISO)
beclomethasone  (ISO)
benzatropine  (ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (ISO)
beta-carboline  (ISO)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bithionol  (ISO)
bopindolol  (ISO)
bretylium tosylate  (ISO)
brilliant green  (ISO)
brimonidine tartrate  (ISO)
bromhexine  (ISO)
brompheniramine  (ISO)
budesonide  (ISO)
bupropion  (ISO)
buspirone  (ISO)
butenafine  (ISO)
Butylparaben  (ISO)
butylscopolamine bromide  (ISO)
cadmium dichloride  (EXP)
capsaicin  (ISO)
carbinoxamine  (ISO)
carvedilol  (ISO)
CGP 52608  (ISO)
chlorhexidine  (ISO)
Chlormadinone acetate  (ISO)
chlorogenic acid  (ISO)
chloroquine  (ISO)
chlorphenamine  (EXP,ISO)
chlorphenesin carbamate  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cilostazol  (ISO)
cimetidine  (EXP,ISO)
cisapride  (ISO)
cisplatin  (EXP,ISO)
clidinium  (ISO)
clomacran  (ISO)
clomipramine  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clorprenaline  (ISO)
clothianidin  (ISO)
clozapine  (ISO)
corticosterone  (EXP)
cortisol  (ISO)
cortisone  (ISO)
crystal violet  (ISO)
cyclobenzaprine  (ISO)
cyclosporin A  (EXP)
cyproheptadine  (ISO)
cyromazine  (ISO)
decabromodiphenyl ether  (EXP)
dequalinium  (ISO)
desipramine  (ISO)
desloratadine  (ISO)
desoximetasone  (ISO)
dexbrompheniramine  (ISO)
dexchlorpheniramine  (ISO)
dextromethorphan  (ISO)
dextropropoxyphene  (ISO)
diazepam  (ISO)
dibenzofurans  (ISO)
dichlorine  (EXP)
dicyclomine  (ISO)
digitonin  (ISO)
dimenhydrinate  (ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dioxygen  (ISO)
diphenhydramine  (ISO)
diphenidol  (ISO)
dipyridamole  (ISO)
disodium selenite  (ISO)
disopyramide  (EXP,ISO)
domperidone  (ISO)
donepezil hydrochloride  (ISO)
dopamine  (EXP)
doxazosin  (ISO)
doxepin  (EXP,ISO)
droperidol  (ISO)
dyclonine  (ISO)
econazole  (ISO)
epalrestat  (ISO)
Eperisone hydrochloride  (ISO)
epinastine  (ISO)
estrone  (ISO)
ethidium  (ISO)
exemestane  (ISO)
famotidine  (EXP,ISO)
fenitrothion  (ISO)
finasteride  (ISO)
flumazenil  (ISO)
fluorometholone  (ISO)
fluoxetine  (ISO)
fluphenazine  (ISO)
Flurandrenolide  (ISO)
formononetin  (EXP)
fructose  (EXP)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
Glu-P-1  (ISO)
Glu-P-2  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
granisetron  (ISO)
Guanabenz  (ISO)
Guanfacine  (ISO)
Halcinonide  (ISO)
haloperidol  (ISO)
harman  (ISO)
Homatropine  (ISO)
hydralazine  (ISO)
hydroxyzine  (ISO)
idebenone  (ISO)
imidacloprid  (ISO)
imipramine  (ISO)
imperatorin  (ISO)
indapamide  (ISO)
indometacin  (ISO)
ipratropium  (ISO)
isoimperatorin  (ISO)
Isopropamide iodide  (ISO)
kainic acid  (ISO)
ketotifen  (ISO)
Lafutidine  (ISO)
lamivudine  (ISO)
lansoprazole  (ISO)
letrozole  (ISO)
leuprolide  (ISO)
Licochalcone B  (ISO)
lidocaine  (ISO)
lisuride  (ISO)
loperamide  (ISO)
lysergol  (ISO)
malathion  (ISO)
maneb  (ISO)
mangiferin  (ISO)
Maprotiline  (ISO)
mechlorethamine  (ISO)
medroxyprogesterone  (ISO)
mefloquine  (ISO)
megestrol acetate  (ISO)
MeIQ  (ISO)
MeIQx  (ISO)
melatonin  (ISO)
Mepenzolate  (ISO)
mepiquat  (EXP)
mepyramine  (ISO)
mercury dichloride  (EXP,ISO)
Mestanolone  (ISO)
metformin  (EXP,ISO)
methoxsalen  (ISO)
methyltestosterone  (ISO)
metoclopramide  (ISO)
metoprolol  (ISO)
mianserin  (ISO)
miconazole  (ISO)
mirtazapine  (ISO)
monobenzone  (ISO)
mosapride citrate dihydrate  (ISO)
Moxonidine  (ISO)
mycophenolic acid  (ISO)
myrtecaine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP,ISO)
nalbuphine  (ISO)
nandrolone  (ISO)
naphthalene  (EXP)
naproxen  (ISO)
nefazodone  (ISO)
nicardipine  (ISO)
nicotine  (ISO)
Nifekalant  (ISO)
nimetazepam  (ISO)
nitenpyram  (ISO)
nocodazole  (ISO)
norethisterone  (ISO)
norfloxacin  (ISO)
nortriptyline  (ISO)
ochratoxin A  (EXP)
olanzapine  (ISO)
omeprazole  (ISO)
Ondansetron  (ISO)
orlistat  (ISO)
orphenadrine  (ISO)
oxaliplatin  (ISO)
oxatomide  (ISO)
oxiconazole  (ISO)
oxybuprocaine  (ISO)
oxybutynin  (ISO)
oxymetazoline  (ISO)
oxymetholone  (ISO)
ozone  (EXP)
p-aminohippuric acid  (ISO)
paraquat  (EXP,ISO)
paroxetine  (ISO)
parthenolide  (ISO)
pecazine  (ISO)
pentamidine  (ISO)
perfluorodecalin  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pergolide  (ISO)
perhexiline  (ISO)
permethrin  (EXP)
perphenazine  (ISO)
Phenelzine  (ISO)
phenformin  (ISO)
Phenoxybenzamine  (ISO)
phentolamine  (ISO)
phenyltoloxamine  (ISO)
PhIP  (ISO)
pioglitazone  (ISO)
Piracetam  (ISO)
piroxicam  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
pralidoxime  (ISO)
prazosin  (ISO)
prednisone  (ISO)
pridinol  (ISO)
primaquine  (ISO)
prinomastat  (ISO)
probenecid  (ISO)
procyclidine  (ISO)
progesterone  (EXP)
promazine  (ISO)
Propantheline  (ISO)
Proparacaine  (ISO)
propranolol  (ISO)
psoralen  (ISO)
pyrimethamine  (ISO)
quercetin  (EXP,ISO)
quinidine  (ISO)
quinine  (ISO)
rabeprazole  (ISO)
raloxifene  (ISO)
ranitidine  (EXP,ISO)
resveratrol  (ISO)
rutin  (EXP)
semustine  (ISO)
sildenafil citrate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sparteine  (ISO)
spiperone  (ISO)
spironolactone  (ISO)
streptozocin  (EXP)
strychnine  (ISO)
sulconazole  (ISO)
sulindac  (ISO)
tacrine  (ISO)
Tegafur  (ISO)
telmisartan  (ISO)
terbutaline  (ISO)
terconazole  (ISO)
testosterone  (EXP)
tetracaine  (ISO)
tetrachloromethane  (EXP)
tetraethylammonium  (EXP,ISO)
tetrahydropalmatine  (ISO)
tetryzoline  (ISO)
thalidomide  (ISO)
thiacloprid  (ISO)
thiamethoxam  (ISO)
thioridazine  (ISO)
tolazoline  (ISO)
tolterodine tartrate  (ISO)
trazodone  (ISO)
triamcinolone acetonide  (ISO)
triazolam  (ISO)
Trihexyphenidyl  (ISO)
trimellitic anhydride  (ISO)
trimipramine  (ISO)
Tripelennamine  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tropisetron  (ISO)
trospium chloride  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
varenicline  (ISO)
verapamil  (EXP,ISO)
VX-745  (ISO)
Xylometazoline  (ISO)
zafirlukast  (ISO)
zolpidem  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Amphoux A, etal., Neuropharmacology. 2006 Jun;50(8):941-52. doi: 10.1016/j.neuropharm.2006.01.005. Epub 2006 Mar 31.
2. Mechanism of electrogenic cation transport by the cloned organic cation transporter 2 from rat. Budiman T, etal., J Biol Chem. 2000 Sep 22;275(38):29413-20. doi: 10.1074/jbc.M004645200.
3. Membrane transporters as mediators of Cisplatin effects and side effects. Ciarimboli G Scientifica (Cairo). 2012;2012:473829. doi: 10.6064/2012/473829. Epub 2012 Nov 25.
4. Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity. Filipski KK, etal., Clin Pharmacol Ther. 2009 Oct;86(4):396-402. doi: 10.1038/clpt.2009.139. Epub 2009 Jul 22.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Metformin pathways: pharmacokinetics and pharmacodynamics. Gong L, etal., Pharmacogenet Genomics. 2012 Nov;22(11):820-7. doi: 10.1097/FPC.0b013e3283559b22.
7. Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2). Grundemann D, etal., J Pharmacol Exp Ther 2003 Feb;304(2):810-7.
8. Selective substrates for non-neuronal monoamine transporters. Grundemann D, etal., Mol Pharmacol 1999 Jul;56(1):1-10.
9. Transport of monoamine transmitters by the organic cation transporter type 2, OCT2. Gründemann D, etal., J Biol Chem. 1998 Nov 20;273(47):30915-20. doi: 10.1074/jbc.273.47.30915.
10. Restored expression and activity of organic ion transporters rOAT1, rOAT3 and rOCT2 after hyperuricemia in the rat kidney. Habu Y, etal., Biochem Pharmacol. 2005 Mar 15;69(6):993-9.
11. Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia. Heemskerk S, etal., Eur J Pharmacol. 2008 Apr 28;584(2-3):390-7. doi: 10.1016/j.ejphar.2008.02.006. Epub 2008 Feb 12.
12. Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice. Hu QH, etal., Eur J Nutr. 2012 Aug;51(5):593-606. doi: 10.1007/s00394-011-0243-y. Epub 2011 Sep 10.
13. Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy. Ji L, etal., Kidney Int. 2002 Aug;62(2):514-24.
14. Reduced antidiabetic effect of metformin and down-regulation of hepatic Oct1 in rats with ethynylestradiol-induced cholestasis. Jin HE, etal., Pharm Res. 2009 Mar;26(3):549-59. doi: 10.1007/s11095-008-9770-5. Epub 2008 Nov 11.
15. Functional characterization of mouse cation transporter mOCT2 compared with mOCT1. Kakehi M, etal., Biochem Biophys Res Commun. 2002 Aug 23;296(3):644-50.
16. Localization of organic cation transporters OCT1 and OCT2 in rat kidney. Karbach U, etal., Am J Physiol Renal Physiol. 2000 Oct;279(4):F679-87.
17. Cell free expression and functional reconstitution of eukaryotic drug transporters. Keller T, etal., Biochemistry. 2008 Apr 15;47(15):4552-64. doi: 10.1021/bi800060w. Epub 2008 Mar 25.
18. Renal uptake of substrates for organic anion transporters Oat1 and Oat3 and organic cation transporters Oct1 and Oct2 is altered in rats with adenine-induced chronic renal failure. Komazawa H, etal., J Pharm Sci. 2013 Mar;102(3):1086-94. doi: 10.1002/jps.23433. Epub 2012 Dec 29.
19. Elevated systemic elimination of cimetidine in rats with acute biliary obstruction: the role of renal organic cation transporter OCT2. Kurata T, etal., Drug Metab Pharmacokinet. 2010;25(4):328-34.
20. Lack of a primary physicochemical determinant in the direct transport of drugs to the brain after nasal administration in rats: potential involvement of transporters in the pathway. Lee KR, etal., Drug Metab Pharmacokinet. 2010;25(5):430-41. doi: 10.2133/dmpk.dmpk-10-rg-049. Epub 2010 Sep 30.
21. Cellular localization of the organic cation transporters, OCT1 and OCT2, in brain microvessel endothelial cells and its implication for MPTP transport across the blood-brain barrier and MPTP-induced dopaminergic toxicity in rodents. Lin CJ, etal., J Neurochem. 2010 Aug;114(3):717-27. doi: 10.1111/j.1471-4159.2010.06801.x. Epub 2010 May 6.
22. Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. Lips KS, etal., Am J Respir Cell Mol Biol. 2005 Jul;33(1):79-88. Epub 2005 Apr 7.
23. Aristolochic acid-induced destruction of organic ion transporters and fatty acid metabolic disorder in the kidney of rats. Lou Y, etal., Toxicol Lett. 2011 Feb 25;201(1):72-9. doi: 10.1016/j.toxlet.2010.12.007. Epub 2010 Dec 15.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Regulation of renal organic ion transporters in cisplatin-induced acute kidney injury and uremia in rats. Morisaki T, etal., Pharm Res. 2008 Nov;25(11):2526-33. doi: 10.1007/s11095-008-9668-2. Epub 2008 Jul 9.
26. Organic cation transporter 2 (SLC22A2), a low-affinity and high-capacity choline transporter, is preferentially enriched on synaptic vesicles in cholinergic neurons. Nakata T, etal., Neuroscience. 2013 Nov 12;252:212-21. doi: 10.1016/j.neuroscience.2013.08.011. Epub 2013 Aug 17.
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. Renal and hepatic transporter expression in type 2 diabetic rats. Nowicki MT, etal., Drug Metab Lett. 2008 Jan;2(1):11-7.
29. Recent advances in molecular pharmacology of the histamine systems: organic cation transporters as a histamine transporter and histamine metabolism. Ogasawara M, etal., J Pharmacol Sci. 2006 May;101(1):24-30. Epub 2006 Apr 28.
30. cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Okuda M, etal., Biochem Biophys Res Commun 1996 Jul 16;224(2):500-7.
31. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
32. Mitigation of cell apoptosis induced by ochratoxin A (OTA) is possibly through organic cation transport 2 (OCT2) knockout. Qi X, etal., Food Chem Toxicol. 2018 Nov;121:15-23. doi: 10.1016/j.fct.2018.08.026. Epub 2018 Aug 16.
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Charge-to-substrate ratio during organic cation uptake by rat OCT2 is voltage dependent and altered by exchange of glutamate 448 with glutamine. Schmitt BM, etal., Am J Physiol Renal Physiol. 2009 Apr;296(4):F709-22. Epub 2009 Feb 11.
37. Nitric oxide-induced regulation of renal organic cation transport after renal ischemia-reperfusion injury. Schneider R, etal., Am J Physiol Renal Physiol. 2011 Nov;301(5):F997-F1004. doi: 10.1152/ajprenal.00264.2011. Epub 2011 Aug 10.
38. Extraneuronal monoamine transporter and organic cation transporters 1 and 2: a review of transport efficiency. Schomig E, etal., Handb Exp Pharmacol. 2006;(175):151-80.
39. Differential localization of organic cation transporters rOCT1 and rOCT2 in the basolateral membrane of rat kidney proximal tubules. Sugawara-Yokoo M, etal., Histochem Cell Biol. 2000 Sep;114(3):175-80. doi: 10.1007/s004180000186.
40. Ventricular choline transport: a role for organic cation transporter 2 expressed in choroid plexus. Sweet DH, etal., J Biol Chem 2001 Nov 9;276(45):41611-9.
41. Regulation of renal organic anion and cation transporters by thymoquinone in cisplatin induced kidney injury. Ulu R, etal., Food Chem Toxicol. 2012 May;50(5):1675-9. doi: 10.1016/j.fct.2012.02.082. Epub 2012 Mar 3.
42. Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. Urakami Y, etal., J Pharmacol Exp Ther. 1998 Nov;287(2):800-5.
43. Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Urakami Y, etal., Pharm Res. 2001 Nov;18(11):1528-34. doi: 10.1023/a:1013070128668.
44. Different affinities of inhibitors to the outwardly and inwardly directed substrate binding site of organic cation transporter 2. Volk C, etal., Mol Pharmacol. 2003 Nov;64(5):1037-47.
45. Mulberroside a possesses potent uricosuric and nephroprotective effects in hyperuricemic mice. Wang CP, etal., Planta Med. 2011 May;77(8):786-94. doi: 10.1055/s-0030-1250599. Epub 2010 Dec 10.
46. Renal tumours in a Tsc1(+)/(-) mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin. Yang J, etal., Eur J Cancer. 2013 Apr;49(6):1479-90. doi: 10.1016/j.ejca.2012.10.027. Epub 2012 Dec 7.
Additional References at PubMed
PMID:12477932   PMID:14718608   PMID:15016452   PMID:15377492   PMID:15878879   PMID:16024787   PMID:16550473   PMID:17567940   PMID:18230276   PMID:18484100   PMID:19056867   PMID:19141712  
PMID:19330287   PMID:19629622   PMID:22005293   PMID:22941487   PMID:23182769   PMID:23774469   PMID:24531880   PMID:24981592   PMID:25876759   PMID:26174463   PMID:27901065   PMID:28414026  
PMID:30951542   PMID:32484793  


Genomics

Comparative Map Data
Slc22a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,668,817 - 50,711,019 (-)NCBIGRCr8
mRatBN7.2148,121,061 - 48,163,268 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,121,061 - 48,163,268 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,812,678 - 48,854,865 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,798,480 - 54,840,630 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,888,183 - 48,930,374 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,318,025 - 48,360,219 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,317,995 - 48,360,261 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,394,014 - 51,435,104 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,395,676 - 42,442,847 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,398,620 - 42,445,782 (-)NCBI
Celera143,920,665 - 43,963,268 (-)NCBICelera
Cytogenetic Map1q11NCBI
SLC22A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386160,216,755 - 160,258,821 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6160,171,061 - 160,277,638 (-)EnsemblGRCh38hg38GRCh38
GRCh376160,637,787 - 160,679,853 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,557,780 - 160,599,949 (-)NCBINCBI36Build 36hg18NCBI36
Build 346160,608,201 - 160,650,370NCBI
Celera6161,284,724 - 161,329,224 (-)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6158,107,747 - 158,154,417 (-)NCBIHuRef
CHM1_16160,900,027 - 160,942,556 (-)NCBICHM1_1
T2T-CHM13v2.06161,462,946 - 161,508,769 (-)NCBIT2T-CHM13v2.0
Slc22a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391712,803,076 - 12,847,376 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1712,803,019 - 12,847,375 (+)EnsemblGRCm39 Ensembl
GRCm381712,584,189 - 12,628,489 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,584,132 - 12,628,488 (+)EnsemblGRCm38mm10GRCm38
MGSCv371712,777,055 - 12,821,354 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,427,547 - 12,471,846 (+)NCBIMGSCv36mm8
Celera1712,614,783 - 12,660,660 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.61NCBI
Slc22a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543920,567,212 - 20,609,105 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543920,567,241 - 20,608,281 (+)NCBIChiLan1.0ChiLan1.0
SLC22A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25180,320,892 - 180,367,795 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16178,223,301 - 178,271,798 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06158,058,226 - 158,150,917 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16163,066,654 - 163,158,469 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6163,065,317 - 163,158,931 (-)Ensemblpanpan1.1panPan2
SLC22A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,327,621 - 49,348,435 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,327,296 - 49,348,435 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha150,170,589 - 50,191,400 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,505,206 - 49,533,863 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,503,308 - 49,533,595 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,395,180 - 49,415,993 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0149,266,805 - 49,288,175 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0149,882,427 - 49,903,195 (-)NCBIUU_Cfam_GSD_1.0
Slc22a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946144,341,980 - 144,375,967 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,594,480 - 11,627,786 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648911,605,403 - 11,627,786 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,289,831 - 7,323,146 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,289,278 - 7,323,418 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.218,980,529 - 9,012,013 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,835,077 - 87,881,410 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1387,833,430 - 87,881,081 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604060,218,540 - 60,262,523 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc22a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248552,623,547 - 2,659,742 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248552,623,595 - 2,661,739 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc22a2
141 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:130
Count of miRNA genes:63
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000023116, ENSRNOT00000051927
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat

Markers in Region
D5Bwg0676e  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,154,389 - 48,154,620 (+)MAPPERmRatBN7.2
Rnor_6.0148,351,346 - 48,351,576NCBIRnor6.0
Rnor_6.01090,107,060 - 90,108,461NCBIRnor6.0
Rnor_5.0151,402,921 - 51,403,152NCBIRnor5.0
Rnor_5.01089,894,422 - 89,895,824NCBIRnor5.0
RGSC_v3.41091,232,990 - 91,234,391UniSTSRGSC3.4
RGSC_v3.4142,433,974 - 42,434,204UniSTSRGSC3.4
Celera143,954,422 - 43,954,652UniSTS
Celera1085,835,407 - 85,836,808UniSTS
Cytogenetic Map10q32.1UniSTS
Cytogenetic Map1q11UniSTS
Slc22a2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,163,134 - 48,163,552 (+)MAPPERmRatBN7.2
Rnor_6.0148,360,086 - 48,360,503NCBIRnor6.0
Rnor_5.0151,393,730 - 51,394,147UniSTSRnor5.0
RGSC_v3.4142,442,714 - 42,443,131UniSTSRGSC3.4
Celera143,963,135 - 43,963,552UniSTS
Cytogenetic Map1q11UniSTS


Related Rat Strains
The following Strains have been annotated to Slc22a2
SD-Slc22a2em1Sage    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 7 25 98 74 76 46 16 46 6 161 57 80 45 45 30

Sequence


Ensembl Acc Id: ENSRNOT00000023116   ⟹   ENSRNOP00000023116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl148,121,061 - 48,163,268 (-)Ensembl
Rnor_6.0 Ensembl148,317,995 - 48,360,261 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000051927   ⟹   ENSRNOP00000041251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl148,318,417 - 48,360,131 (-)Ensembl
RefSeq Acc Id: NM_031584   ⟹   NP_113772
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,668,817 - 50,711,019 (-)NCBI
mRatBN7.2148,121,061 - 48,163,268 (-)NCBI
Rnor_6.0148,318,025 - 48,360,219 (-)NCBI
Rnor_5.0151,394,014 - 51,435,104 (+)NCBI
RGSC_v3.4142,395,676 - 42,442,847 (-)RGD
Celera143,920,665 - 43,963,268 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113772 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA11754 (Get FASTA)   NCBI Sequence Viewer  
  CAA66979 (Get FASTA)   NCBI Sequence Viewer  
  CAB52215 (Get FASTA)   NCBI Sequence Viewer  
  EDL83062 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023116.2
GenBank Protein Q9R0W2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113772   ⟸   NM_031584
- UniProtKB: P97558 (UniProtKB/Swiss-Prot),   P70485 (UniProtKB/Swiss-Prot),   Q9R0W2 (UniProtKB/Swiss-Prot),   A0A0G2JSP9 (UniProtKB/TrEMBL),   A6KJX5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000041251   ⟸   ENSRNOT00000051927
Ensembl Acc Id: ENSRNOP00000023116   ⟸   ENSRNOT00000023116
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R0W2-F1-model_v2 AlphaFold Q9R0W2 1-555 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689625
Promoter ID:EPDNEW_R144
Type:initiation region
Name:Slc22a2_1
Description:solute carrier family 22 member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0148,360,221 - 48,360,281EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61936 AgrOrtholog
BioCyc Gene G2FUF-61570 BioCyc
Ensembl Genes ENSRNOG00000016625 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023116.6 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_sugar_transport-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orgcat_transp/SVOP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29503 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29503 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 22 MEMBER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sugar_tr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SLC22A2 RGD
PhenoGen Slc22a2 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016625 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSP9 ENTREZGENE, UniProtKB/TrEMBL
  A6KJX5 ENTREZGENE, UniProtKB/TrEMBL
  P70485 ENTREZGENE
  P97558 ENTREZGENE
  Q9R0W2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P70485 UniProtKB/Swiss-Prot
  P97558 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Slc22a2  solute carrier family 22 member 2  Slc22a2  solute carrier family 22 (organic cation transporter), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc22a2  solute carrier family 22 (organic cation transporter), member 2    solute carrier family 22, member 2  Name updated 1299863 APPROVED
2002-06-10 Slc22a2  solute carrier family 22, member 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization expressed on the apical plasma membrane and is excluded from the nucleus and basal region of choroid plexus cells 628453
gene_expression expressed in the choroid plexus of the ventricles of the brain 628453
gene_function organic ion transporter activity includes transport of tetraethylammonium, histamine, and gunaidine 634067
gene_function facilitates small organic cations entering into the cell via a potential dependent, Na+-independent, facilitative diffusion mechanism; transports choline across the ventricular membrane of choroid plexus 628453
gene_process may mediate central nervous system choline homeostasis 628453
gene_regulation transport activity is inhibited by xenobiotics, drugs, neurotransmitters, and neurotoxins 628453