SLC22A2 (solute carrier family 22 member 2) - Rat Genome Database
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Gene: SLC22A2 (solute carrier family 22 member 2) Homo sapiens
Analyze
Symbol: SLC22A2
Name: solute carrier family 22 member 2
RGD ID: 1342518
HGNC Page HGNC
Description: Exhibits transmembrane transporter activity. Involved in several processes, including cation transport; norepinephrine uptake; and toxin transport. Localizes to apical plasma membrane. Implicated in acute kidney failure.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hOCT2; MGC32628; OCT2; organic cation transporter (OCT2); organic cation transporter 2; solute carrier family 22 (organic cation transporter), member 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6160,171,061 - 160,277,638 (-)EnsemblGRCh38hg38GRCh38
GRCh386160,216,755 - 160,258,821 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376160,637,794 - 160,679,963 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,557,780 - 160,599,949 (-)NCBINCBI36hg18NCBI36
Build 346160,608,201 - 160,650,370NCBI
Celera6161,284,724 - 161,329,224 (-)NCBI
Cytogenetic Map6q25.3NCBI
HuRef6158,107,747 - 158,154,417 (-)NCBIHuRef
CHM1_16160,900,027 - 160,942,556 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (EXP)
(+)-pilocarpine  (EXP)
(-)-noscapine  (EXP)
(-)-selegiline  (EXP)
(E)-thiamethoxam  (EXP)
(S)-atropine  (EXP)
(S)-fenfluramine  (EXP)
(S)-nicotine  (EXP)
1,1'-diethyl-2,2'-cyanine  (EXP)
1,1-dichloroethene  (ISO)
1,3-diphenylguanidine  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methyl-1,4-diazepane  (EXP)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-methylnicotinamide  (EXP)
1-naphthyl isothiocyanate  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (ISO)
17alpha-hydroxyprogesterone  (EXP)
17beta-estradiol  (ISO)
2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (EXP)
2-Amino-3-methyl-9H-pyrido[2,3-b]indole  (EXP)
2-Amino-9H-pyrido[2,3-b]indole  (EXP)
2-hydroxy-2,2-diphenylacetic acid (1,1-dimethyl-3-piperidin-1-iumyl) ester  (EXP)
2-hydroxy-2,2-diphenylacetic acid (1-methyl-1-azoniabicyclo[2.2.2]octan-3-yl) ester  (EXP)
2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4',5-tetrachlorosalicylanilide  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-dimethoxybenzoic acid 4-[ethyl-[1-(4-methoxyphenyl)propan-2-yl]amino]butyl ester  (EXP)
3-[2-(ethylamino)-1-hydroxyethyl]phenol  (EXP)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone  (EXP)
4-[1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl]phenol  (EXP)
4-[6-(diaminomethylideneamino)-1-oxohexoxy]benzoic acid ethyl ester  (EXP)
4-amino-5-chloro-2-methoxy-N-[1-(phenylmethyl)-4-piperidinyl]benzamide  (EXP)
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide  (EXP)
5-azaorotic acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (ISO)
9-aminoacridine  (EXP)
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol  (EXP)
acetamiprid  (EXP)
acetylsalicylic acid  (EXP)
aclacinomycin A  (EXP)
aconitine  (EXP)
adapalene  (EXP)
adrenosterone  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
allopurinol  (ISO)
alprazolam  (EXP)
alprenolol  (EXP)
amiloride  (EXP)
amitraz  (EXP)
amitriptyline  (EXP)
ammonium chloride  (ISO)
anastrozole  (EXP)
androsterone  (EXP)
angelicin  (ISO)
antazoline  (EXP)
apomorphine  (EXP)
atrazine  (ISO)
atropine  (EXP)
auranofin  (EXP)
azelastine  (EXP)
azithromycin  (EXP)
bazedoxifene  (EXP)
beclomethasone  (EXP)
benzatropine  (EXP)
benzethonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-carboline  (EXP)
bisoprolol  (EXP)
bisphenol A  (ISO)
bisphenol F  (EXP)
bithionol  (EXP)
bopindolol  (EXP)
bretylium tosylate  (EXP)
brilliant green  (EXP)
brimonidine tartrate  (EXP)
bromhexine  (EXP)
brompheniramine  (EXP)
budesonide  (EXP)
bupropion  (EXP)
buspirone  (EXP)
butenafine  (EXP)
Butylparaben  (EXP)
butylscopolamine bromide  (EXP)
cadmium dichloride  (ISO)
capsaicin  (EXP)
carbinoxamine  (EXP)
carvedilol  (EXP)
chlorhexidine  (EXP)
Chlormadinone acetate  (EXP)
chlorogenic acid  (ISO)
chloroquine  (EXP)
chlorphenamine  (EXP,ISO)
chlorphenesin carbamate  (EXP)
chlorpromazine  (EXP)
chlorpyrifos  (EXP)
ciguatoxin CTX1B  (ISO)
cilostazol  (EXP)
cimetidine  (EXP,ISO)
cisapride  (EXP)
cisplatin  (EXP,ISO)
clidinium  (EXP)
clomacran  (EXP)
clomipramine  (EXP)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
clorprenaline  (EXP)
clothianidin  (EXP)
clozapine  (EXP)
corticosterone  (ISO)
cortisol  (EXP)
cortisone  (EXP)
crystal violet  (EXP)
cyclobenzaprine  (EXP)
cyclosporin A  (ISO)
cyproheptadine  (EXP)
cyromazine  (EXP)
decabromodiphenyl ether  (ISO)
dequalinium  (EXP)
desipramine  (EXP)
desloratadine  (EXP)
desoximetasone  (EXP)
dexbrompheniramine  (EXP)
dexchlorpheniramine  (EXP)
dextromethorphan  (EXP)
dextropropoxyphene  (EXP)
diazepam  (EXP)
dichlorine  (ISO)
dicyclomine  (EXP)
digitonin  (EXP)
dimenhydrinate  (EXP)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (EXP)
dioxygen  (ISO)
diphenhydramine  (EXP)
diphenidol  (EXP)
dipyridamole  (EXP)
disodium selenite  (EXP)
disopyramide  (EXP,ISO)
domperidone  (EXP)
donepezil hydrochloride  (EXP)
dopamine  (ISO)
doxazosin  (EXP)
doxepin  (EXP)
droperidol  (EXP)
dyclonine  (EXP)
econazole  (EXP)
epalrestat  (EXP)
Eperisone hydrochloride  (EXP)
epinastine  (EXP)
estrone  (EXP)
ethidium  (EXP,ISO)
exemestane  (EXP)
famotidine  (EXP,ISO)
fenitrothion  (EXP)
finasteride  (EXP)
flumazenil  (EXP)
fluorometholone  (EXP)
fluoxetine  (EXP)
fluphenazine  (EXP)
Flurandrenolide  (EXP)
formononetin  (ISO)
fructose  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
Glu-P-1  (EXP)
Glu-P-2  (EXP)
glycyrrhizinic acid  (EXP)
granisetron  (EXP)
Guanabenz  (EXP)
Guanfacine  (EXP)
Halcinonide  (EXP)
haloperidol  (EXP)
harman  (EXP)
Homatropine  (EXP)
hydralazine  (EXP)
hydroxyzine  (EXP)
idebenone  (EXP)
imidacloprid  (EXP)
imipramine  (EXP)
imperatorin  (ISO)
indapamide  (EXP)
indometacin  (EXP)
ipratropium  (EXP)
isoimperatorin  (ISO)
Isopropamide iodide  (EXP)
kainic acid  (EXP)
ketotifen  (EXP)
Lafutidine  (EXP)
lamivudine  (EXP)
lansoprazole  (EXP)
letrozole  (EXP)
leuprolide  (EXP)
lidocaine  (EXP)
lisuride  (EXP)
loperamide  (EXP)
lysergol  (EXP)
malathion  (EXP)
maneb  (ISO)
mangiferin  (ISO)
Maprotiline  (EXP)
mechlorethamine  (EXP)
medroxyprogesterone  (EXP)
mefloquine  (EXP)
megestrol acetate  (EXP)
MeIQ  (EXP)
MeIQx  (EXP)
melatonin  (EXP,ISO)
Mepenzolate  (EXP)
mepyramine  (EXP)
mercury dichloride  (EXP,ISO)
Mestanolone  (EXP)
metformin  (EXP,ISO)
methoxsalen  (ISO)
methyltestosterone  (EXP)
metoclopramide  (EXP)
metoprolol  (EXP)
mianserin  (EXP)
miconazole  (EXP)
mirtazapine  (EXP)
monobenzone  (EXP)
Mosapride citrate  (EXP)
Moxonidine  (EXP)
mycophenolic acid  (EXP)
myrtecaine  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP,ISO)
nalbuphine  (EXP)
nandrolone  (EXP)
naphthalene  (ISO)
naproxen  (EXP)
nefazodone  (EXP)
Nicardipine  (EXP)
nicotine  (EXP)
Nifekalant  (EXP)
nimetazepam  (EXP)
nitenpyram  (EXP)
nocodazole  (EXP)
norethisterone  (EXP)
norfloxacin  (EXP)
nortriptyline  (EXP)
ochratoxin A  (ISO)
olanzapine  (EXP)
omeprazole  (EXP)
Ondansetron  (EXP,ISO)
orlistat  (EXP)
orphenadrine  (EXP)
Oxatomide  (EXP)
oxiconazole  (EXP)
oxybuprocaine  (EXP)
oxybutynin  (EXP)
oxymetazoline  (EXP)
oxymetholone  (EXP)
ozone  (ISO)
p-aminohippuric acid  (EXP)
paraquat  (EXP,ISO)
paroxetine  (EXP)
parthenolide  (EXP)
pecazine  (EXP)
pentamidine  (EXP)
perfluorodecalin  (EXP)
pergolide  (EXP)
perhexiline  (EXP)
perphenazine  (EXP)
Phenelzine  (EXP)
phenformin  (EXP)
Phenoxybenzamine  (EXP)
phentolamine  (EXP)
phenyltoloxamine  (EXP)
PhIP  (EXP)
pioglitazone  (EXP)
Piracetam  (EXP)
piroxicam  (EXP)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
pralidoxime  (EXP)
prazosin  (EXP)
prednisone  (EXP)
pridinol  (EXP)
primaquine  (EXP)
prinomastat  (EXP)
probenecid  (ISO)
procyclidine  (EXP)
progesterone  (ISO)
promazine  (EXP)
Propantheline  (EXP)
Proparacaine  (EXP)
propranolol  (EXP)
psoralen  (ISO)
pyrimethamine  (EXP)
quercetin  (ISO)
quinidine  (EXP)
quinine  (EXP)
rabeprazole  (EXP)
raloxifene  (EXP)
ranitidine  (EXP,ISO)
rutin  (ISO)
semustine  (EXP)
sildenafil citrate  (EXP)
sodium dichromate  (ISO)
sparteine  (EXP)
spiperone  (EXP)
spironolactone  (EXP)
streptozocin  (ISO)
strychnine  (EXP)
sulconazole  (EXP)
sulindac  (EXP)
tacrine  (EXP)
Tegafur  (EXP)
telmisartan  (EXP)
terbutaline  (EXP)
terconazole  (EXP)
testosterone  (ISO)
tetracaine  (EXP)
tetrachloromethane  (ISO)
tetraethylammonium  (EXP,ISO)
tetryzoline  (EXP)
thalidomide  (EXP)
thiacloprid  (EXP)
thiamethoxam  (EXP)
thioridazine  (EXP)
tolazoline  (EXP)
tolterodine tartrate  (EXP)
trazodone  (EXP)
triamcinolone acetonide  (EXP)
triazolam  (EXP)
Trihexyphenidyl  (EXP)
trimellitic anhydride  (ISO)
trimipramine  (EXP)
Tripelennamine  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
tropisetron  (EXP)
trospium chloride  (EXP)
valdecoxib  (EXP)
valproic acid  (EXP)
vancomycin  (ISO)
varenicline  (EXP)
verapamil  (EXP)
VX-745  (EXP)
Xylometazoline  (EXP)
zafirlukast  (EXP)
zolpidem  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
1. Ciarimboli G Scientifica (Cairo). 2012;2012:473829. doi: 10.6064/2012/473829. Epub 2012 Nov 25.
2. Filipski KK, etal., Clin Pharmacol Ther. 2009 Oct;86(4):396-402. doi: 10.1038/clpt.2009.139. Epub 2009 Jul 22.
3. GOA_HUMAN data from the GO Consortium
4. Gong L, etal., Pharmacogenet Genomics. 2012 Nov;22(11):820-7. doi: 10.1097/FPC.0b013e3283559b22.
5. Habu Y, etal., Biochem Pharmacol. 2005 Mar 15;69(6):993-9.
6. Heemskerk S, etal., Eur J Pharmacol. 2008 Apr 28;584(2-3):390-7. doi: 10.1016/j.ejphar.2008.02.006. Epub 2008 Feb 12.
7. Hu QH, etal., Eur J Nutr. 2012 Aug;51(5):593-606. doi: 10.1007/s00394-011-0243-y. Epub 2011 Sep 10.
8. Ji L, etal., Kidney Int. 2002 Aug;62(2):514-24.
9. Jin HE, etal., Pharm Res. 2009 Mar;26(3):549-59. doi: 10.1007/s11095-008-9770-5. Epub 2008 Nov 11.
10. Komazawa H, etal., J Pharm Sci. 2013 Mar;102(3):1086-94. doi: 10.1002/jps.23433. Epub 2012 Dec 29.
11. Kurata T, etal., Drug Metab Pharmacokinet. 2010;25(4):328-34.
12. Lou Y, etal., Toxicol Lett. 2011 Feb 25;201(1):72-9. doi: 10.1016/j.toxlet.2010.12.007. Epub 2010 Dec 15.
13. Morisaki T, etal., Pharm Res. 2008 Nov;25(11):2526-33. doi: 10.1007/s11095-008-9668-2. Epub 2008 Jul 9.
14. Nowicki MT, etal., Drug Metab Lett. 2008 Jan;2(1):11-7.
15. Pipeline to import SMPDB annotations from SMPDB into RGD
16. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. RGD automated import pipeline for gene-chemical interactions
18. Schneider R, etal., Am J Physiol Renal Physiol. 2011 Nov;301(5):F997-F1004. doi: 10.1152/ajprenal.00264.2011. Epub 2011 Aug 10.
19. Ulu R, etal., Food Chem Toxicol. 2012 May;50(5):1675-9. doi: 10.1016/j.fct.2012.02.082. Epub 2012 Mar 3.
20. Wang CP, etal., Planta Med. 2011 May;77(8):786-94. doi: 10.1055/s-0030-1250599. Epub 2010 Dec 10.
21. Yang J, etal., Eur J Cancer. 2013 Apr;49(6):1479-90. doi: 10.1016/j.ejca.2012.10.027. Epub 2012 Dec 7.
Additional References at PubMed
PMID:1727476   PMID:7690421   PMID:8902060   PMID:9078256   PMID:9260930   PMID:9605850   PMID:9687576   PMID:9933568   PMID:10942111   PMID:11447227   PMID:11483518   PMID:11953440  
PMID:12089365   PMID:12142729   PMID:12388397   PMID:12477932   PMID:12538837   PMID:15135235   PMID:15499192   PMID:15817714   PMID:16024787   PMID:16141367   PMID:16314463   PMID:16368738  
PMID:16513443   PMID:16951202   PMID:16990275   PMID:17060063   PMID:17111267   PMID:17220237   PMID:17393420   PMID:17495125   PMID:17971819   PMID:18029348   PMID:18401339   PMID:18414781  
PMID:18508876   PMID:18551044   PMID:18559608   PMID:18728938   PMID:19056867   PMID:19141712   PMID:19343046   PMID:19483665   PMID:19536068   PMID:19833842   PMID:19913121   PMID:20053795  
PMID:20067471   PMID:20173083   PMID:20371711   PMID:20383145   PMID:20383146   PMID:20429798   PMID:20477935   PMID:20628086   PMID:20679960   PMID:20682687   PMID:21128598   PMID:21346370  
PMID:21553234   PMID:21873635   PMID:21988832   PMID:22085643   PMID:22223530   PMID:22483271   PMID:22525860   PMID:22569819   PMID:22573376   PMID:22590580   PMID:22735389   PMID:22806583  
PMID:22875535   PMID:22913740   PMID:23137377   PMID:23341218   PMID:23424657   PMID:23545524   PMID:23630107   PMID:23776246   PMID:23864433   PMID:24102360   PMID:24291757   PMID:24427340  
PMID:24530383   PMID:24533710   PMID:24643204   PMID:24816252   PMID:25019617   PMID:25143296   PMID:25573751   PMID:25662675   PMID:25823781   PMID:25883089   PMID:26590417   PMID:26674735  
PMID:27178732   PMID:27319306   PMID:27590272   PMID:27609360   PMID:27828777   PMID:28414026   PMID:28714373   PMID:28767196   PMID:28992563   PMID:29236753   PMID:29624501   PMID:29794161  
PMID:29987050   PMID:30168369   PMID:30280653   PMID:30561642   PMID:30910922   PMID:31083486   PMID:31088315   PMID:31318583   PMID:31586073   PMID:31591331   PMID:31836927  


Genomics

Comparative Map Data
SLC22A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6160,171,061 - 160,277,638 (-)EnsemblGRCh38hg38GRCh38
GRCh386160,216,755 - 160,258,821 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376160,637,794 - 160,679,963 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,557,780 - 160,599,949 (-)NCBINCBI36hg18NCBI36
Build 346160,608,201 - 160,650,370NCBI
Celera6161,284,724 - 161,329,224 (-)NCBI
Cytogenetic Map6q25.3NCBI
HuRef6158,107,747 - 158,154,417 (-)NCBIHuRef
CHM1_16160,900,027 - 160,942,556 (-)NCBICHM1_1
Slc22a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391712,803,076 - 12,847,376 (+)NCBIGRCm39mm39
GRCm381712,584,189 - 12,628,489 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,584,132 - 12,628,488 (+)EnsemblGRCm38mm10GRCm38
MGSCv371712,777,055 - 12,821,354 (+)NCBIGRCm37mm9NCBIm37
MGSCv361712,427,547 - 12,471,846 (+)NCBImm8
Celera1712,614,783 - 12,660,660 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.61NCBI
Slc22a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0148,318,025 - 48,360,219 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,317,995 - 48,360,261 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,394,014 - 51,435,104 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,395,676 - 42,442,847 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1142,398,620 - 42,445,782 (-)NCBI
Celera143,920,665 - 43,963,268 (-)NCBICelera
Cytogenetic Map1q11NCBI
Slc22a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543920,567,212 - 20,609,105 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543920,567,241 - 20,608,281 (+)NCBIChiLan1.0ChiLan1.0
SLC22A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16163,066,654 - 163,158,469 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6163,065,317 - 163,158,931 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06158,058,226 - 158,150,917 (-)NCBIMhudiblu_PPA_v0panPan3
SLC22A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl149,327,296 - 49,348,435 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1149,327,621 - 49,348,435 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Slc22a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648911,605,403 - 11,627,786 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,289,831 - 7,323,146 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,289,278 - 7,323,418 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.218,980,529 - 9,012,013 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,835,077 - 87,881,410 (-)NCBI
ChlSab1.1 Ensembl1387,833,430 - 87,881,081 (-)Ensembl
Slc22a2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248552,623,595 - 2,661,739 (+)NCBI

Position Markers
SHGC-81309  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,660,901 - 160,661,229UniSTSGRCh37
Build 366160,580,891 - 160,581,219RGDNCBI36
Celera6161,310,162 - 161,310,490RGD
Cytogenetic Map6q25.3UniSTS
HuRef6158,135,355 - 158,135,683UniSTS
TNG Radiation Hybrid Map679809.0UniSTS
SLC22A2_2598  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,637,782 - 160,638,631UniSTSGRCh37
Build 366160,557,772 - 160,558,621RGDNCBI36
Celera6161,284,712 - 161,285,561RGD
HuRef6158,107,735 - 158,108,584UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1012
Count of miRNA genes:682
Interacting mature miRNAs:761
Transcripts:ENST00000366952, ENST00000366953, ENST00000486916, ENST00000489644, ENST00000491092, ENST00000498556
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 3 3 207 3 1
Low 51 94 19 8 7 7 131 74 49 81 40 11 2 104 1
Below cutoff 1818 1866 1015 379 528 286 3183 1626 2700 63 1091 717 94 730 2248

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000366952   ⟹   ENSP00000355919
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6160,244,185 - 160,277,638 (-)Ensembl
RefSeq Acc Id: ENST00000366953   ⟹   ENSP00000355920
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6160,216,755 - 160,258,821 (-)Ensembl
RefSeq Acc Id: ENST00000486916
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6160,171,061 - 160,245,541 (-)Ensembl
RefSeq Acc Id: ENST00000489644
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6160,257,750 - 160,258,739 (-)Ensembl
RefSeq Acc Id: ENST00000491092
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6160,217,453 - 160,258,758 (-)Ensembl
RefSeq Acc Id: ENST00000498556
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6160,217,014 - 160,218,284 (-)Ensembl
RefSeq Acc Id: NM_003058   ⟹   NP_003049
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386160,216,755 - 160,258,821 (-)NCBI
GRCh376160,637,794 - 160,679,963 (-)ENTREZGENE
Build 366160,557,780 - 160,599,949 (-)NCBI Archive
HuRef6158,107,747 - 158,154,417 (-)ENTREZGENE
CHM1_16160,900,027 - 160,942,556 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_003049   ⟸   NM_003058
- UniProtKB: O15244 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000355919   ⟸   ENST00000366952
RefSeq Acc Id: ENSP00000355920   ⟸   ENST00000366953
Protein Domains
MFS

Promoters
RGD ID:7209605
Promoter ID:EPDNEW_H10549
Type:initiation region
Name:SLC22A2_1
Description:solute carrier family 22 member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386160,258,821 - 160,258,881EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6q24.1-27(chr6:141132990-169339571)x3 copy number gain See cases [RCV000050604] Chr6:141132990..169339571 [GRCh38]
Chr6:141454127..169739666 [GRCh37]
Chr6:141495820..169481591 [NCBI36]
Chr6:6q24.1-27
pathogenic
GRCh38/hg38 6q25.2-27(chr6:152376338-170583214)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051902]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051902]|See cases [RCV000051902] Chr6:152376338..170583214 [GRCh38]
Chr6:152697473..170892302 [GRCh37]
Chr6:152739166..170734227 [NCBI36]
Chr6:6q25.2-27
pathogenic
GRCh38/hg38 6q25.3-27(chr6:158664768-170612001)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051904]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051904]|See cases [RCV000051904] Chr6:158664768..170612001 [GRCh38]
Chr6:159085800..170921089 [GRCh37]
Chr6:159005788..170763014 [NCBI36]
Chr6:6q25.3-27
pathogenic
GRCh38/hg38 6q25.2-27(chr6:154118058-170602152)x1 copy number loss See cases [RCV000052207] Chr6:154118058..170602152 [GRCh38]
Chr6:154439193..170911240 [GRCh37]
Chr6:154480885..170753165 [NCBI36]
Chr6:6q25.2-27
pathogenic
GRCh38/hg38 6q25.3-27(chr6:159454639-170612001)x1 copy number loss See cases [RCV000052209] Chr6:159454639..170612001 [GRCh38]
Chr6:159875671..170921089 [GRCh37]
Chr6:159795661..170763014 [NCBI36]
Chr6:6q25.3-27
pathogenic
GRCh38/hg38 6q25.3-27(chr6:159825913-170612001)x1 copy number loss See cases [RCV000052211] Chr6:159825913..170612001 [GRCh38]
Chr6:160246945..170921089 [GRCh37]
Chr6:160166935..170763014 [NCBI36]
Chr6:6q25.3-27
pathogenic
NM_003058.3(SLC22A2):c.550G>A (p.Val184Ile) single nucleotide variant Malignant melanoma [RCV000067203] Chr6:160250671 [GRCh38]
Chr6:160671703 [GRCh37]
Chr6:160591693 [NCBI36]
Chr6:6q25.3
not provided
NM_003058.3(SLC22A2):c.39G>A (p.Gly13=) single nucleotide variant Malignant melanoma [RCV000067204] Chr6:160258719 [GRCh38]
Chr6:160679751 [GRCh37]
Chr6:160599741 [NCBI36]
Chr6:6q25.3
not provided
NM_003058.3(SLC22A2):c.1159G>A (p.Glu387Lys) single nucleotide variant Malignant melanoma [RCV000061343] Chr6:160243692 [GRCh38]
Chr6:160664724 [GRCh37]
Chr6:160584714 [NCBI36]
Chr6:6q25.3
not provided
GRCh38/hg38 6q25.2-27(chr6:154539655-170714507)x1 copy number loss See cases [RCV000137381] Chr6:154539655..170714507 [GRCh38]
Chr6:154860789..171023595 [GRCh37]
Chr6:154902481..170865520 [NCBI36]
Chr6:6q25.2-27
pathogenic
GRCh38/hg38 6q25.3-26(chr6:155378049-163133499)x1 copy number loss See cases [RCV000137831] Chr6:155378049..163133499 [GRCh38]
Chr6:155699183..163554531 [GRCh37]
Chr6:155740875..163474521 [NCBI36]
Chr6:6q25.3-26
pathogenic
GRCh38/hg38 6q25.3-27(chr6:159915390-170714507)x1 copy number loss See cases [RCV000139636] Chr6:159915390..170714507 [GRCh38]
Chr6:160336422..171023595 [GRCh37]
Chr6:160256412..170865520 [NCBI36]
Chr6:6q25.3-27
pathogenic
GRCh38/hg38 6q25.2-27(chr6:152793402-170610394)x1 copy number loss See cases [RCV000141880] Chr6:152793402..170610394 [GRCh38]
Chr6:153114537..170919482 [GRCh37]
Chr6:153156230..170761407 [NCBI36]
Chr6:6q25.2-27
pathogenic
GRCh38/hg38 6q25.2-27(chr6:152376338-170612001)x3 copy number gain See cases [RCV000142594] Chr6:152376338..170612001 [GRCh38]
Chr6:152697473..170921089 [GRCh37]
Chr6:152739166..170763014 [NCBI36]
Chr6:6q25.2-27
pathogenic
GRCh38/hg38 6q23.2-27(chr6:133537271-165875545)x3 copy number gain See cases [RCV000143444] Chr6:133537271..165875545 [GRCh38]
Chr6:133858409..166289033 [GRCh37]
Chr6:133900102..166209023 [NCBI36]
Chr6:6q23.2-27
pathogenic
GRCh38/hg38 6q25.3-26(chr6:158585724-160899783)x3 copy number gain See cases [RCV000143618] Chr6:158585724..160899783 [GRCh38]
Chr6:159006756..161320815 [GRCh37]
Chr6:158926744..161240805 [NCBI36]
Chr6:6q25.3-26
uncertain significance
GRCh37/hg19 6q25.1-27(chr6:151214792-170892243)x3 copy number gain See cases [RCV000449011] Chr6:151214792..170892243 [GRCh37]
Chr6:6q25.1-27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q25.3-27(chr6:159844762-170919482)x3 copy number gain not provided [RCV000682734] Chr6:159844762..170919482 [GRCh37]
Chr6:6q25.3-27
pathogenic
GRCh37/hg19 6q25.3-26(chr6:160524800-161855470)x3 copy number gain not provided [RCV000682735] Chr6:160524800..161855470 [GRCh37]
Chr6:6q25.3-26
uncertain significance
46,XX,der(6)(q25.1,q28)dn.seq[GRCh37/hg19]der(6)(6pter->6q25.2(+)(154768571)::q25.2(+)(154778901),q25.2(+)154778992::q25.2(-)(154774048),q25.2(-)(154768571)::q25.2(-)(154768571),q25.1(-)(~151443183-151443483))dn complex Coffin-Siris syndrome 1 [RCV000714957] Chr6:151443333..171115067 [GRCh37]
Chr6:6q25.1-27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q25.1-27(chr6:150284435-170919470)x3 copy number gain not provided [RCV000746100] Chr6:150284435..170919470 [GRCh37]
Chr6:6q25.1-27
pathogenic
GRCh37/hg19 6q25.3-27(chr6:159155998-171054786)x3 copy number gain not provided [RCV000746132] Chr6:159155998..171054786 [GRCh37]
Chr6:6q25.3-27
pathogenic
GRCh37/hg19 6q25.3(chr6:160628053-160638076)x1 copy number loss not provided [RCV000746140] Chr6:160628053..160638076 [GRCh37]
Chr6:6q25.3
benign
GRCh37/hg19 6q25.3(chr6:157262571-160992289)x3 copy number gain not provided [RCV000848057] Chr6:157262571..160992289 [GRCh37]
Chr6:6q25.3
uncertain significance
NM_003058.4(SLC22A2):c.1575C>A (p.Thr525=) single nucleotide variant not provided [RCV000954671] Chr6:160224731 [GRCh38]
Chr6:160645763 [GRCh37]
Chr6:6q25.3
benign
NM_003058.4(SLC22A2):c.1194C>T (p.Ile398=) single nucleotide variant not provided [RCV000915381] Chr6:160243657 [GRCh38]
Chr6:160664689 [GRCh37]
Chr6:6q25.3
likely benign
GRCh37/hg19 6q25.3(chr6:160587123-160666378)x1 copy number loss not provided [RCV001005866] Chr6:160587123..160666378 [GRCh37]
Chr6:6q25.3
uncertain significance
GRCh37/hg19 6q25.3(chr6:160593076-160644511)x1 copy number loss not provided [RCV001258755] Chr6:160593076..160644511 [GRCh37]
Chr6:6q25.3
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10966 AgrOrtholog
COSMIC SLC22A2 COSMIC
Ensembl Genes ENSG00000112499 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000355919 UniProtKB/TrEMBL
  ENSP00000355920 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000366952 UniProtKB/TrEMBL
  ENST00000366953 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000112499 GTEx
HGNC ID HGNC:10966 ENTREZGENE
Human Proteome Map SLC22A2 Human Proteome Map
InterPro MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_sugar_transport-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orgcat_transp/SVOP UniProtKB/Swiss-Prot
  Sugar_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6582 UniProtKB/Swiss-Prot
NCBI Gene 6582 ENTREZGENE
OMIM 602608 OMIM
Pfam Sugar_tr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA331 PharmGKB, RGD
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs 2A0119 UniProtKB/Swiss-Prot
UniGene Hs.436385 ENTREZGENE
UniProt O15244 ENTREZGENE
  Q5T7Q5_HUMAN UniProtKB/TrEMBL
  S22A2_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary Q5T7Q6 UniProtKB/Swiss-Prot
  Q6PIQ8 UniProtKB/Swiss-Prot
  Q8NG62 UniProtKB/Swiss-Prot
  Q9NQB9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-23 SLC22A2  solute carrier family 22 member 2    solute carrier family 22 (organic cation transporter), member 2  Symbol and/or name change 5135510 APPROVED
2011-08-16 SLC22A2  solute carrier family 22 (organic cation transporter), member 2  SLC22A2  solute carrier family 22 (organic cation transporter), member 2  Symbol and/or name change 5135510 APPROVED