RGD Reference Report - Dual odontogenic origins develop at the early stage of rat maxillary incisor development. - Rat Genome Database

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Dual odontogenic origins develop at the early stage of rat maxillary incisor development.

Authors: Kriangkrai, R  Iseki, S  Eto, K  Chareonvit, S 
Citation: Kriangkrai R, etal., Anat Embryol (Berl). 2006 Mar;211(2):101-8. Epub 2006 Jan 17.
RGD ID: 2289007
Pubmed: PMID:16416307   (View Abstract at PubMed)
DOI: DOI:10.1007/s00429-005-0068-7   (Journal Full-text)

Developmental process of rat maxillary incisor has been studied through histological analysis and investigation of tooth-related gene expression patterns at initial tooth development. The tooth-related genes studied here are fibroblast growth factor-8 (Fgf-8), pituitary homeobox gene-2 (Pitx-2), sonic hedgehog (Shh), muscle segment homeobox-1 (Msx-1), paired box-9 (Pax-9) and bone morphogenetic protein-4 (Bmp-4). The genes are expressed in oral epithelium and/or ectomesenchyme at the stage of epithelial thickening to the early bud stage of tooth development. Both the histological observation and tooth-related gene expression patterns during early stage of maxillary incisor development demonstrate that dual odontogenic origins aligned medio-laterally in the medial nasal process develop, subsequently only single functional maxillary incisor dental placode forms. The cascade of tooth-related gene expression patterns in rat maxillary incisor studied here is quite similar to those of the previous studies in mouse mandibular molar, even though the origins of oral epithelium and ectomesenchyme involved in development of maxillary incisor and mandibular molar are different. Thus, we conclude that maxillary incisor and mandibular molar share a similar signaling control of Fgf-8, Pitx-2, Shh, Msx-1, Pax-9 and Bmp-4 genes at the stage of oral epithelial thickening to the early bud stage of tooth development.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
odontogenesis of dentin-containing tooth  IEP 2289007 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pitx2  (paired-like homeodomain 2)

Objects referenced in this article
Gene Bmp4 bone morphogenetic protein 4 Rattus norvegicus
Gene Fgf8 fibroblast growth factor 8 Rattus norvegicus

Additional Information