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Gene: Slc22a2 (solute carrier family 22 member 2) Rattus norvegicus
Symbol: Slc22a2
Name: solute carrier family 22 member 2
Description: Exhibits choline transmembrane transporter activity; quaternary ammonium group transmembrane transporter activity; and steroid binding activity. Involved in histamine transport and quaternary ammonium group transport. Localizes to basolateral plasma membrane and integral component of plasma membrane. Used to study acute kidney failure. Biomarker of cholestasis (multiple); hyperuricemia; and kidney failure (multiple). Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to human SLC22A2 (solute carrier family 22 member 2); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH 11-deoxycorticosterone; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
Also known as: OCT2; OCT2r; organic cation transporter 2; rOCT2; solute carrier family 22 (organic cation transporter), member 2; solute carrier family 22, member 2
Homo sapiens (human) : SLC22A2 (solute carrier family 22 member 2)  HGNC  Alliance
Mus musculus (house mouse) : Slc22a2 (solute carrier family 22 (organic cation transporter), member 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc22a2 (solute carrier family 22 member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC22A2 (solute carrier family 22 member 2)
Canis lupus familiaris (dog) : SLC22A2 (solute carrier family 22 member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc22a2 (solute carrier family 22 member 2)
Sus scrofa (pig) : SLC22A2 (solute carrier family 22 member 2)
Chlorocebus sabaeus (African green monkey) : SLC22A2 (solute carrier family 22 member 2)
Heterocephalus glaber (naked mole-rat) : Slc22a2 (solute carrier family 22 member 2)
more info ...
Is Marker For: Strains:   SD-Slc22a2em1Sage  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0148,318,025 - 48,360,219 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,317,995 - 48,360,261 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,394,014 - 51,435,104 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,395,676 - 42,442,847 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1142,398,620 - 42,445,782 (-)NCBI
Celera143,920,665 - 43,963,268 (-)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Slc22a2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61936
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2020-01-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.