Ppp3cc (protein phosphatase 3 catalytic subunit gamma) - Rat Genome Database
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Gene: Ppp3cc (protein phosphatase 3 catalytic subunit gamma) Rattus norvegicus
Analyze
Symbol: Ppp3cc
Name: protein phosphatase 3 catalytic subunit gamma
RGD ID: 621616
Description: Predicted to have calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Involved in brain development and positive regulation of synaptic vesicle endocytosis. Localizes to glutamatergic synapse and presynapse. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PPP3CC (protein phosphatase 3 catalytic subunit gamma); PARTICIPATES IN calcineurin signaling pathway; dopamine signaling pathway; schizophrenia pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; ethanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma); protein phosphatase 3, catalytic subunit, gamma; protein phosphatase 3, catalytic subunit, gamma isoform; protein phosphatase 3, catalytic subunit, gamma isozyme; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21545,289,917 - 45,362,012 (-)NCBI
Rnor_6.0 Ensembl1551,896,615 - 51,967,897 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01551,896,427 - 51,968,075 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01555,615,454 - 55,692,782 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,616,635 - 50,688,593 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11550,656,759 - 50,661,916 (-)NCBI
Celera1544,969,817 - 45,041,567 (-)NCBICelera
Cytogenetic Map15p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:12177418   PMID:12477932   PMID:17101875   PMID:19154138   PMID:23376485  


Genomics

Comparative Map Data
Ppp3cc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21545,289,917 - 45,362,012 (-)NCBI
Rnor_6.0 Ensembl1551,896,615 - 51,967,897 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01551,896,427 - 51,968,075 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01555,615,454 - 55,692,782 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,616,635 - 50,688,593 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11550,656,759 - 50,661,916 (-)NCBI
Celera1544,969,817 - 45,041,567 (-)NCBICelera
Cytogenetic Map15p11NCBI
PPP3CC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl822,440,819 - 22,541,142 (+)EnsemblGRCh38hg38GRCh38
GRCh38822,441,053 - 22,541,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37822,298,591 - 22,398,638 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37822,298,483 - 22,398,657 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,354,541 - 22,454,583 (+)NCBINCBI36hg18NCBI36
Build 34822,354,540 - 22,454,580NCBI
Celera821,260,229 - 21,360,247 (+)NCBI
Cytogenetic Map8p21.3NCBI
HuRef820,840,793 - 20,940,821 (+)NCBIHuRef
CHM1_1822,500,579 - 22,601,011 (+)NCBICHM1_1
Ppp3cc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,455,314 - 70,526,979 (-)NCBIGRCm39mm39
GRCm381470,217,864 - 70,289,536 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,217,865 - 70,289,471 (-)EnsemblGRCm38mm10GRCm38
MGSCv371470,617,705 - 70,689,256 (-)NCBIGRCm37mm9NCBIm37
MGSCv361468,952,978 - 69,024,529 (-)NCBImm8
Celera1467,759,280 - 67,830,918 (-)NCBICelera
Cytogenetic Map14D2NCBI
Ppp3cc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540345,916,002 - 45,968,185 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540345,915,985 - 45,969,350 (+)NCBIChiLan1.0ChiLan1.0
PPP3CC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1818,629,269 - 18,732,041 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl818,629,261 - 18,729,995 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0821,690,598 - 21,791,335 (+)NCBIMhudiblu_PPA_v0panPan3
PPP3CC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2534,725,226 - 34,838,994 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12534,732,268 - 34,839,743 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ppp3cc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365556,216,202 - 6,283,012 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP3CC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl146,639,206 - 6,803,670 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1146,711,789 - 6,799,318 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2147,143,029 - 7,224,529 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP3CC
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1820,522,829 - 20,621,445 (+)NCBI
Ppp3cc
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475817,969,777 - 18,048,476 (+)NCBI

Position Markers
D15Got229  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01551,939,856 - 51,939,996NCBIRnor6.0
Rnor_5.01555,664,901 - 55,665,041UniSTSRnor5.0
RGSC_v3.41550,660,921 - 50,661,061UniSTSRGSC3.4
Celera1545,013,683 - 45,013,823UniSTS
Cytogenetic Map15p11UniSTS
RH143458  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X151,819,554 - 151,819,670NCBIRnor6.0
Rnor_5.0X151,809,605 - 151,809,721UniSTSRnor5.0
RGSC_v3.4X153,397,829 - 153,397,945UniSTSRGSC3.4
CeleraX141,796,043 - 141,796,159UniSTS
Cytogenetic Map15p16UniSTS
Cytogenetic Map15p11UniSTS
RH138866  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01551,890,168 - 51,890,297NCBIRnor6.0
Rnor_5.01555,616,295 - 55,616,424UniSTSRnor5.0
RGSC_v3.41550,610,443 - 50,610,572UniSTSRGSC3.4
Celera1544,963,373 - 44,963,502UniSTS
Cytogenetic Map15p11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15162301382Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15232787753535766Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151071919155719191Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151549236072568189Rat
9590272Scort14Serum corticosterone level QTL 142.780.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)151698090761980907Rat
8694427Bw163Body weight QTL 1634.820.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)151698090761980907Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151724964162249641Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151724964162249641Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151724964162249641Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151809320881255430Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151851391388036354Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152102134252831189Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1526381041106550657Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1526381041106550657Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1526381041106550657Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152870974173709741Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)153321910189640841Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)153321910189640841Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)153321910189640841Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)153321910189640841Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)153321910189640841Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)153948079762596410Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153974955779033707Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153974955779033707Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154106809486068094Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154275724156027084Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154309747052831189Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1543097470106550657Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:43
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000012993
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 32 16 19 16 8 11 74 34 41 11 8
Low 25 25 25 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_134367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC126842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ376198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ376199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ376200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M58442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000012993   ⟹   ENSRNOP00000012993
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1551,896,818 - 51,967,806 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082505   ⟹   ENSRNOP00000075488
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1551,896,615 - 51,967,897 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084166   ⟹   ENSRNOP00000069433
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1551,896,818 - 51,967,806 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091826   ⟹   ENSRNOP00000074438
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1551,916,378 - 51,967,806 (-)Ensembl
RefSeq Acc Id: NM_134367   ⟹   NP_599194
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21545,290,538 - 45,361,832 (-)NCBI
Rnor_6.01551,896,612 - 51,967,897 (-)NCBI
Rnor_5.01555,615,454 - 55,692,782 (-)NCBI
RGSC_v3.41550,616,635 - 50,688,593 (-)RGD
Celera1544,969,817 - 45,041,567 (-)RGD
Sequence:
RefSeq Acc Id: XM_008770813   ⟹   XP_008769035
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21545,290,538 - 45,362,009 (-)NCBI
Rnor_6.01551,896,427 - 51,968,075 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770814   ⟹   XP_008769036
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21545,290,538 - 45,362,009 (-)NCBI
Rnor_6.01551,896,427 - 51,968,074 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770816   ⟹   XP_008769038
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21545,290,538 - 45,362,009 (-)NCBI
Rnor_6.01551,896,427 - 51,968,075 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770817   ⟹   XP_008769039
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01551,896,427 - 51,965,842 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092973   ⟹   XP_038948901
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21545,289,917 - 45,362,012 (-)NCBI
RefSeq Acc Id: XM_039092974   ⟹   XP_038948902
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21545,289,917 - 45,362,010 (-)NCBI
RefSeq Acc Id: XM_039092975   ⟹   XP_038948903
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21545,290,538 - 45,362,009 (-)NCBI
RefSeq Acc Id: XM_039092976   ⟹   XP_038948904
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21545,289,917 - 45,362,009 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_599194   ⟸   NM_134367
- UniProtKB: Q6AYJ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769035   ⟸   XM_008770813
- Peptide Label: isoform X1
- UniProtKB: E2CWF0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769036   ⟸   XM_008770814
- Peptide Label: isoform X4
- UniProtKB: E2CWF1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769038   ⟸   XM_008770816
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_008769039   ⟸   XM_008770817
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000075488   ⟸   ENSRNOT00000082505
RefSeq Acc Id: ENSRNOP00000012993   ⟸   ENSRNOT00000012993
RefSeq Acc Id: ENSRNOP00000069433   ⟸   ENSRNOT00000084166
RefSeq Acc Id: ENSRNOP00000074438   ⟸   ENSRNOT00000091826
RefSeq Acc Id: XP_038948901   ⟸   XM_039092973
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038948902   ⟸   XM_039092974
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038948904   ⟸   XM_039092976
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038948903   ⟸   XM_039092975
- Peptide Label: isoform X5
Protein Domains
SER_THR_PHOSPHATASE

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621616 AgrOrtholog
Ensembl Genes ENSRNOG00000009745 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000012993 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000069433 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000074438 UniProtKB/TrEMBL
  ENSRNOP00000075488 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012993 UniProtKB/TrEMBL
  ENSRNOT00000082505 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000084166 UniProtKB/TrEMBL
  ENSRNOT00000091826 UniProtKB/TrEMBL
Gene3D-CATH 3.60.21.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7114037 IMAGE-MGC_LOAD
InterPro Metallo-depent_PP-like UniProtKB/TrEMBL
  Metallo_PEstase_dom UniProtKB/TrEMBL
  MPP_PP2B UniProtKB/TrEMBL
  PP2B UniProtKB/TrEMBL
  Ser/Thr-sp_prot-phosphatase UniProtKB/TrEMBL
KEGG Report rno:171378 UniProtKB/TrEMBL
MGC_CLONE MGC:93954 IMAGE-MGC_LOAD
NCBI Gene 171378 ENTREZGENE
PANTHER PTHR45673 UniProtKB/TrEMBL
Pfam Metallophos UniProtKB/TrEMBL
PhenoGen Ppp3cc PhenoGen
PRINTS STPHPHTASE UniProtKB/TrEMBL
PROSITE SER_THR_PHOSPHATASE UniProtKB/TrEMBL
SMART PP2Ac UniProtKB/TrEMBL
UniProt E2CWF0 ENTREZGENE, UniProtKB/TrEMBL
  E2CWF1 ENTREZGENE, UniProtKB/TrEMBL
  E2CWF2_RAT UniProtKB/TrEMBL
  Q6AYJ0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1M7P9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Ppp3cc  protein phosphatase 3 catalytic subunit gamma  Ppp3cc  protein phosphatase 3, catalytic subunit, gamma isozyme  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-26 Ppp3cc  protein phosphatase 3, catalytic subunit, gamma isozyme  Ppp3cc  protein phosphatase 3, catalytic subunit, gamma isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ppp3cc  protein phosphatase 3, catalytic subunit, gamma isoform    protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma)  Name updated 1299863 APPROVED
2002-08-07 Ppp3cc  protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process does not mediate mitochondrial enzyme adaptations to endurance exercise training 724651