Slc22a2 (solute carrier family 22 member 2) - Rat Genome Database

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Gene: Slc22a2 (solute carrier family 22 member 2) Rattus norvegicus
Analyze
Symbol: Slc22a2
Name: solute carrier family 22 member 2
RGD ID: 61936
Description: Enables several functions, including monoamine transmembrane transporter activity; organic cation transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in several processes, including acetylcholine transport; histamine transport; and monoamine transport. Located in apical plasma membrane and basolateral plasma membrane. Is active in cholinergic synapse; presynaptic membrane; and synaptic vesicle membrane. Used to study acute kidney failure. Biomarker of cholestasis (multiple); hyperuricemia; and kidney failure (multiple). Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to human SLC22A2 (solute carrier family 22 member 2); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH (R)-carnitine; 11-deoxycorticosterone; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: OCT2; OCT2r; organic cation transporter 2; rOCT2; solute carrier family 22 (organic cation transporter), member 2; solute carrier family 22, member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SD-Slc22a2em1Sage  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,668,817 - 50,711,019 (-)NCBIGRCr8
mRatBN7.2148,121,061 - 48,163,268 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,121,061 - 48,163,268 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,812,678 - 48,854,865 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,798,480 - 54,840,630 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,888,183 - 48,930,374 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,318,025 - 48,360,219 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,317,995 - 48,360,261 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,394,014 - 51,435,104 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,395,676 - 42,442,847 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,398,620 - 42,445,782 (-)NCBI
Celera143,920,665 - 43,963,268 (-)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Slc22a2Ratacute kidney failure treatmentIDA 7243179 RGD 
Slc22a2Ratacute kidney failure susceptibilityISOSLC22A2 (Homo sapiens)7243884DNA:SNP: :808G>T (rs316019) humanRGD 
Slc22a2Ratacute kidney failure  IEP 7243880mRNA:decreased expression:kidneyRGD 
Slc22a2Ratend stage renal disease  IEP 7243883protein:decreased expression:kidney and plasma membraneRGD 
Slc22a2Ratend stage renal disease  IEP 7243177 RGD 
Slc22a2RatEndotoxemia treatmentIDA 7243881 RGD 
Slc22a2RatExperimental Diabetes Mellitus  IEP 2312728protein:decreased expression:kidneyRGD 
Slc22a2Ratextrahepatic cholestasis  IEP 7243879protein:increased expression:kidneyRGD 
Slc22a2Rathyperuricemia treatmentISOSlc22a2 (Mus musculus)7244192 RGD 
Slc22a2Rathyperuricemia treatmentISOSlc22a2 (Mus musculus)7243180 RGD 
Slc22a2Rathyperuricemia  IEP 7243882mRNA and protein:decreased expression:kidneyRGD 
Slc22a2Ratintrahepatic cholestasis  IEP 7243885mRNA and protein:decreased expression:kidneyRGD 
Slc22a2Ratkidney failure  IEP 7243878mRNA and protein:decreased expression:kidney cortexRGD 
Slc22a2RatKidney Neoplasms  ISOSlc22a2 (Mus musculus)7243178mRNA:decreased expression:kidneyRGD 
Slc22a2RatKidney Reperfusion Injury  IEP 7243877 RGD 
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Slc22a2Rat3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome  ISOSLC22A2 (Homo sapiens)8554872ClinVar Annotator: match by term: 3-methylglutaconic aciduria with deafness more ...ClinVarPMID:15220921 more ...
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Slc22a2Ratkidney disease  ISOSLC22A2 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:22525860
Slc22a2Ratobesity  ISOSLC22A2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27401566
Slc22a2RatPoisoning  ISOSLC22A2 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:22525860

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Slc22a2Rat(+)-artemisinin multiple interactionsISOSLC22A2 (Homo sapiens)6480464artemisinin inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]CTDPMID:27504015
Slc22a2Rat(+)-pilocarpine multiple interactionsISOSLC22A2 (Homo sapiens)6480464Pilocarpine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]CTDPMID:21599003
Slc22a2Rat(-)-noscapine multiple interactionsISOSLC22A2 (Homo sapiens)6480464Noscapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]CTDPMID:21599003
Slc22a2Rat(-)-selegiline multiple interactionsISOSLC22A2 (Homo sapiens)6480464Selegiline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]CTDPMID:21599003
Slc22a2Rat(E)-thiamethoxam decreases activityISOSLC22A2 (Homo sapiens)6480464Thiamethoxam results in decreased activity of SLC22A2 proteinCTDPMID:31364238
Slc22a2Rat(R)-carnitine decreases expressionEXP 6480464Carnitine results in decreased expression of SLC22A2 proteinCTDPMID:25669660
Slc22a2Rat(S)-atropine multiple interactionsISOSLC22A2 (Homo sapiens)6480464Hyoscyamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]CTDPMID:21599003
Slc22a2Rat(S)-fenfluramine multiple interactionsISOSLC22A2 (Homo sapiens)6480464Dexfenfluramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]CTDPMID:21599003
Slc22a2Rat(S)-nicotine multiple interactionsISOSLC22A2 (Homo sapiens)6480464Nicotine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]CTDPMID:23770354
Slc22a2Rat(S)-nicotine affects response to substanceISOSLC22A2 (Homo sapiens)6480464SLC22A2 gene SNP affects the susceptibility to NicotineCTDPMID:25143296
Slc22a2Rat1,1'-diethyl-2,2'-cyanine multiple interactionsISOSLC22A2 (Homo sapiens)6480464pseudoisocyanine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]CTDPMID:12110607
Slc22a2Rat1,1-dichloroethene decreases expressionISOSlc22a2 (Mus musculus)6480464vinylidene chloride results in decreased expression of SLC22A2 mRNACTDPMID:26682919
Slc22a2Rat1,3-diphenylguanidine multiple interactionsISOSLC22A2 (Homo sapiens)6480464diphenylguanidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]CTDPMID:21599003
Slc22a2Rat1-[(4-chlorophenyl)-phenylmethyl]-4-methyl-1,4-diazepane multiple interactionsISOSLC22A2 (Homo sapiens)6480464homochlorocyclizine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]CTDPMID:21599003
Slc22a2Rat1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole multiple interactionsISOSLC22A2 (Homo sapiens)6480464sulconazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]CTDPMID:21599003
Slc22a2Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases response to substanceISOSlc22a2 (Mus musculus)6480464SLC22A2 protein results in increased susceptibility to 1-Methyl-4-phenyl-1 more ...CTDPMID:25248837
Slc22a2Rat1-methylnicotinamide increases importISOSLC22A2 (Homo sapiens)6480464SLC22A2 results in increased import of N(1)-methylnicotinamideCTDPMID:9260930
Slc22a2Rat1-naphthyl isothiocyanate increases expressionISOSlc22a2 (Mus musculus)64804641-Naphthylisothiocyanate results in increased expression of SLC22A2 mRNACTDPMID:15913567
Slc22a2Rat1-naphthyl isothiocyanate multiple interactionsISOSlc22a2 (Mus musculus)6480464O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1 and 2-diolate inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SLC22A2 mRNA]CTDPMID:15913567
Slc22a2Rat11-deoxycorticosterone multiple interactionsEXP 6480464Desoxycorticosterone inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]CTDPMID:9830022

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Biological Process
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Original Reference(s)
Slc22a2Ratacetylcholine transport involved_inIEAUniProtKB:O15244 and ensembl:ENSP000003559201600115GO_REF:0000107EnsemblGO_REF:0000107
Slc22a2Ratacetylcholine transport involved_inISOSLC22A2 (Homo sapiens)1624291 PMID:15817714RGDPMID:15817714
Slc22a2Ratacetylcholine transport involved_inIDA 2317432PMID:15817714UniProt 
Slc22a2Ratamine transport involved_inIEAUniProtKB:O15244 and ensembl:ENSP000003559201600115GO_REF:0000107EnsemblGO_REF:0000107
Slc22a2Ratamine transport involved_inISOSLC22A2 (Homo sapiens)1624291 PMID:9687576RGDPMID:9687576
Slc22a2Ratamino acid import across plasma membrane involved_inISOSLC22A2 (Homo sapiens)1624291 PMID:23864433RGDPMID:23864433
Slc22a2Ratamino acid import across plasma membrane involved_inIEAUniProtKB:O15244 and ensembl:ENSP000003559201600115GO_REF:0000107EnsemblGO_REF:0000107
Slc22a2Ratcellular detoxification involved_inIDA 30309940PMID:20924140ARUK-UCL 
Slc22a2Ratcellular detoxification involved_inISOSlc22a2 (Mus musculus)1624291 PMID:20477935RGDPMID:20477935
Slc22a2Ratcellular detoxification involved_inIEAUniProtKB:O70577 and ensembl:ENSMUSP000000411861600115GO_REF:0000107EnsemblGO_REF:0000107
Slc22a2Ratcellular detoxification involved_inIMP 30309941PMID:20477935ARUK-UCL 
Slc22a2Ratcellular detoxification involved_inIEAUniProtKB:O15244 and ensembl:ENSP000003559201600115GO_REF:0000107EnsemblGO_REF:0000107
Slc22a2Ratcellular detoxification involved_inISOSLC22A2 (Homo sapiens)1624291 PMID:20477935 more ...RGDPMID:20477935 more ...
Slc22a2Ratcholine transport involved_inIEAUniProtKB:O15244 and ensembl:ENSP000003559201600115GO_REF:0000107EnsemblGO_REF:0000107
Slc22a2Ratcholine transport involved_inISOSLC22A2 (Homo sapiens)1624291 PMID:9687576RGDPMID:9687576
Slc22a2Ratdopamine transport involved_inIDA 155663558PMID:16581093UniProt 
Slc22a2Ratdopamine transport involved_inIEAUniProtKB:O15244 and ensembl:ENSP000003559201600115GO_REF:0000107EnsemblGO_REF:0000107
Slc22a2Ratdopamine transport involved_inISOSLC22A2 (Homo sapiens)1624291 PMID:16581093RGDPMID:16581093
Slc22a2Ratdopamine transport involved_inIDA 155888554PMID:9812985UniProt 
Slc22a2Ratdopamine uptake involved_inIEAUniProtKB:O15244 and ensembl:ENSP000003559201600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
Slc22a2Ratapical plasma membrane located_inIEAUniProtKB:O70577 and ensembl:ENSMUSP000000411861600115GO_REF:0000107EnsemblGO_REF:0000107
Slc22a2Ratapical plasma membrane located_inIEAUniProtKB-SubCell:SL-00151600115GO_REF:0000044UniProtGO_REF:0000044
Slc22a2Ratapical plasma membrane located_inIDA 30309941PMID:20477935ARUK-UCL 
Slc22a2Ratapical plasma membrane located_inIDA 2317432PMID:15817714UniProt 
Slc22a2Ratapical plasma membrane located_inISOSLC22A2 (Homo sapiens)1624291 PMID:15817714 and PMID:20477935RGDPMID:15817714 and PMID:20477935
Slc22a2Ratapical plasma membrane located_inIEAUniProtKB:O15244 and ensembl:ENSP000003559201600115GO_REF:0000107EnsemblGO_REF:0000107
Slc22a2Ratapical plasma membrane located_inISOSlc22a2 (Mus musculus)1624291 PMID:20477935RGDPMID:20477935
Slc22a2Ratbasal plasma membrane located_inISOSLC22A2 (Homo sapiens)1624291 PMID:35307651RGDPMID:35307651
Slc22a2Ratbasal plasma membrane located_inIEAUniProtKB-SubCell:SL-00241600115GO_REF:0000044UniProtGO_REF:0000044
Slc22a2Ratbasal plasma membrane located_inIEAUniProtKB:O15244 and ensembl:ENSP000003559201600115GO_REF:0000107EnsemblGO_REF:0000107
Slc22a2Ratbasolateral plasma membrane  IDA 1643124renal proximal tubulesRGD 
Slc22a2Ratbasolateral plasma membrane located_inIEAUniProtKB-SubCell:SL-00261600115GO_REF:0000044UniProtGO_REF:0000044
Slc22a2Ratbasolateral plasma membrane located_inIDA 155663544PMID:11083459UniProt 
Slc22a2Ratbasolateral plasma membrane  IDA 1643123 RGD 
Slc22a2Ratcholinergic synapse is_active_inIDA 155230726PMID:23958595SynGO 
Slc22a2Ratendomembrane system located_inIEAUniProtKB-SubCell:SL-01471600115GO_REF:0000044UniProtGO_REF:0000044
Slc22a2Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Slc22a2Ratmembrane located_inIEAInterPro:IPR004749 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Slc22a2Ratplasma membrane located_inISOSLC22A2 (Homo sapiens)1624291 PMID:23137377RGDPMID:23137377
Slc22a2Ratplasma membrane located_inIEAUniProtKB:O15244 and ensembl:ENSP000003559201600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Slc22a2Ratacetylcholine transmembrane transporter activity enablesIDA 2317432PMID:15817714UniProt 
Slc22a2Ratacetylcholine transmembrane transporter activity enablesISOSLC22A2 (Homo sapiens)1624291 PMID:15817714RGDPMID:15817714
Slc22a2Ratacetylcholine transmembrane transporter activity enablesIEAUniProtKB:O15244 and ensembl:ENSP000003559201600115GO_REF:0000107EnsemblGO_REF:0000107
Slc22a2Ratamine transmembrane transporter activity enablesIEAUniProtKB:O15244 and ensembl:ENSP000003559201600115GO_REF:0000107EnsemblGO_REF:0000107
Slc22a2Ratamine transmembrane transporter activity enablesISOSLC22A2 (Homo sapiens)1624291 PMID:9687576RGDPMID:9687576
Slc22a2Ratcholine transmembrane transporter activity enablesIEAUniProtKB:O15244 and ensembl:ENSP000003559201600115GO_REF:0000107EnsemblGO_REF:0000107
Slc22a2Ratcholine transmembrane transporter activity  IDA 628453 RGD 
Slc22a2Ratcholine transmembrane transporter activity enablesISOSLC22A2 (Homo sapiens)1624291 PMID:9687576RGDPMID:9687576
Slc22a2Ratefflux transmembrane transporter activity enablesIEAUniProtKB:O15244 and ensembl:ENSP000003559201600115GO_REF:0000107EnsemblGO_REF:0000107
Slc22a2Ratefflux transmembrane transporter activity enablesISOSLC22A2 (Homo sapiens)1624291 PMID:9687576RGDPMID:9687576
Slc22a2RatL-amino acid transmembrane transporter activity enablesISOSLC22A2 (Homo sapiens)1624291 PMID:23864433RGDPMID:23864433
Slc22a2RatL-amino acid transmembrane transporter activity enablesIEAUniProtKB:O15244 and ensembl:ENSP000003559201600115GO_REF:0000107EnsemblGO_REF:0000107
Slc22a2RatL-arginine transmembrane transporter activity enablesIEAUniProtKB:O15244 and ensembl:ENSP000003559201600115GO_REF:0000107EnsemblGO_REF:0000107
Slc22a2RatL-arginine transmembrane transporter activity enablesISOSLC22A2 (Homo sapiens)1624291 PMID:23864433RGDPMID:23864433
Slc22a2Ratmonoamine transmembrane transporter activity enablesIEAUniProtKB:O15244 and ensembl:ENSP000003559201600115GO_REF:0000107EnsemblGO_REF:0000107
Slc22a2Ratmonoamine transmembrane transporter activity enablesISOSLC22A2 (Homo sapiens)1624291 PMID:12089365 more ...RGDPMID:12089365 more ...
Slc22a2Ratmonoamine transmembrane transporter activity enablesIDA 155663558PMID:16581093UniProt 
Slc22a2Ratmonoamine transmembrane transporter activity enablesISSUniProtKB:O152441600115GO_REF:0000024UniProtGO_REF:0000024
Slc22a2Ratmonoamine transmembrane transporter activity enablesIDA 155888554PMID:9812985UniProt 
Slc22a2Ratmonoamine transmembrane transporter activity enablesIDA 155888557PMID:11758759UniProt 
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RGD Manual Annotations


  
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Slc22a2Ratcisplatin response pathway   ISOSLC22A2 (Homo sapiens)8548480 RGD 
Slc22a2Ratmetformin pharmacokinetics pathway   ISOSLC22A2 (Homo sapiens)7794727 RGD 

Imported Annotations - SMPDB

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Slc22a2Ratamiloride pharmacodynamics pathway  ISOSLC22A2 (Homo sapiens)10402751 SMPDBSMP:00133
Slc22a2Ratbendroflumethiazide pharmacodynamics pathway  ISOSLC22A2 (Homo sapiens)10402751 SMPDBSMP:00090
Slc22a2Ratbumetanide pharmacodynamics pathway  ISOSLC22A2 (Homo sapiens)10402751 SMPDBSMP:00088
Slc22a2Ratchlorothiazide pharmacodynamics pathway  ISOSLC22A2 (Homo sapiens)10402751 SMPDBSMP:00078
Slc22a2Ratchlorthalidone pharmacodynamics pathway  ISOSLC22A2 (Homo sapiens)10402751 SMPDBSMP:00122
Slc22a2Ratcystinuria pathway  ISOSLC22A2 (Homo sapiens)10402751 SMPDBSMP:00723
Slc22a2Rateplerenone pharmacodynamics pathway  ISOSLC22A2 (Homo sapiens)10402751 SMPDBSMP:00135
Slc22a2Ratetacrynic acid pharmacodynamics pathway  ISOSLC22A2 (Homo sapiens)10402751 SMPDBSMP:00097
Slc22a2Ratfurosemide pharmacodynamics pathway  ISOSLC22A2 (Homo sapiens)10402751 SMPDBSMP:00115
Slc22a2RatHartnup disease pathway  ISOSLC22A2 (Homo sapiens)10402751 SMPDBSMP:00189
Slc22a2Rathydrochlorothiazide pharmacodynamics pathway  ISOSLC22A2 (Homo sapiens)10402751 SMPDBSMP:00100
Slc22a2Rathydroflumethiazide pharmacodynamics pathway  ISOSLC22A2 (Homo sapiens)10402751 SMPDBSMP:00108
Slc22a2Ratiminoglycinuria pathway  ISOSLC22A2 (Homo sapiens)10402751 SMPDBSMP:00193
Slc22a2Ratlamivudine pharmacokinetics pathway  ISOSLC22A2 (Homo sapiens)10402751 SMPDBSMP:00649
Slc22a2Ratlysinuric protein intolerance pathway  ISOSLC22A2 (Homo sapiens)10402751 SMPDBSMP:00585
Slc22a2Ratlysinuric protein intolerance pathway  ISOSLC22A2 (Homo sapiens)10402751 SMPDBSMP:00197
Slc22a2Ratmetolazone pharmacodynamics pathway  ISOSLC22A2 (Homo sapiens)10402751 SMPDBSMP:00105
Slc22a2Ratspironolactone pharmacodynamics pathway  ISOSLC22A2 (Homo sapiens)10402751 SMPDBSMP:00134
Slc22a2Rattorasemide pharmacodynamics pathway  ISOSLC22A2 (Homo sapiens)10402751 SMPDBSMP:00118
Slc22a2Rattriamterene pharmacodynamics pathway  ISOSLC22A2 (Homo sapiens)10402751 SMPDBSMP:00132
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Reference Title
Reference Citation
1. Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Amphoux A, etal., Neuropharmacology. 2006 Jun;50(8):941-52. doi: 10.1016/j.neuropharm.2006.01.005. Epub 2006 Mar 31.
2. Mechanism of electrogenic cation transport by the cloned organic cation transporter 2 from rat. Budiman T, etal., J Biol Chem. 2000 Sep 22;275(38):29413-20. doi: 10.1074/jbc.M004645200.
3. Membrane transporters as mediators of Cisplatin effects and side effects. Ciarimboli G Scientifica (Cairo). 2012;2012:473829. doi: 10.6064/2012/473829. Epub 2012 Nov 25.
4. Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity. Filipski KK, etal., Clin Pharmacol Ther. 2009 Oct;86(4):396-402. doi: 10.1038/clpt.2009.139. Epub 2009 Jul 22.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Metformin pathways: pharmacokinetics and pharmacodynamics. Gong L, etal., Pharmacogenet Genomics. 2012 Nov;22(11):820-7. doi: 10.1097/FPC.0b013e3283559b22.
7. Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2). Grundemann D, etal., J Pharmacol Exp Ther 2003 Feb;304(2):810-7.
8. Selective substrates for non-neuronal monoamine transporters. Grundemann D, etal., Mol Pharmacol 1999 Jul;56(1):1-10.
9. Transport of monoamine transmitters by the organic cation transporter type 2, OCT2. Gründemann D, etal., J Biol Chem. 1998 Nov 20;273(47):30915-20. doi: 10.1074/jbc.273.47.30915.
10. Restored expression and activity of organic ion transporters rOAT1, rOAT3 and rOCT2 after hyperuricemia in the rat kidney. Habu Y, etal., Biochem Pharmacol. 2005 Mar 15;69(6):993-9.
11. Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia. Heemskerk S, etal., Eur J Pharmacol. 2008 Apr 28;584(2-3):390-7. doi: 10.1016/j.ejphar.2008.02.006. Epub 2008 Feb 12.
12. Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice. Hu QH, etal., Eur J Nutr. 2012 Aug;51(5):593-606. doi: 10.1007/s00394-011-0243-y. Epub 2011 Sep 10.
13. Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy. Ji L, etal., Kidney Int. 2002 Aug;62(2):514-24.
14. Reduced antidiabetic effect of metformin and down-regulation of hepatic Oct1 in rats with ethynylestradiol-induced cholestasis. Jin HE, etal., Pharm Res. 2009 Mar;26(3):549-59. doi: 10.1007/s11095-008-9770-5. Epub 2008 Nov 11.
15. Functional characterization of mouse cation transporter mOCT2 compared with mOCT1. Kakehi M, etal., Biochem Biophys Res Commun. 2002 Aug 23;296(3):644-50.
16. Localization of organic cation transporters OCT1 and OCT2 in rat kidney. Karbach U, etal., Am J Physiol Renal Physiol. 2000 Oct;279(4):F679-87.
17. Cell free expression and functional reconstitution of eukaryotic drug transporters. Keller T, etal., Biochemistry. 2008 Apr 15;47(15):4552-64. doi: 10.1021/bi800060w. Epub 2008 Mar 25.
18. Renal uptake of substrates for organic anion transporters Oat1 and Oat3 and organic cation transporters Oct1 and Oct2 is altered in rats with adenine-induced chronic renal failure. Komazawa H, etal., J Pharm Sci. 2013 Mar;102(3):1086-94. doi: 10.1002/jps.23433. Epub 2012 Dec 29.
19. Elevated systemic elimination of cimetidine in rats with acute biliary obstruction: the role of renal organic cation transporter OCT2. Kurata T, etal., Drug Metab Pharmacokinet. 2010;25(4):328-34.
20. Lack of a primary physicochemical determinant in the direct transport of drugs to the brain after nasal administration in rats: potential involvement of transporters in the pathway. Lee KR, etal., Drug Metab Pharmacokinet. 2010;25(5):430-41. doi: 10.2133/dmpk.dmpk-10-rg-049. Epub 2010 Sep 30.
1 to 20 of 46 rows
PMID:12477932   PMID:14718608   PMID:15016452   PMID:15377492   PMID:15878879   PMID:16024787   PMID:16550473   PMID:17567940   PMID:18230276   PMID:18484100   PMID:19056867   PMID:19141712  
PMID:19330287   PMID:19629622   PMID:22005293   PMID:22941487   PMID:23182769   PMID:23774469   PMID:24531880   PMID:24981592   PMID:25876759   PMID:26174463   PMID:27901065   PMID:28414026  
PMID:30951542   PMID:32484793  



Slc22a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,668,817 - 50,711,019 (-)NCBIGRCr8
mRatBN7.2148,121,061 - 48,163,268 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,121,061 - 48,163,268 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,812,678 - 48,854,865 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,798,480 - 54,840,630 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,888,183 - 48,930,374 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,318,025 - 48,360,219 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,317,995 - 48,360,261 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,394,014 - 51,435,104 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,395,676 - 42,442,847 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,398,620 - 42,445,782 (-)NCBI
Celera143,920,665 - 43,963,268 (-)NCBICelera
Cytogenetic Map1q11NCBI
SLC22A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386160,216,755 - 160,258,821 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6160,171,061 - 160,277,638 (-)EnsemblGRCh38hg38GRCh38
GRCh376160,637,787 - 160,679,853 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,557,780 - 160,599,949 (-)NCBINCBI36Build 36hg18NCBI36
Build 346160,608,201 - 160,650,370NCBI
Celera6161,284,724 - 161,329,224 (-)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6158,107,747 - 158,154,417 (-)NCBIHuRef
CHM1_16160,900,027 - 160,942,556 (-)NCBICHM1_1
T2T-CHM13v2.06161,462,946 - 161,508,769 (-)NCBIT2T-CHM13v2.0
Slc22a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391712,803,076 - 12,847,376 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1712,803,019 - 12,847,375 (+)EnsemblGRCm39 Ensembl
GRCm381712,584,189 - 12,628,489 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,584,132 - 12,628,488 (+)EnsemblGRCm38mm10GRCm38
MGSCv371712,777,055 - 12,821,354 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,427,547 - 12,471,846 (+)NCBIMGSCv36mm8
Celera1712,614,783 - 12,660,660 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.61NCBI
Slc22a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543920,567,212 - 20,609,105 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543920,567,241 - 20,608,281 (+)NCBIChiLan1.0ChiLan1.0
SLC22A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25180,320,892 - 180,367,795 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16178,223,301 - 178,271,798 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06158,058,226 - 158,150,917 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16163,066,654 - 163,158,469 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6163,065,317 - 163,158,931 (-)Ensemblpanpan1.1panPan2
SLC22A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,327,621 - 49,348,435 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,327,296 - 49,348,435 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha150,170,589 - 50,191,400 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,505,206 - 49,533,863 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,503,308 - 49,533,595 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,395,180 - 49,415,993 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0149,266,805 - 49,288,175 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0149,882,427 - 49,903,195 (-)NCBIUU_Cfam_GSD_1.0
Slc22a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946144,341,980 - 144,375,967 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,594,480 - 11,627,786 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648911,605,403 - 11,627,786 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,289,831 - 7,323,146 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,289,278 - 7,323,418 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.218,980,529 - 9,012,013 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,835,077 - 87,881,410 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1387,833,430 - 87,881,081 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604060,218,540 - 60,262,523 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc22a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248552,623,547 - 2,659,742 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248552,623,595 - 2,661,739 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Slc22a2
141 total Variants


Assembly: Rnor_5.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
1 51408306 51408307 T A snv DOB/Oda (KyushuU) View more Information
1 51414374 51414375 A G snv DOB/Oda (KyushuU) View more Information

Predicted Target Of
Summary Value
Count of predictions:130
Count of miRNA genes:63
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000023116, ENSRNOT00000051927
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 45 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat

1 to 10 of 45 rows
D5Bwg0676e  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,154,389 - 48,154,620 (+)MAPPERmRatBN7.2
Rnor_6.0148,351,346 - 48,351,576NCBIRnor6.0
Rnor_6.01090,107,060 - 90,108,461NCBIRnor6.0
Rnor_5.0151,402,921 - 51,403,152NCBIRnor5.0
Rnor_5.01089,894,422 - 89,895,824NCBIRnor5.0
RGSC_v3.41091,232,990 - 91,234,391UniSTSRGSC3.4
RGSC_v3.4142,433,974 - 42,434,204UniSTSRGSC3.4
Celera143,954,422 - 43,954,652UniSTS
Celera1085,835,407 - 85,836,808UniSTS
Cytogenetic Map10q32.1UniSTS
Cytogenetic Map1q11UniSTS
Slc22a2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,163,134 - 48,163,552 (+)MAPPERmRatBN7.2
Rnor_6.0148,360,086 - 48,360,503NCBIRnor6.0
Rnor_5.0151,393,730 - 51,394,147UniSTSRnor5.0
RGSC_v3.4142,442,714 - 42,443,131UniSTSRGSC3.4
Celera143,963,135 - 43,963,552UniSTS
Cytogenetic Map1q11UniSTS


The following Strains have been annotated to Slc22a2
SD-Slc22a2em1Sage    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 7 25 98 74 76 46 16 46 6 161 57 80 45 45 30



Ensembl Acc Id: ENSRNOT00000023116   ⟹   ENSRNOP00000023116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl148,121,061 - 48,163,268 (-)Ensembl
Rnor_6.0 Ensembl148,317,995 - 48,360,261 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000051927   ⟹   ENSRNOP00000041251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl148,318,417 - 48,360,131 (-)Ensembl
RefSeq Acc Id: NM_031584   ⟹   NP_113772
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,668,817 - 50,711,019 (-)NCBI
mRatBN7.2148,121,061 - 48,163,268 (-)NCBI
Rnor_6.0148,318,025 - 48,360,219 (-)NCBI
Rnor_5.0151,394,014 - 51,435,104 (+)NCBI
RGSC_v3.4142,395,676 - 42,442,847 (-)RGD
Celera143,920,665 - 43,963,268 (-)RGD
Sequence:
Protein RefSeqs NP_113772 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA11754 (Get FASTA)   NCBI Sequence Viewer  
  CAA66979 (Get FASTA)   NCBI Sequence Viewer  
  CAB52215 (Get FASTA)   NCBI Sequence Viewer  
  EDL83062 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023116
GenBank Protein Q9R0W2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113772   ⟸   NM_031584
- UniProtKB: P97558 (UniProtKB/Swiss-Prot),   P70485 (UniProtKB/Swiss-Prot),   Q9R0W2 (UniProtKB/Swiss-Prot),   A0A0G2JSP9 (UniProtKB/TrEMBL),   A6KJX5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000041251   ⟸   ENSRNOT00000051927
Ensembl Acc Id: ENSRNOP00000023116   ⟸   ENSRNOT00000023116
Major facilitator superfamily (MFS) profile

Name Modeler Protein Id AA Range Protein Structure
AF-Q9R0W2-F1-model_v2 AlphaFold Q9R0W2 1-555 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13689625
Promoter ID:EPDNEW_R144
Type:initiation region
Name:Slc22a2_1
Description:solute carrier family 22 member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0148,360,221 - 48,360,281EPDNEW


1 to 26 of 26 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-61570 BioCyc
Ensembl Genes ENSRNOG00000016625 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000023116 ENTREZGENE
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
InterPro MFS_dom UniProtKB/Swiss-Prot
  MFS_sugar_transport-like UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  Orgcat_transp/SVOP UniProtKB/Swiss-Prot
  Sugar_transporter_CS UniProtKB/Swiss-Prot
KEGG Report rno:29503 UniProtKB/Swiss-Prot
NCBI Gene 29503 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/Swiss-Prot
Pfam Sugar_tr UniProtKB/Swiss-Prot
PharmGKB SLC22A2 RGD
PhenoGen Slc22a2 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016625 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
UniProt A0A0G2JSP9 ENTREZGENE, UniProtKB/TrEMBL
  A6KJX5 ENTREZGENE, UniProtKB/TrEMBL
  P70485 ENTREZGENE
  P97558 ENTREZGENE
  Q9R0W2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P70485 UniProtKB/Swiss-Prot
  P97558 UniProtKB/Swiss-Prot
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Slc22a2  solute carrier family 22 member 2  Slc22a2  solute carrier family 22 (organic cation transporter), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc22a2  solute carrier family 22 (organic cation transporter), member 2    solute carrier family 22, member 2  Name updated 1299863 APPROVED
2002-06-10 Slc22a2  solute carrier family 22, member 2      Name updated 70584 APPROVED

Note Type Note Reference
gene_cellular_localization expressed on the apical plasma membrane and is excluded from the nucleus and basal region of choroid plexus cells 628453
gene_expression expressed in the choroid plexus of the ventricles of the brain 628453
gene_function organic ion transporter activity includes transport of tetraethylammonium, histamine, and gunaidine 634067
gene_function facilitates small organic cations entering into the cell via a potential dependent, Na+-independent, facilitative diffusion mechanism; transports choline across the ventricular membrane of choroid plexus 628453
gene_process may mediate central nervous system choline homeostasis 628453
gene_regulation transport activity is inhibited by xenobiotics, drugs, neurotransmitters, and neurotoxins 628453