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Metformin is an antihyperglycemic drug used in the first-line treatment of Diabetes Mellitus type 2 (T2D). Its administration lowers the amount of circulating glucose, both basal and postprandial. The drug is used as monotherapy but also in combination with other anti-diabetic drugs. Metformin is distributed in several tissues through the action of several transporters. The uptake and efflux of the drug are the major components of its pharmacokinetics profile as metformin is not metabolized and

Pathway Diagram:

Elsevier Inc. excreted metformine uptaken metformin Slc47a2 Slc47a1 Slc22a2 Slc22a1 Slc22a3 Slc29a4 Metformin Metformin ---> uptaken metformin uptaken metformin ---> excreted metformine

Genes in Pathway:

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metformin pharmacokinetics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc22a1 solute carrier family 22 member 1 JBrowse link 1 48,273,639 48,300,645 RGD:7794727
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:7794727
G Slc22a3 solute carrier family 22 member 3 JBrowse link 1 48,433,079 48,521,261 RGD:7794727
G Slc29a4 solute carrier family 29 member 4 JBrowse link 12 13,914,114 13,924,511 RGD:7794727
G Slc47a1 solute carrier family 47 member 1 JBrowse link 10 47,631,425 47,685,379 RGD:7794727
G Slc47a2 solute carrier family 47 member 2 JBrowse link 10 47,587,909 47,631,373 RGD:7794727

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the metformin pharmacokinetics pathway

References Associated with the metformin pharmacokinetics pathway:

Ontology Path Diagram:

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