Slc22a2 (solute carrier family 22 member 2)

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Gene: Slc22a2 (solute carrier family 22 member 2) Chinchilla lanigera

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Symbol:

Slc22a2

Name:

solute carrier family 22 member 2

RGD ID:

8725502

Description:

ENCODES a protein that exhibits acetylcholine transmembrane transporter activity (ortholog); amine transmembrane transporter activity (ortholog); choline transmembrane transporter activity (ortholog); INVOLVED IN acetylcholine transport (ortholog); amine transport (ortholog); amino acid import across plasma membrane (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (ortholog); acute kidney failure (ortholog); end stage renal disease (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

solute carrier family 22 (organic cation transporter), member 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955439	20,567,212 - 20,609,105 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955439	20,567,241 - 20,608,281 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (ISO)

acute kidney failure (ISO)

end stage renal disease (ISO)

Endotoxemia (ISO)

Experimental Diabetes Mellitus (ISO)

extrahepatic cholestasis (ISO)

hyperuricemia (ISO)

intrahepatic cholestasis (ISO)

kidney disease (ISO)

kidney failure (ISO)

Kidney Neoplasms (ISO)

Kidney Reperfusion Injury (ISO)

obesity (ISO)

Poisoning (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acetylcholine transport (ISO)

amine transport (ISO)

amino acid import across plasma membrane (ISO)

cellular detoxification (ISO)

choline transport (ISO)

dopamine transport (ISO)

dopamine uptake (ISO)

epinephrine transport (ISO)

export across plasma membrane (ISO)

histamine transport (ISO)

histamine uptake (ISO)

L-alpha-amino acid transmembrane transport (ISO)

L-arginine import across plasma membrane (ISO)

monoatomic cation transport (ISO)

neurotransmitter transport (ISO)

norepinephrine transport (ISO)

norepinephrine uptake (ISO)

organic cation transport (ISO)

prostaglandin transport (ISO)

putrescine transport (ISO)

quaternary ammonium group transport (ISO)

serotonin transport (ISO)

serotonin uptake (ISO)

thiamine transmembrane transport (ISO)

xenobiotic transport (ISO)

Cellular Component

apical plasma membrane (ISO)

basal plasma membrane (ISO)

basolateral plasma membrane (ISO)

cholinergic synapse (ISO)

plasma membrane (ISO)

presynaptic membrane (ISO)

synaptic vesicle membrane (ISO)

Molecular Function

acetylcholine transmembrane transporter activity (ISO)

amine transmembrane transporter activity (ISO)

choline transmembrane transporter activity (ISO)

efflux transmembrane transporter activity (ISO)

L-amino acid transmembrane transporter activity (ISO)

L-arginine transmembrane transporter activity (ISO)

monoamine transmembrane transporter activity (ISO)

neurotransmitter transmembrane transporter activity (ISO)

organic anion transmembrane transporter activity (ISO)

organic cation transmembrane transporter activity (ISO)

prostaglandin transmembrane transporter activity (ISO)

putrescine transmembrane transporter activity (ISO)

pyrimidine nucleoside transmembrane transporter activity (ISO)

quaternary ammonium group transmembrane transporter activity (ISO)

steroid binding (ISO)

thiamine transmembrane transporter activity (ISO)

toxin transmembrane transporter activity (ISO)

xenobiotic transmembrane transporter activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

amiloride pharmacodynamics pathway (ISO)

bendroflumethiazide pharmacodynamics pathway (ISO)

bumetanide pharmacodynamics pathway (ISO)

chlorothiazide pharmacodynamics pathway (ISO)

chlorthalidone pharmacodynamics pathway (ISO)

cisplatin response pathway (ISO)

cystinuria pathway (ISO)

eplerenone pharmacodynamics pathway (ISO)

etacrynic acid pharmacodynamics pathway (ISO)

furosemide pharmacodynamics pathway (ISO)

Hartnup disease pathway (ISO)

hydrochlorothiazide pharmacodynamics pathway (ISO)

hydroflumethiazide pharmacodynamics pathway (ISO)

iminoglycinuria pathway (ISO)

lamivudine pharmacokinetics pathway (ISO)

lysinuric protein intolerance pathway (ISO)

metformin pharmacokinetics pathway (ISO)

metolazone pharmacodynamics pathway (ISO)

spironolactone pharmacodynamics pathway (ISO)

torasemide pharmacodynamics pathway (ISO)

triamterene pharmacodynamics pathway (ISO)

trichlormethiazide pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Slc22a2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955439	20,567,212 - 20,609,105 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955439	20,567,241 - 20,608,281 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC22A2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	160,216,755 - 160,258,821 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	160,171,061 - 160,277,638 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	160,637,787 - 160,679,853 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	160,557,780 - 160,599,949 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	160,608,201 - 160,650,370	NCBI
Celera	6	161,284,724 - 161,329,224 (-)	NCBI		Celera
Cytogenetic Map	6	q25.3	NCBI
HuRef	6	158,107,747 - 158,154,417 (-)	NCBI		HuRef
CHM1_1	6	160,900,027 - 160,942,556 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	161,462,946 - 161,508,769 (-)	NCBI		T2T-CHM13v2.0

Slc22a2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	12,803,076 - 12,847,376 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	12,803,019 - 12,847,375 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	12,584,189 - 12,628,489 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	12,584,132 - 12,628,488 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	12,777,055 - 12,821,354 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	12,427,547 - 12,471,846 (+)	NCBI		MGSCv36	mm8
Celera	17	12,614,783 - 12,660,660 (+)	NCBI		Celera
Cytogenetic Map	17	A1	NCBI
cM Map	17	8.61	NCBI

Slc22a2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	50,668,817 - 50,711,019 (-)	NCBI		GRCr8
mRatBN7.2	1	48,121,061 - 48,163,268 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	48,121,061 - 48,163,268 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	48,812,678 - 48,854,865 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	54,798,480 - 54,840,630 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	48,888,183 - 48,930,374 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	48,318,025 - 48,360,219 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	48,317,995 - 48,360,261 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	51,394,014 - 51,435,104 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	42,395,676 - 42,442,847 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	42,398,620 - 42,445,782 (-)	NCBI
Celera	1	43,920,665 - 43,963,268 (-)	NCBI		Celera
Cytogenetic Map	1	q11	NCBI

SLC22A2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	180,320,892 - 180,367,795 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	178,223,301 - 178,271,798 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	158,058,226 - 158,150,917 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	163,066,654 - 163,158,469 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	163,065,317 - 163,158,931 (-)	Ensembl	panpan1.1		panPan2

SLC22A2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	49,327,621 - 49,348,435 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	49,327,296 - 49,348,435 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	50,170,589 - 50,191,400 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	49,505,206 - 49,533,863 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	49,503,308 - 49,533,595 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	49,395,180 - 49,415,993 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	49,266,805 - 49,288,175 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	49,882,427 - 49,903,195 (-)	NCBI		UU_Cfam_GSD_1.0

Slc22a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	144,341,980 - 144,375,967 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936489	11,594,480 - 11,627,786 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936489	11,605,403 - 11,627,786 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC22A2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	7,289,831 - 7,323,146 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	7,289,278 - 7,323,418 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	8,980,529 - 9,012,013 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC22A2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	87,835,077 - 87,881,410 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	87,833,430 - 87,881,081 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	60,218,540 - 60,262,523 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc22a2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624855	2,623,547 - 2,659,742 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624855	2,623,595 - 2,661,739 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005390703	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005390704	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01036118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01036119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCQ01009150	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000003670 ⟹ ENSCLAP00000003596

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955439	20,567,212 - 20,609,105 (+)	Ensembl

RefSeq Acc Id:

XM_005390703 ⟹ XP_005390760

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955439	20,567,242 - 20,608,281 (+)	NCBI

Sequence:

show sequence

AGACAAACTCAGAGAGAATGTTACAATAAACACAACACTGCGCCTCAGGGGCCTGATCTAACTA
TTTCTGGGCAACAGCAGGACCTTCCCTCACTGGAGAGGGGTACAGTTCAAAGTTGGCCCAACCG
AGGAGAAGCCCGGCTGATAGGCTGGTCCCTTTCTAAAGTCAACTAACTCTCACCCTTCAACTAT
TGGTCCTGAGTTGTGCTGAGCTGGTTGCAGCCGCTCTCAACAGCACTTGGGACATTGCACTGGA
CTTGTCAGGGCTGTAGCCTCCAGGAATCATGCCATCCATGGATGATATTTTAGAGCATATAGGG
GAATTCCATTTTTTCCAGAAACAAACATTTTTCCTCTTAACTCTGCTCTCAGCTGCCTTTACCC
CCATCTATGTGGGCATCGTCTTCTTCGGCTTCACCCCCAACCACCACTGCTGGAGCCCCGGGGT
GGCCGAGCTGAGTCAGCGATGTGGCTGGAGCCAGGCTGAAGAGCTCAACTACACAGTGCCAGGC
CTGGGGGCTGAGAATGAGGCCTTTCTCCACCAGTGCATGCAGTACCAGGTGGACTGGAACCAGA
GCACCCTTAGCTGCGTGGACCCTCTGTCCAGCCTGCCTGACAACAGGAGCCGCCTGCCACTGGG
CCCCTGTCAGCACGGCTGGGTGTACGACACGCCTGGCTCCTCCATCGTCACTGAGTTCAACCTA
GTGTGTACCAACTCCTGGATGCTGGACCTGTTTCAGTCAGCTGTGAATGTAGGGTTTTTTGTTG
GTGCTGTGGCCATTGGCTACCTAGCAGACAGGTTTGGCCGTAAAATCTGCCTCTTGATAACAAT
TCTCATAAATGCTTCATCTGGGGTTCTCATGGCCATTTCCCCAAACTACACATGGATGTTACTG
TTTCGCTTGATCCAAGGACTGGTCAGCAAAGCAGGCTGGATAATCGGCTATACTCTGATTACAG
AATTTGTCGGACTGAGCTATCGGAGAACAGTGGGGATTTTTTACCAAGTTGCCTTTACCATTGG
GCTCCTGGTGCTAGCAGGGGTGGCATATGCTCTTCCTCACTGGAGGTGGTTGCAGCTTGTAGTC
ACTCTGCCTAACTTCTTCTTCCTTCTCTATTACTGGTGCATCCCTGAGTCTCCAAGGTGGTTGA
TCTCCCAGAACAAAACCAGGCAAGCAATGAAGATCATTAAGCACATCGCTAAGAAAAATGGAAA
GTCAATGCCAGCCTCTCTTCAGAGCCTGAGAGCAGATGAGGAAGCTGGAGAGAAGTTGAACCCT
TCATTTCTTGACTTGGTCAGAACCCCTCAGATAAGGAAACACACTTTGATCTTGATGTATATTT
GGTTCACAAGCTCTGTTCTCTACCAGGGCCTTATCATGCACATGGGCCTTGCAGGGAGCAATAT
CTACCTGGATTTCTTCTATTCTGCCCTGGTTGAATTCCCAGCCGCCTTCATTGTCATCCTCACC
ATTGACCGCATTGGTCGCCGTTATCCTTGGGCTGTGTCAAATATGGTGGCAGGGGCTGCCTGTC
TTGCTTCGGTTTTTATCCCTGATGATCTACACTGGCTTAAAGTCACCATTGCATGCTTAGGTAG
GATGGGAATCACGATGGCTTTCGAAATGGTTTGCCTAGTCAATGCTGAACTGTACCCCACATTC
ATTAGGAATCTTGGCGTGCTTGTCTGTTCCTCAGTGTGTGACATCGGTGGCATCCTCACGCCTT
TCCTGGTCTACCGCCTCACAGATATCTGGCAGGAGCTCCCACTCGTGGTATTCGCCATTTTTGG
CTTGGTAGCCGGAGGACTGGTGTTATTGCTCCCAGAGACCAAAGGGAAGGCTCTGCCTGAGACC
ATTGAGGAAGCTGAAGCCATGCAGAGCAGACCAAGAAAATATAAGGAAAATATGATTTACCTCC
AAGTAAAGAAACCAGACAATCCACTAAACTAAGAAGAAAGACCATGGCTCCTACTGTGGTCTTG
CTTTGATGCTGCCAAAACCAGAAGCAGAGATTTCCTCACTTATCACAAAGCCCATGCAATTCAC
CCATACTTACCCTTGAACTTCGTCAACTTAGAGCTATAGCCAGTGGAGTTTATTGCTCTGTAAA
AGTCCCCCTACAGACTGGATCCTGCCACGATCTTCCAGCTCGCTCTGTCCTCAGAACTCCCAGG
CCATTGGTTTGCTTGAATTTCTTCTCACCTTTGTATTTCTTCATTTGGTTCCTTTCCCACATGA
CATCAAACCAGAATATATAAGGGAACTGTGGGTGAGGGAAAACAAATAAAAAAGATCTGAAAAA
ACAATACAA

hide sequence

RefSeq Acc Id:

XM_005390704 ⟹ XP_005390761

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955439	20,567,241 - 20,608,281 (+)	NCBI

Sequence:

show sequence

GAGACAAACTCAGAGAGAATGTTACAATAAACACAACACTGCGCCTCAGGGGCCTGATCTAACT
ATTTCTGGGCAACAGCAGGACCTTCCCTCACTGGAGAGGGGTACAGTTCAAAGTTGGCCCAACC
GAGGAGAAGCCCGGCTGATAGGCTGGTCCCTTTCTAAAGTCAACTAACTCTCACCCTTCAACTA
TTGGTCCTGAGTTGTGCTGAGCTGGTTGCAGCCGCTCTCAACAGCACTTGGGACATTGCACTGG
ACTTGTCAGGGCTGTAGCCTCCAGGAATCATGCCATCCATGGATGATATTTTAGAGCATATAGG
GGAATTCCATTTTTTCCAGAAACAAACATTTTTCCTCTTAACTCTGCTCTCAGCTGCCTTTACC
CCCATCTATGTGGGCATCGTCTTCTTCGGCTTCACCCCCAACCACCACTGCTGGAGCCCCGGGG
TGGCCGAGCTGAGTCAGCGATGTGGCTGGAGCCAGGCTGAAGAGCTCAACTACACAGTGCCAGG
CCTGGGGGCTGAGAATGAGGCCTTTCTCCACCAGTGCATGCAGTACCAGGTGGACTGGAACCAG
AGCACCCTTAGCTGCGTGGACCCTCTGTCCAGCCTGCCTGACAACAGGAGCCGCCTGCCACTGG
GCCCCTGTCAGCACGGCTGGGTGTACGACACGCCTGGCTCCTCCATCGTCACTGAGTTCAACCT
AGTGTGTACCAACTCCTGGATGCTGGACCTGTTTCAGTCAGCTGTGAATGTAGGGTTTTTTGTT
GGTGCTGTGGCCATTGGCTACCTAGCAGACAGGTTTGGCCGTAAAATCTGCCTCTTGATAACAA
TTCTCATAAATGCTTCATCTGGGGTTCTCATGGCCATTTCCCCAAACTACACATGGATGTTACT
GTTTCGCTTGATCCAAGGACTGGTCAGCAAAGCAGGCTGGATAATCGGCTATACTCTGATTACA
GAATTTGTCGGACTGAGCTATCGGAGAACAGTGGGGATTTTTTACCAAGTTGCCTTTACCATTG
GGCTCCTGGTGCTAGCAGGGGTGGCATATGCTCTTCCTCACTGGAGGTGGTTGCAGCTTGTAGT
CACTCTGCCTAACTTCTTCTTCCTTCTCTATTACTGGTGCATCCCTGAGTCTCCAAGGTGGTTG
ATCTCCCAGAACAAAACCAGGCAAGCAATGAAGATCATTAAGCACATCGCTAAGAAAAATGGAA
AGTCAATGCCAGCCTCTCTTCAGAGCCTGAGAGCAGATGAGGAAGCTGGAGAGAAGTTGAACCC
TTCATTTCTTGACTTGGTCAGAACCCCTCAGATAAGGAAACACACTTTGATCTTGATGTATATT
TGGTTCACAAGCTCTGTTCTCTACCAGGGCCTTATCATGCACATGGGCCTTGCAGGGAGCAATA
TCTACCTGGATTTCTTCTATTCTGCCCTGGTTGAATTCCCAGCCGCCTTCATTGTCATCCTCAC
CATTGACCGCATTGGTCGCCGTTATCCTTGGGCTGTGTCAAATATGGTGGCAGGGGCTGCCTGT
CTTGCTTCGGTTTTTATCCCTGATGATCTACACTGGCTTAAAGTCACCATTGCATGCTTAGGTA
GGATGGGAATCACGATGGCTTTCGAAATGGTTTGCCTAGTCAATGCTGAACTGTACCCCACATT
CATTAGGAATCTTGGCGTGCTTGTCTGTTCCTCAGTGTGTGACATCGGTGGCATCCTCACGCCT
TTCCTGGTCTACCGCCTCACAGATATCTGGCAGGAGCTCCCACTCGTGGTATTCGCCATTTTTG
GCTTGGTAGCCGGAGGACTGGTGTTATTGCTCCCAGAGACCAAAGGGAAGGCTCTGCCTGAGAC
CATTGAGGAAGCTGAAGCCATGCAGAGACCAAGAAAATATAAGGAAAATATGATTTACCTCCAA
GTAAAGAAACCAGACAATCCACTAAACTAAGAAGAAAGACCATGGCTCCTACTGTGGTCTTGCT
TTGATGCTGCCAAAACCAGAAGCAGAGATTTCCTCACTTATCACAAAGCCCATGCAATTCACCC
ATACTTACCCTTGAACTTCGTCAACTTAGAGCTATAGCCAGTGGAGTTTATTGCTCTGTAAAAG
TCCCCCTACAGACTGGATCCTGCCACGATCTTCCAGCTCGCTCTGTCCTCAGAACTCCCAGGCC
ATTGGTTTGCTTGAATTTCTTCTCACCTTTGTATTTCTTCATTTGGTTCCTTTCCCACATGACA
TCAAACCAGAATATATAAGGGAACTGTGGGTGAGGGAAAACAAATAAAAAAGATCTGAAAAAAC
AATACAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005390760	(Get FASTA)	NCBI Sequence Viewer
	XP_005390761	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000003596
	ENSCLAP00000003596.1

RefSeq Acc Id:

XP_005390761 ⟸ XM_005390704

- Peptide Label:

isoform X2

- Sequence:

show sequence

MPSMDDILEHIGEFHFFQKQTFFLLTLLSAAFTPIYVGIVFFGFTPNHHCWSPGVAELSQRCGW
SQAEELNYTVPGLGAENEAFLHQCMQYQVDWNQSTLSCVDPLSSLPDNRSRLPLGPCQHGWVYD
TPGSSIVTEFNLVCTNSWMLDLFQSAVNVGFFVGAVAIGYLADRFGRKICLLITILINASSGVL
MAISPNYTWMLLFRLIQGLVSKAGWIIGYTLITEFVGLSYRRTVGIFYQVAFTIGLLVLAGVAY
ALPHWRWLQLVVTLPNFFFLLYYWCIPESPRWLISQNKTRQAMKIIKHIAKKNGKSMPASLQSL
RADEEAGEKLNPSFLDLVRTPQIRKHTLILMYIWFTSSVLYQGLIMHMGLAGSNIYLDFFYSAL
VEFPAAFIVILTIDRIGRRYPWAVSNMVAGAACLASVFIPDDLHWLKVTIACLGRMGITMAFEM
VCLVNAELYPTFIRNLGVLVCSSVCDIGGILTPFLVYRLTDIWQELPLVVFAIFGLVAGGLVLL
LPETKGKALPETIEEAEAMQRPRKYKENMIYLQVKKPDNPLN

hide sequence

RefSeq Acc Id:	XP_005390760 ⟸ XM_005390703
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C2UNR3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPSMDDILEHIGEFHFFQKQTFFLLTLLSAAFTPIYVGIVFFGFTPNHHCWSPGVAELSQRCGW SQAEELNYTVPGLGAENEAFLHQCMQYQVDWNQSTLSCVDPLSSLPDNRSRLPLGPCQHGWVYD TPGSSIVTEFNLVCTNSWMLDLFQSAVNVGFFVGAVAIGYLADRFGRKICLLITILINASSGVL MAISPNYTWMLLFRLIQGLVSKAGWIIGYTLITEFVGLSYRRTVGIFYQVAFTIGLLVLAGVAY ALPHWRWLQLVVTLPNFFFLLYYWCIPESPRWLISQNKTRQAMKIIKHIAKKNGKSMPASLQSL RADEEAGEKLNPSFLDLVRTPQIRKHTLILMYIWFTSSVLYQGLIMHMGLAGSNIYLDFFYSAL VEFPAAFIVILTIDRIGRRYPWAVSNMVAGAACLASVFIPDDLHWLKVTIACLGRMGITMAFEM VCLVNAELYPTFIRNLGVLVCSSVCDIGGILTPFLVYRLTDIWQELPLVVFAIFGLVAGGLVLL LPETKGKALPETIEEAEAMQSRPRKYKENMIYLQVKKPDNPLN hide sequence

Ensembl Acc Id:

ENSCLAP00000003596 ⟸ ENSCLAT00000003670

Protein Domains

Major facilitator superfamily (MFS) profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000002562	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000003670	ENTREZGENE
	ENSCLAT00000003670.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1250.20	UniProtKB/TrEMBL
InterPro	MFS_dom	UniProtKB/TrEMBL
	MFS_sugar_transport-like	UniProtKB/TrEMBL
	MFS_trans_sf	UniProtKB/TrEMBL
	Orgcat_transp/SVOP	UniProtKB/TrEMBL
	Sugar_transporter_CS	UniProtKB/TrEMBL
NCBI Gene	Slc22a2	ENTREZGENE
PANTHER	SOLUTE CARRIER FAMILY 22 MEMBER	UniProtKB/TrEMBL
	SOLUTE CARRIER FAMILY 22 MEMBER 2	UniProtKB/TrEMBL
Pfam	Sugar_tr	UniProtKB/TrEMBL
PROSITE	MFS	UniProtKB/TrEMBL
	SUGAR_TRANSPORT_1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF103473	UniProtKB/TrEMBL
UniProt	A0A8C2UNR3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Slc22a2	solute carrier family 22 member 2		solute carrier family 22 (organic cation transporter), member 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB