Cxcl2 (C-X-C motif chemokine ligand 2) - Rat Genome Database

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Gene: Cxcl2 (C-X-C motif chemokine ligand 2) Rattus norvegicus
Symbol: Cxcl2
Name: C-X-C motif chemokine ligand 2
RGD ID: 70069
Description: Enables chemokine activity. Involved in several processes, including cellular response to interleukin-1; cellular response to lipopolysaccharide; and neutrophil chemotaxis. Located in extracellular space. Biomarker of several diseases, including acute necrotizing pancreatitis; bile duct disease (multiple); brain edema; pleurisy; and pneumonia (multiple). Orthologous to human CXCL2 (C-X-C motif chemokine ligand 2); PARTICIPATES IN chemokine mediated signaling pathway; cytokine mediated signaling pathway; NOD-like receptor signaling pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
Previously known as: C-X-C motif chemokine 2; chemokine (C-X-C motif) ligand 2; CINC-3; cytokine-induced neutrophil chemoattractant 3; macrophage inflammatory protein 2; Mip-2; MIP2; Scyb2; small inducible cytokine subfamily member 2; small inducible cytokine subfamily, member 2
RGD Orthologs
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81417,465,210 - 17,467,255 (-)NCBIGRCr8
mRatBN7.21417,181,030 - 17,183,075 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,181,062 - 17,183,075 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,181,873 - 17,183,917 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,500,809 - 18,502,853 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,192,924 - 17,194,968 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,731,346 - 18,733,391 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,731,378 - 18,733,391 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,640,312 - 18,642,357 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,677,129 - 18,679,175 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,677,128 - 18,679,175 (-)NCBI
Celera1416,558,112 - 16,560,157 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(E)-cinnamyl alcohol  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-nicotine  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,3-benzothiazole-2-thiol  (ISO)
1,4-phenylenediamine  (ISO)
1,7-dimethylxanthine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
13,14-dihydro-15-ketoprostaglandin D2  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2''-galloylhyperin  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-naphthylamine  (ISO)
2-tert-butylhydroquinone  (ISO)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-acetyldeoxynivalenol  (ISO)
3-aminobenzamide  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-fluorouracil  (ISO)
6alpha-methylprednisolone  (ISO)
acrolein  (ISO)
Actein  (EXP)
aflatoxin B1  (ISO)
Aflatoxin G1  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
amiloride  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
amlexanox  (ISO)
ammonium chloride  (EXP)
Ammothamnine  (EXP)
amphibole asbestos  (EXP,ISO)
amphotericin B  (ISO)
ampicillin  (ISO)
andrographolide  (EXP,ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
argatroban  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
asperentin  (ISO)
azathioprine  (ISO)
azetidine  (ISO)
Bardoxolone methyl  (ISO)
benzalkonium chloride  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
beta-D-glucosamine  (EXP)
beta-eudesmol  (ISO)
beta-naphthoflavone  (ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
boron nitride  (ISO)
bortezomib  (EXP,ISO)
Botulinum toxin type A  (ISO)
Brevianamide A  (ISO)
budesonide  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
carmustine  (ISO)
carrageenan  (EXP,ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chloroethene  (ISO)
chlorothalonil  (ISO)
cholesterol  (ISO)
choline  (ISO)
chondroitin sulfate  (ISO)
cinnamyl alcohol  (ISO)
ciprofloxacin  (ISO)
cirsilineol  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
citral  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP,ISO)
corosolic acid  (ISO)
crocidolite asbestos  (EXP,ISO)
crotonaldehyde  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dantrolene  (ISO)
decabromodiphenyl ether  (EXP)
Decursin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Diallyl sulfide  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (EXP,ISO)
dicloxacillin  (ISO)
diflorasone  (ISO)
dimercaprol  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
diuron  (EXP)
divanadium pentaoxide  (ISO)
dizocilpine maleate  (ISO)
dobutamine  (ISO)
domperidone  (ISO)
dopexamine  (ISO)
doxorubicin  (ISO)
edaravone  (EXP)
elemental selenium  (ISO)
emodin  (EXP)
endosulfan  (EXP)
enflurane  (EXP)
ethanol  (EXP,ISO)
ethylene glycol dimethacrylate  (ISO)
excitatory amino acid agonist  (ISO)
ferroheme b  (ISO)
flavonoids  (EXP)
flucloxacillin  (ISO)
flutamide  (ISO)
fomepizole  (EXP)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
Fusarenone X  (ISO)
gadolinium trichloride  (EXP,ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
geranial  (ISO)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (ISO)
graphite  (EXP)
halothane  (EXP,ISO)
heme b  (ISO)
heparin  (EXP)
hexadecanoic acid  (ISO)
hydrogen chloride  (EXP)
hydrogen peroxide  (EXP,ISO)
ibuprofen  (EXP,ISO)
imidurea  (ISO)
indometacin  (EXP,ISO)
iron atom  (EXP)
iron trichloride  (EXP)
iron(0)  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
isoeugenol  (ISO)
isoflurane  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP)
lipoxin A4  (ISO)
lithocholic acid  (ISO)
LY294002  (ISO)
lycopene  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
manganese(II) sulfate  (EXP)
maslinic acid  (ISO)
mercaptopurine  (EXP)
mercury dichloride  (EXP)
metacetamol  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methimazole  (EXP,ISO)
methotrexate  (EXP,ISO)
methyl methacrylate  (ISO)
methyl salicylate  (ISO)
methylmercury chloride  (EXP,ISO)
metoclopramide  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (ISO)
Muraglitazar  (EXP)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
naphthalenes  (EXP)
naproxen  (EXP)
naringin  (ISO)
neocuproine  (ISO)
neoechinulin A  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP,ISO)
nicotine  (ISO)
nitrofen  (EXP)
nitrogen dioxide  (EXP,ISO)
Nivalenol  (ISO)
nonivamide  (ISO)
o-anisidine  (ISO)
obeticholic acid  (ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oligopeptide  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
pentanal  (ISO)
Pentoxifylline  (EXP)
peptidoglycan  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phalloidin  (ISO)
phenanthridone  (ISO)
phenobarbital  (EXP)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(I:C)  (EXP)
polymyxin B2  (ISO)
pravastatin  (EXP,ISO)
prednisolone  (ISO)
Primycin  (ISO)
procymidone  (EXP)
progesterone  (ISO)
propan-2-ol  (ISO)
propanal  (ISO)
prostaglandin D2  (ISO)
prostaglandin E1  (ISO)
purine-6-thiol  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
quartz  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quinomethionate  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP)
ranitidine  (EXP)
reactive oxygen species  (EXP,ISO)
resolvin D1  (ISO)
resolvin D2  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
ritonavir  (ISO)
Roridin A  (ISO)
rotenone  (EXP)
ryanodine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
salicylic acid  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium dodecyl sulfate  (ISO)
sterigmatocystin  (ISO)
styrene  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sumatriptan  (EXP)
tamoxifen  (EXP)
tauro-beta-muricholic acid  (ISO)
taurocholic acid  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetradecane  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP,ISO)
Tiron  (ISO)
titanium dioxide  (EXP,ISO)
TMC-120A  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trans-caffeic acid  (ISO)
trans-isoeugenol  (ISO)
triadimefon  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
troglitazone  (EXP,ISO)
tropisetron  (EXP)
trovafloxacin  (ISO)
tungsten  (EXP)
tunicamycin  (ISO)
undecane  (EXP)
ursodeoxycholic acid  (ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vanadyl sulfate  (ISO)
vinclozolin  (EXP)
vitamin D  (ISO)
wortmannin  (EXP,ISO)
XL147  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc oxide  (EXP,ISO)
zinc protoporphyrin  (EXP)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,IDA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Role of cytokine-induced neutrophil chemoattractant-2 (CINC-2) alpha in a rat model of chronic bronchopulmonary infections with Pseudomonas aeruginosa. Amano H, etal., Cytokine. 2000 Nov;12(11):1662-8.
2. Influence of mesh materials on the expression of mediators involved in wound healing. Asarias JR, etal., J Invest Surg. 2011;24(2):87-98.
3. Treating viral exacerbations of chronic obstructive pulmonary disease: insights from a mouse model of cigarette smoke and H1N1 influenza infection. Bauer CM, etal., PLoS One. 2010 Oct 12;5(10):e13251.
4. Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19. Blanco-Melo D, etal., Cell. 2020 May 28;181(5):1036-1045.e9. doi: 10.1016/j.cell.2020.04.026. Epub 2020 May 15.
5. Ischemia-reperfusion of rat myocardium activates nuclear factor-KappaB and induces neutrophil infiltration via lipopolysaccharide-induced CXC chemokine. Chandrasekar B, etal., Circulation. 2001 May 8;103(18):2296-302.
6. Apocynin attenuates ventilator-induced lung injury in an isolated and perfused rat lung model. Chiang CH, etal., Intensive Care Med. 2011 May 27.
7. Lung and liver injury following hepatic ischemia/reperfusion in the rat is increased by exogenous lipopolysaccharide which also increases hepatic TNF production in vivo and in vitro. Colletti LM and Green M, Shock. 2001 Oct;16(4):312-9.
8. The ratio of ELR+ to ELR- CXC chemokines affects the lung and liver injury following hepatic ischemia/ reperfusion in the rat. Colletti LM, etal., Hepatology. 2000 Feb;31(2):435-45.
9. Chemokine MIP-2/CXCL2, acting on CXCR2, induces motor neuron death in primary cultures. De Paola M, etal., Neuroimmunomodulation. 2007;14(6):310-6. Epub 2008 Apr 3.
10. [Role of early growth response factor-1 signal pathway in acute intrahepatic cholestatic hepatic injury in rats]. Ding Y, etal., Zhonghua Gan Zang Bing Za Zhi. 2008 Mar;16(3):215-9.
11. Cloning, expression, and functional characterization of rat MIP-2: a neutrophil chemoattractant and epithelial cell mitogen. Driscoll KE, etal., J Leukoc Biol 1995 Sep;58(3):359-64.
12. Impairment of leukocyte trafficking in a murine pleuritis model by IL-4 and IL-10. Fine JS, etal., Inflammation. 2003 Aug;27(4):161-74.
13. Irsogladine maleate regulates neutrophil migration and E-cadherin expression in gingival epithelium stimulated by Aggregatibacter actinomycetemcomitans. Fujita T, etal., Biochem Pharmacol. 2010 May 15;79(10):1496-505. Epub 2010 Jan 22.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Characterization of the inflammatory response during acute and post-acute phases after severe burn. Gauglitz GG, etal., Shock. 2008 Nov;30(5):503-7.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Pneumocystis carinii beta-glucan induces release of macrophage inflammatory protein-2 from primary rat alveolar epithelial cells via a receptor distinct from CD11b/CD18. Hahn PY and Limper AH, J Eukaryot Microbiol 2001;Suppl:157S.
18. Differential host gene responses in mice infected with two highly pathogenic avian influenza viruses of subtype H5N1 isolated from wild birds in Thailand. Hayashi T, etal., Virology. 2011 Mar 30;412(1):9-18. Epub 2011 Jan 19.
19. Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1. Hsu JT, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Jun;294(6):R1825-31. Epub 2008 Apr 23.
20. Platonin mitigates acute lung injury induced by bilateral lower limb ischemia-reperfusion in rats. Hsu KY, etal., J Surg Res. 2011 May 15;167(2):e255-62. Epub 2010 Apr 24.
21. Vitamin A and retinoic acid act synergistically to increase lung retinyl esters during normoxia and reduce hyperoxic lung injury in newborn mice. James ML, etal., Pediatr Res. 2010 Jun;67(6):591-7.
22. Transcriptional profiling of lipopolysaccharide-induced acute lung injury. Jeyaseelan S, etal., Infect Immun. 2004 Dec;72(12):7247-56.
23. Protection against sepsis-induced lung injury by selective inhibition of protein kinase C-delta (delta-PKC). Kilpatrick LE, etal., J Leukoc Biol. 2011 Jan;89(1):3-10. Epub 2010 Aug 19.
24. Macrophage-dependent regulation of neutrophil mobilization and chemotaxis during development of sterile peritonitis in the rat. Knudsen E, etal., Eur J Haematol 2002 Nov-Dec;69(5-6):284-96.
25. Role of neutrophils and NADPH phagocyte oxidase in host defense against respiratory infection with virulent Francisella tularensis in mice. KuoLee R, etal., Microbes Infect. 2011 May;13(5):447-56. Epub 2011 Jan 26.
26. Blockade of cysteine-rich protein 61 attenuates renal inflammation and fibrosis after ischemic kidney injury. Lai CF, etal., Am J Physiol Renal Physiol. 2014 Sep 1;307(5):F581-92. doi: 10.1152/ajprenal.00670.2013. Epub 2014 Jun 11.
27. The role of keratinocyte-derived chemokine in hemorrhage-induced acute lung injury in mice. Lee BH, etal., J Korean Med Sci. 2009 Oct;24(5):775-81. Epub 2009 Sep 23.
28. Effect of glucocorticoid pretreatment on oxidative liver injury and survival in jaundiced rats with endotoxin cholangitis. Lee CW, etal., World J Surg. 2006 Dec;30(12):2217-26. doi: 10.1007/s00268-006-0143-0.
29. Effect of compound IMMLG5521, a novel coumarin derivative, on carrageenan-induced pleurisy in rats. Li ZP, etal., Eur J Pharmacol. 2011 Jul 1;661(1-3):118-23. Epub 2011 Apr 27.
30. Chemokine production by rat alveolar macrophages is inhibited by taurine chloramine. Liu Y and Quinn MR, Immunol Lett 2002 Jan 1;80(1):27-32.
31. In mice, tuberculosis progression is associated with intensive inflammatory response and the accumulation of Gr-1 cells in the lungs. Lyadova IV, etal., PLoS One. 2010 May 4;5(5):e10469.
32. Low intensity laser therapy (LILT) in vivo acts on the neutrophils recruitment and chemokines/cytokines levels in a model of acute pulmonary inflammation induced by aerosol of lipopolysaccharide from Escherichia coli in rat. Mafra de Lima F, etal., J Photochem Photobiol B. 2010 Dec 2;101(3):271-8. Epub 2010 Jul 27.
33. Single-dose gamma-irradiation induces up-regulation of chemokine gene expression and recruitment of granulocytes into the portal area but not into other regions of rat hepatic tissue. Malik IA, etal., Am J Pathol. 2010 Apr;176(4):1801-15. Epub 2010 Feb 25.
34. Alveolar epithelial cells secrete chemokines in response to IL-1beta and lipopolysaccharide but not to ozone. Manzer R, etal., Am J Respir Cell Mol Biol. 2006 Feb;34(2):158-66. Epub 2005 Oct 20.
35. CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation. Marcos V, etal., Nat Med. 2010 Sep;16(9):1018-23. Epub 2010 Sep 5.
36. Gene Data Set MGD Curation, June 12, 2002
37. Rat coronaviruses infect rat alveolar type I epithelial cells and induce expression of CXC chemokines. Miura TA, etal., Virology. 2007 Dec 20;369(2):288-98. Epub 2007 Sep 5.
38. Novel experimental Pseudomonas aeruginosa lung infection model mimicking long-term host-pathogen interactions in cystic fibrosis. Moser C, etal., APMIS. 2009 Feb;117(2):95-107.
39. Activation of nuclear factor kappa B and cytokine imbalance in experimental alcoholic liver disease in the rat. Nanji AA, etal., Hepatology. 1999 Oct;30(4):934-43.
40. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
41. Mechanisms of acute inflammatory lung injury induced by abdominal sepsis. Neumann B, etal., Int Immunol. 1999 Feb;11(2):217-27.
42. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
43. Biomarkers of acute respiratory allergen exposure: screening for sensitization potential. Pucheu-Haston CM, etal., Toxicol Appl Pharmacol. 2010 Apr 15;244(2):144-55. Epub 2010 Jan 4.
44. Superimposed gastric aspiration increases the severity of inflammation and permeability injury in a rat model of lung contusion. Raghavendran K, etal., J Surg Res. 2009 Aug;155(2):273-82. Epub 2008 Sep 16.
45. Preliminary investigation of a mice model of Klebsiella pneumoniae subsp. ozaenae induced pneumonia. Renois F, etal., Microbes Infect. 2011 Jun 30.
46. GOA pipeline RGD automated data pipeline
47. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
48. The temporal expression, cellular localization, and inhibition of the chemokines MIP-2 and MCP-1 after traumatic brain injury in the rat. Rhodes JK, etal., J Neurotrauma. 2009 Apr;26(4):507-25.
49. A rat model of picornavirus-induced airway infection and inflammation. Rosenthal LA, etal., Virol J. 2009 Aug 11;6:122.
50. Soot nanoparticles promote biotransformation, oxidative stress, and inflammation in murine lungs. Rouse RL, etal., Am J Respir Cell Mol Biol. 2008 Aug;39(2):198-207. Epub 2008 Mar 26.
51. The murine neutrophil-chemoattractant chemokines LIX, KC, and MIP-2 have distinct induction kinetics, tissue distributions, and tissue-specific sensitivities to glucocorticoid regulation in endotoxemia. Rovai LE, etal., J Leukoc Biol. 1998 Oct;64(4):494-502.
52. Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation. Sharma AK, etal., Respir Res. 2009 Jun 26;10:58.
53. Hepatic interferon regulatory factor 8 expression mediates liver ischemia/reperfusion injury in mice. Shi G, etal., Biochem Pharmacol. 2021 Oct;192:114728. doi: 10.1016/j.bcp.2021.114728. Epub 2021 Aug 13.
54. Identification of a common receptor for three types of rat cytokine-induced neutrophil chemoattractants (CINCs). Shibata F, etal., Cytokine. 2000 Sep;12(9):1368-73.
55. Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice. Su X, etal., Inflamm Res. 2011 Jul;60(7):619-32. Epub 2011 Feb 8.
56. Chemokine-dependent neutrophil recruitment in a murine model of Legionella pneumonia: potential role of neutrophils as immunoregulatory cells. Tateda K, etal., Infect Immun. 2001 Apr;69(4):2017-24.
57. Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature. Thomas M, etal., Synapse. 2009 Oct;63(10):881-94.
58. The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury. Uchida Y, etal., Transplantation. 2010 May 15;89(9):1050-6.
59. Role of the Fas/FasL system in a model of RSV infection in mechanically ventilated mice. van den Berg E, etal., Am J Physiol Lung Cell Mol Physiol. 2011 Jul 8.
60. Elevated levels of macrophage inflammatory protein 2 in severe murine peritonitis increase neutrophil recruitment and mortality. Walley KR, etal., Infect Immun. 1997 Sep;65(9):3847-51.
61. Nitric oxide induces MIP-2 transcription in rat renal mesangial cells and in a rat model of glomerulonephritis. Walpen S, etal., FASEB J 2001 Mar;15(3):571-3.
62. Delay of LPS-induced acute lung injury resolution by soluble immune complexes is neutrophil dependent. Wu CL, etal., Shock. 2009 Sep;32(3):276-85.
63. Correlation of macrophage inflammatory protein-2 expression and brain edema in rats after intracerebral hemorrhage. Wu H, etal., Int J Clin Exp Pathol. 2009;2(1):83-90. Epub 2008 Jun 2.
64. [Effects of N-acetylcysteine on mRNA expression of monocyte chemotactic protein and macrophage inflammatory protein 2 in acute necrotizing pancreatitis: experiment with rats] Xu CF, etal., Zhonghua Yi Xue Za Zhi. 2008 Mar 11;88(10):711-5.
65. Akt pathway is required for oestrogen-mediated attenuation of lung injury in a rodent model of cerulein-induced acute pancreatitis. Yang SJ, etal., Injury. 2011 Jul;42(7):638-42. Epub 2010 Aug 14.
66. Dysregulated macrophage-inflammatory protein-2 expression drives illness in bacterial superinfection of influenza. Zavitz CC, etal., J Immunol. 2010 Feb 15;184(4):2001-13. Epub 2010 Jan 11.
67. Compartmentalization of macrophage inflammatory protein-2, but not cytokine-induced neutrophil chemoattractant, in rats challenged with intratracheal endotoxin. Zhang P, etal., Shock 2002 Feb;17(2):104-8.
68. A novel ELR-CXC chemokine antagonist reduces intestinal ischemia reperfusion-induced mortality, and local and remote organ injury. Zhao X, etal., J Surg Res. 2010 Aug;162(2):264-73. Epub 2009 Jun 6.
Additional References at PubMed
PMID:1415488   PMID:7883948   PMID:8043001   PMID:8471066   PMID:8607872   PMID:12055258   PMID:12661899   PMID:12829448   PMID:12949249   PMID:14617513   PMID:14624457   PMID:15045510  
PMID:15319184   PMID:15935092   PMID:16132691   PMID:16239543   PMID:16522746   PMID:16618742   PMID:16818791   PMID:18622025   PMID:19912257   PMID:20034917   PMID:20186460   PMID:21148126  
PMID:22379036   PMID:22871113   PMID:24280128   PMID:25084278   PMID:26502930   PMID:27525872   PMID:27967265   PMID:28820395   PMID:30707086   PMID:31422522   PMID:34850541   PMID:37121693  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81417,465,210 - 17,467,255 (-)NCBIGRCr8
mRatBN7.21417,181,030 - 17,183,075 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,181,062 - 17,183,075 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,181,873 - 17,183,917 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,500,809 - 18,502,853 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,192,924 - 17,194,968 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,731,346 - 18,733,391 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,731,378 - 18,733,391 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,640,312 - 18,642,357 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,677,129 - 18,679,175 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,677,128 - 18,679,175 (-)NCBI
Celera1416,558,112 - 16,560,157 (-)NCBICelera
Cytogenetic Map14p22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38474,097,040 - 74,099,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl474,097,040 - 74,099,196 (-)EnsemblGRCh38hg38GRCh38
GRCh37474,962,757 - 74,964,912 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36475,181,616 - 75,183,861 (-)NCBINCBI36Build 36hg18NCBI36
Build 34475,327,790 - 75,329,927NCBI
Celera472,322,837 - 72,325,084 (-)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,773,657 - 70,775,906 (-)NCBIHuRef
CHM1_1474,998,593 - 75,000,838 (-)NCBICHM1_1
T2T-CHM13v2.0477,440,641 - 77,442,796 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39591,051,758 - 91,053,797 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl591,051,730 - 91,053,797 (+)EnsemblGRCm39 Ensembl
GRCm38590,903,899 - 90,905,938 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,903,871 - 90,905,938 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,332,925 - 91,334,964 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36591,979,099 - 91,981,138 (+)NCBIMGSCv36mm8
Celera589,048,217 - 89,050,256 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2355,960,804 - 55,963,432 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1456,150,028 - 56,152,424 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0450,092,989 - 50,095,541 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1455,925,562 - 55,927,809 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl455,925,562 - 55,986,555 (+)Ensemblpanpan1.1panPan2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl870,157,214 - 70,159,138 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1870,157,253 - 70,159,145 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2874,310,094 - 74,311,988 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Variants in Cxcl2
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:68
Interacting mature miRNAs:78
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21417,181,661 - 17,181,770 (+)MAPPERmRatBN7.2
Rnor_6.01418,731,978 - 18,732,086NCBIRnor6.0
Rnor_5.01418,640,944 - 18,641,052UniSTSRnor5.0
RGSC_v3.41418,677,762 - 18,677,870UniSTSRGSC3.4
Celera1416,558,744 - 16,558,852UniSTS
Cytogenetic Map14p22UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Low 5 5 1 2 10
Below cutoff 2 15 20 13 10 13 2 2 14 13 22 1 2


RefSeq Acc Id: ENSRNOT00000003745   ⟹   ENSRNOP00000003745
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1417,181,062 - 17,183,075 (-)Ensembl
Rnor_6.0 Ensembl1418,731,378 - 18,733,391 (-)Ensembl
RefSeq Acc Id: NM_053647   ⟹   NP_446099
Rat AssemblyChrPosition (strand)Source
GRCr81417,465,210 - 17,467,255 (-)NCBI
mRatBN7.21417,181,030 - 17,183,075 (-)NCBI
Rnor_6.01418,731,346 - 18,733,391 (-)NCBI
Rnor_5.01418,640,312 - 18,642,357 (-)NCBI
RGSC_v3.41418,677,129 - 18,679,175 (-)RGD
Celera1416,558,112 - 16,560,157 (-)RGD
RefSeq Acc Id: NP_446099   ⟸   NM_053647
- Peptide Label: precursor
- UniProtKB: Q5WA60 (UniProtKB/Swiss-Prot),   P30348 (UniProtKB/Swiss-Prot),   A6KKD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003745   ⟸   ENSRNOT00000003745
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30348-F1-model_v2 AlphaFold P30348 1-100 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699225
Promoter ID:EPDNEW_R9749
Type:single initiation site
Description:C-X-C motif chemokine ligand 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01418,733,393 - 18,733,453EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70069 AgrOrtholog
BioCyc Gene G2FUF-16212 BioCyc
Ensembl Genes ENSRNOG00000002792 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055006401 UniProtKB/Swiss-Prot
  ENSRNOG00055025603 UniProtKB/Swiss-Prot
  ENSRNOG00060018134 UniProtKB/Swiss-Prot
  ENSRNOG00065017097 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003745 ENTREZGENE
  ENSRNOT00000003745.7 UniProtKB/Swiss-Prot
  ENSRNOT00055010402 UniProtKB/Swiss-Prot
  ENSRNOT00055044184 UniProtKB/Swiss-Prot
  ENSRNOT00060031130 UniProtKB/Swiss-Prot
  ENSRNOT00065028541 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CXC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CXC_Chemokine_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114105 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cxcl2 PhenoGen
RatGTEx ENSRNOG00000002792 RatGTEx
  ENSRNOG00055006401 RatGTEx
  ENSRNOG00055025603 RatGTEx
  ENSRNOG00060018134 RatGTEx
  ENSRNOG00065017097 RatGTEx
SMART SCY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Interleukin 8-like chemokines UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt Secondary Q5WA60 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Cxcl2  C-X-C motif chemokine ligand 2  Cxcl2  chemokine (C-X-C motif) ligand 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Cxcl2  chemokine (C-X-C motif) ligand 2  Scyb2  small inducible cytokine subfamily, member 2  Symbol and Name updated 629477 APPROVED
2002-06-10 Scyb2  small inducible cytokine subfamily, member 2      Symbol and Name status set to approved 70586 APPROVED
2002-02-27 Scyb2  small inducible cytokine subfamily, member 2      Name updated to reflect Human and Mouse nomenclature 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function C-X-C chemokine 70649
gene_process triggers the attraction of polymorphonuclear leukocytes 70649
gene_regulation increased localization to bronchoalveolar lavage (BAL) fluid induced by intratracheal lipopolysaccharide 727566