RGD Reference Report - The role of bone morphogenetic protein 4 in inner ear development and function. - Rat Genome Database

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The role of bone morphogenetic protein 4 in inner ear development and function.

Authors: Blauwkamp, MN  Beyer, LA  Kabara, L  Takemura, K  Buck, T  King, WM  Dolan, DF  Barald, KF  Raphael, Y  Koenig, RJ 
Citation: Blauwkamp MN, etal., Hear Res. 2007 Mar;225(1-2):71-9. Epub 2006 Dec 28.
RGD ID: 8698665
Pubmed: PMID:17275231   (View Abstract at PubMed)
PMCID: PMC1868473   (View Article at PubMed Central)
DOI: DOI:10.1016/j.heares.2006.12.010   (Journal Full-text)

Bone Morphogenetic Protein 4 (BMP4) is a member of the TGF-beta superfamily and is known to be important for the normal development of many tissues and organs, including the inner ear. Bmp4 homozygous null mice die as embryos, but Bmp4 heterozygous null (Bmp4(+/-)) mice are viable and some adults exhibit a circling phenotype, suggestive of an inner ear defect. To understand the role of BMP4 in inner ear development and function, we have begun to study C57BL/6 Bmp4(+/-) mice. Quantitative testing of the vestibulo-collic reflex, which helps maintain head stability, demonstrated that Bmp4(+/-) mice that exhibit circling behavior have a poor response in the yaw axis, consistent with semicircular canal dysfunction. Although the hair cells of the ampullae were grossly normal, the stereocilia were greatly reduced in number. Auditory brainstem responses showed that Bmp4(+/-) mice have elevated hearing thresholds and immunohistochemical staining demonstrated decreased numbers of neuronal processes in the organ of Corti. Thus Bmp4(+/-) mice have structural and functional deficits in the inner ear.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BMP4HumanHearing Loss  ISOBmp4 (Mus musculus) RGD 
Bmp4RatHearing Loss  ISOBmp4 (Mus musculus) RGD 
Bmp4MouseHearing Loss  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bmp4  (bone morphogenetic protein 4)

Genes (Mus musculus)
Bmp4  (bone morphogenetic protein 4)

Genes (Homo sapiens)
BMP4  (bone morphogenetic protein 4)


Additional Information