Bmp4 (bone morphogenetic protein 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Bmp4 (bone morphogenetic protein 4) Rattus norvegicus
Analyze
Symbol: Bmp4
Name: bone morphogenetic protein 4
RGD ID: 2213
Description: Enables growth factor activity and identical protein binding activity. Involved in several processes, including cardiac muscle hypertrophy in response to stress; lung development; and positive regulation of cell differentiation. Acts upstream of or within positive regulation of ossification and positive regulation of transcription by RNA polymerase II. Located in extracellular space and vesicle. Biomarker of Barrett's esophagus; congenital diaphragmatic hernia; epilepsy; peptic esophagitis; and prolactinoma. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and syndromic microphthalmia 6. Orthologous to human BMP4 (bone morphogenetic protein 4); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; glypican signaling pathway; basal cell carcinoma pathway; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BMP-2B; BMP-4; BOMPR4A; bone morphogenetic protein 2B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81522,098,191 - 22,113,145 (-)NCBIGRCr8
mRatBN7.21519,618,538 - 19,633,494 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1519,618,542 - 19,623,306 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1522,400,667 - 22,404,237 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01523,358,675 - 23,362,245 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01521,608,597 - 21,612,175 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01520,776,060 - 20,791,013 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1520,776,054 - 20,822,740 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01524,734,987 - 24,749,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41522,283,171 - 22,286,757 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11522,298,892 - 22,305,718 (-)NCBI
Celera1520,029,866 - 20,033,452 (-)NCBICelera
RH 3.4 Map15185.6RGD
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
ACTH-secreting pituitary adenoma  (ISO)
Acute Otitis Media  (ISO)
Alzheimer's disease  (ISO)
amenorrhea  (ISO)
Anorectal Malformations  (IEP,ISO)
APLASIA/HYPOPLASIA INVOLVING BONES OF THE LOWER LIMBS  (ISO)
atrial heart septal defect  (ISO)
atrioventricular septal defect  (ISS)
Axenfeld-Rieger syndrome type 3  (ISS)
Barrett's esophagus  (IEP,ISO)
Brain Hypoxia-Ischemia  (IEP)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
CAKUT  (ISO)
CAKUT2  (ISO)
calcinosis  (ISO)
Cardiomegaly  (ISO)
cartilage disease  (ISO)
Cartilage Fractures  (ISO)
CHARGE syndrome  (ISO)
Choroidal Neovascularization  (ISO)
cleft lip  (ISO)
cleft palate-lateral synechia syndrome  (ISS)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (IEP)
Congenital Limb Deformities  (IEP)
Cranial Nerve Injuries  (IEP)
Diaphragmatic Hernia  (ISO)
dystonia 5  (ISO)
Endometrioid Carcinomas  (ISO)
epilepsy  (IEP)
esophagitis  (ISO)
Experimental Liver Cirrhosis  (IEP)
Femoral Fractures  (IDA,IEP,ISO)
Fetal Growth Retardation  (IEP)
fibrodysplasia ossificans progressiva  (ISS)
Focal Cortical Dysplasia of Taylor  (ISO)
genetic disease  (ISO)
Gliosis  (IEP)
granulosa cell tumor  (ISO)
Hearing Loss  (ISO)
hereditary spastic paraplegia 28  (ISO)
Hyperoxia  (IEP)
Kapur Toriello Syndrome  (ISO)
keratoconus  (ISO)
macular degeneration  (ISO)
melanoma  (ISO)
Multicystic Dysplastic Kidney  (ISO)
myositis ossificans  (ISO)
ocular hypertension  (ISO)
Oral Lichen Planus  (ISO)
orofacial cleft  (ISO)
orofacial cleft 11  (ISO)
ossification of the posterior longitudinal ligament of spine  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Experimental  (ISO)
osteoporosis  (ISO)
otosclerosis  (ISO)
peptic esophagitis  (IEP)
Peters anomaly  (ISO)
physical disorder  (ISS)
progressive osseous heteroplasia  (ISO)
prolactinoma  (IEP,ISO)
prostate carcinoma  (ISO)
psoriatic arthritis  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
Skull Fractures  (ISO)
Spinal Cord Injuries  (IDA,ISO)
strabismus  (ISO)
Stroke  (IMP)
syndromic microphthalmia  (ISO)
syndromic microphthalmia 6  (ISO)
Tibial Fractures  (IEP)
tooth agenesis  (ISO)
Tracheoesophageal Fistula  (IEP)
tuberous sclerosis  (ISO)
urinary system disease  (ISS)
Vitamin A Deficiency  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
adenosine  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-Zearalanol  (EXP)
aluminium oxide  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
angiotensin II  (ISO)
antimonite  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
bacitracin  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
busulfan  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cordycepin  (ISO)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dichromium trioxide  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethylenediaminetetraacetic acid  (ISO)
Ethylenethiourea  (EXP)
flavonoids  (EXP)
flusilazole  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
hydrogen peroxide  (ISO)
icariin  (EXP,ISO)
iloprost  (ISO)
indole-3-methanol  (EXP)
isoprenaline  (EXP)
kaempferol  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
maneb  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
metformin  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mitomycin C  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
naringin  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
nitrates  (EXP)
nitrofen  (EXP)
ochratoxin A  (ISO)
octreotide  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
pasireotide  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pinosylvin  (ISO)
potassium chromate  (ISO)
progesterone  (EXP)
propiconazole  (EXP)
Ptaquiloside  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chlorate  (EXP)
sodium dichromate  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (EXP)
trans-pinosylvin  (ISO)
trichostatin A  (EXP,ISO)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ameloblast differentiation  (IEA,ISO)
anatomical structure formation involved in morphogenesis  (ISO)
anatomical structure regression  (IEP)
angiogenesis  (ISO)
anterior/posterior axis specification  (IEA,ISO)
aortic valve morphogenesis  (IEA,ISO)
apoptotic process involved in endocardial cushion morphogenesis  (ISO)
blood vessel development  (ISO)
blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IEA,ISO,ISS)
BMP signaling pathway  (IBA,IEA,ISO,ISS)
bone development  (ISO)
branching involved in prostate gland morphogenesis  (IEA,ISO)
branching involved in ureteric bud morphogenesis  (IEA,ISO,ISS)
bronchus development  (IEA,ISO)
bud dilation involved in lung branching  (IEA,ISO)
bud elongation involved in lung branching  (IEA,ISO)
camera-type eye development  (ISO)
camera-type eye morphogenesis  (ISO)
cardiac jelly development  (ISO)
cardiac muscle cell differentiation  (IEA,ISO)
cardiac muscle hypertrophy in response to stress  (IMP)
cardiac right ventricle morphogenesis  (ISO)
cartilage development  (IEA)
cell differentiation  (IEA)
cell fate commitment  (ISO)
cell population proliferation  (ISO)
cellular response to BMP stimulus  (IEP,ISO)
cellular response to dexamethasone stimulus  (IDA)
cellular response to growth factor stimulus  (ISO)
cellular response to mechanical stimulus  (IEP)
cellular response to oxidative stress  (IDA)
cellular response to thyroid hormone stimulus  (IEP)
chondrocyte differentiation  (IEA,ISO,ISS)
coronary vasculature development  (IEA,ISO)
cranial suture morphogenesis  (IEA,ISO)
deltoid tuberosity development  (IEA,ISO,ISS)
dorsal/ventral neural tube patterning  (IEA,ISO)
embryonic cranial skeleton morphogenesis  (IEA,ISO)
embryonic digit morphogenesis  (IEA,ISO)
embryonic hindlimb morphogenesis  (IEA,ISO)
embryonic limb morphogenesis  (ISO)
embryonic morphogenesis  (ISO)
embryonic skeletal joint morphogenesis  (IEA,ISO)
embryonic skeletal system development  (ISO)
embryonic skeletal system morphogenesis  (ISO)
endocardial cushion development  (IEA,ISO)
endochondral ossification  (IEA,ISO,ISS)
endoderm development  (IEA,ISO)
epithelial cell proliferation  (ISO)
epithelial cell proliferation involved in lung morphogenesis  (IEA,ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
epithelial tube branching involved in lung morphogenesis  (IEP,ISO)
epithelial-mesenchymal cell signaling  (IEA,ISO)
epithelium development  (ISO)
erythrocyte differentiation  (IEA,ISO)
eye development  (ISO)
forebrain development  (ISO)
gene expression  (ISO)
germ cell development  (IEA,ISO)
glomerular capillary formation  (IEA,ISO,ISS)
heart development  (ISO)
heart induction  (IEA,ISO,ISS)
heart morphogenesis  (ISO)
hematopoietic progenitor cell differentiation  (ISO,ISS)
inner ear auditory receptor cell differentiation  (IEA,ISO)
intermediate mesodermal cell differentiation  (IEA,ISO,ISS)
kidney development  (ISO,ISS)
lens induction in camera-type eye  (IEA,ISO)
lung alveolus development  (IEA,ISO)
lung development  (ISO)
lung lobe development  (IEP)
lung morphogenesis  (ISO)
lung vasculature development  (IEA,ISO,ISS)
lymphoid progenitor cell differentiation  (IEA,ISO,ISS)
macrophage differentiation  (IEA,ISO)
mammary gland formation  (IEA,ISO)
membranous septum morphogenesis  (IEA,ISO)
mesoderm development  (NAS)
mesoderm formation  (ISO)
mesodermal cell differentiation  (ISO)
mesodermal cell fate determination  (IEA,ISO)
mesonephros development  (ISO,ISS)
metanephros development  (IEA,ISO)
monocyte differentiation  (IEA,ISO)
muscular septum morphogenesis  (ISO)
negative regulation of branching involved in ureteric bud morphogenesis  (IEA,ISO,ISS)
negative regulation of cell cycle  (ISO,ISS)
negative regulation of cell population proliferation  (ISO,ISS)
negative regulation of chondrocyte differentiation  (IEA,ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of glomerular mesangial cell proliferation  (IEA,ISO,ISS)
negative regulation of glomerulus development  (IEA,ISO,ISS)
negative regulation of immature T cell proliferation in thymus  (IEA,ISO,ISS)
negative regulation of mesenchymal cell proliferation involved in ureter development  (IEA,ISO,ISS)
negative regulation of metanephric comma-shaped body morphogenesis  (IEA,ISO,ISS)
negative regulation of metanephric S-shaped body morphogenesis  (IEA,ISO,ISS)
negative regulation of miRNA transcription  (IEA,ISO)
negative regulation of mitotic nuclear division  (IEA,ISO,ISS)
negative regulation of myoblast differentiation  (IEA,ISO)
negative regulation of oligodendrocyte differentiation  (IMP)
negative regulation of prostatic bud formation  (IEA,ISO)
negative regulation of striated muscle tissue development  (IEA,ISO)
negative regulation of T cell differentiation in thymus  (ISO)
negative regulation of thymocyte apoptotic process  (IEA,ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
nephric duct formation  (IEA,ISO,ISS)
neural tube closure  (IEA,ISO)
neuron fate commitment  (IEA,ISO)
odontogenesis  (ISO,ISS)
odontogenesis of dentin-containing tooth  (IEA,ISO)
organ induction  (ISO)
ossification  (IEA)
osteoblast differentiation  (IEA,ISO,ISS)
outflow tract morphogenesis  (ISO)
outflow tract septum morphogenesis  (IEA,ISO)
ovarian follicle development  (IMP)
pericyte cell differentiation  (IEA,ISO)
pharyngeal arch artery morphogenesis  (IEA,ISO)
pituitary gland development  (IEA,ISO)
positive chemotaxis  (IEA)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of BMP signaling pathway  (IEA,ISO,ISS)
positive regulation of bone mineralization  (IDA,IEA,ISO,ISS)
positive regulation of branching involved in lung morphogenesis  (IEA,ISO,ISS)
positive regulation of branching involved in ureteric bud morphogenesis  (IMP)
positive regulation of calcium ion transport into cytosol  (IMP)
positive regulation of cardiac muscle fiber development  (IEA,ISO,ISS)
positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis  (IEA,ISO)
positive regulation of cartilage development  (IEA,ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IMP,ISO,ISS)
positive regulation of collagen biosynthetic process  (IEA,ISO,ISS)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of endothelial cell apoptotic process  (IMP)
positive regulation of endothelial cell differentiation  (IEA,ISO)
positive regulation of endothelial cell proliferation  (IEA,ISO)
positive regulation of epidermal cell differentiation  (IEA,ISO,ISS)
positive regulation of epithelial cell differentiation  (ISO)
positive regulation of epithelial cell proliferation  (ISO,ISS)
positive regulation of epithelial to mesenchymal transition  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of hepatocyte differentiation  (IMP)
positive regulation of mesenchymal stem cell proliferation  (IMP)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of neuron differentiation  (IEA,IMP,ISO)
positive regulation of neuron projection development  (IDA,IMP)
positive regulation of odontoblast differentiation  (IEA,ISO,ISS)
positive regulation of ossification  (IDA,IMP,ISO)
positive regulation of osteoblast differentiation  (IDA,IEA,IMP,ISO,ISS)
positive regulation of p38MAPK cascade  (IEA,ISO)
positive regulation of primary miRNA processing  (IEA,ISO)
positive regulation of programmed cell death  (ISO)
positive regulation of protein localization to nucleus  (IEA,ISO,ISS)
positive regulation of protein phosphorylation  (IEA,ISO)
positive regulation of SMAD protein signal transduction  (IEA,ISO,ISS)
positive regulation of smooth muscle cell proliferation  (IEA,ISO)
positive regulation of store-operated calcium channel activity  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,ISO)
post-embryonic development  (IEA,ISO)
prostate gland morphogenesis  (ISO)
prostatic bud formation  (IEA,ISO)
pulmonary valve morphogenesis  (IEA,ISO)
regulation of branching involved in prostate gland morphogenesis  (IEA,ISO)
regulation of cartilage development  (ISO)
regulation of cell differentiation  (IDA,ISO)
regulation of cell fate commitment  (IEA,ISO,ISS)
regulation of ERK1 and ERK2 cascade  (IDA)
regulation of gene expression  (ISO)
regulation of mesodermal cell differentiation  (IEA,ISO)
regulation of miRNA transcription  (ISO)
regulation of morphogenesis of a branching structure  (ISO)
regulation of odontogenesis of dentin-containing tooth  (IEA,ISO)
regulation of protein import into nucleus  (IEA,ISO)
regulation of smooth muscle cell differentiation  (IEA,ISO)
regulation of smooth muscle cell proliferation  (ISO)
renal system process  (IEA,ISO)
response to estradiol  (IEP)
response to glucocorticoid  (IEP)
response to mechanical stimulus  (IEP)
response to nitric oxide  (IEP)
response to organic cyclic compound  (IEP)
response to retinoic acid  (IEP)
response to testosterone  (IEP)
retina development in camera-type eye  (IEP)
secondary heart field specification  (IEA,ISO,ISS)
signal transduction  (IEA)
skeletal system development  (ISO)
smooth muscle cell differentiation  (IEA,ISO)
smooth muscle tissue development  (IEA,ISO,ISS)
specification of animal organ position  (IEA,ISO)
telencephalon development  (ISO)
telencephalon regionalization  (IEA,ISO)
tendon cell differentiation  (IEA,ISO,ISS)
tongue morphogenesis  (IEP)
trachea development  (ISO)
trachea formation  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)
type B pancreatic cell development  (IEA,ISO,ISS)
ureter morphogenesis  (IEA,ISO)
ureteric bud development  (ISO)
vasculature development  (ISO)

Cellular Component
extracellular region  (IEA,ISO)
extracellular space  (IBA,IDA,IEA,ISO)
vesicle  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7. Alarmo EL, etal., Breast Cancer Res Treat. 2007 Jun;103(2):239-46. Epub 2006 Sep 21.
2. Signaling by bone morphogenetic proteins and Smad1 modulates the postnatal differentiation of cerebellar cells. Angley C, etal., J Neurosci 2003 Jan 1;23(1):260-8.
3. Preliminary Analysis of the Nonsynonymous Polymorphism rs17563 in BMP4 Gene in Brazilian Population Suggests Protection for Nonsyndromic Cleft Lip and Palate. Araújo TK, etal., Plast Surg Int. 2012;2012:247104. doi: 10.1155/2012/247104. Epub 2012 Nov 27.
4. Bone morphogenetic protein 4 mediates estrogen-regulated sensory axon plasticity in the adult female reproductive tract. Bhattacherjee A, etal., J Neurosci. 2013 Jan 16;33(3):1050-61a. doi: 10.1523/JNEUROSCI.1704-12.2013.
5. The role of bone morphogenetic protein 4 in inner ear development and function. Blauwkamp MN, etal., Hear Res. 2007 Mar;225(1-2):71-9. Epub 2006 Dec 28.
6. Dominant-stable beta-catenin expression causes cell fate alterations and Wnt signaling antagonist expression in a murine granulosa cell tumor model. Boerboom D, etal., Cancer Res. 2006 Feb 15;66(4):1964-73.
7. A predicted functional single-nucleotide polymorphism of bone morphogenetic protein-4 gene affects mRNA expression and shows a significant association with cutaneous melanoma in Southern Italian population. Capasso M, etal., J Cancer Res Clin Oncol. 2009 Dec;135(12):1799-807. doi: 10.1007/s00432-009-0628-y. Epub 2009 Jun 26.
8. Bone morphogenetic protein-2 and -4 limit the number of enteric neurons but promote development of a TrkC-expressing neurotrophin-3-dependent subset. Chalazonitis A, etal., J Neurosci 2004 Apr 28;24(17):4266-82.
9. Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure. Chang B, etal., BMC Genet. 2001;2:18. Epub 2001 Nov 6.
10. Cloning and sequence of bone morphogenetic protein 4 cDNA from fetal rat calvarial cell. Chen D, etal., Biochim Biophys Acta 1993 Sep 23;1174(3):289-92.
11. Autocrine BMP4 signaling involves effect of cholesterol myristate on proliferation of mesenchymal stem cells. Chen DF, etal., Steroids. 2009 Nov-Dec;74(13-14):1066-72. doi: 10.1016/j.steroids.2009.08.008. Epub 2009 Aug 31.
12. Faulty bone morphogenetic protein signaling in esophageal atresia with tracheoesophageal fistula. Crowley AR, etal., J Pediatr Surg. 2006 Jul;41(7):1208-13.
13. Downregulation of bone morphogenetic protein 4 expression in coronary arterial endothelial cells: role of shear stress and the cAMP/protein kinase A pathway. Csiszar A, etal., Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):776-82. Epub 2007 Feb 1.
14. Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury. Davies JE, etal., J Biol. 2008 Sep 19;7(7):24. doi: 10.1186/jbiol85.
15. Gene expression pathways induced by axotomy and decentralization of rat superior cervical ganglion neurons. Del Signore A, etal., Eur J Neurosci. 2006 Jan;23(1):65-74.
16. Rare variants in BMP2 and BMP4 found in otosclerosis patients reduce Smad signaling. Ealy M, etal., Otol Neurotol. 2014 Mar;35(3):395-400. doi: 10.1097/MAO.0000000000000244.
17. Effect of stretching stress on gene transcription related to early-phase differentiation in rat periodontal ligament cells. Enokiya Y, etal., Bull Tokyo Dent Coll. 2010;51(3):129-37.
18. Recombinant bone morphogenetic protein (BMP)-2 regulates costochondral growth plate chondrocytes and induces expression of BMP-2 and BMP-4 in a cell maturation-dependent manner. Erickson DM, etal., J Orthop Res. 1997 May;15(3):371-80.
19. Bone morphogenetic protein 4 mediates bile duct ligation induced liver fibrosis through activation of Smad1 and ERK1/2 in rat hepatic stellate cells. Fan J, etal., J Cell Physiol. 2006 May;207(2):499-505.
20. Bone morphogenetic protein-4 induced rat hepatic progenitor cell (WB-F344 cell) differentiation toward hepatocyte lineage. Fan J, etal., J Cell Physiol. 2009 Jul;220(1):72-81. doi: 10.1002/jcp.21731.
21. Spatial and temporal patterns of expression of Noggin and BMP4 in embryonic and postnatal rat hippocampus. Fan X, etal., Brain Res Dev Brain Res 2003 Dec 19;146(1-2):51-8.
22. Subtype-specific regulation of receptor internalization and recycling by the carboxyl-terminal domains of the human A1 and rat A3 adenosine receptors: consequences for agonist-stimulated translocation of arrestin3. Ferguson G, etal., Biochemistry 2002 Dec 17;41(50):14748-61.
23. The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways. Fukada T, etal., PLoS One. 2008;3(11):e3642. doi: 10.1371/journal.pone.0003642. Epub 2008 Nov 5.
24. Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions. Fuller ML, etal., Ann Neurol. 2007 Sep;62(3):288-300.
25. Intrinsic and extrinsic inhibition of oligodendrocyte development by rat retina. Gao L, etal., Dev Biol. 2006 Feb 15;290(2):277-86. Epub 2006 Jan 4.
26. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
27. Modulation of expression and cell surface binding of members of the transforming growth factor-beta superfamily during retinoic acid-induced osteoblastic differentiation of multipotential mesenchymal cells. Gazit D, etal., Mol Endocrinol. 1993 Feb;7(2):189-98.
28. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
29. Association of BMP4 polymorphisms with isolated tooth agenesis in a Chinese Han population: a case-control study. Gong M, etal., Eur Rev Med Pharmacol Sci. 2015 Jun;19(12):2188-94.
30. Expression of bone morphogenetic protein-4 in the cortical lesions of focal cortical dysplasia IIb and the tuberous sclerosis complex. Guo W, etal., J Mol Neurosci. 2013 May;50(1):7-13. doi: 10.1007/s12031-012-9841-2. Epub 2012 Jul 3.
31. Identification of early response genes and pathway activated by androgens in the initial segment and caput regions of the regressed rat epididymis. Hamzeh M and Robaire B, Endocrinology. 2010 Sep;151(9):4504-14. Epub 2010 Jul 21.
32. Effect of a fibrin-fibronectin sealing system as a carrier for recombinant human bone morphogenetic protein-4 on bone formation in rat calvarial defects. Han DK, etal., J Periodontol. 2005 Dec;76(12):2216-22.
33. Mutation screening of BMP4 and Id2 genes in Chinese patients with congenital ureteropelvic junction obstruction. He JL, etal., Eur J Pediatr. 2012 Mar;171(3):451-6. doi: 10.1007/s00431-011-1561-z. Epub 2011 Sep 17.
34. BMP4 modulates fibroblast growth factor-mediated induction of proximal and distal lung differentiation in mouse embryonic tracheal epithelium in mesenchyme-free culture. Hyatt BA, etal., Dev Dyn 2002 Oct;225(2):153-65.
35. Changes in homeobox-containing gene expression during ectopic bone formation induced by bone morphogenetic protein. Iimura T, etal., Biochem Biophys Res Commun 1994 Jun 15;201(2):980-7.
36. Prenatal exposure to di-n-butyl phthalate induces anorectal malformations in male rat offspring. Jiang JT, etal., Toxicology. 2011 Dec 18;290(2-3):322-6. doi: 10.1016/j.tox.2011.10.008. Epub 2011 Oct 18.
37. The mutation in Chd7 causes misexpression of Bmp4 and developmental defects in telencephalic midline. Jiang X, etal., Am J Pathol. 2012 Aug;181(2):626-41. doi: 10.1016/j.ajpath.2012.05.006. Epub 2012 May 29.
38. Differential expression patterns of Wnt and beta-catenin/TCF target genes in the uterus of immature female rats exposed to 17alpha-ethynyl estradiol. Katayama S, etal., Toxicol Sci. 2006 Jun;91(2):419-30. Epub 2006 Mar 21.
39. Apoptosis of oral epithelial cells in oral lichen planus caused by upregulation of BMP-4. Kim SG, etal., J Oral Pathol Med. 2006 Jan;35(1):37-45.
40. The expression of molecular mediators in the idiopathic cutaneous calcification and ossification. Kim SY, etal., J Cutan Pathol. 2008 Sep;35(9):826-31. doi: 10.1111/j.1600-0560.2007.00904.x. Epub 2008 Apr 18.
41. Different levels of TIMPs and MMPs in human lateral and medial rectus muscle tissue excised from strabismic patients. Kitada M, etal., Strabismus. 2003 Sep;11(3):145-55.
42. Bone morphogenetic protein 4 mediates apoptosis of capillary endothelial cells during rat pupillary membrane regression. Kiyono M and Shibuya M, Mol Cell Biol. 2003 Jul;23(13):4627-36.
43. Expression and purification of biologically active rat bone morphogenetic protein-4 produced as inclusion bodies in recombinant Escherichia coli. Klosch B, etal., Biotechnol Lett. 2005 Oct;27(20):1559-64.
44. Dual odontogenic origins develop at the early stage of rat maxillary incisor development. Kriangkrai R, etal., Anat Embryol (Berl). 2006 Mar;211(2):101-8. Epub 2006 Jan 17.
45. Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells. Kuroda R, etal., Arthritis Rheum. 2006 Feb;54(2):433-42.
46. Expression of bone morphogenetic proteins, the subfamily of the transforming growth factor-beta superfamily, in renal cell carcinoma. Kwak C, etal., J Urol. 2007 Sep;178(3 Pt 1):1062-7. Epub 2007 Jul 20.
47. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
48. Evaluation of differentially expressed genes identified in keratoconus. Lee JE, etal., Mol Vis. 2009 Nov 28;15:2480-7.
49. Zhonghua nan ke xue = National journal of andrology Li ZL, etal., Zhonghua Nan Ke Xue. 2006 Feb;12(2):126-8, 132.
50. Association of bone morphogenetic protein 4 gene polymorphisms with nonsyndromic cleft lip with or without cleft palate in Chinese children. Lin JY, etal., DNA Cell Biol. 2008 Nov;27(11):601-5. doi: 10.1089/dna.2008.0777.
51. Rat adipose-derived stromal cells expressing BMP4 induce ectopic bone formation in vitro and in vivo. Lin L, etal., Acta Pharmacol Sin. 2006 Dec;27(12):1608-15.
52. Gene expression dynamics during bone healing and osseointegration. Lin Z, etal., J Periodontol. 2011 Jul;82(7):1007-17. doi: 10.1902/jop.2010.100577. Epub 2010 Dec 13.
53. Bone morphogenetic protein 4 enhances canonical transient receptor potential expression, store-operated Ca2+ entry, and basal [Ca2+]i in rat distal pulmonary arterial smooth muscle cells. Lu W, etal., Am J Physiol Cell Physiol. 2010 Dec;299(6):C1370-8. doi: 10.1152/ajpcell.00040.2010. Epub 2010 Sep 15.
54. Sonic hedgehog, BMP4, and Hox genes in the development of anorectal malformations in Ethylenethiourea-exposed fetal rats. Mandhan P, etal., J Pediatr Surg. 2006 Dec;41(12):2041-5.
55. Identification of new thyroid hormone-regulated genes in rat brain neuronal cultures. Martel J, etal., Neuroreport. 2002 Oct 28;13(15):1849-51.
56. BMP4 expression in the developing rat retina. Maruyama Y, etal., Brain Res. 2006 Nov 29;1122(1):116-21. Epub 2006 Oct 27.
57. The influence of sex on the chondrogenic potential of muscle-derived stem cells: implications for cartilage regeneration and repair. Matsumoto T, etal., Arthritis Rheum. 2008 Dec;58(12):3809-19. doi: 10.1002/art.24125.
58. Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1. Matsumoto T, etal., Arthritis Rheum. 2009 May;60(5):1390-405. doi: 10.1002/art.24443.
59. T allele at site 6007 of bone morphogenetic protein-4 gene increases genetic susceptibility to ossification of the posterior longitudinal ligament in male Chinese Han population. Meng XL, etal., Chin Med J (Engl). 2010 Sep;123(18):2537-42.
60. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
61. Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cells. Milano F, etal., Gastroenterology. 2007 Jun;132(7):2412-21. Epub 2007 Mar 19.
62. Bone morphogenetic protein 4 stimulates neuronal differentiation of neuronal stem cells through the ERK pathway. Moon BS, etal., Exp Mol Med. 2009 Feb 28;41(2):116-25.
63. Phenotype characterization and sequence analysis of BMP2 and BMP4 variants in two Mexican families with oligodontia. Mu Y, etal., Genet Mol Res. 2012 Nov 28;11(4):4110-20. doi: 10.4238/2012.September.25.5.
64. Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins. Nahar NN, etal., J Bone Miner Metab. 2008;26(5):514-9. Epub 2008 Aug 30.
65. Busulfan-induced central polydactyly, syndactyly and cleft hand or foot: a common mechanism of disruption leads to divergent phenotypes. Naruse T, etal., Dev Growth Differ. 2007 Aug;49(6):533-41.
66. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
67. Expression of bone morphogenic proteins and receptors at the injured growth plate cartilage in young rats. Ngo TQ, etal., J Histochem Cytochem. 2006 Aug;54(8):945-54. Epub 2006 May 1.
68. Bone morphogenetic protein-4 acts as an ovarian follicle survival factor and promotes primordial follicle development. Nilsson EE and Skinner MK, Biol Reprod. 2003 Oct;69(4):1265-72. Epub 2003 Jun 11.
69. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
70. Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk. Paez-Pereda M, etal., Proc Natl Acad Sci U S A 2003 Feb 4;100(3):1034-9.
71. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
72. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
73. Common variations in BMP4 confer genetic susceptibility to sporadic congenital heart disease in a Han Chinese population. Qian B, etal., Pediatr Cardiol. 2014 Dec;35(8):1442-7. doi: 10.1007/s00246-014-0951-1. Epub 2014 Jul 15.
74. Delayed myelination in an intrauterine growth retardation model is mediated by oxidative stress upregulating bone morphogenetic protein 4. Reid MV, etal., J Neuropathol Exp Neurol. 2012 Jul;71(7):640-53. doi: 10.1097/NEN.0b013e31825cfa81.
75. Study of the association between the BMP4 gene and congenital anomalies of the kidney and urinary tract. Reis GS, etal., J Pediatr (Rio J). 2014 Jan-Feb;90(1):58-64. doi: 10.1016/j.jped.2013.06.004. Epub 2013 Oct 13.
76. GOA pipeline RGD automated data pipeline
77. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
78. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
79. In vivo bone formation in fracture repair induced by direct retroviral-based gene therapy with bone morphogenetic protein-4. Rundle CH, etal., Bone. 2003 Jun;32(6):591-601.
80. Bone morphogenetic proteins prevent bone marrow stromal cell-mediated oligodendroglial differentiation of transplanted adult neural progenitor cells in the injured spinal cord. Sandner B, etal., Stem Cell Res. 2013 Sep;11(2):758-71. doi: 10.1016/j.scr.2013.05.003. Epub 2013 May 16.
81. Mechanical tension-stress induces expression of bone morphogenetic protein (BMP)-2 and BMP-4, but not BMP-6, BMP-7, and GDF-5 mRNA, during distraction osteogenesis. Sato M, etal., J Bone Miner Res. 1999 Jul;14(7):1084-95.
82. Tissue remodeling in the acute otitis media mouse model. Sautter NB, etal., Int J Pediatr Otorhinolaryngol. 2011 Nov;75(11):1368-71. doi: 10.1016/j.ijporl.2011.07.026. Epub 2011 Sep 1.
83. Association of bone morphogenetic proteins with otosclerosis. Schrauwen I, etal., J Bone Miner Res. 2008 Apr;23(4):507-16.
84. Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas. Schwartz DR, etal., Cancer Res. 2003 Jun 1;63(11):2913-22.
85. Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva. Shafritz AB, etal., N Engl J Med 1996 Aug 22;335(8):555-61.
86. BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy. Shahid M, etal., Am J Physiol Heart Circ Physiol. 2016 Apr 15;310(8):H984-94. doi: 10.1152/ajpheart.00879.2015. Epub 2016 Feb 12.
87. Structural and functional healing of critical-size segmental bone defects by transduced muscle-derived cells expressing BMP4. Shen HC, etal., J Gene Med. 2004 Sep;6(9):984-91.
88. Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways. Shields JM, etal., J Biol Chem 2002 Mar 22;277(12):9790-9.
89. Effect of nitric oxide on fibroblast growth factor-10 and bone morphogenetic protein 4 expressions in the branching morphogenesis of fetal rat lung explants. Shinkai M, etal., J Pediatr Surg. 2005 Jun;40(6):1030-3.
90. Effects of dexamethasone exposure on rat metanephric development: in vitro and in vivo studies. Singh RR, etal., Am J Physiol Renal Physiol. 2007 Aug;293(2):F548-54. Epub 2007 May 30.
91. Localization of bone morphogenetic proteins (BMPs)-2, -4, and -6 within megakaryocytes and platelets. Sipe JB, etal., Bone. 2004 Dec;35(6):1316-22.
92. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
93. Bone morphogenetic protein-4 contributes to the down-regulation of Kv4.3 K+ channels in pathological cardiac hypertrophy. Sun B, etal., Biochem Biophys Res Commun. 2013 Jul 12;436(4):591-4. doi: 10.1016/j.bbrc.2013.05.113. Epub 2013 Jun 6.
94. Downregulation of GATA4 and GATA6 in the heart of rats with nitrofen-induced diaphragmatic hernia. Takayasu H, etal., J Pediatr Surg. 2008 Feb;43(2):362-6. doi: 10.1016/j.jpedsurg.2007.10.047.
95. Noggin and BMP4 co-modulate adult hippocampal neurogenesis in the APP(swe)/PS1(DeltaE9) transgenic mouse model of Alzheimer's disease. Tang J, etal., Biochem Biophys Res Commun. 2009 Jul 31;385(3):341-5. doi: 10.1016/j.bbrc.2009.05.067. Epub 2009 May 20.
96. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
97. Altered gene expression during rat Wolffian duct development in response to in utero exposure to the antiandrogen linuron. Turner KJ, etal., Toxicol Sci. 2003 Jul;74(1):114-28. Epub 2003 May 2.
98. Spatial expression of Sonic hedgehog in the lung epithelium during branching morphogenesis. Urase K, etal., Biochem Biophys Res Commun. 1996 Aug 5;225(1):161-6.
99. Over-expression of BMP4 inhibits experimental choroidal neovascularization by modulating VEGF and MMP-9. Xu J, etal., Angiogenesis. 2012 Jun;15(2):213-27. doi: 10.1007/s10456-012-9254-4. Epub 2012 Mar 4.
100. Transcriptional regulation of bone morphogenetic protein 4 by tumor necrosis factor and its relationship with age-related macular degeneration. Xu J, etal., FASEB J. 2011 Jul;25(7):2221-33. doi: 10.1096/fj.10-178350. Epub 2011 Mar 16.
101. Expression of bone morphogenetic proteins and rat distal-less homolog genes following rat femoral fracture. Yaoita H, etal., J Bone Miner Metab. 2000;18(2):63-70.
102. Involvement of over-expressed BMP4 in pentylenetetrazol kindling-induced cell proliferation in the dentate gyrus of adult rats. Yin J, etal., Biochem Biophys Res Commun. 2007 Mar 30;355(1):54-60. Epub 2007 Jan 29.
103. Effect of hyperbaric oxygen on neurological recovery of neonatal rats following hypoxic-ischemic brain damage and its underlying mechanism. Yin X, etal., Int J Clin Exp Pathol. 2013;6(1):66-75. Epub 2012 Nov 20.
104. Bone marrow stromal cells upregulate expression of bone morphogenetic proteins 2 and 4, gap junction protein connexin-43 and synaptophysin after stroke in rats. Zhang C, etal., Neuroscience. 2006 Aug 25;141(2):687-95. Epub 2006 May 30.
105. Down-regulation of SHH/BMP4 signalling in human anorectal malformations. Zhang J, etal., J Int Med Res. 2009 Nov-Dec;37(6):1842-50.
106. Bone morphogenetic proteins and noggin: inhibiting and inducing fungiform taste papilla development. Zhou Y, etal., Dev Biol. 2006 Sep 1;297(1):198-213. Epub 2006 May 24.
107. BMP4 mediates oxidative stress-induced retinal pigment epithelial cell senescence and is overexpressed in age-related macular degeneration. Zhu D, etal., J Biol Chem. 2009 Apr 3;284(14):9529-39. doi: 10.1074/jbc.M809393200. Epub 2009 Jan 21.
Additional References at PubMed
PMID:1521591   PMID:3201241   PMID:7657163   PMID:7799920   PMID:7811286   PMID:7848824   PMID:8104708   PMID:8358941   PMID:8674409   PMID:8769660   PMID:8898217   PMID:9187146  
PMID:9244299   PMID:9268572   PMID:9389648   PMID:9420335   PMID:9477322   PMID:9501024   PMID:9585504   PMID:9664686   PMID:9786991   PMID:9806931   PMID:9851982   PMID:10021330  
PMID:10340755   PMID:10391928   PMID:10704389   PMID:10706139   PMID:10964473   PMID:11023873   PMID:11401393   PMID:11436557   PMID:11493558   PMID:11502704   PMID:11719201   PMID:11865031  
PMID:12141440   PMID:12399320   PMID:12421925   PMID:12619935   PMID:12631064   PMID:12975322   PMID:14623234   PMID:14654219   PMID:14681194   PMID:14749725   PMID:15048926   PMID:15070745  
PMID:15218525   PMID:15289457   PMID:15381701   PMID:15451575   PMID:15516325   PMID:15525533   PMID:15591122   PMID:15634693   PMID:15716346   PMID:15772937   PMID:15800000   PMID:15936012  
PMID:15975920   PMID:16154126   PMID:16179481   PMID:16414041   PMID:16546160   PMID:16604073   PMID:16712836   PMID:16816361   PMID:16855091   PMID:16887039   PMID:16916379   PMID:16958105  
PMID:17071745   PMID:17118062   PMID:17244894   PMID:17350185   PMID:17442697   PMID:17472960   PMID:17481601   PMID:17522159   PMID:17555714   PMID:17600318   PMID:17698011   PMID:17720811  
PMID:17850284   PMID:17881493   PMID:17953369   PMID:17992660   PMID:18028901   PMID:18272846   PMID:18305125   PMID:18326817   PMID:18367557   PMID:18372242   PMID:18393306   PMID:18436533  
PMID:18437684   PMID:18462699   PMID:18548003   PMID:18622394   PMID:18643848   PMID:18692041   PMID:18776146   PMID:18787191   PMID:18823971   PMID:18924235   PMID:18997172   PMID:19001364  
PMID:19325147   PMID:19342445   PMID:19850029   PMID:20019778   PMID:20048761   PMID:20059955   PMID:20079000   PMID:20406889   PMID:20501701   PMID:20559569   PMID:20573232   PMID:20638445  
PMID:20650884   PMID:20702560   PMID:20705941   PMID:20886368   PMID:20926379   PMID:20936960   PMID:20959141   PMID:21145505   PMID:21149635   PMID:21281623   PMID:21520255   PMID:21599637  
PMID:21873793   PMID:22064324   PMID:22363399   PMID:22508088   PMID:22521772   PMID:22529382   PMID:22547442   PMID:22573687   PMID:22700770   PMID:23335245   PMID:23404565   PMID:23526217  
PMID:23610558   PMID:23863481   PMID:24603907   PMID:24637016   PMID:24648278   PMID:24835669   PMID:24906886   PMID:25091895   PMID:25828920   PMID:25854185   PMID:26208387   PMID:26634236  
PMID:26865179   PMID:27573468   PMID:28124060   PMID:29850574   PMID:29959980   PMID:31881217   PMID:32830897   PMID:33194000   PMID:34537186   PMID:35477223   PMID:35605369   PMID:36746787  
PMID:36906487  


Genomics

Comparative Map Data
Bmp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81522,098,191 - 22,113,145 (-)NCBIGRCr8
mRatBN7.21519,618,538 - 19,633,494 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1519,618,542 - 19,623,306 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1522,400,667 - 22,404,237 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01523,358,675 - 23,362,245 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01521,608,597 - 21,612,175 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01520,776,060 - 20,791,013 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1520,776,054 - 20,822,740 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01524,734,987 - 24,749,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41522,283,171 - 22,286,757 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11522,298,892 - 22,305,718 (-)NCBI
Celera1520,029,866 - 20,033,452 (-)NCBICelera
RH 3.4 Map15185.6RGD
Cytogenetic Map15p14NCBI
BMP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381453,949,736 - 53,956,891 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1453,949,736 - 53,958,761 (-)EnsemblGRCh38hg38GRCh38
GRCh371454,416,454 - 54,423,609 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361453,486,204 - 53,493,304 (-)NCBINCBI36Build 36hg18NCBI36
Build 341453,486,206 - 53,491,020NCBI
Celera1434,466,196 - 34,473,296 (-)NCBICelera
Cytogenetic Map14q22.2NCBI
HuRef1434,579,652 - 34,586,754 (-)NCBIHuRef
CHM1_11454,355,438 - 54,362,538 (-)NCBICHM1_1
T2T-CHM13v2.01448,157,959 - 48,165,118 (-)NCBIT2T-CHM13v2.0
Bmp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391446,620,982 - 46,628,126 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1446,620,977 - 46,628,126 (-)EnsemblGRCm39 Ensembl
GRCm381446,383,525 - 46,390,669 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1446,383,520 - 46,390,669 (-)EnsemblGRCm38mm10GRCm38
MGSCv371447,003,195 - 47,010,274 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361445,305,736 - 45,309,065 (-)NCBIMGSCv36mm8
Celera1442,555,453 - 42,562,519 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1423.95NCBI
Bmp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554099,432,841 - 9,440,303 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554099,432,835 - 9,439,680 (+)NCBIChiLan1.0ChiLan1.0
BMP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21555,076,681 - 55,083,868 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11454,293,198 - 54,548,492 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01434,542,132 - 34,549,286 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11452,821,872 - 52,828,781 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1452,821,872 - 52,828,752 (-)Ensemblpanpan1.1panPan2
BMP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1829,997,563 - 30,254,307 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl829,997,569 - 30,004,557 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha829,765,711 - 29,772,707 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0830,252,884 - 30,601,864 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl830,252,890 - 30,259,884 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1829,856,480 - 29,863,475 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0829,933,754 - 29,940,734 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0830,299,531 - 30,306,532 (-)NCBIUU_Cfam_GSD_1.0
Dog Cytomap8q21NCBI
Bmp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864075,280,082 - 75,287,313 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366971,056,636 - 1,061,468 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366971,054,237 - 1,061,468 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1183,416,146 - 183,422,637 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11183,415,989 - 183,422,888 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21203,773,963 - 203,780,310 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BMP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12431,097,673 - 31,104,774 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2431,097,538 - 31,101,225 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605319,326,010 - 19,333,125 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bmp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473115,263,274 - 15,269,743 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473115,262,480 - 15,269,196 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bmp4
78 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:59
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000012957
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15226636822711984Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat

Markers in Region
D14Mit129  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,618,758 - 19,618,897 (+)MAPPERmRatBN7.2
Rnor_6.01520,776,281 - 20,776,419NCBIRnor6.0
Rnor_5.01524,735,204 - 24,735,342UniSTSRnor5.0
RGSC_v3.41522,283,236 - 22,283,374UniSTSRGSC3.4
Celera1520,029,931 - 20,030,069UniSTS
Cytogenetic Map15p14UniSTS
PMC156609P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,622,147 - 19,622,245 (+)MAPPERmRatBN7.2
Rnor_6.01520,822,537 - 20,822,634NCBIRnor6.0
Rnor_6.01520,779,669 - 20,779,766NCBIRnor6.0
Rnor_5.01524,738,592 - 24,738,689UniSTSRnor5.0
Rnor_5.01524,780,296 - 24,780,393UniSTSRnor5.0
RGSC_v3.41522,286,624 - 22,286,721UniSTSRGSC3.4
Celera1520,033,319 - 20,033,416UniSTS
Cytogenetic Map15p14UniSTS
RH94860  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,618,749 - 19,618,960 (+)MAPPERmRatBN7.2
Rnor_6.01520,776,272 - 20,776,482NCBIRnor6.0
Rnor_5.01524,735,195 - 24,735,405UniSTSRnor5.0
RGSC_v3.41522,283,227 - 22,283,437UniSTSRGSC3.4
Celera1520,029,922 - 20,030,132UniSTS
RH 3.4 Map15185.6UniSTS
Cytogenetic Map15p14UniSTS
PMC34552P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,619,310 - 19,619,610 (+)MAPPERmRatBN7.2
Rnor_6.01520,776,833 - 20,777,132NCBIRnor6.0
Rnor_5.01524,735,756 - 24,736,055UniSTSRnor5.0
RGSC_v3.41522,283,788 - 22,284,087UniSTSRGSC3.4
Celera1520,030,483 - 20,030,782UniSTS
Cytogenetic Map15p14UniSTS
MARC_5761-5762:996690803:2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,621,068 - 19,622,227 (+)MAPPERmRatBN7.2
Rnor_6.01520,778,590 - 20,779,748NCBIRnor6.0
Rnor_5.01524,737,513 - 24,738,671UniSTSRnor5.0
RGSC_v3.41522,285,545 - 22,286,703UniSTSRGSC3.4
Celera1520,032,240 - 20,033,398UniSTS
Cytogenetic Map15p14UniSTS
Bmp4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,619,173 - 19,620,744 (+)MAPPERmRatBN7.2
Rnor_6.01520,776,696 - 20,778,265NCBIRnor6.0
Rnor_5.01524,735,619 - 24,737,188UniSTSRnor5.0
RGSC_v3.41522,283,651 - 22,285,220UniSTSRGSC3.4
Celera1520,030,346 - 20,031,915UniSTS
Cytogenetic Map15p14UniSTS
UniSTS:496641  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,620,727 - 19,621,089 (+)MAPPERmRatBN7.2
Rnor_6.01520,778,249 - 20,778,610NCBIRnor6.0
Rnor_5.01524,737,172 - 24,737,533UniSTSRnor5.0
RGSC_v3.41522,285,204 - 22,285,565UniSTSRGSC3.4
Celera1520,031,899 - 20,032,260UniSTS
Cytogenetic Map15p14UniSTS
UniSTS:497280  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,619,508 - 19,620,747 (+)MAPPERmRatBN7.2
Rnor_6.01520,777,031 - 20,778,268NCBIRnor6.0
Rnor_5.01524,735,954 - 24,737,191UniSTSRnor5.0
RGSC_v3.41522,283,986 - 22,285,223UniSTSRGSC3.4
Celera1520,030,681 - 20,031,918UniSTS
Cytogenetic Map15p14UniSTS
BMP4_296  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,618,636 - 19,619,550 (+)MAPPERmRatBN7.2
Rnor_6.01520,776,159 - 20,777,072NCBIRnor6.0
Rnor_5.01524,735,082 - 24,735,995UniSTSRnor5.0
RGSC_v3.41522,283,114 - 22,284,027UniSTSRGSC3.4
Celera1520,029,809 - 20,030,722UniSTS
Cytogenetic Map15p14UniSTS
Bmp4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,619,526 - 19,620,924 (+)MAPPERmRatBN7.2
Rnor_6.01520,777,049 - 20,778,445NCBIRnor6.0
Rnor_5.01524,735,972 - 24,737,368UniSTSRnor5.0
RGSC_v3.41522,284,004 - 22,285,400UniSTSRGSC3.4
Celera1520,030,699 - 20,032,095UniSTS
Cytogenetic Map15p14UniSTS
Bmp4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,620,976 - 19,621,090 (+)MAPPERmRatBN7.2
Rnor_6.01520,778,498 - 20,778,611NCBIRnor6.0
Rnor_5.01524,737,421 - 24,737,534UniSTSRnor5.0
Celera1520,032,148 - 20,032,261UniSTS
Cytogenetic Map15p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 20 2 2 4 2 7 35 24 11
Low 1 23 51 35 15 35 8 11 67 12 8
Below cutoff 4 4 4 5

Sequence


Ensembl Acc Id: ENSRNOT00000012957   ⟹   ENSRNOP00000012957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1519,618,542 - 19,623,306 (-)Ensembl
Rnor_6.0 Ensembl1520,776,054 - 20,822,740 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083268   ⟹   ENSRNOP00000075142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1519,618,542 - 19,622,271 (-)Ensembl
Rnor_6.0 Ensembl1520,776,254 - 20,783,063 (-)Ensembl
RefSeq Acc Id: NM_012827   ⟹   NP_036959
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81522,098,347 - 22,101,933 (-)NCBI
mRatBN7.21519,618,694 - 19,622,281 (-)NCBI
Rnor_6.01520,776,216 - 20,779,802 (-)NCBI
Rnor_5.01524,734,987 - 24,749,935 (-)NCBI
RGSC_v3.41522,283,171 - 22,286,757 (-)RGD
Celera1520,029,866 - 20,033,452 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251746   ⟹   XP_006251808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81522,098,191 - 22,102,990 (-)NCBI
mRatBN7.21519,618,538 - 19,623,326 (-)NCBI
Rnor_6.01520,776,060 - 20,780,873 (-)NCBI
Rnor_5.01524,734,987 - 24,749,935 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251747   ⟹   XP_006251809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81522,098,191 - 22,102,974 (-)NCBI
mRatBN7.21519,618,538 - 19,623,349 (-)NCBI
Rnor_6.01520,776,060 - 20,780,873 (-)NCBI
Rnor_5.01524,734,987 - 24,749,935 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251748   ⟹   XP_006251810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81522,098,191 - 22,105,271 (-)NCBI
mRatBN7.21519,618,538 - 19,625,562 (-)NCBI
Rnor_6.01520,776,060 - 20,783,093 (-)NCBI
Rnor_5.01524,734,987 - 24,749,935 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251749   ⟹   XP_006251811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81522,098,191 - 22,102,990 (-)NCBI
mRatBN7.21519,618,538 - 19,623,301 (-)NCBI
Rnor_6.01520,776,060 - 20,780,845 (-)NCBI
Rnor_5.01524,734,987 - 24,749,935 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251751   ⟹   XP_006251813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81522,098,191 - 22,113,145 (-)NCBI
mRatBN7.21519,618,538 - 19,633,494 (-)NCBI
Rnor_6.01520,776,060 - 20,791,013 (-)NCBI
Rnor_5.01524,734,987 - 24,749,935 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770501   ⟹   XP_008768723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81522,098,191 - 22,102,959 (-)NCBI
mRatBN7.21519,618,538 - 19,622,467 (-)NCBI
Rnor_6.01520,776,060 - 20,780,101 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093006   ⟹   XP_038948934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81522,098,191 - 22,103,212 (-)NCBI
mRatBN7.21519,618,538 - 19,623,560 (-)NCBI
RefSeq Acc Id: XM_063273995   ⟹   XP_063130065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81522,098,191 - 22,105,213 (-)NCBI
RefSeq Acc Id: NP_036959   ⟸   NM_012827
- Peptide Label: precursor
- UniProtKB: Q6AYU9 (UniProtKB/TrEMBL),   F7FF39 (UniProtKB/TrEMBL),   Q811S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251813   ⟸   XM_006251751
- Peptide Label: isoform X1
- UniProtKB: Q6AYU9 (UniProtKB/TrEMBL),   F7FF39 (UniProtKB/TrEMBL),   Q811S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251810   ⟸   XM_006251748
- Peptide Label: isoform X1
- UniProtKB: Q6AYU9 (UniProtKB/TrEMBL),   F7FF39 (UniProtKB/TrEMBL),   Q811S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251811   ⟸   XM_006251749
- Peptide Label: isoform X1
- UniProtKB: Q6AYU9 (UniProtKB/TrEMBL),   F7FF39 (UniProtKB/TrEMBL),   Q811S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251809   ⟸   XM_006251747
- Peptide Label: isoform X1
- UniProtKB: Q6AYU9 (UniProtKB/TrEMBL),   F7FF39 (UniProtKB/TrEMBL),   Q811S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251808   ⟸   XM_006251746
- Peptide Label: isoform X1
- UniProtKB: Q6AYU9 (UniProtKB/TrEMBL),   F7FF39 (UniProtKB/TrEMBL),   Q811S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768723   ⟸   XM_008770501
- Peptide Label: isoform X1
- UniProtKB: Q6AYU9 (UniProtKB/TrEMBL),   F7FF39 (UniProtKB/TrEMBL),   Q811S3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012957   ⟸   ENSRNOT00000012957
Ensembl Acc Id: ENSRNOP00000075142   ⟸   ENSRNOT00000083268
RefSeq Acc Id: XP_038948934   ⟸   XM_039093006
- Peptide Label: isoform X1
- UniProtKB: Q6AYU9 (UniProtKB/TrEMBL),   F7FF39 (UniProtKB/TrEMBL),   Q811S3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130065   ⟸   XM_063273995
- Peptide Label: isoform X2
- UniProtKB: Q811S3 (UniProtKB/TrEMBL)
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q06826-F1-model_v2 AlphaFold Q06826 1-408 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699600
Promoter ID:EPDNEW_R10124
Type:single initiation site
Name:Bmp4_2
Description:bone morphogenetic protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10125  EPDNEW_R10126  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01520,779,791 - 20,779,851EPDNEW
RGD ID:13699601
Promoter ID:EPDNEW_R10125
Type:multiple initiation site
Name:Bmp4_3
Description:bone morphogenetic protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10124  EPDNEW_R10126  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01520,783,069 - 20,783,129EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2213 AgrOrtholog
BioCyc Gene G2FUF-14183 BioCyc
Ensembl Genes ENSRNOG00000009694 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012957.7 UniProtKB/TrEMBL
  ENSRNOT00000083268.2 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.970 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7121295 IMAGE-MGC_LOAD
InterPro BMP4_TGF_beta-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25296 UniProtKB/TrEMBL
MGC_CLONE MGC:93647 IMAGE-MGC_LOAD
NCBI Gene 25296 ENTREZGENE
PANTHER BONE MORPHOGENETIC PROTEIN 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bmp4 PhenoGen
PRINTS INHIBINA UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009694 RatGTEx
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC219813
UniProt A0A0G2K9V2_RAT UniProtKB/TrEMBL
  BMP4_RAT UniProtKB/Swiss-Prot
  F7FF39 ENTREZGENE, UniProtKB/TrEMBL
  Q06826 ENTREZGENE
  Q6AYU9 ENTREZGENE, UniProtKB/TrEMBL
  Q811S3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Bmp4  Bone morphogenetic protein 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in primary fetal rat calvarial cells 631792
gene_function growth factor molecule 631793
gene_mutations_overexpression overexpressed in prolactinomas 629544
gene_process stimulates cell proliferation and expression of c-Myc 629544
gene_process involved in regulating postnatal cerebellar differentiation 631793
gene_process regulates expansion of proximal epithelial cells during lung differentiation 631794
gene_process increases the activity of cyclin-dependent kinase inhibitor p21 and plays a role in apoptosis 625588
gene_product member of the transforming growth factor beta superfamily 631792
gene_product member of the transforming growth factor-beta family 625588
gene_protein 408 amino acids 631792
gene_regulation mRNA expression is suppressed by activated Ras 625588