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Gene: Bmp4 (bone morphogenetic protein 4) Rattus norvegicus
Symbol: Bmp4
Name: bone morphogenetic protein 4
Description: Exhibits growth factor activity and identical protein binding activity. Involved in several processes, including animal organ development; positive regulation of calcium ion transport; and positive regulation of cell differentiation. Localizes to cytoplasm; extracellular space; and vesicle. Biomarker of Barrett's esophagus; congenital diaphragmatic hernia; epilepsy; peptic esophagitis; and prolactinoma. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and otosclerosis. Orthologous to human BMP4 (bone morphogenetic protein 4); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; glypican signaling pathway; basal cell carcinoma pathway; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane.
Type: protein-coding
Also known as: BMP-2B; BMP-4; BOMPR4A; bone morphogenetic protein 2B
Homo sapiens (human) : BMP4 (bone morphogenetic protein 4)  HGNC  Alliance
Mus musculus (house mouse) : Bmp4 (bone morphogenetic protein 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bmp4 (bone morphogenetic protein 4)
Pan paniscus (bonobo/pygmy chimpanzee) : BMP4 (bone morphogenetic protein 4)
Canis lupus familiaris (dog) : BMP4 (bone morphogenetic protein 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bmp4 (bone morphogenetic protein 4)
Sus scrofa (pig) : BMP4 (bone morphogenetic protein 4)
Chlorocebus sabaeus (African green monkey) : BMP4 (bone morphogenetic protein 4)
Heterocephalus glaber (naked mole-rat) : Bmp4 (bone morphogenetic protein 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01520,776,060 - 20,791,013 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1520,776,054 - 20,822,740 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01524,734,987 - 24,749,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41522,283,171 - 22,286,757 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11522,298,892 - 22,305,718 (-)NCBI
Celera1520,029,866 - 20,033,452 (-)NCBICelera
Cytogenetic Map15p14NCBI
RH 3.4 Map15185.6RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Bmp4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2213
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.