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Gene: SLC22A2 (solute carrier family 22 member 2) Canis lupus familiaris

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Symbol:

SLC22A2

Name:

solute carrier family 22 member 2

RGD ID:

12235605

Description:

ENCODES a protein that exhibits choline transmembrane transporter activity (ortholog); organic cation transmembrane transporter activity (ortholog); quaternary ammonium group transmembrane transporter activity (ortholog); INVOLVED IN histamine transport (ortholog); monoatomic cation transport (ortholog); organic cation transport (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (ortholog); acute kidney failure (ortholog); end stage renal disease (ortholog); FOUND IN basolateral plasma membrane (ortholog); cholinergic synapse (ortholog); presynaptic membrane (ortholog); INTERACTS WITH cimetidine; penconazole; tebuconazole

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

OCT2; organic cation transporter 2; solute carrier family 22 (organic cation transporter), member 2; solute carrier family 22, member 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	49,327,621 - 49,348,435 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	49,327,296 - 49,348,435 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	50,170,589 - 50,191,400 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	49,505,206 - 49,533,863 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	49,503,308 - 49,533,595 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	49,395,180 - 49,415,993 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	49,266,805 - 49,288,175 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	49,882,427 - 49,903,195 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (ISO)

acute kidney failure (ISO)

end stage renal disease (ISO)

Endotoxemia (ISO)

Experimental Diabetes Mellitus (ISO)

extrahepatic cholestasis (ISO)

hyperuricemia (ISO)

intrahepatic cholestasis (ISO)

kidney disease (ISO)

kidney failure (ISO)

Kidney Neoplasms (ISO)

Kidney Reperfusion Injury (ISO)

obesity (ISO)

Poisoning (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

cimetidine (EXP)

penconazole (EXP)

tebuconazole (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acetylcholine transport (IEA)

amine transport (IEA)

amino acid import across plasma membrane (IEA)

cellular detoxification (IEA)

choline transport (IEA)

dopamine transport (IEA)

dopamine uptake (IEA)

epinephrine transport (IEA)

export across plasma membrane (IEA)

histamine transport (IEA,ISO)

histamine uptake (IEA)

L-alpha-amino acid transmembrane transport (IEA)

L-arginine import across plasma membrane (IEA)

L-arginine transmembrane transport (IEA)

monoatomic cation transport (IEA,ISO)

monoatomic ion transport (IEA)

neurotransmitter transport (IEA)

norepinephrine transport (IEA)

norepinephrine uptake (IEA)

organic cation transport (IEA,ISO)

prostaglandin transport (IEA)

putrescine transport (IEA)

quaternary ammonium group transport (IEA,ISO)

serotonin transport (IEA)

serotonin uptake (IEA)

thiamine transmembrane transport (IEA)

transmembrane transport (IEA)

xenobiotic transport (IEA)

Cellular Component

apical plasma membrane (IEA)

basal plasma membrane (IEA)

basolateral plasma membrane (IEA,ISO)

cholinergic synapse (ISO)

membrane (IEA)

plasma membrane (IEA)

presynapse (IEA)

presynaptic membrane (ISO)

synaptic vesicle membrane (ISO)

Molecular Function

acetylcholine transmembrane transporter activity (IEA)

amine transmembrane transporter activity (IEA)

choline transmembrane transporter activity (IEA,ISO)

efflux transmembrane transporter activity (IEA)

L-amino acid transmembrane transporter activity (IEA)

L-arginine transmembrane transporter activity (IEA)

monoamine transmembrane transporter activity (IEA)

neurotransmitter transmembrane transporter activity (IEA)

organic anion transmembrane transporter activity (IEA)

organic cation transmembrane transporter activity (IEA,ISO)

prostaglandin transmembrane transporter activity (IEA)

putrescine transmembrane transporter activity (IEA)

pyrimidine nucleoside transmembrane transporter activity (IEA)

quaternary ammonium group transmembrane transporter activity (IEA,ISO)

steroid binding (ISO)

thiamine transmembrane transporter activity (IEA)

toxin transmembrane transporter activity (IEA)

transmembrane transporter activity (IEA)

xenobiotic transmembrane transporter activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

amiloride pharmacodynamics pathway (ISO)

bendroflumethiazide pharmacodynamics pathway (ISO)

bumetanide pharmacodynamics pathway (ISO)

chlorothiazide pharmacodynamics pathway (ISO)

chlorthalidone pharmacodynamics pathway (ISO)

cisplatin response pathway (ISO)

cystinuria pathway (ISO)

eplerenone pharmacodynamics pathway (ISO)

etacrynic acid pharmacodynamics pathway (ISO)

furosemide pharmacodynamics pathway (ISO)

Hartnup disease pathway (ISO)

hydrochlorothiazide pharmacodynamics pathway (ISO)

hydroflumethiazide pharmacodynamics pathway (ISO)

iminoglycinuria pathway (ISO)

lamivudine pharmacokinetics pathway (ISO)

lysinuric protein intolerance pathway (ISO)

metformin pharmacokinetics pathway (ISO)

metolazone pharmacodynamics pathway (ISO)

spironolactone pharmacodynamics pathway (ISO)

torasemide pharmacodynamics pathway (ISO)

triamterene pharmacodynamics pathway (ISO)

trichlormethiazide pharmacodynamics pathway (ISO)

References

Additional References at PubMed

PMID:11561104	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

SLC22A2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	49,327,621 - 49,348,435 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	49,327,296 - 49,348,435 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	50,170,589 - 50,191,400 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	49,505,206 - 49,533,863 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	49,503,308 - 49,533,595 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	49,395,180 - 49,415,993 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	49,266,805 - 49,288,175 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	49,882,427 - 49,903,195 (-)	NCBI		UU_Cfam_GSD_1.0

SLC22A2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	160,216,755 - 160,258,821 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	160,171,061 - 160,277,638 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	160,637,787 - 160,679,853 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	160,557,780 - 160,599,949 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	160,608,201 - 160,650,370	NCBI
Celera	6	161,284,724 - 161,329,224 (-)	NCBI		Celera
Cytogenetic Map	6	q25.3	NCBI
HuRef	6	158,107,747 - 158,154,417 (-)	NCBI		HuRef
CHM1_1	6	160,900,027 - 160,942,556 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	161,462,946 - 161,508,769 (-)	NCBI		T2T-CHM13v2.0

Slc22a2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	12,803,076 - 12,847,376 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	12,803,019 - 12,847,375 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	12,584,189 - 12,628,489 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	12,584,132 - 12,628,488 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	12,777,055 - 12,821,354 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	12,427,547 - 12,471,846 (+)	NCBI		MGSCv36	mm8
Celera	17	12,614,783 - 12,660,660 (+)	NCBI		Celera
Cytogenetic Map	17	A1	NCBI
cM Map	17	8.61	NCBI

Slc22a2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	50,668,817 - 50,711,019 (-)	NCBI		GRCr8
mRatBN7.2	1	48,121,061 - 48,163,268 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	48,121,061 - 48,163,268 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	48,812,678 - 48,854,865 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	54,798,480 - 54,840,630 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	48,888,183 - 48,930,374 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	48,318,025 - 48,360,219 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	48,317,995 - 48,360,261 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	51,394,014 - 51,435,104 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	42,395,676 - 42,442,847 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	42,398,620 - 42,445,782 (-)	NCBI
Celera	1	43,920,665 - 43,963,268 (-)	NCBI		Celera
Cytogenetic Map	1	q11	NCBI

Slc22a2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955439	20,567,212 - 20,609,105 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955439	20,567,241 - 20,608,281 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC22A2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	180,320,892 - 180,367,795 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	178,223,301 - 178,271,798 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	158,058,226 - 158,150,917 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	163,066,654 - 163,158,469 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	163,065,317 - 163,158,931 (-)	Ensembl	panpan1.1		panPan2

Slc22a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	144,341,980 - 144,375,967 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936489	11,594,480 - 11,627,786 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936489	11,605,403 - 11,627,786 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC22A2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	7,289,831 - 7,323,146 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	7,289,278 - 7,323,418 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	8,980,529 - 9,012,013 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC22A2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	87,835,077 - 87,881,410 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	87,833,430 - 87,881,081 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	60,218,540 - 60,262,523 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc22a2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624855	2,623,547 - 2,659,742 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624855	2,623,595 - 2,661,739 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in SLC22A2
360 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	4	5	19	17	15	6	6	6	6	25	15	12	14	9

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001286961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038653379	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY028623	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000354	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000001168 ⟹ ENSCAFP00000001067

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	1	49,327,296 - 49,348,435 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845003792 ⟹ ENSCAFP00845003016

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	1	49,503,308 - 49,533,595 (-)	Ensembl

RefSeq Acc Id:

NM_001286961 ⟹ NP_001273890

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	1	49,327,621 - 49,348,435 (-)	NCBI
Dog10K_Boxer_Tasha	1	50,170,589 - 50,191,400 (-)	NCBI
ROS_Cfam_1.0	1	49,512,839 - 49,533,623 (-)	NCBI
UMICH_Zoey_3.1	1	49,395,180 - 49,415,993 (-)	NCBI
UNSW_CanFamBas_1.0	1	49,266,805 - 49,288,175 (-)	NCBI
UU_Cfam_GSD_1.0	1	49,882,427 - 49,903,195 (-)	NCBI

Sequence:

show sequence

TGGAAATCAGCCTGAGCCAGGAAAGGTCTGGATCAAAGGCTGGTCACTTTCTGAAATAAACTCC
CTCCCACCGTTAGACTCTTGCTCAAGAGCTGTGCTGAGCTGGCCAGGGCCTCGCACCAGCGCAG
GGAAAAGCATCGGGACCTCTCCTGCCTCCGGAGATAATGCCAACTGTGGATGACATTCTGGAGC
ACATAGGGGAATTTAACTTTTTCCAGAAGCAGACGTTTTTCCTCTTAGCGCTCATGTCTGTAGC
GTTCACCCCCGTCTACGTGGGCATCGTCTTCCTGGCCTTCACCCCGGATCACCGCTGCCTGAGC
CCCGGGGCGGCCGAGCTGGGCCGGCGATGCGGCTGGAGCGCGGCGGAGGAGCTCAACTACACGG
TGCCGGGCCCGGGGCCCGCGGGCGACGCCTTCCCCCGCCAGTGCCGCAGCTACGCGGTGGACTG
GAACCAGAGCGCCCTGGGCTGCGTGGACCCGCTGGCCGGCCTGGCCGCCAACAGGAGCCACCTG
CCGCTCGGGCCCTGTCTGCACGGCTGGGCCTACGACACGCCCGGCTCCTCCATCGTGACCGAGT
TTAATCTAGTGTGTGCCAATTCCTGGATGCTGGACCTGTTTCAGTCGGCTGTGAACGTAGGATT
TTTTATCGGTTCTGTGGGTATCGGCTACCTAGCAGACAGGTTTGGCCGTAAGCTCTGCCTCTTG
GTCACAATCCTCATAAACACTGCATCTGGAGTTCTCATGGCTGTCTCCCCAAACTATACATGGG
TGTTAATTTTCCGCTTGATCCAGGGGCTGGTCAGCAAGGCAGGCTGGTTAATAGGCTACATCCA
GATTACAGAATTTGTCGGGCGGAGCTATCGGAGAACTGTGGGCATCGTTTACCAAGTGGCCTTC
ACCGTTGGGCTCCTGCTGCTGGCTGGGGTGGCGTATGTGCTTCCTCACTGGAGGTGGCTGCAGG
TCACTGTTACTCTGCCCAACATCTGCTTCTTGCTCTATTACTGGTGCATTCCTGAGTCTCCGAG
GTGGCTGATCTCCCAGAGTAAAAATGCTAAAGCCATGAGGATCCTTAAGTACATTGCAAAGAAA
AATGGAAAATCTCTGCCTGCCTCCCTTCAGAGCCTCAGACCTGATGAAGAAGTTGATGAGAAGT
TGAATCCGTCATTTCTTGACTTGATCAGAACCCCTCAAATAAGAAAACACACTTTGATCTTGAT
GTACAACTGGTTCACAAGCTCTGTTCTCTACCAAGGCCTCATCATGCACATGGGCCTTGCAGGG
AGCAATATCTACTTGGATTTCTTCTACTCTGCCCTGGTGGAATTCCCAGCTGCCATCATCATCA
TCCTCACTATTGACCGTATAGGTCGTCGGTATCCATGGGCTACATCAAATATAGTGGCAGGAGC
AGCCTGCCTTGCATCAGTTTTCATCCCTGAAGATCTACAGTGGCTAAGAGTTACGGTCTCGTGC
TTGGGTAGAATGGGGATTACAATGGCCTTCGAAATGGTTTGCCTGGTCAATGCGGAACTGTACC
CTACGTTCATCAGGAATCTTGGTGTCCTTGTCTGCTCCTCAATGTGTGACATCGGTGGCATCAT
CACACCCTTCCTGGTCTACCGGCTTACCAATATCTGGCATGAGCTCCCACTGGTGGTTTTTGCT
GTGGTTGGCTTGGTTGCTGGGGGACTGGTGTTGCTGCTCCCGGAGACCAAAGGGAAGGCTTTGC
CTGAGACTATTGATGAAGCTGAAAACATGCAGAGGTAG

hide sequence

RefSeq Acc Id:

XM_038653379 ⟹ XP_038509307

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	1	49,505,206 - 49,533,863 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001273890	(Get FASTA)	NCBI Sequence Viewer
	XP_038509307	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAK32954	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000001067.4
	ENSCAFP00040000170.1
	ENSCAFP00845003016
	ENSCAFP00845003016.1

RefSeq Acc Id:

NP_001273890 ⟸ NM_001286961

- UniProtKB:

A0A8C0L1Y3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPTVDDILEHIGEFNFFQKQTFFLLALMSVAFTPVYVGIVFLAFTPDHRCLSPGAAELGRRCGW
SAAEELNYTVPGPGPAGDAFPRQCRSYAVDWNQSALGCVDPLAGLAANRSHLPLGPCLHGWAYD
TPGSSIVTEFNLVCANSWMLDLFQSAVNVGFFIGSVGIGYLADRFGRKLCLLVTILINTASGVL
MAVSPNYTWVLIFRLIQGLVSKAGWLIGYIQITEFVGRSYRRTVGIVYQVAFTVGLLLLAGVAY
VLPHWRWLQVTVTLPNICFLLYYWCIPESPRWLISQSKNAKAMRILKYIAKKNGKSLPASLQSL
RPDEEVDEKLNPSFLDLIRTPQIRKHTLILMYNWFTSSVLYQGLIMHMGLAGSNIYLDFFYSAL
VEFPAAIIIILTIDRIGRRYPWATSNIVAGAACLASVFIPEDLQWLRVTVSCLGRMGITMAFEM
VCLVNAELYPTFIRNLGVLVCSSMCDIGGIITPFLVYRLTNIWHELPLVVFAVVGLVAGGLVLL
LPETKGKALPETIDEAENMQR

hide sequence

Ensembl Acc Id:

ENSCAFP00000001067 ⟸ ENSCAFT00000001168

RefSeq Acc Id:	XP_038509307 ⟸ XM_038653379
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0PP54 (UniProtKB/TrEMBL), A0A8I3MNK2 (UniProtKB/TrEMBL), A0A8C0L1Y3 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845003016 ⟸ ENSCAFT00845003792

Protein Domains

Major facilitator superfamily (MFS) profile

Promoters

RGD ID:

13682022

Promoter ID:

EPDNEW_C90

Type:

initiation region

Name:

SLC22A2_1

Description:

Canis lupus familiaris solute carrier family 22 , member 2 ,mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	1	49,348,327 - 49,348,387	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000000757	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00040000151	UniProtKB/TrEMBL
	ENSCAFG00845002163	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000001168.5	UniProtKB/TrEMBL
	ENSCAFT00040000221.1	UniProtKB/TrEMBL
	ENSCAFT00845003792	ENTREZGENE
	ENSCAFT00845003792.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1250.20	UniProtKB/TrEMBL
InterPro	MFS_dom	UniProtKB/TrEMBL
	MFS_sugar_transport-like	UniProtKB/TrEMBL
	MFS_trans_sf	UniProtKB/TrEMBL
	Orgcat_transp/SVOP	UniProtKB/TrEMBL
	Sugar_transporter_CS	UniProtKB/TrEMBL
NCBI Gene	SLC22A2	ENTREZGENE
PANTHER	SOLUTE CARRIER FAMILY 22 MEMBER	UniProtKB/TrEMBL
	SOLUTE CARRIER FAMILY 22 MEMBER 2	UniProtKB/TrEMBL
Pfam	Sugar_tr	UniProtKB/TrEMBL
PROSITE	MFS	UniProtKB/TrEMBL
	SUGAR_TRANSPORT_1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF103473	UniProtKB/TrEMBL
UniProt	A0A8C0L1Y3	ENTREZGENE
	A0A8C0PP54	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3MNK2	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:53985	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-04-10	SLC22A2	solute carrier family 22 member 2		solute carrier family 22 (organic cation transporter), member 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB