Bmp4 (bone morphogenetic protein 4) - Rat Genome Database

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Gene: Bmp4 (bone morphogenetic protein 4) Rattus norvegicus
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Symbol: Bmp4
Name: bone morphogenetic protein 4
RGD ID: 2213
Description: Exhibits growth factor activity and identical protein binding activity. Involved in several processes, including animal organ development; positive regulation of calcium ion transport; and positive regulation of cell differentiation. Localizes to cytoplasm; extracellular space; and vesicle. Biomarker of Barrett's esophagus; congenital diaphragmatic hernia; epilepsy; peptic esophagitis; and prolactinoma. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and otosclerosis. Orthologous to human BMP4 (bone morphogenetic protein 4); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; glypican signaling pathway; basal cell carcinoma pathway; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: BMP-2B; BMP-4; BOMPR4A; bone morphogenetic protein 2B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21519,618,538 - 19,633,494 (-)NCBI
Rnor_6.0 Ensembl1520,776,054 - 20,822,740 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01520,776,060 - 20,791,013 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01524,734,987 - 24,749,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41522,283,171 - 22,286,757 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11522,298,892 - 22,305,718 (-)NCBI
Celera1520,029,866 - 20,033,452 (-)NCBICelera
RH 3.4 Map15185.6RGD
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
ACTH-secreting pituitary adenoma  (ISO)
Alzheimer's disease  (ISO)
amenorrhea  (ISO)
Anorectal Malformations  (IEP,ISO)
APLASIA/HYPOPLASIA INVOLVING BONES OF THE LOWER LIMBS  (ISO)
atrial heart septal defect  (ISO)
atrioventricular septal defect  (ISS)
Axenfeld-Rieger syndrome type 3  (ISS)
Barrett's esophagus  (IEP,ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
CAKUT  (ISO)
CAKUT2  (ISO)
calcinosis  (ISO)
Cardiomegaly  (ISO)
cartilage disease  (ISO)
CHARGE syndrome  (ISO)
Choroidal Neovascularization  (ISO)
cleft lip  (ISO)
cleft palate-lateral synechia syndrome  (ISS)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (IEP)
Congenital Limb Deformities  (IEP)
Cranial Nerve Injuries  (IEP)
Diaphragmatic Hernia  (ISO)
Endometrioid Carcinomas  (ISO)
epilepsy  (IEP)
esophagitis  (ISO)
Experimental Liver Cirrhosis  (IEP)
Femoral Fractures  (IDA,IEP,ISO)
Fetal Growth Retardation  (IEP)
fibrodysplasia ossificans progressiva  (ISS)
Focal Cortical Dysplasia of Taylor  (ISO)
Fractures, Cartilage  (ISO)
genetic disease  (ISO)
Gliosis  (IEP)
granulosa cell tumor  (ISO)
Hearing Loss  (ISO)
Hyperoxia  (IEP)
Hypoxia-Ischemia, Brain  (IEP)
keratoconus  (ISO)
macular degeneration  (ISO)
melanoma  (ISO)
Multicystic Dysplastic Kidney  (ISO)
myositis ossificans  (ISO)
ocular hypertension  (ISO)
Oral Lichen Planus  (ISO)
orofacial cleft  (ISO)
orofacial cleft 11  (ISO)
ossification of the posterior longitudinal ligament of spine  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Experimental  (ISO)
otosclerosis  (ISO)
peptic esophagitis  (IEP)
physical disorder  (ISS)
progressive osseous heteroplasia  (ISO)
prolactinoma  (IEP,ISO)
prostate carcinoma  (ISO)
psoriatic arthritis  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
Skull Fractures  (ISO)
Spinal Cord Injuries  (IDA,ISO)
strabismus  (ISO)
Stroke  (IMP)
syndromic microphthalmia  (ISO)
syndromic microphthalmia 6  (ISO)
Tibial Fractures  (IEP)
tooth agenesis  (ISO)
Tracheoesophageal Fistula  (IEP)
tuberous sclerosis  (ISO)
urinary system disease  (ISS)
Vitamin A Deficiency  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
antimonite  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
bacitracin  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
busulfan  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dichromium trioxide  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethylenediaminetetraacetic acid  (ISO)
Ethylenethiourea  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
glycidol  (EXP)
hydrogen peroxide  (ISO)
icariin  (EXP,ISO)
iloprost  (ISO)
indole-3-methanol  (EXP)
kaempferol  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
linuron  (EXP)
lithium chloride  (ISO)
maneb  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mitomycin C  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
naringin  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
nitrates  (EXP)
nitrofen  (EXP)
ochratoxin A  (ISO)
octreotide  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
pasireotide  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pinosylvin  (ISO)
potassium chromate  (ISO)
progesterone  (EXP)
Ptaquiloside  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chlorate  (EXP)
sodium dichromate  (ISO)
sulforaphane  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
topotecan  (EXP)
trans-pinosylvin  (ISO)
trichostatin A  (EXP,ISO)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPKK activity  (IEA,ISO,ISS)
anatomical structure formation involved in morphogenesis  (ISO)
anatomical structure regression  (IEP)
angiogenesis  (ISO)
anterior/posterior axis specification  (IEA,ISO)
aortic valve morphogenesis  (IEA,ISO)
apoptotic process involved in endocardial cushion morphogenesis  (ISO)
blood vessel development  (ISO)
blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IEA,ISO,ISS)
BMP signaling pathway  (ISO,ISS)
BMP signaling pathway involved in heart development  (IEA,ISO)
BMP signaling pathway involved in heart induction  (IEA,ISO,ISS)
BMP signaling pathway involved in nephric duct formation  (IEA,ISO,ISS)
BMP signaling pathway involved in renal system segmentation  (IEA,ISO,ISS)
BMP signaling pathway involved in ureter morphogenesis  (IEA,ISO,ISS)
bone development  (ISO)
brain development  (IEP)
branching involved in prostate gland morphogenesis  (IEA,ISO)
branching involved in ureteric bud morphogenesis  (IEA,ISO,ISS)
branching morphogenesis of an epithelial tube  (ISO,ISS)
bronchus development  (ISO)
bud dilation involved in lung branching  (ISO)
bud elongation involved in lung branching  (IEA,ISO)
camera-type eye development  (ISO)
camera-type eye morphogenesis  (ISO)
cardiac jelly development  (ISO)
cardiac muscle cell differentiation  (IEA,ISO)
cardiac right ventricle morphogenesis  (ISO)
cell fate commitment  (ISO)
cell population proliferation  (NAS)
cellular response to BMP stimulus  (IEP,ISO)
cellular response to dexamethasone stimulus  (IDA)
cellular response to growth factor stimulus  (ISO)
cellular response to mechanical stimulus  (IEP)
cellular response to oxidative stress  (IDA)
cellular response to thyroid hormone stimulus  (IEP)
chondrocyte differentiation  (IEA,ISO,ISS)
cloacal septation  (IEA,ISO)
common-partner SMAD protein phosphorylation  (IEA,ISO,ISS)
coronary vasculature development  (IEA,ISO)
cranial suture morphogenesis  (IEA,ISO)
deltoid tuberosity development  (IEA,ISO,ISS)
dorsal/ventral neural tube patterning  (IEA,ISO)
embryonic cranial skeleton morphogenesis  (IEA,ISO)
embryonic digit morphogenesis  (IEA,ISO)
embryonic hindlimb morphogenesis  (IEA,ISO)
embryonic limb morphogenesis  (ISO)
embryonic morphogenesis  (ISO)
embryonic skeletal joint morphogenesis  (IEA,ISO)
embryonic skeletal system development  (ISO)
embryonic skeletal system morphogenesis  (ISO)
endocardial cushion development  (IEA,ISO)
endochondral ossification  (IEA,ISO,ISS)
endoderm development  (IEA,ISO)
epithelial cell proliferation involved in lung morphogenesis  (ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
epithelial tube branching involved in lung morphogenesis  (IEP,ISO)
epithelial-mesenchymal cell signaling  (IEA,ISO)
epithelium development  (ISO)
erythrocyte differentiation  (IEA,ISO)
eye development  (ISO)
forebrain development  (ISO)
germ cell development  (IEA,ISO)
glomerular capillary formation  (IEA,ISO,ISS)
glomerular visceral epithelial cell development  (IEA,ISO)
heart development  (ISO)
hematopoietic progenitor cell differentiation  (ISO,ISS)
inner ear receptor cell differentiation  (IEA,ISO)
intermediate mesodermal cell differentiation  (IEA,ISO,ISS)
kidney development  (ISO,ISS)
lens induction in camera-type eye  (IEA,ISO)
lung alveolus development  (ISO)
lung development  (ISO)
lung lobe development  (IEP)
lung morphogenesis  (ISO)
lymphoid progenitor cell differentiation  (IEA,ISO,ISS)
macrophage differentiation  (IEA,ISO)
mammary gland formation  (IEA,ISO)
membranous septum morphogenesis  (IEA,ISO)
mesenchymal cell differentiation involved in kidney development  (IEA,ISO)
mesenchymal cell differentiation involved in renal system development  (ISO)
mesenchymal cell proliferation involved in ureter development  (IEA,ISO)
mesenchymal cell proliferation involved in ureteric bud development  (IEA,ISO)
mesenchymal to epithelial transition involved in metanephros morphogenesis  (IEA,ISO,ISS)
mesoderm development  (NAS)
mesoderm formation  (ISO)
mesodermal cell differentiation  (ISO)
mesodermal cell fate determination  (IEA,ISO)
mesonephros development  (ISO,ISS)
metanephric collecting duct development  (IEA,ISO,ISS)
metanephros development  (ISO)
monocyte differentiation  (IEA,ISO)
muscular septum morphogenesis  (ISO)
negative regulation of apoptotic process  (IBA,ISO,ISS)
negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway  (IEA,ISO,ISS)
negative regulation of branching involved in ureteric bud morphogenesis  (IEA,ISO,ISS)
negative regulation of cell cycle  (ISO,ISS)
negative regulation of cell death  (ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell proliferation involved in heart morphogenesis  (IEA,ISO,ISS)
negative regulation of chondrocyte differentiation  (IEA,ISO)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of glomerular mesangial cell proliferation  (IEA,ISO,ISS)
negative regulation of glomerulus development  (IEA,ISO,ISS)
negative regulation of immature T cell proliferation in thymus  (IEA,ISO,ISS)
negative regulation of MAP kinase activity  (IEA,ISO,ISS)
negative regulation of mesenchymal cell proliferation involved in ureter development  (IEA,ISO,ISS)
negative regulation of metanephric comma-shaped body morphogenesis  (IEA,ISO,ISS)
negative regulation of metanephric S-shaped body morphogenesis  (IEA,ISO,ISS)
negative regulation of mitotic nuclear division  (IEA,ISO,ISS)
negative regulation of myoblast differentiation  (ISO)
negative regulation of oligodendrocyte differentiation  (IMP)
negative regulation of phosphorylation  (ISO,ISS)
negative regulation of pri-miRNA transcription by RNA polymerase II  (IEA,ISO)
negative regulation of prostatic bud formation  (IEA,ISO)
negative regulation of striated muscle tissue development  (ISO)
negative regulation of T cell differentiation in thymus  (ISO)
negative regulation of thymocyte apoptotic process  (IEA,ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IBA,ISO)
negative regulation of transcription, DNA-templated  (ISO,ISS)
neural tube closure  (IEA,ISO)
neuron fate commitment  (IEA,ISO)
odontogenesis  (IEP,ISO,ISS)
odontogenesis of dentin-containing tooth  (IEA,ISO)
organ induction  (ISO)
osteoblast differentiation  (IEA,ISO,ISS)
outflow tract morphogenesis  (ISO)
outflow tract septum morphogenesis  (IEA,ISO)
ovarian follicle development  (IMP)
pharyngeal arch artery morphogenesis  (IEA,ISO)
pituitary gland development  (IEA,ISO)
positive chemotaxis  (IEA)
positive regulation of apoptotic process  (IEA,ISO,ISS)
positive regulation of BMP signaling pathway  (IEA,ISO,ISS)
positive regulation of bone mineralization  (IDA,IEA,ISO,ISS)
positive regulation of branching involved in lung morphogenesis  (IEA,ISO,ISS)
positive regulation of branching involved in ureteric bud morphogenesis  (IMP)
positive regulation of calcium ion transport into cytosol  (IMP)
positive regulation of cardiac muscle fiber development  (IEA,ISO,ISS)
positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis  (IEA,ISO)
positive regulation of cartilage development  (ISO)
positive regulation of cell death  (ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IMP,ISO,ISS)
positive regulation of cell proliferation involved in outflow tract morphogenesis  (IEA,ISO)
positive regulation of collagen biosynthetic process  (IEA,ISO,ISS)
positive regulation of endothelial cell apoptotic process  (IMP)
positive regulation of endothelial cell differentiation  (IEA,ISO)
positive regulation of endothelial cell migration  (IEA,ISO,ISS)
positive regulation of endothelial cell proliferation  (IEA,ISO,ISS)
positive regulation of epidermal cell differentiation  (IEA,ISO,ISS)
positive regulation of epithelial cell proliferation  (ISO,ISS)
positive regulation of epithelial to mesenchymal transition  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of hepatocyte differentiation  (IMP)
positive regulation of kidney development  (IEA,ISO,ISS)
positive regulation of mesenchymal stem cell proliferation  (IMP)
positive regulation of neuron differentiation  (IEA,IMP,ISO)
positive regulation of neuron projection development  (IDA,IMP)
positive regulation of ossification  (IMP,ISO)
positive regulation of osteoblast differentiation  (IDA,IEA,IMP,ISO,ISS)
positive regulation of pathway-restricted SMAD protein phosphorylation  (IBA,IEA,ISO,ISS)
positive regulation of pri-miRNA transcription by RNA polymerase II  (IEA,ISO)
positive regulation of production of miRNAs involved in gene silencing by miRNA  (IEA,ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of SMAD protein signal transduction  (IEA,ISO,ISS)
positive regulation of smooth muscle cell proliferation  (IEA,ISO,ISS)
positive regulation of store-operated calcium channel activity  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO,ISS)
post-embryonic development  (IEA,ISO)
prostate gland morphogenesis  (ISO)
protein localization to nucleus  (IEA,ISO,ISS)
pulmonary artery endothelial tube morphogenesis  (IEA,ISO,ISS)
pulmonary valve morphogenesis  (IEA,ISO)
regulation of branching involved in prostate gland morphogenesis  (IEA,ISO)
regulation of cartilage development  (ISO)
regulation of cell differentiation  (IDA,ISO)
regulation of cell fate commitment  (IEA,ISO,ISS)
regulation of ERK1 and ERK2 cascade  (IDA)
regulation of gene expression  (ISO)
regulation of morphogenesis of a branching structure  (ISO)
regulation of odontogenesis of dentin-containing tooth  (IEA,ISO)
regulation of pathway-restricted SMAD protein phosphorylation  (ISO,ISS)
regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
regulation of protein import into nucleus  (ISO)
regulation of smooth muscle cell differentiation  (IEA,ISO)
regulation of smooth muscle cell proliferation  (ISO)
renal system process  (IEA,ISO)
response to estradiol  (IEP)
response to glucocorticoid  (IEP)
response to mechanical stimulus  (IEP)
response to nitric oxide  (IEP)
response to organic cyclic compound  (IEP)
response to retinoic acid  (IEP)
response to testosterone  (IEP)
retina development in camera-type eye  (IEP)
secondary heart field specification  (IEA,ISO,ISS)
skeletal system development  (ISO)
SMAD protein signal transduction  (IBA,IEA,ISO,ISS)
smooth muscle cell differentiation  (ISO)
smooth muscle tissue development  (ISO,ISS)
specification of animal organ position  (IEA,ISO)
specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway  (IEA,ISO,ISS)
steroid hormone mediated signaling pathway  (IEA,ISO,ISS)
telencephalon development  (ISO)
telencephalon regionalization  (IEA,ISO)
tendon cell differentiation  (IEA,ISO,ISS)
tissue development  (ISO)
tongue morphogenesis  (IEP)
trachea development  (ISO)
trachea formation  (IEA,ISO)
type B pancreatic cell development  (IEA,ISO,ISS)
ureter epithelial cell differentiation  (IEA,ISO,ISS)
ureter smooth muscle cell differentiation  (IEA,ISO,ISS)
ureteric bud development  (ISO)
vasculature development  (ISO)
wound healing  (IEP)

Cellular Component
cytoplasm  (IDA)
extracellular region  (ISO)
extracellular space  (IBA,IDA,IEA,ISO)
vesicle  (IDA)

Molecular Function

References

References - curated
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Additional References at PubMed
PMID:1521591   PMID:3201241   PMID:7657163   PMID:7799920   PMID:7811286   PMID:7848824   PMID:8104708   PMID:8358941   PMID:8674409   PMID:8769660   PMID:8898217   PMID:9187146  
PMID:9244299   PMID:9268572   PMID:9389648   PMID:9420335   PMID:9477322   PMID:9501024   PMID:9585504   PMID:9664686   PMID:9786991   PMID:9806931   PMID:9851982   PMID:10021330  
PMID:10340755   PMID:10391928   PMID:10704389   PMID:10706139   PMID:10964473   PMID:11023873   PMID:11401393   PMID:11436557   PMID:11493558   PMID:11502704   PMID:11719201   PMID:11865031  
PMID:12141440   PMID:12399320   PMID:12421925   PMID:12619935   PMID:12631064   PMID:12975322   PMID:14623234   PMID:14654219   PMID:14681194   PMID:14749725   PMID:15048926   PMID:15070745  
PMID:15218525   PMID:15289457   PMID:15381701   PMID:15451575   PMID:15516325   PMID:15525533   PMID:15591122   PMID:15634693   PMID:15716346   PMID:15772937   PMID:15800000   PMID:15936012  
PMID:15975920   PMID:16154126   PMID:16179481   PMID:16414041   PMID:16546160   PMID:16604073   PMID:16712836   PMID:16816361   PMID:16855091   PMID:16887039   PMID:16916379   PMID:16958105  
PMID:17071745   PMID:17118062   PMID:17244894   PMID:17350185   PMID:17442697   PMID:17472960   PMID:17481601   PMID:17522159   PMID:17555714   PMID:17600318   PMID:17698011   PMID:17720811  
PMID:17850284   PMID:17881493   PMID:17953369   PMID:17992660   PMID:18028901   PMID:18272846   PMID:18305125   PMID:18326817   PMID:18367557   PMID:18372242   PMID:18393306   PMID:18436533  
PMID:18437684   PMID:18462699   PMID:18548003   PMID:18622394   PMID:18643848   PMID:18692041   PMID:18776146   PMID:18787191   PMID:18823971   PMID:18924235   PMID:18997172   PMID:19001364  
PMID:19325147   PMID:19342445   PMID:19850029   PMID:20019778   PMID:20048761   PMID:20059955   PMID:20079000   PMID:20406889   PMID:20501701   PMID:20559569   PMID:20573232   PMID:20638445  
PMID:20650884   PMID:20702560   PMID:20705941   PMID:20886368   PMID:20926379   PMID:20936960   PMID:20959141   PMID:21145505   PMID:21149635   PMID:21281623   PMID:21520255   PMID:21599637  
PMID:21873793   PMID:22064324   PMID:22363399   PMID:22508088   PMID:22521772   PMID:22529382   PMID:22547442   PMID:22573687   PMID:22700770   PMID:23335245   PMID:23404565   PMID:23526217  
PMID:23610558   PMID:23863481   PMID:24603907   PMID:24637016   PMID:24648278   PMID:24835669   PMID:24906886   PMID:25091895   PMID:25828920   PMID:25854185   PMID:26208387   PMID:26634236  
PMID:26865179   PMID:27573468   PMID:28124060   PMID:29850574   PMID:29959980   PMID:31881217  


Genomics

Comparative Map Data
Bmp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21519,618,538 - 19,633,494 (-)NCBI
Rnor_6.0 Ensembl1520,776,054 - 20,822,740 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01520,776,060 - 20,791,013 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01524,734,987 - 24,749,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41522,283,171 - 22,286,757 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11522,298,892 - 22,305,718 (-)NCBI
Celera1520,029,866 - 20,033,452 (-)NCBICelera
RH 3.4 Map15185.6RGD
Cytogenetic Map15p14NCBI
BMP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1453,949,736 - 53,958,761 (-)EnsemblGRCh38hg38GRCh38
GRCh381453,949,736 - 53,956,891 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371454,416,454 - 54,423,609 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361453,486,204 - 53,493,304 (-)NCBINCBI36hg18NCBI36
Build 341453,486,206 - 53,491,020NCBI
Celera1434,466,196 - 34,473,296 (-)NCBI
Cytogenetic Map14q22.2NCBI
HuRef1434,579,652 - 34,586,754 (-)NCBIHuRef
CHM1_11454,355,438 - 54,362,564 (-)NCBICHM1_1
Bmp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391446,620,982 - 46,628,126 (-)NCBIGRCm39mm39
GRCm39 Ensembl1446,620,977 - 46,628,126 (-)Ensembl
GRCm381446,383,525 - 46,390,669 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1446,383,520 - 46,390,669 (-)EnsemblGRCm38mm10GRCm38
MGSCv371447,003,195 - 47,010,274 (-)NCBIGRCm37mm9NCBIm37
MGSCv361445,305,736 - 45,309,065 (-)NCBImm8
Celera1442,555,453 - 42,562,519 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1423.95NCBI
Bmp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554099,432,841 - 9,440,303 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554099,432,835 - 9,439,680 (+)NCBIChiLan1.0ChiLan1.0
BMP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11452,821,872 - 52,828,781 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1452,821,872 - 52,828,752 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01434,542,132 - 34,549,286 (-)NCBIMhudiblu_PPA_v0panPan3
BMP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1829,997,563 - 30,254,307 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl829,997,569 - 30,004,557 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha829,765,711 - 29,772,707 (-)NCBI
ROS_Cfam_1.0830,252,884 - 30,601,864 (-)NCBI
UMICH_Zoey_3.1829,856,480 - 29,863,475 (-)NCBI
UNSW_CanFamBas_1.0829,933,754 - 29,940,734 (-)NCBI
UU_Cfam_GSD_1.0830,299,531 - 30,306,532 (-)NCBI
Dog Cytomap8q21NCBI
Bmp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864075,280,082 - 75,287,313 (+)NCBI
SpeTri2.0NW_0049366971,054,237 - 1,061,468 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1183,416,134 - 183,792,417 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11183,415,989 - 183,422,888 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21203,773,963 - 203,780,310 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BMP4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12431,097,673 - 31,104,774 (-)NCBI
ChlSab1.1 Ensembl2431,097,538 - 31,101,225 (-)Ensembl
Vero_WHO_p1.0NW_02366605319,326,010 - 19,333,125 (-)NCBI
Bmp4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473115,262,480 - 15,269,196 (+)NCBI

Position Markers
D14Mit129  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,618,758 - 19,618,897 (+)MAPPER
Rnor_6.01520,776,281 - 20,776,419NCBIRnor6.0
Rnor_5.01524,735,204 - 24,735,342UniSTSRnor5.0
RGSC_v3.41522,283,236 - 22,283,374UniSTSRGSC3.4
Celera1520,029,931 - 20,030,069UniSTS
Cytogenetic Map15p14UniSTS
PMC156609P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,622,147 - 19,622,245 (+)MAPPER
Rnor_6.01520,822,537 - 20,822,634NCBIRnor6.0
Rnor_6.01520,779,669 - 20,779,766NCBIRnor6.0
Rnor_5.01524,738,592 - 24,738,689UniSTSRnor5.0
Rnor_5.01524,780,296 - 24,780,393UniSTSRnor5.0
RGSC_v3.41522,286,624 - 22,286,721UniSTSRGSC3.4
Celera1520,033,319 - 20,033,416UniSTS
Cytogenetic Map15p14UniSTS
RH94860  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,618,749 - 19,618,960 (+)MAPPER
Rnor_6.01520,776,272 - 20,776,482NCBIRnor6.0
Rnor_5.01524,735,195 - 24,735,405UniSTSRnor5.0
RGSC_v3.41522,283,227 - 22,283,437UniSTSRGSC3.4
Celera1520,029,922 - 20,030,132UniSTS
RH 3.4 Map15185.6UniSTS
Cytogenetic Map15p14UniSTS
PMC34552P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,619,310 - 19,619,610 (+)MAPPER
Rnor_6.01520,776,833 - 20,777,132NCBIRnor6.0
Rnor_5.01524,735,756 - 24,736,055UniSTSRnor5.0
RGSC_v3.41522,283,788 - 22,284,087UniSTSRGSC3.4
Celera1520,030,483 - 20,030,782UniSTS
Cytogenetic Map15p14UniSTS
MARC_5761-5762:996690803:2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,621,068 - 19,622,227 (+)MAPPER
Rnor_6.01520,778,590 - 20,779,748NCBIRnor6.0
Rnor_5.01524,737,513 - 24,738,671UniSTSRnor5.0
RGSC_v3.41522,285,545 - 22,286,703UniSTSRGSC3.4
Celera1520,032,240 - 20,033,398UniSTS
Cytogenetic Map15p14UniSTS
Bmp4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,619,173 - 19,620,744 (+)MAPPER
Rnor_6.01520,776,696 - 20,778,265NCBIRnor6.0
Rnor_5.01524,735,619 - 24,737,188UniSTSRnor5.0
RGSC_v3.41522,283,651 - 22,285,220UniSTSRGSC3.4
Celera1520,030,346 - 20,031,915UniSTS
Cytogenetic Map15p14UniSTS
UniSTS:496641  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,620,727 - 19,621,089 (+)MAPPER
Rnor_6.01520,778,249 - 20,778,610NCBIRnor6.0
Rnor_5.01524,737,172 - 24,737,533UniSTSRnor5.0
RGSC_v3.41522,285,204 - 22,285,565UniSTSRGSC3.4
Celera1520,031,899 - 20,032,260UniSTS
Cytogenetic Map15p14UniSTS
UniSTS:497280  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,619,508 - 19,620,747 (+)MAPPER
Rnor_6.01520,777,031 - 20,778,268NCBIRnor6.0
Rnor_5.01524,735,954 - 24,737,191UniSTSRnor5.0
RGSC_v3.41522,283,986 - 22,285,223UniSTSRGSC3.4
Celera1520,030,681 - 20,031,918UniSTS
Cytogenetic Map15p14UniSTS
BMP4_296  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,618,636 - 19,619,550 (+)MAPPER
Rnor_6.01520,776,159 - 20,777,072NCBIRnor6.0
Rnor_5.01524,735,082 - 24,735,995UniSTSRnor5.0
RGSC_v3.41522,283,114 - 22,284,027UniSTSRGSC3.4
Celera1520,029,809 - 20,030,722UniSTS
Cytogenetic Map15p14UniSTS
Bmp4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,619,526 - 19,620,924 (+)MAPPER
Rnor_6.01520,777,049 - 20,778,445NCBIRnor6.0
Rnor_5.01524,735,972 - 24,737,368UniSTSRnor5.0
RGSC_v3.41522,284,004 - 22,285,400UniSTSRGSC3.4
Celera1520,030,699 - 20,032,095UniSTS
Cytogenetic Map15p14UniSTS
Bmp4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21519,620,976 - 19,621,090 (+)MAPPER
Rnor_6.01520,778,498 - 20,778,611NCBIRnor6.0
Rnor_5.01524,737,421 - 24,737,534UniSTSRnor5.0
Celera1520,032,148 - 20,032,261UniSTS
Cytogenetic Map15p14UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15130597196Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15137708474Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15137708474Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15137708474Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15142844179Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15143521446Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15162301382Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)colorectal tumor number (CMO:0001794)15232787726288802Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15232787726288802Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15232787753535766Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15388113148881131Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151071919155719191Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151549236072568189Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151582824233657761Rat
9590272Scort14Serum corticosterone level QTL 142.780.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)151698090761980907Rat
8694427Bw163Body weight QTL 1634.820.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)151698090761980907Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151724964162249641Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151724964162249641Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151724964162249641Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151809320881255430Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151851391388036354Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:59
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000012957
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 20 2 2 4 2 7 35 24 11
Low 1 23 51 35 15 35 8 11 67 12 8
Below cutoff 4 4 4 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012957   ⟹   ENSRNOP00000012957
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1520,776,054 - 20,822,740 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083268   ⟹   ENSRNOP00000075142
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1520,776,254 - 20,783,063 (-)Ensembl
RefSeq Acc Id: NM_012827   ⟹   NP_036959
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21519,618,694 - 19,622,281 (-)NCBI
Rnor_6.01520,776,216 - 20,779,802 (-)NCBI
Rnor_5.01524,734,987 - 24,749,935 (-)NCBI
RGSC_v3.41522,283,171 - 22,286,757 (-)RGD
Celera1520,029,866 - 20,033,452 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251746   ⟹   XP_006251808
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21519,618,538 - 19,623,326 (-)NCBI
Rnor_6.01520,776,060 - 20,780,873 (-)NCBI
Rnor_5.01524,734,987 - 24,749,935 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251747   ⟹   XP_006251809
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21519,618,538 - 19,623,349 (-)NCBI
Rnor_6.01520,776,060 - 20,780,873 (-)NCBI
Rnor_5.01524,734,987 - 24,749,935 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251748   ⟹   XP_006251810
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21519,618,538 - 19,625,562 (-)NCBI
Rnor_6.01520,776,060 - 20,783,093 (-)NCBI
Rnor_5.01524,734,987 - 24,749,935 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251749   ⟹   XP_006251811
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21519,618,538 - 19,623,301 (-)NCBI
Rnor_6.01520,776,060 - 20,780,845 (-)NCBI
Rnor_5.01524,734,987 - 24,749,935 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251751   ⟹   XP_006251813
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21519,618,538 - 19,633,494 (-)NCBI
Rnor_6.01520,776,060 - 20,791,013 (-)NCBI
Rnor_5.01524,734,987 - 24,749,935 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770501   ⟹   XP_008768723
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21519,618,538 - 19,622,467 (-)NCBI
Rnor_6.01520,776,060 - 20,780,101 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093006   ⟹   XP_038948934
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21519,618,538 - 19,623,560 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_036959   ⟸   NM_012827
- Peptide Label: precursor
- UniProtKB: Q6AYU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251813   ⟸   XM_006251751
- Peptide Label: isoform X1
- UniProtKB: Q6AYU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251810   ⟸   XM_006251748
- Peptide Label: isoform X1
- UniProtKB: Q6AYU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251811   ⟸   XM_006251749
- Peptide Label: isoform X1
- UniProtKB: Q6AYU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251809   ⟸   XM_006251747
- Peptide Label: isoform X1
- UniProtKB: Q6AYU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251808   ⟸   XM_006251746
- Peptide Label: isoform X1
- UniProtKB: Q6AYU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768723   ⟸   XM_008770501
- Peptide Label: isoform X1
- UniProtKB: Q6AYU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012957   ⟸   ENSRNOT00000012957
RefSeq Acc Id: ENSRNOP00000075142   ⟸   ENSRNOT00000083268
RefSeq Acc Id: XP_038948934   ⟸   XM_039093006
- Peptide Label: isoform X1
Protein Domains
TGF_BETA_2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699600
Promoter ID:EPDNEW_R10124
Type:single initiation site
Name:Bmp4_2
Description:bone morphogenetic protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10125  EPDNEW_R10126  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01520,779,791 - 20,779,851EPDNEW
RGD ID:13699601
Promoter ID:EPDNEW_R10125
Type:multiple initiation site
Name:Bmp4_3
Description:bone morphogenetic protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10124  EPDNEW_R10126  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01520,783,069 - 20,783,129EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2213 AgrOrtholog
Ensembl Genes ENSRNOG00000009694 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000012957 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000075142 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012957 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000083268 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7121295 IMAGE-MGC_LOAD
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25296 UniProtKB/TrEMBL
MGC_CLONE MGC:93647 IMAGE-MGC_LOAD
NCBI Gene 25296 ENTREZGENE
PANTHER PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bmp4 PhenoGen
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC219813
UniProt BMP4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6AYU9 ENTREZGENE, UniProtKB/TrEMBL
  Q811S3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Bmp4  Bone morphogenetic protein 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in primary fetal rat calvarial cells 631792
gene_function growth factor molecule 631793
gene_mutations_overexpression overexpressed in prolactinomas 629544
gene_process stimulates cell proliferation and expression of c-Myc 629544
gene_process involved in regulating postnatal cerebellar differentiation 631793
gene_process regulates expansion of proximal epithelial cells during lung differentiation 631794
gene_process increases the activity of cyclin-dependent kinase inhibitor p21 and plays a role in apoptosis 625588
gene_product member of the transforming growth factor beta superfamily 631792
gene_product member of the transforming growth factor-beta family 625588
gene_protein 408 amino acids 631792
gene_regulation mRNA expression is suppressed by activated Ras 625588