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Platinum (Pt)-containing drugs, or platinating agents such as cisplatin, carboplatin and oxaliplatin are chemotherapy agents used in the treatment of a number of solid tumors. It is agreed that the main target of these compounds is DNA with the drugs forming DNA adducts. Pt-induced DNA lesions activate the DNA damage response machinery halting DNA replication and promoting cell cycle arrest, the nucleotide excision repair (NER) pathway and apoptosis and as such, they are toxic to proliferating c

Pathway Diagram:

Elsevier Inc. Slc22a4 ---> uptaken_cisplatin Slc31a1 ---> uptaken_cisplatin uptaken_cisplatin ---> Slc47a1 Slc22a4 Slc47a1 Slc31a1 Slc22a2 Hearing Disorders solid tumors kidney toxicity Peripheral Nervous System Diseases Slc22a2 ---> uptaken_cisplatin aquated_cisplatin ---> cisplatin drug pathway uptaken_cisplatin aquated_cisplatin aquated_cisplatin --+> Peripheral Nervous System Diseases aquated_cisplatin --+> kidney toxicity aquated_cisplatin --+> Hearing Disorders uptaken_cisplatin ---> aquated_cisplatin cisplatin drug pathway aquated_cisplatin ---| solid tumors

Genes in Pathway:

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cisplatin response pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:8548480
G Slc22a4 solute carrier family 22 member 4 JBrowse link 10 39,334,972 39,373,508 RGD:8548480
G Slc31a1 solute carrier family 31 member 1 JBrowse link 5 78,222,504 78,249,358 RGD:8548480
G Slc47a1 solute carrier family 47 member 1 JBrowse link 10 47,631,425 47,685,379 RGD:8548480

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the cisplatin response pathway

References Associated with the cisplatin response pathway:

Ontology Path Diagram:

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