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METFORMIN PHARMACOKINETICS PATHWAY (PW:0001489)

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Description

Metformin is an antihyperglycemic drug used in the first-line treatment of Diabetes Mellitus type 2 (T2D). Its administration lowers the amount of circulating glucose, both basal and postprandial. The drug is used as monotherapy but also in combination with other anti-diabetic drugs. Metformin is distributed in several tissues through the action of several transporters. The uptake and efflux of the drug are the major components of its pharmacokinetics profile as metformin is not metabolized and

Pathway Diagram:

Elsevier Inc. excreted metformine uptaken metformin Slc47a2 Slc47a1 Slc22a2 Slc22a1 Slc22a3 Slc29a4 Metformin Metformin ---> uptaken metformin uptaken metformin ---> excreted metformine
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Genes in Pathway:


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metformin pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a1 solute carrier family 22 member 1 ISO RGD PMID:22722338 RGD:7794727 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436
JBrowse link
G Slc22a2 solute carrier family 22 member 2 ISO RGD PMID:22722338 RGD:7794727 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
JBrowse link
G Slc22a3 solute carrier family 22 member 3 ISO RGD PMID:22722338 RGD:7794727 NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353
JBrowse link
G Slc29a4 solute carrier family 29 member 4 ISO RGD PMID:22722338 RGD:7794727 NCBI chr12:16,967,047...16,998,276
Ensembl chr12:16,967,047...16,988,338
JBrowse link
G Slc47a1 solute carrier family 47 member 1 ISO RGD PMID:22722338 RGD:7794727 NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096
JBrowse link
G Slc47a2 solute carrier family 47 member 2 ISO RGD PMID:22722338 RGD:7794727 NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425
JBrowse link

Pathway Gene Annotations

Disease Annotations Associated with Genes in the metformin pharmacokinetics pathway
Pathway Annotations Associated with Genes in the metformin pharmacokinetics pathway

References Associated with the metformin pharmacokinetics pathway:

Ontology Path Diagram:

paths to the root
paths to the root

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