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Gene: Chrnb4 (cholinergic receptor nicotinic beta 4 subunit) Rattus norvegicus
Symbol: Chrnb4
Name: cholinergic receptor nicotinic beta 4 subunit
Description: Exhibits acetylcholine binding activity. Predicted to contribute to acetylcholine receptor activity. Predicted to be involved in several processes, including behavioral response to nicotine; chemical synaptic transmission; and positive regulation of transmission of nerve impulse. Localizes to acetylcholine-gated channel complex and neuron projection. Orthologous to human CHRNB4 (cholinergic receptor nicotinic beta 4 subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH (S)-anabasine; (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: Acetylcholine receptor beta 4; cholinergic receptor, nicotinic beta 4; cholinergic receptor, nicotinic, beta 4; cholinergic receptor, nicotinic, beta 4 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 4; N-alpha 2; neuronal acetylcholine receptor non-alpha-2 chain; neuronal acetylcholine receptor subunit beta-4
Homo sapiens (human) : CHRNB4 (cholinergic receptor nicotinic beta 4 subunit)  HGNC  Alliance
Mus musculus (house mouse) : Chrnb4 (cholinergic receptor, nicotinic, beta polypeptide 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chrnb4 (cholinergic receptor nicotinic beta 4 subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : CHRNB4 (cholinergic receptor nicotinic beta 4 subunit)
Canis lupus familiaris (dog) : CHRNB4 (cholinergic receptor nicotinic beta 4 subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrnb4 (cholinergic receptor nicotinic beta 4 subunit)
Sus scrofa (pig) : CHRNB4 (cholinergic receptor nicotinic beta 4 subunit)
Chlorocebus sabaeus (African green monkey) : CHRNB4 (cholinergic receptor nicotinic beta 4 subunit)
Heterocephalus glaber (naked mole-rat) : Chrnb4 (cholinergic receptor nicotinic beta 4 subunit)
more info ...
Allele / Splice: Chrnb4em5Mcwi  
Genetic Models: LEW-Chrnb4em5Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0859,610,489 - 59,629,073 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,609,693 - 59,629,133 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0858,192,375 - 58,210,959 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4858,586,961 - 58,605,545 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1858,605,220 - 58,624,659 (-)NCBI
Celera854,902,516 - 54,921,100 (-)NCBICelera
Cytogenetic Map8q24NCBI
RH 3.4 Map8614.4RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Chrnb4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2351
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.