Bmp4 (bone morphogenetic protein 4) - Rat Genome Database

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Gene: Bmp4 (bone morphogenetic protein 4) Mus musculus
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Symbol: Bmp4
Name: bone morphogenetic protein 4
RGD ID: 10244
MGI Page MGI
Description: Enables heparin binding activity. Involved in several processes, including circulatory system development; positive regulation of cell differentiation; and regulation of morphogenesis of a branching structure. Acts upstream of with a positive effect on positive regulation of protein localization to nucleus. Acts upstream of or within several processes, including embryonic morphogenesis; morphogenesis of a branching epithelium; and nervous system development. Located in extracellular space. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Axenfeld-Rieger syndrome type 3; atrioventricular septal defect; cleft palate-lateral synechia syndrome; fibrodysplasia ossificans progressiva; and urinary system disease. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and syndromic microphthalmia 6. Orthologous to human BMP4 (bone morphogenetic protein 4).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Bmp-; BMP-2B; Bmp-4; Bmp2; Bmp2b; Bmp2b-; Bmp2b-1; Bmp2b1; bone morphogenetic protein 2B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Bmp4-ps  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391446,620,982 - 46,628,126 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1446,620,977 - 46,628,126 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381446,383,525 - 46,390,669 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1446,383,520 - 46,390,669 (-)Ensemblmm10GRCm38
MGSCv371447,003,195 - 47,010,274 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361445,305,736 - 45,309,065 (-)NCBIMGSCv36mm8
Celera1442,555,453 - 42,562,519 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1423.95NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
ACTH-secreting pituitary adenoma  (ISO)
Acute Otitis Media  (IEP)
Alzheimer's disease  (IEP)
amenorrhea  (ISO)
Anorectal Malformations  (ISO)
APLASIA/HYPOPLASIA INVOLVING BONES OF THE LOWER LIMBS  (ISO)
atrial heart septal defect  (ISO)
atrioventricular septal defect  (IAGP)
Axenfeld-Rieger syndrome type 3  (IAGP)
Barrett's esophagus  (ISO)
Brain Hypoxia-Ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
CAKUT  (ISO)
CAKUT2  (ISO)
calcinosis  (ISO)
Cardiomegaly  (IEP)
cartilage disease  (ISO)
Cartilage Fractures  (ISO)
CHARGE syndrome  (IEP)
Choroidal Neovascularization  (IDA,IEP)
cleft lip  (ISO)
cleft palate-lateral synechia syndrome  (IAGP)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
Congenital Limb Deformities  (ISO)
Cranial Nerve Injuries  (ISO)
Diaphragmatic Hernia  (ISO)
DOPA-responsive dystonia  (ISO)
Endometrioid Carcinomas  (ISO)
epilepsy  (ISO)
esophagitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Femoral Fractures  (ISO)
Fetal Growth Retardation  (ISO)
fibrodysplasia ossificans progressiva  (IAGP)
Focal Cortical Dysplasia of Taylor  (ISO)
genetic disease  (ISO)
Gliosis  (ISO)
granulosa cell tumor  (IEP)
Hearing Loss  (IMP)
hereditary spastic paraplegia 28  (ISO)
Hyperoxia  (ISO)
Kapur Toriello Syndrome  (ISO)
keratoconus  (ISO)
macular degeneration  (ISO)
melanoma  (ISO)
Multicystic Dysplastic Kidney  (ISO)
myositis ossificans  (ISO)
ocular hypertension  (IMP)
Oral Lichen Planus  (ISO)
orofacial cleft  (ISO)
orofacial cleft 11  (ISO)
ossification of the posterior longitudinal ligament of spine  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Experimental  (ISO)
osteoporosis  (ISO)
otosclerosis  (ISO)
peptic esophagitis  (ISO)
Peters anomaly  (ISO)
physical disorder  (IAGP)
progressive osseous heteroplasia  (ISO)
prolactinoma  (IEP,ISO)
prostate carcinoma  (ISO)
psoriatic arthritis  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
Skull Fractures  (ISO)
Spinal Cord Injuries  (ISO)
strabismus  (ISO)
Stroke  (ISO)
syndromic microphthalmia  (ISO)
syndromic microphthalmia 6  (ISO)
Tibial Fractures  (ISO)
tooth agenesis  (ISO)
Tracheoesophageal Fistula  (ISO)
tuberous sclerosis  (ISO)
urinary system disease  (IAGP)
Vitamin A Deficiency  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-amphetamine  (EXP)
(S)-nicotine  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acrylamide  (EXP)
adenosine  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
alpha-Zearalanol  (ISO)
aluminium oxide  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
angiotensin II  (EXP)
antimonite  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
bacitracin  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bucladesine  (ISO)
busulfan  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
casticin  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dichromium trioxide  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (EXP)
dioxygen  (EXP)
disodium selenite  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
erastin  (EXP)
ethylenediaminetetraacetic acid  (ISO)
Ethylenethiourea  (ISO)
flavonoids  (ISO)
flusilazole  (EXP)
folic acid  (EXP)
fulvestrant  (ISO)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glycidol  (ISO)
hydrogen peroxide  (EXP,ISO)
icariin  (EXP,ISO)
iloprost  (ISO)
indole-3-methanol  (ISO)
isoprenaline  (ISO)
kaempferol  (EXP)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
maneb  (EXP)
manganese(II) chloride  (EXP)
mercury dibromide  (ISO)
metformin  (ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mitomycin C  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
naringin  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nitrates  (ISO)
nitrofen  (ISO)
ochratoxin A  (ISO)
octreotide  (ISO)
orphenadrine  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
pasireotide  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
Picein  (EXP)
pinosylvin  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
Ptaquiloside  (EXP)
quercetin  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (EXP)
rifampicin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chlorate  (ISO)
sodium dichromate  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trans-pinosylvin  (ISO)
trichostatin A  (ISO)
tyrphostin AG 1478  (ISO)
urethane  (EXP,ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ameloblast differentiation  (IDA,IEA)
anatomical structure formation involved in morphogenesis  (IGI)
anatomical structure regression  (ISO)
angiogenesis  (IMP)
anterior/posterior axis specification  (IGI)
aortic valve morphogenesis  (IMP)
apoptotic process involved in endocardial cushion morphogenesis  (IMP)
blood vessel development  (IDA)
blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IEA,ISO,ISS)
BMP signaling pathway  (IBA,IDA,IEA,IGI,IMP,ISO,ISS)
bone development  (IDA)
branching involved in prostate gland morphogenesis  (IMP)
branching involved in ureteric bud morphogenesis  (IEA,IGI,ISO,ISS)
bronchus development  (IEA,ISO)
bud dilation involved in lung branching  (IEA,ISO)
bud elongation involved in lung branching  (IDA)
camera-type eye development  (IGI,IMP)
camera-type eye morphogenesis  (IMP)
cardiac jelly development  (IMP)
cardiac muscle cell differentiation  (IGI,NAS)
cardiac muscle hypertrophy in response to stress  (ISO)
cardiac right ventricle morphogenesis  (IMP)
cartilage development  (IEA)
cell differentiation  (IEA)
cell fate commitment  (IDA)
cell population proliferation  (IGI)
cellular response to BMP stimulus  (IEA,ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to growth factor stimulus  (IDA)
cellular response to mechanical stimulus  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to thyroid hormone stimulus  (ISO)
chondrocyte differentiation  (IDA,IMP)
coronary vasculature development  (IMP)
cranial suture morphogenesis  (IDA)
deltoid tuberosity development  (IMP)
dorsal/ventral neural tube patterning  (IDA)
embryonic cranial skeleton morphogenesis  (IMP)
embryonic digit morphogenesis  (IGI)
embryonic hindlimb morphogenesis  (IGI)
embryonic limb morphogenesis  (IGI,IMP)
embryonic morphogenesis  (IMP)
embryonic skeletal joint morphogenesis  (IGI,IMP)
embryonic skeletal system development  (IMP)
embryonic skeletal system morphogenesis  (IMP)
endocardial cushion development  (IMP)
endochondral ossification  (IMP)
endoderm development  (IDA)
epithelial cell proliferation  (IGI)
epithelial cell proliferation involved in lung morphogenesis  (IEA,ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (IMP)
epithelial tube branching involved in lung morphogenesis  (IEA,ISO)
epithelial-mesenchymal cell signaling  (IDA)
epithelium development  (IDA)
erythrocyte differentiation  (IDA)
eye development  (IGI)
forebrain development  (IGI,IMP)
gene expression  (IDA)
germ cell development  (IMP)
glomerular capillary formation  (IMP)
heart development  (IMP)
heart induction  (IEA,ISO,ISS)
heart morphogenesis  (IBA,IEA,ISO)
hematopoietic progenitor cell differentiation  (IDA,IEA,ISO,ISS)
inner ear auditory receptor cell differentiation  (IGI)
intermediate mesodermal cell differentiation  (IEA,ISO,ISS)
kidney development  (IEA,IGI,IMP,ISO,ISS)
lens induction in camera-type eye  (IMP)
lung alveolus development  (IEA,ISO)
lung development  (IMP)
lung lobe development  (ISO)
lung morphogenesis  (IEA,ISO)
lung vasculature development  (IEA,ISO,ISS)
lymphoid progenitor cell differentiation  (IEA,ISO,ISS)
macrophage differentiation  (IEA,ISO)
mammary gland formation  (IMP)
membranous septum morphogenesis  (IMP)
mesoderm development  (IEA,ISO)
mesoderm formation  (IDA)
mesodermal cell differentiation  (IDA)
mesodermal cell fate determination  (IMP)
mesonephros development  (IEA,ISS)
metanephros development  (IDA,IMP)
monocyte differentiation  (IEA,ISO)
muscular septum morphogenesis  (IMP)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of branching involved in ureteric bud morphogenesis  (IDA,IEA,IGI,ISO)
negative regulation of cell cycle  (IEA,ISO,ISS)
negative regulation of cell differentiation  (IEA)
negative regulation of cell population proliferation  (IEA,ISO,ISS)
negative regulation of chondrocyte differentiation  (IDA)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of epithelial cell proliferation  (IGI,IMP)
negative regulation of extrinsic apoptotic signaling pathway  (IMP)
negative regulation of gene expression  (IDA,IEA,ISO)
negative regulation of glomerular mesangial cell proliferation  (IEA,ISO,ISS)
negative regulation of glomerulus development  (IEA,ISO,ISS)
negative regulation of immature T cell proliferation in thymus  (IEA,ISO,ISS)
negative regulation of mesenchymal cell proliferation involved in ureter development  (IEA,ISO,ISS)
negative regulation of metanephric comma-shaped body morphogenesis  (IEA,ISO,ISS)
negative regulation of metanephric S-shaped body morphogenesis  (IEA,ISO,ISS)
negative regulation of miRNA transcription  (IEA,ISO)
negative regulation of mitotic nuclear division  (IEA,ISO,ISS)
negative regulation of multicellular organismal process  (IEA)
negative regulation of myoblast differentiation  (IEA,ISO)
negative regulation of oligodendrocyte differentiation  (ISO)
negative regulation of prostatic bud formation  (IDA,IMP)
negative regulation of striated muscle tissue development  (IEA,ISO)
negative regulation of T cell differentiation in thymus  (IEA,ISO)
negative regulation of thymocyte apoptotic process  (IEA,ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IDA,IEA,IMP,ISO)
nephric duct formation  (IEA,ISO,ISS)
neural tube closure  (IDA)
neuron fate commitment  (IDA,IMP)
odontogenesis  (IEA,ISO,ISS)
odontogenesis of dentin-containing tooth  (IDA,IGI)
organ induction  (IMP)
ossification  (IEA)
osteoblast differentiation  (IDA,IEA,ISO,ISS)
outflow tract morphogenesis  (IGI)
outflow tract septum morphogenesis  (IMP)
ovarian follicle development  (ISO)
pericyte cell differentiation  (IDA)
pharyngeal arch artery morphogenesis  (IMP)
pituitary gland development  (IEA,IMP)
positive chemotaxis  (ISS)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of BMP signaling pathway  (IDA)
positive regulation of bone mineralization  (IEA,ISO,ISS)
positive regulation of branching involved in lung morphogenesis  (IMP)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of calcium ion transport into cytosol  (ISO)
positive regulation of cardiac muscle fiber development  (IEA,ISO,ISS)
positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis  (IGI)
positive regulation of cartilage development  (IEA,ISO)
positive regulation of cell migration  (IEA,IMP)
positive regulation of cell population proliferation  (IEA,IMP,ISO,ISS)
positive regulation of collagen biosynthetic process  (IEA,ISO,ISS)
positive regulation of DNA-templated transcription  (IEA,ISO,ISS,TAS)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of endothelial cell differentiation  (IDA)
positive regulation of endothelial cell migration  (TAS)
positive regulation of endothelial cell proliferation  (IDA)
positive regulation of epidermal cell differentiation  (IEA,ISO,ISS)
positive regulation of epithelial cell differentiation  (IDA)
positive regulation of epithelial cell proliferation  (IEA,ISO,ISS)
positive regulation of epithelial to mesenchymal transition  (IGI)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of gene expression  (IDA,IEA,IMP,ISO)
positive regulation of hepatocyte differentiation  (ISO)
positive regulation of mesenchymal stem cell proliferation  (ISO)
positive regulation of miRNA transcription  (IEA,IGI)
positive regulation of morphogenesis of an epithelium  (IEA)
positive regulation of neuron differentiation  (IDA,IEA,ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of odontoblast differentiation  (IEA,IMP)
positive regulation of ossification  (IDA,IEA,ISO)
positive regulation of osteoblast differentiation  (IEA,ISO,ISS)
positive regulation of p38MAPK cascade  (IEA,ISO)
positive regulation of primary miRNA processing  (IEA,ISO)
positive regulation of programmed cell death  (IEA,ISO)
positive regulation of protein localization to nucleus  (IMP)
positive regulation of protein phosphorylation  (IMP,ISO)
positive regulation of SMAD protein signal transduction  (IEA,ISO,ISS)
positive regulation of smooth muscle cell proliferation  (IEA,ISO)
positive regulation of store-operated calcium channel activity  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,IGI,IMP,ISO)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (TAS)
post-embryonic development  (IEA,IMP,ISO)
programmed cell death  (ISO)
prostate gland morphogenesis  (IMP)
prostatic bud formation  (IMP)
pulmonary valve morphogenesis  (IMP)
regulation of BMP signaling pathway  (ISO)
regulation of branching involved in prostate gland morphogenesis  (IMP)
regulation of branching involved in ureteric bud morphogenesis  (IEA)
regulation of cartilage development  (IDA,IEA)
regulation of cell differentiation  (IGI,ISO)
regulation of cell fate commitment  (IEA,ISO,ISS)
regulation of endothelial cell proliferation  (TAS)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of gene expression  (IDA,IMP)
regulation of MAPK cascade  (IEA)
regulation of mesodermal cell differentiation  (IDA,IGI)
regulation of miRNA transcription  (ISO)
regulation of morphogenesis of a branching structure  (IMP)
regulation of odontogenesis of dentin-containing tooth  (IEA,IGI)
regulation of protein import into nucleus  (IEA,ISO)
regulation of smooth muscle cell differentiation  (IDA,IGI)
regulation of smooth muscle cell proliferation  (IDA,IEA)
renal system process  (IMP)
response to estradiol  (ISO)
response to glucocorticoid  (ISO)
response to mechanical stimulus  (ISO)
response to nitric oxide  (ISO)
response to retinoic acid  (ISO)
response to testosterone  (ISO)
retina development in camera-type eye  (ISO)
secondary heart field specification  (IEA,ISO,ISS)
sensory organ morphogenesis  (IEA)
skeletal system development  (IDA,IMP)
smooth muscle cell differentiation  (IDA)
smooth muscle tissue development  (IEA,IMP)
specification of animal organ position  (IMP)
stem cell differentiation  (IDA)
telencephalon development  (IEA,ISO)
telencephalon regionalization  (IDA,IEA,IGI)
tendon cell differentiation  (IMP)
tongue morphogenesis  (ISO)
trachea development  (IEA,ISO)
trachea formation  (IMP)
transcription by RNA polymerase II  (IDA)
type B pancreatic cell development  (IEA,ISO,ISS)
ureter morphogenesis  (IMP)
ureteric bud development  (IDA,IEA,IMP,ISO)
vasculature development  (IMP)

Cellular Component
extracellular region  (IDA,IEA,TAS)
extracellular space  (IBA,IDA,IEA,ISO)
vesicle  (ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal allantois morphology  (IAGP)
abnormal amniotic cavity morphology  (IAGP)
abnormal angiogenesis  (IAGP)
abnormal anterior eye segment morphology  (IAGP)
abnormal aortic arch and aortic arch branch attachment  (IAGP)
abnormal apical ectodermal ridge morphology  (IAGP)
abnormal artery morphology  (IAGP)
abnormal atrioventricular cushion morphology  (IAGP)
abnormal autopod morphology  (IAGP)
abnormal bone marrow cavity morphology  (IAGP)
abnormal bone marrow development  (IAGP)
abnormal bone ossification  (IAGP)
abnormal canal of Schlemm morphology  (IAGP)
abnormal cardiac mesenchyme morphology  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cartilage development  (IAGP)
abnormal caudal vertebrae morphology  (IAGP)
abnormal chorion morphology  (IAGP)
abnormal conotruncal ridge morphology  (IAGP)
abnormal cornea morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal diencephalon morphology  (IAGP)
abnormal digit morphology  (IAGP)
abnormal ear development  (IAGP)
abnormal embryo development  (IEA)
abnormal embryo size  (IEA)
abnormal embryo turning  (IEA)
abnormal embryonic cloaca development  (IAGP)
abnormal endolymphatic duct morphology  (IAGP)
abnormal external female genitalia morphology  (IAGP)
abnormal extraembryonic mesoderm development  (IAGP)
abnormal eye anterior chamber depth  (IEA)
abnormal eye development  (IAGP)
abnormal eye distance/ position  (IAGP)
abnormal eye electrophysiology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal eye size  (IAGP)
abnormal face development  (IAGP)
abnormal fertility/fecundity  (IAGP)
abnormal fibula morphology  (IAGP)
abnormal forebrain development  (IEA)
abnormal forebrain morphology  (IAGP)
abnormal foregut morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal forelimb stylopod morphology  (IAGP)
abnormal forelimb zeugopod morphology  (IAGP)
abnormal frontal bone morphology  (IAGP)
abnormal head mesenchyme morphology  (IAGP)
abnormal heart and great artery attachment  (IAGP)
abnormal heart development  (IAGP)
abnormal heart looping  (IAGP)
abnormal heart morphology  (IEA)
abnormal heart right ventricle morphology  (IAGP)
abnormal heart right ventricle pressure  (IAGP)
abnormal heart ventricle outflow tract morphology  (IAGP)
abnormal hindbrain development  (IEA)
abnormal hindlimb bud morphology  (IAGP)
abnormal hindlimb stylopod morphology  (IAGP)
abnormal hindlimb zeugopod morphology  (IAGP)
abnormal inner ear morphology  (IAGP)
abnormal interdigital cell death  (IAGP)
abnormal interparietal bone morphology  (IAGP)
abnormal iridocorneal angle  (IAGP)
abnormal iris morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal kidney mesenchyme morphology  (IAGP)
abnormal lateral ganglionic eminence morphology  (IAGP)
abnormal lateral plate mesoderm morphology  (IAGP)
abnormal lateral semicircular canal morphology  (IAGP)
abnormal lens induction  (IAGP)
abnormal limb development  (IAGP)
abnormal line of Schwalbe morphology  (IAGP)
abnormal liver bud morphology  (IAGP)
abnormal long bone diaphysis morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal male reproductive system morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal mandibular angle morphology  (IAGP)
abnormal mandibular condyloid process morphology  (IAGP)
abnormal maxilla morphology  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal metanephric mesenchyme morphology  (IAGP)
abnormal midbrain development  (IEA)
abnormal mouth morphology  (IAGP)
abnormal nasal bone morphology  (IAGP)
abnormal nasal cartilage morphology  (IAGP)
abnormal nephrogenic zone morphology  (IAGP)
abnormal neural tube closure  (IEA)
abnormal nose morphology  (IAGP)
abnormal optic disk morphology  (IAGP)
abnormal optic nerve morphology  (IAGP)
abnormal organ of Corti morphology  (IAGP)
abnormal pharyngeal arch artery morphology  (IAGP)
abnormal placement of pupils  (IAGP)
abnormal posterior eye segment morphology  (IAGP)
abnormal posterior primitive streak morphology  (IAGP)
abnormal primitive node morphology  (IAGP)
abnormal prostate gland anterior lobe morphology  (IAGP)
abnormal pulmonary artery morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal/urinary system morphology  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal retina blood vessel pattern  (IAGP)
abnormal retina inner nuclear layer morphology  (IEA)
abnormal retina morphology  (IAGP)
abnormal retina outer nuclear layer morphology  (IEA)
abnormal retina photoreceptor layer morphology  (IAGP)
abnormal rib morphology  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal scala media morphology  (IAGP)
abnormal semicircular canal ampulla morphology  (IAGP)
abnormal semicircular canal morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal sensory neuron innervation pattern  (IAGP)
abnormal skeleton development  (IAGP)
abnormal snout morphology  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal sternum ossification  (IAGP)
abnormal tail morphology  (IAGP)
abnormal temporal bone squamous part morphology  (IAGP)
abnormal thoracic cage morphology  (IAGP)
abnormal truncus arteriosus septation  (IAGP)
abnormal tympanic ring morphology  (IAGP)
abnormal ureter development  (IAGP)
abnormal ureter morphology  (IAGP)
abnormal ureter smooth muscle morphology  (IAGP)
abnormal ureteral orifice morphology  (IAGP)
abnormal ureteric bud elongation  (IAGP)
abnormal ureterovesical junction morphology  (IAGP)
abnormal utricle morphology  (IAGP)
abnormal vascular endothelial cell physiology  (IAGP)
abnormal vascular smooth muscle morphology  (IAGP)
abnormal vertebrae development  (IAGP)
abnormal vertebral arch development  (IAGP)
abnormal vertebral arch morphology  (IAGP)
abnormal vertebral body development  (IAGP)
abnormal vertebral spinous process morphology  (IAGP)
abnormal vestibular saccule morphology  (IAGP)
abnormal vestibulocollic reflex  (IAGP)
abnormal visceral yolk sac mesenchyme morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitreous body morphology  (IAGP)
abnormal Wolffian duct morphology  (IAGP)
absent alisphenoid bone  (IAGP)
absent allantois  (IAGP)
absent frontal bone  (IAGP)
absent lateral semicircular canal  (IAGP)
absent mandible  (IAGP)
absent mandibular angle  (IAGP)
absent mandibular condyloid process  (IAGP)
absent mandibular coronoid process  (IAGP)
absent maxilla  (IAGP)
absent nasal bone  (IAGP)
absent nasal septum  (IAGP)
absent optic nerve  (IAGP)
absent primordial germ cells  (IAGP)
absent Rathke's pouch  (IAGP)
absent Schlemm's canal  (IAGP)
absent semicircular canals  (IAGP)
absent temporal bone squamous part  (IAGP)
absent tongue  (IAGP)
absent trabecular meshwork  (IAGP)
absent tympanic ring  (IAGP)
absent urinary bladder  (IAGP)
absent visceral yolk sac blood islands  (IAGP)
absent vitelline blood vessels  (IAGP)
absent zygomatic bone  (IAGP)
anal stenosis  (IAGP)
anophthalmia  (IAGP)
anterior cortical cataract  (IAGP)
anterior iris synechia  (IAGP)
anterior subcapsular cataract  (IAGP)
aortopulmonary window  (IAGP)
asymmetric rib joints  (IAGP)
atrial septal defect  (IAGP)
bifid ureter  (IAGP)
broad limb buds  (IAGP)
buphthalmos  (IAGP)
cataract  (IAGP)
cervical vertebral fusion  (IAGP)
circling  (IAGP)
cleft palate  (IAGP)
common atrioventricular valve  (IAGP)
complete atrioventricular septal defect  (IAGP)
conotruncal ridge hypoplasia  (IAGP)
cornea opacity  (IAGP)
decreased anxiety-related response  (IEA)
decreased autopod size  (IAGP)
decreased body weight  (IAGP)
decreased cornea thickness  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased hair follicle number  (IAGP)
decreased lateral semicircular canal size  (IAGP)
decreased litter size  (IAGP)
decreased primordial germ cell number  (IAGP)
decreased rib number  (IAGP)
decreased total retina thickness  (IEA)
decreased tympanic ring size  (IAGP)
decreased vestibular hair cell stereocilia number  (IAGP)
delayed bone ossification  (IAGP)
delayed endochondral bone ossification  (IAGP)
delayed hepatic development  (IAGP)
dilated kidney calyx  (IAGP)
dilated ureter  (IAGP)
double outlet right ventricle  (IAGP)
duplex kidney  (IAGP)
ectopic ureter  (IAGP)
ectopic ureteric bud  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality prior to tooth bud stage  (IEA)
embryonic lethality, complete penetrance  (IAGP)
enlarged kidney  (IAGP)
enlarged Meckel's cartilage  (IAGP)
external male genitalia hypoplasia  (IAGP)
eyelids fail to open  (IAGP)
failure of primitive streak formation  (IAGP)
failure of ventral body wall closure  (IAGP)
fused joints  (IAGP)
heart right ventricle hypertrophy  (IAGP)
holoprosencephaly  (IAGP)
hydronephrosis  (IAGP)
hydrops fetalis  (IAGP)
hydroureter  (IAGP)
hyperactivity  (IEA)
hypoplastic trabecular meshwork  (IAGP)
impaired hearing  (IAGP)
impaired osteoblast differentiation  (IAGP)
impaired skin barrier function  (IAGP)
increased circulating glucose level  (IAGP)
increased grip strength  (IEA)
increased metanephric mesenchyme apoptosis  (IAGP)
increased opacity of vitreous body  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
interrupted aortic arch, type b  (IAGP)
iris hypoplasia  (IAGP)
irregularly shaped pupil  (IAGP)
kidney atrophy  (IAGP)
kidney cyst  (IAGP)
kinked tail  (IAGP)
large anterior fontanelle  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lowered ear position  (IAGP)
microphthalmia  (IAGP)
mydriasis  (IAGP)
no abnormal phenotype detected  (IAGP)
ocular hypertension  (IAGP)
omphalocele  (IAGP)
oral atresia  (IAGP)
ostium primum atrial septal defect  (IAGP)
partial atrioventricular septal defect  (IAGP)
pericardial edema  (IAGP)
pericardial effusion  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
perinatal lethality  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
persistence of hyaloid vascular system  (IAGP)
persistent truncus arteriosus  (IAGP)
polycystic kidney  (IAGP)
polydactyly  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
preaxial polydactyly  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
reduced female fertility  (IAGP)
renal hypoplasia  (IAGP)
retina detachment  (IAGP)
retrognathia  (IAGP)
rib fusion  (IAGP)
round head  (IAGP)
semilunar valve hypoplasia  (IAGP)
seminiferous tubule degeneration  (IAGP)
short face  (IAGP)
short frontal bone  (IAGP)
short mandible  (IAGP)
short maxilla  (IAGP)
short nasal bone  (IAGP)
short ribs  (IAGP)
short tail  (IAGP)
single external naris  (IAGP)
single kidney  (IAGP)
sirenomelia  (IAGP)
small alisphenoid bone  (IAGP)
small allantois  (IAGP)
small frontal bone  (IAGP)
small interparietal bone  (IAGP)
small kidney  (IAGP)
small mandibular coronoid process  (IAGP)
small nasal bone  (IAGP)
small temporal bone squamous part  (IAGP)
small testis  (IAGP)
small vertebral body  (IAGP)
small zygomatic bone  (IAGP)
split xiphoid process  (IAGP)
syndactyly  (IAGP)
thick myocardium  (IAGP)
thin retina ganglion layer  (IAGP)
thin retina inner nuclear layer  (IAGP)
thoracic vertebral fusion  (IAGP)
References

References - curated
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67. Down-regulation of SHH/BMP4 signalling in human anorectal malformations. Zhang J, etal., J Int Med Res. 2009 Nov-Dec;37(6):1842-50.
68. BMP4 mediates oxidative stress-induced retinal pigment epithelial cell senescence and is overexpressed in age-related macular degeneration. Zhu D, etal., J Biol Chem. 2009 Apr 3;284(14):9529-39. doi: 10.1074/jbc.M809393200. Epub 2009 Jan 21.
Additional References at PubMed
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PMID:7588050   PMID:7589793   PMID:7657163   PMID:7799920   PMID:7811286   PMID:7848824   PMID:7915533   PMID:8055537   PMID:8104708   PMID:8339498   PMID:8358941   PMID:8436293  
PMID:8507180   PMID:8530045   PMID:8647435   PMID:8651889   PMID:8674409   PMID:8698813   PMID:8769660   PMID:8787747   PMID:8793505   PMID:8808404   PMID:8833241   PMID:8896987  
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PMID:23250216   PMID:23266329   PMID:23293290   PMID:23341776   PMID:23344708   PMID:23344953   PMID:23349763   PMID:23351706   PMID:23358455   PMID:23360989   PMID:23361844   PMID:23372768  
PMID:23376422   PMID:23382810   PMID:23383068   PMID:23388637   PMID:23390542   PMID:23396188   PMID:23409123   PMID:23426374   PMID:23431057   PMID:23449471   PMID:23451037   PMID:23451260  
PMID:23457544   PMID:23460641   PMID:23469192   PMID:23472198   PMID:23473983   PMID:23497137   PMID:23506836   PMID:23516636   PMID:23521771   PMID:23536097   PMID:23546880   PMID:23552073  
PMID:23560082   PMID:23563729   PMID:23584254   PMID:23584732   PMID:23592779   PMID:23610558   PMID:23614009   PMID:23620511   PMID:23620745   PMID:23624311   PMID:23626735   PMID:23633510  
PMID:23641053   PMID:23665221   PMID:23666531   PMID:23674600   PMID:23675417   PMID:23690951   PMID:23702483   PMID:23712751   PMID:23720040   PMID:23720046   PMID:23720048   PMID:23754280  
PMID:23760955   PMID:23791818   PMID:23813480   PMID:23816882   PMID:23824573   PMID:23843349   PMID:23863481   PMID:23869763   PMID:23880664   PMID:23891934   PMID:23892366   PMID:23911203  
PMID:23913870   PMID:23946445   PMID:23946491   PMID:23951403   PMID:23993924   PMID:23994639   PMID:24003036   PMID:24052814   PMID:24055172   PMID:24058167   PMID:24067355   PMID:24068957  
PMID:24080013   PMID:24131634   PMID:24173808   PMID:24191021   PMID:24194600   PMID:24202302   PMID:24240189   PMID:24260306   PMID:24283209   PMID:24324671   PMID:24336726   PMID:24361260  
PMID:24368139   PMID:24370450   PMID:24385915   PMID:24391519   PMID:24398041   PMID:24415953   PMID:24417671   PMID:24465223   PMID:24479159   PMID:24491691   PMID:24510064   PMID:24523460  
PMID:24553180   PMID:24558432   PMID:24583261   PMID:24586192   PMID:24586749   PMID:24603907   PMID:24633704   PMID:24648278   PMID:24661562   PMID:24680892   PMID:24689077   PMID:24690996  
PMID:24727668   PMID:24751878   PMID:24785830   PMID:24803588   PMID:24803680   PMID:24835669   PMID:24859004   PMID:24886827   PMID:24912677   PMID:24927531   PMID:24946904   PMID:24952961  
PMID:24990742   PMID:24993941   PMID:24996922   PMID:25009997   PMID:25043193   PMID:25043473   PMID:25057208   PMID:25082703   PMID:25082826   PMID:25100655   PMID:25114215   PMID:25139858  
PMID:25142202   PMID:25166858   PMID:25224959   PMID:25249461   PMID:25249463   PMID:25249603   PMID:25274628   PMID:25300579   PMID:25329657   PMID:25378163   PMID:25382630   PMID:25428587  
PMID:25456500   PMID:25480920   PMID:25488119   PMID:25488669   PMID:25491151   PMID:25514175   PMID:25528224   PMID:25546423   PMID:25588837   PMID:25605781   PMID:25617432   PMID:25624266  
PMID:25626636   PMID:25631042   PMID:25670795   PMID:25673119   PMID:25715693   PMID:25759071   PMID:25774506   PMID:25775517   PMID:25778399   PMID:25778822   PMID:25792196   PMID:25810530  
PMID:25828920   PMID:25902523   PMID:25916343   PMID:25926361   PMID:26044505   PMID:26047795   PMID:26062940   PMID:26093309   PMID:26113728   PMID:26121233   PMID:26136503   PMID:26173459  
PMID:26235626   PMID:26238476   PMID:26284287   PMID:26295701   PMID:26321050   PMID:26329601   PMID:26407529   PMID:26411367   PMID:26439398   PMID:26443636   PMID:26450967   PMID:26452989  
PMID:26459142   PMID:26534985   PMID:26555052   PMID:26590087   PMID:26595646   PMID:26661618   PMID:26666591   PMID:26671461   PMID:26681207   PMID:26685326   PMID:26701347   PMID:26721501  
PMID:26745863   PMID:26748560   PMID:26764381   PMID:26769046   PMID:26771354   PMID:26782975   PMID:26811382   PMID:26813283   PMID:26826495   PMID:26827654   PMID:26921474   PMID:26952187  
PMID:26959361   PMID:26975355   PMID:27030507   PMID:27061115   PMID:27068110   PMID:27106761   PMID:27120109   PMID:27143755   PMID:27144312   PMID:27146352   PMID:27178193   PMID:27184910  
PMID:27217206   PMID:27226536   PMID:27234941   PMID:27239041   PMID:27297885   PMID:27320915   PMID:27324164   PMID:27355685   PMID:27405641   PMID:27435625   PMID:27447109   PMID:27447537  
PMID:27479530   PMID:27498006   PMID:27521049   PMID:27522322   PMID:27524617   PMID:27567726   PMID:27601729   PMID:27606604   PMID:27633082   PMID:27633990   PMID:27633995   PMID:27680507  
PMID:27713059   PMID:27732085   PMID:27760115   PMID:27760309   PMID:27770432   PMID:27771509   PMID:27815243   PMID:27827819   PMID:27856416   PMID:27861793   PMID:27864336   PMID:27917898  
PMID:27922003   PMID:28009286   PMID:28011632   PMID:28031177   PMID:28052872   PMID:28069742   PMID:28170287   PMID:28172500   PMID:28186649   PMID:28238550   PMID:28250050   PMID:28442710  
PMID:28484278   PMID:28501478   PMID:28527696   PMID:28538179   PMID:28542142   PMID:28572510   PMID:28579317   PMID:28605600   PMID:28615657   PMID:28619823   PMID:28640846   PMID:28650075  
PMID:28655168   PMID:28687930   PMID:28692808   PMID:28705896   PMID:28797033   PMID:28807898   PMID:28819138   PMID:28827394   PMID:28839193   PMID:28844842   PMID:28846100   PMID:28859094  
PMID:28880267   PMID:28883412   PMID:28922976   PMID:28938441   PMID:28941984   PMID:29029363   PMID:29031500   PMID:29093060   PMID:29109083   PMID:29126155   PMID:29135976   PMID:29139542  
PMID:29148101   PMID:29180744   PMID:29184513   PMID:29229773   PMID:29229885   PMID:29273440   PMID:29292497   PMID:29330161   PMID:29352015   PMID:29357412   PMID:29386134   PMID:29393463  
PMID:29409032   PMID:29428562   PMID:29436597   PMID:29459093   PMID:29462349   PMID:29463648   PMID:29467244   PMID:29467473   PMID:29475039   PMID:29483282   PMID:29489425   PMID:29567669  
PMID:29665134   PMID:29700203   PMID:29738572   PMID:29752282   PMID:29769265   PMID:29771958   PMID:29779282   PMID:29780169   PMID:29852132   PMID:29866044   PMID:29950483   PMID:30008200  
PMID:30044535   PMID:30061196   PMID:30097516   PMID:30116001   PMID:30134070   PMID:30158674   PMID:30169530   PMID:30201295   PMID:30235284   PMID:30254141   PMID:30292786   PMID:30305289  
PMID:30352686   PMID:30377232   PMID:30413887   PMID:30418981   PMID:30424580   PMID:30478225   PMID:30499042   PMID:30504125   PMID:30559277   PMID:30566624   PMID:30570432   PMID:30595533  
PMID:30630826   PMID:30638444   PMID:30651296   PMID:30653268   PMID:30692543   PMID:30714224   PMID:30745426   PMID:30778164   PMID:30794158   PMID:30840660   PMID:30842446   PMID:30853186  
PMID:30854720   PMID:30872278   PMID:30905259   PMID:30916783   PMID:30929920   PMID:30944105   PMID:30963569   PMID:30980961   PMID:31024170   PMID:31028279   PMID:31038803   PMID:31171577  
PMID:31239243   PMID:31242421   PMID:31242446   PMID:31242448   PMID:31260508   PMID:31308417   PMID:31311865   PMID:31315026   PMID:31341279   PMID:31365875   PMID:31442442   PMID:31486675  
PMID:31504243   PMID:31566563   PMID:31591643   PMID:31624071   PMID:31649032   PMID:31676552   PMID:31729356   PMID:31784461   PMID:31843520   PMID:31896583   PMID:31911574   PMID:31932950  
PMID:31941699   PMID:32001436   PMID:32015493   PMID:32029225   PMID:32127020   PMID:32139667   PMID:32147304   PMID:32243674   PMID:32317081   PMID:32319178   PMID:32319199   PMID:32433954  
PMID:32439755   PMID:32439762   PMID:32457985   PMID:32461130   PMID:32467233   PMID:32492250   PMID:32521258   PMID:32537777   PMID:32616504   PMID:32655758   PMID:32664967   PMID:32708917  
PMID:32715478   PMID:32747435   PMID:32760291   PMID:32778568   PMID:32803667   PMID:32840212   PMID:32855417   PMID:32866472   PMID:32878924   PMID:32882513   PMID:32901292   PMID:33060561  
PMID:33177537   PMID:33248111   PMID:33302058   PMID:33329029   PMID:33363172   PMID:33452226   PMID:33469032   PMID:33547543   PMID:33548738   PMID:33580754   PMID:33659251   PMID:33681192  
PMID:33693507   PMID:33759298   PMID:33795231   PMID:33819486   PMID:33895484   PMID:34047208   PMID:34061311   PMID:34091985   PMID:34129836   PMID:34150743   PMID:34256037   PMID:34289374  
PMID:34321664   PMID:34321999   PMID:34323105   PMID:34383890   PMID:34440796   PMID:34445433   PMID:34464660   PMID:34483952   PMID:34499867   PMID:34576009   PMID:34630166   PMID:34637797  
PMID:34845186   PMID:34851738   PMID:34928956   PMID:34995814   PMID:35020897   PMID:35103284   PMID:35147915   PMID:35151207   PMID:35225230   PMID:35364055   PMID:35421372   PMID:35662681  
PMID:35666994   PMID:35676931   PMID:35682694   PMID:35729116   PMID:35803228   PMID:35831953   PMID:35905011   PMID:35907860   PMID:35915750   PMID:35951005   PMID:36026468   PMID:36094016  
PMID:36115458   PMID:36137018   PMID:36414704   PMID:36457800   PMID:36521641   PMID:36566565   PMID:36706916   PMID:36746787   PMID:36762637   PMID:36800350   PMID:36825302   PMID:36910145  
PMID:36916392   PMID:36941249   PMID:36960826   PMID:36994549   PMID:37082965   PMID:37230380   PMID:37237002   PMID:37246809   PMID:37279265   PMID:37415159   PMID:37471320   PMID:37497597  
PMID:37555328   PMID:37577930   PMID:37589451   PMID:37607547   PMID:37702066   PMID:37794731   PMID:37845394   PMID:38101122   PMID:38176908   PMID:38355793   PMID:38404688   PMID:38727271  
PMID:38752427   PMID:38871845   PMID:38910391   PMID:38923264   PMID:39196111   PMID:39216769   PMID:39294373   PMID:39798644   PMID:39817691   PMID:39890843   PMID:40072077  


Genomics

Comparative Map Data
Bmp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391446,620,982 - 46,628,126 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1446,620,977 - 46,628,126 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381446,383,525 - 46,390,669 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1446,383,520 - 46,390,669 (-)Ensemblmm10GRCm38
MGSCv371447,003,195 - 47,010,274 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361445,305,736 - 45,309,065 (-)NCBIMGSCv36mm8
Celera1442,555,453 - 42,562,519 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1423.95NCBI
BMP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381453,949,736 - 53,956,891 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1453,949,736 - 53,958,761 (-)Ensemblhg38GRCh38
GRCh371454,416,454 - 54,423,609 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361453,486,204 - 53,493,304 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341453,486,206 - 53,491,020NCBI
Celera1434,466,196 - 34,473,296 (-)NCBICelera
Cytogenetic Map14q22.2NCBI
HuRef1434,579,652 - 34,586,754 (-)NCBIHuRef
CHM1_11454,355,438 - 54,362,538 (-)NCBICHM1_1
T2T-CHM13v2.01448,157,959 - 48,165,118 (-)NCBIT2T-CHM13v2.0
Bmp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81522,098,191 - 22,113,145 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1522,098,470 - 22,105,172 (-)EnsemblGRCr8
mRatBN7.21519,618,538 - 19,633,494 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1519,618,542 - 19,623,306 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1522,400,667 - 22,404,237 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01523,358,675 - 23,362,245 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01521,608,597 - 21,612,175 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01520,776,060 - 20,791,013 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1520,776,054 - 20,822,740 (-)Ensemblrn6Rnor6.0
Rnor_5.01524,734,987 - 24,749,935 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41522,283,171 - 22,286,757 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1520,029,866 - 20,033,452 (-)NCBICelera
RGSC_v3.11522,298,892 - 22,305,718 (-)NCBI
RH 3.4 Map15185.6RGD
Cytogenetic Map15p14NCBI
Bmp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554099,432,841 - 9,440,303 (+)Ensembl
ChiLan1.0NW_0049554099,432,835 - 9,439,680 (+)NCBIChiLan1.0ChiLan1.0
BMP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21555,076,681 - 55,083,868 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11454,293,198 - 54,548,492 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01434,542,132 - 34,549,286 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11452,821,872 - 52,828,781 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1452,821,872 - 52,828,752 (-)EnsemblpanPan2panpan1.1
BMP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1829,997,563 - 30,254,307 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl829,997,569 - 30,004,557 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha829,765,711 - 29,772,707 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0830,252,884 - 30,601,864 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl830,252,890 - 30,259,884 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1829,856,480 - 29,863,475 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0829,933,754 - 29,940,734 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0830,299,531 - 30,306,532 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dog Cytomap8q21NCBI
Bmp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864075,280,082 - 75,287,313 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366971,056,636 - 1,061,468 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366971,054,237 - 1,061,468 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1183,416,146 - 183,422,637 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11183,415,989 - 183,422,888 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21203,773,963 - 203,780,310 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BMP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12431,097,673 - 31,104,774 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2431,097,538 - 31,101,225 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605319,326,010 - 19,333,125 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bmp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473115,263,274 - 15,269,743 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473115,262,480 - 15,269,196 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Bmp4
279 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:355
Count of miRNA genes:255
Interacting mature miRNAs:274
Transcripts:ENSMUST00000074077, ENSMUST00000100676, ENSMUST00000135408
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
27226775Tibl7_mtibia length 7, 5 week (mouse)143032195748837457Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300544Hypn_mhyperinsulinemia (mouse)Not determined141516061649160765Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
4141864Mrdq4_mmodifier of retinal degeneration QTL 4 (mouse)Not determined992324548765082Mouse
27226752Femd4_mfemur midshaft diameter 4, 5 week (mouse)141376927347237457Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
27226748Femd8_mfemur midshaft diameter 8, 10 week (mouse)141376927346737457Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
27226744Metcl6_mmetatarsal-calcaneal length 6, 5 week (mouse)143032195752937457Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143322195759437449Mouse
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
27226727Tibl21_mtibia length 21, 16 week (mouse)143412195752937457Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse

Markers in Region
Bmp4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381446,385,970 - 46,386,083UniSTSGRCm38
MGSCv371447,005,396 - 47,005,757UniSTSGRCm37
MGSCv371447,004,179 - 47,005,415UniSTSGRCm37
MGSCv371447,004,197 - 47,005,592UniSTSGRCm37
MGSCv371447,003,844 - 47,005,412UniSTSGRCm37
Celera1442,557,900 - 42,558,013UniSTS
Cytogenetic Map14C1UniSTS
cM Map1415.0UniSTS
cM Map1415.0UniSTS
RH94860  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381446,383,740 - 46,383,955UniSTSGRCm38
MGSCv371447,003,415 - 47,003,630UniSTSGRCm37
Celera1442,555,675 - 42,555,884UniSTS
Cytogenetic Map14C1UniSTS
cM Map1415.0UniSTS
D14Mit129  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381446,383,749 - 46,383,892UniSTSGRCm38
MGSCv371447,003,424 - 47,003,567UniSTSGRCm37
Celera1442,555,684 - 42,555,821UniSTS
Cytogenetic Map14C1UniSTS
cM Map1414.5UniSTS
Whitehead Genetic1421.9UniSTS
Whitehead_YAC14 UniSTS
PMC156609P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381446,387,153 - 46,387,250UniSTSGRCm38
MGSCv371447,006,828 - 47,006,925UniSTSGRCm37
Celera1442,559,084 - 42,559,181UniSTS
Cytogenetic Map14C1UniSTS
cM Map1415.0UniSTS
PMC316400P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381446,383,870 - 46,384,663UniSTSGRCm38
MGSCv371447,003,545 - 47,004,338UniSTSGRCm37
Celera1442,555,799 - 42,556,592UniSTS
Cytogenetic Map14C1UniSTS
cM Map1415.0UniSTS
PMC316400P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381446,383,870 - 46,384,344UniSTSGRCm38
MGSCv371447,003,545 - 47,004,019UniSTSGRCm37
Celera1442,555,799 - 42,556,273UniSTS
Cytogenetic Map14C1UniSTS
cM Map1415.0UniSTS
MARC_5761-5762:996690803:2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381446,386,062 - 46,387,232UniSTSGRCm38
MGSCv371447,005,737 - 47,006,907UniSTSGRCm37
Celera1442,557,992 - 42,559,163UniSTS
Cytogenetic Map14C1UniSTS
cM Map1415.0UniSTS
BMP4_296  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381446,383,621 - 46,384,545UniSTSGRCm38
MGSCv371447,003,296 - 47,004,220UniSTSGRCm37
Celera1442,555,554 - 42,556,474UniSTS
Cytogenetic Map14C1UniSTS
cM Map1415.0UniSTS
Bmp4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14C1UniSTS
Bmp4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14C1UniSTS
Bmp4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381446,384,169 - 46,385,737UniSTSGRCm38
MGSCv371447,003,844 - 47,005,412UniSTSGRCm37
Celera1442,556,098 - 42,557,667UniSTS
Cytogenetic Map14C1UniSTS
cM Map1415.0UniSTS
Bmp4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381446,384,522 - 46,385,917UniSTSGRCm38
MGSCv371447,004,197 - 47,005,592UniSTSGRCm37
Celera1442,556,451 - 42,557,847UniSTS
Cytogenetic Map14C1UniSTS
Bmp4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381446,385,721 - 46,386,082UniSTSGRCm38
MGSCv371447,005,396 - 47,005,757UniSTSGRCm37
Celera1442,557,651 - 42,558,012UniSTS
Cytogenetic Map14C1UniSTS
Bmp4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381446,384,504 - 46,385,740UniSTSGRCm38
MGSCv371447,004,179 - 47,005,415UniSTSGRCm37
Celera1442,556,433 - 42,557,670UniSTS
Cytogenetic Map14C1UniSTS
Bmp4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14C1UniSTS
cM Map1415.0UniSTS
Bmp4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14C1UniSTS
Bmp4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14C1UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000074077   ⟹   ENSMUSP00000073720
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1446,620,977 - 46,628,126 (-)Ensembl
GRCm38.p6 Ensembl1446,383,520 - 46,390,669 (-)Ensembl
Ensembl Acc Id: ENSMUST00000100676   ⟹   ENSMUSP00000098242
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1446,621,164 - 46,628,007 (-)Ensembl
GRCm38.p6 Ensembl1446,383,707 - 46,390,550 (-)Ensembl
Ensembl Acc Id: ENSMUST00000135408
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1446,624,453 - 46,627,992 (-)Ensembl
GRCm38.p6 Ensembl1446,386,996 - 46,390,535 (-)Ensembl
Ensembl Acc Id: ENSMUST00000226759
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1446,623,443 - 46,624,761 (-)Ensembl
GRCm38.p6 Ensembl1446,385,986 - 46,387,304 (-)Ensembl
RefSeq Acc Id: NM_001316360   ⟹   NP_001303289
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391446,620,982 - 46,628,126 (-)NCBI
GRCm381446,383,525 - 46,390,669 (-)NCBI
Sequence:
RefSeq Acc Id: NM_007554   ⟹   NP_031580
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391446,620,982 - 46,628,126 (-)NCBI
GRCm381446,383,525 - 46,390,669 (-)NCBI
MGSCv371447,003,195 - 47,010,274 (-)RGD
Celera1442,555,453 - 42,562,519 (-)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_031580   ⟸   NM_007554
- Peptide Label: preproprotein
- UniProtKB: P21275 (UniProtKB/Swiss-Prot),   Q3ULR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001303289   ⟸   NM_001316360
- Peptide Label: preproprotein
- UniProtKB: P21275 (UniProtKB/Swiss-Prot),   Q3ULR1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000073720   ⟸   ENSMUST00000074077
Ensembl Acc Id: ENSMUSP00000098242   ⟸   ENSMUST00000100676
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21275-F1-model_v2 AlphaFold P21275 1-408 view protein structure

Promoters
RGD ID:8682046
Promoter ID:EPDNEW_M19054
Type:initiation region
Name:Bmp4_1
Description:Mus musculus bone morphogenetic protein 4 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19055  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381446,387,275 - 46,387,335EPDNEW
RGD ID:8682048
Promoter ID:EPDNEW_M19055
Type:initiation region
Name:Bmp4_2
Description:Mus musculus bone morphogenetic protein 4 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19054  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381446,390,582 - 46,390,642EPDNEW
RGD ID:6849024
Promoter ID:MM_XEF:2202
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_130851
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361447,008,026 - 47,008,657 (-)MPROMDB
RGD ID:6824730
Promoter ID:MM_KWN:16446
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung,   MEF_B6
Transcripts:ENSMUST00000100676,   OTTMUST00000046636,   OTTMUST00000046638
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361447,009,916 - 47,010,416 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88180 AgrOrtholog
Ensembl Genes ENSMUSG00000021835 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000074077 ENTREZGENE
  ENSMUST00000074077.12 UniProtKB/Swiss-Prot
  ENSMUST00000100676 ENTREZGENE
  ENSMUST00000100676.3 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
  2.60.120.970 UniProtKB/Swiss-Prot
InterPro BMP4_TGF_beta-like UniProtKB/Swiss-Prot
  Cystine-knot_cytokine UniProtKB/Swiss-Prot
  TGF-b_C UniProtKB/Swiss-Prot
  TGF-b_propeptide UniProtKB/Swiss-Prot
  TGF-beta-rel UniProtKB/Swiss-Prot
  TGFb_CS UniProtKB/Swiss-Prot
KEGG Report mmu:12159 UniProtKB/Swiss-Prot
MGD MGI:88180 ENTREZGENE
NCBI Gene 12159 ENTREZGENE
PANTHER BONE MORPHOGENETIC PROTEIN 4 UniProtKB/Swiss-Prot
  PTHR11848 UniProtKB/Swiss-Prot
Pfam TGF_beta UniProtKB/Swiss-Prot
  TGFb_propeptide UniProtKB/Swiss-Prot
PhenoGen Bmp4 PhenoGen
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot
  TGF_BETA_2 UniProtKB/Swiss-Prot
SMART TGFB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt BMP4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3ULR1 ENTREZGENE, UniProtKB/TrEMBL