Bmp4 (bone morphogenetic protein 4) - Rat Genome Database

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Gene: Bmp4 (bone morphogenetic protein 4) Mus musculus
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Symbol: Bmp4
Name: bone morphogenetic protein 4
RGD ID: 10244
MGI Page MGI
Description: Enables heparin binding activity. Involved in several processes, including circulatory system development; positive regulation of cell differentiation; and regulation of morphogenesis of a branching structure. Acts upstream of with a positive effect on positive regulation of protein localization to nucleus. Acts upstream of or within several processes, including embryonic morphogenesis; morphogenesis of a branching epithelium; and nervous system development. Located in extracellular space. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Axenfeld-Rieger syndrome type 3; atrioventricular septal defect; cleft palate-lateral synechia syndrome; fibrodysplasia ossificans progressiva; and urinary system disease. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and syndromic microphthalmia 6. Orthologous to human BMP4 (bone morphogenetic protein 4).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Bmp-; BMP-2B; Bmp-4; Bmp2; Bmp2b; Bmp2b-; Bmp2b-1; Bmp2b1; bone morphogenetic protein 2B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Bmp4-ps  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391446,620,982 - 46,628,126 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1446,620,977 - 46,628,126 (-)EnsemblGRCm39 Ensembl
GRCm381446,383,525 - 46,390,669 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1446,383,520 - 46,390,669 (-)EnsemblGRCm38mm10GRCm38
MGSCv371447,003,195 - 47,010,274 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361445,305,736 - 45,309,065 (-)NCBIMGSCv36mm8
Celera1442,555,453 - 42,562,519 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1423.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
ACTH-secreting pituitary adenoma  (ISO)
Acute Otitis Media  (IEP)
Alzheimer's disease  (IEP)
amenorrhea  (ISO)
Anorectal Malformations  (ISO)
APLASIA/HYPOPLASIA INVOLVING BONES OF THE LOWER LIMBS  (ISO)
atrial heart septal defect  (ISO)
atrioventricular septal defect  (IAGP)
Axenfeld-Rieger syndrome type 3  (IAGP)
Barrett's esophagus  (ISO)
Brain Hypoxia-Ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
CAKUT  (ISO)
CAKUT2  (ISO)
calcinosis  (ISO)
Cardiomegaly  (IEP)
cartilage disease  (ISO)
Cartilage Fractures  (ISO)
CHARGE syndrome  (IEP)
Choroidal Neovascularization  (IDA,IEP)
cleft lip  (ISO)
cleft palate-lateral synechia syndrome  (IAGP)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
Congenital Limb Deformities  (ISO)
Cranial Nerve Injuries  (ISO)
Diaphragmatic Hernia  (ISO)
DOPA-responsive dystonia  (ISO)
Endometrioid Carcinomas  (ISO)
epilepsy  (ISO)
esophagitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Femoral Fractures  (ISO)
Fetal Growth Retardation  (ISO)
fibrodysplasia ossificans progressiva  (IAGP)
Focal Cortical Dysplasia of Taylor  (ISO)
genetic disease  (ISO)
Gliosis  (ISO)
granulosa cell tumor  (IEP)
Hearing Loss  (IMP)
hereditary spastic paraplegia 28  (ISO)
Hyperoxia  (ISO)
Kapur Toriello Syndrome  (ISO)
keratoconus  (ISO)
macular degeneration  (ISO)
melanoma  (ISO)
Multicystic Dysplastic Kidney  (ISO)
myositis ossificans  (ISO)
ocular hypertension  (IMP)
Oral Lichen Planus  (ISO)
orofacial cleft  (ISO)
orofacial cleft 11  (ISO)
ossification of the posterior longitudinal ligament of spine  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Experimental  (ISO)
osteoporosis  (ISO)
otosclerosis  (ISO)
peptic esophagitis  (ISO)
Peters anomaly  (ISO)
physical disorder  (IAGP)
progressive osseous heteroplasia  (ISO)
prolactinoma  (IEP,ISO)
prostate carcinoma  (ISO)
psoriatic arthritis  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
Skull Fractures  (ISO)
Spinal Cord Injuries  (ISO)
strabismus  (ISO)
Stroke  (ISO)
syndromic microphthalmia  (ISO)
syndromic microphthalmia 6  (ISO)
Tibial Fractures  (ISO)
tooth agenesis  (ISO)
Tracheoesophageal Fistula  (ISO)
tuberous sclerosis  (ISO)
urinary system disease  (IAGP)
Vitamin A Deficiency  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-amphetamine  (EXP)
(S)-nicotine  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acrylamide  (EXP)
adenosine  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
alpha-Zearalanol  (ISO)
aluminium oxide  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
angiotensin II  (EXP)
antimonite  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
bacitracin  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bucladesine  (ISO)
busulfan  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
casticin  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dichromium trioxide  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (EXP)
dioxygen  (EXP)
disodium selenite  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
ethylenediaminetetraacetic acid  (ISO)
Ethylenethiourea  (ISO)
flavonoids  (ISO)
flusilazole  (EXP)
folic acid  (EXP)
fulvestrant  (ISO)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glycidol  (ISO)
hydrogen peroxide  (EXP,ISO)
icariin  (EXP,ISO)
iloprost  (ISO)
indole-3-methanol  (ISO)
isoprenaline  (ISO)
kaempferol  (EXP)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
maneb  (EXP)
manganese(II) chloride  (EXP)
mercury dibromide  (ISO)
metformin  (ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mitomycin C  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
naringin  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nitrates  (ISO)
nitrofen  (ISO)
ochratoxin A  (ISO)
octreotide  (ISO)
orphenadrine  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
pasireotide  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pinosylvin  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
Ptaquiloside  (EXP)
quercetin  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (EXP)
rifampicin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chlorate  (ISO)
sodium dichromate  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trans-pinosylvin  (ISO)
trichostatin A  (ISO)
tyrphostin AG 1478  (ISO)
urethane  (EXP,ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ameloblast differentiation  (IDA)
anatomical structure formation involved in morphogenesis  (IGI)
anatomical structure regression  (ISO)
angiogenesis  (IMP)
anterior/posterior axis specification  (IGI)
aortic valve morphogenesis  (IMP)
apoptotic process involved in endocardial cushion morphogenesis  (IMP)
blood vessel development  (IDA)
blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO,ISS)
BMP signaling pathway  (IBA,IDA,IGI,IMP,ISO,ISS)
bone development  (IDA)
branching involved in prostate gland morphogenesis  (IMP)
branching involved in ureteric bud morphogenesis  (IGI,ISO)
bronchus development  (ISO)
bud dilation involved in lung branching  (ISO)
bud elongation involved in lung branching  (IDA)
camera-type eye development  (IGI,IMP)
camera-type eye morphogenesis  (IMP)
cardiac jelly development  (IMP)
cardiac muscle cell differentiation  (IGI,NAS)
cardiac muscle hypertrophy in response to stress  (ISO)
cardiac right ventricle morphogenesis  (IMP)
cartilage development  (IEA)
cell differentiation  (IEA)
cell fate commitment  (IDA)
cell population proliferation  (IGI)
cellular response to BMP stimulus  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to growth factor stimulus  (IDA)
cellular response to mechanical stimulus  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to thyroid hormone stimulus  (ISO)
chondrocyte differentiation  (IDA,IMP)
coronary vasculature development  (IMP)
cranial suture morphogenesis  (IDA)
deltoid tuberosity development  (IMP)
dorsal/ventral neural tube patterning  (IDA)
embryonic cranial skeleton morphogenesis  (IMP)
embryonic digit morphogenesis  (IGI)
embryonic hindlimb morphogenesis  (IGI)
embryonic limb morphogenesis  (IGI,IMP)
embryonic morphogenesis  (IMP)
embryonic skeletal joint morphogenesis  (IGI,IMP)
embryonic skeletal system development  (IMP)
embryonic skeletal system morphogenesis  (IMP)
endocardial cushion development  (IMP)
endochondral ossification  (IMP)
endoderm development  (IDA)
epithelial cell proliferation  (IGI)
epithelial cell proliferation involved in lung morphogenesis  (ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (IMP)
epithelial tube branching involved in lung morphogenesis  (ISO)
epithelial-mesenchymal cell signaling  (IDA)
epithelium development  (IDA)
erythrocyte differentiation  (IDA)
eye development  (IGI)
forebrain development  (IGI,IMP)
gene expression  (IDA)
germ cell development  (IMP)
glomerular capillary formation  (IMP)
heart development  (IMP)
heart induction  (ISO)
heart morphogenesis  (ISO)
hematopoietic progenitor cell differentiation  (IDA,ISO)
inner ear auditory receptor cell differentiation  (IGI)
intermediate mesodermal cell differentiation  (ISO,ISS)
kidney development  (IGI,IMP,ISO,ISS)
lens induction in camera-type eye  (IMP)
lung alveolus development  (ISO)
lung development  (IMP)
lung lobe development  (ISO)
lung morphogenesis  (ISO)
lung vasculature development  (ISO,ISS)
lymphoid progenitor cell differentiation  (ISO,ISS)
macrophage differentiation  (IEA,ISO)
mammary gland formation  (IMP)
membranous septum morphogenesis  (IMP)
mesoderm formation  (IDA)
mesodermal cell differentiation  (IDA)
mesodermal cell fate determination  (IMP)
mesonephros development  (ISO)
metanephros development  (IDA,IMP)
monocyte differentiation  (IEA,ISO)
muscular septum morphogenesis  (IMP)
negative regulation of branching involved in ureteric bud morphogenesis  (IDA,IGI,ISO)
negative regulation of cell cycle  (ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of chondrocyte differentiation  (IDA)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of epithelial cell proliferation  (IGI,IMP)
negative regulation of extrinsic apoptotic signaling pathway  (IMP)
negative regulation of gene expression  (IDA,ISO)
negative regulation of glomerular mesangial cell proliferation  (ISO,ISS)
negative regulation of glomerulus development  (ISO,ISS)
negative regulation of immature T cell proliferation in thymus  (ISO,ISS)
negative regulation of mesenchymal cell proliferation involved in ureter development  (ISO,ISS)
negative regulation of metanephric comma-shaped body morphogenesis  (ISO,ISS)
negative regulation of metanephric S-shaped body morphogenesis  (ISO,ISS)
negative regulation of miRNA transcription  (IEA,ISO)
negative regulation of mitotic nuclear division  (ISO,ISS)
negative regulation of myoblast differentiation  (ISO)
negative regulation of oligodendrocyte differentiation  (ISO)
negative regulation of prostatic bud formation  (IDA,IMP)
negative regulation of striated muscle tissue development  (ISO)
negative regulation of T cell differentiation in thymus  (ISO)
negative regulation of thymocyte apoptotic process  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
nephric duct formation  (ISO)
neural tube closure  (IDA)
neuron fate commitment  (IDA,IMP)
odontogenesis  (ISO,ISS)
odontogenesis of dentin-containing tooth  (IDA,IGI)
organ induction  (IMP)
ossification  (IEA)
osteoblast differentiation  (IDA,ISO,ISS)
outflow tract morphogenesis  (IGI)
outflow tract septum morphogenesis  (IMP)
ovarian follicle development  (ISO)
pericyte cell differentiation  (IDA)
pharyngeal arch artery morphogenesis  (IMP)
pituitary gland development  (IMP)
positive chemotaxis  (ISS)
positive regulation of apoptotic process  (ISO)
positive regulation of BMP signaling pathway  (IDA)
positive regulation of bone mineralization  (ISO,ISS)
positive regulation of branching involved in lung morphogenesis  (IMP)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of calcium ion transport into cytosol  (ISO)
positive regulation of cardiac muscle fiber development  (ISO,ISS)
positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis  (IGI)
positive regulation of cartilage development  (ISO)
positive regulation of cell migration  (IMP)
positive regulation of cell population proliferation  (IMP,ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of DNA-templated transcription  (ISO,ISS,TAS)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of endothelial cell differentiation  (IDA)
positive regulation of endothelial cell migration  (TAS)
positive regulation of endothelial cell proliferation  (IDA)
positive regulation of epidermal cell differentiation  (ISO,ISS)
positive regulation of epithelial cell differentiation  (IDA)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (IGI)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of gene expression  (IDA,IMP,ISO)
positive regulation of hepatocyte differentiation  (ISO)
positive regulation of mesenchymal stem cell proliferation  (ISO)
positive regulation of miRNA transcription  (IGI)
positive regulation of neuron differentiation  (IDA,ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of odontoblast differentiation  (IMP)
positive regulation of ossification  (IDA,ISO)
positive regulation of osteoblast differentiation  (ISO,ISS)
positive regulation of p38MAPK cascade  (IEA,ISO)
positive regulation of primary miRNA processing  (IEA,ISO)
positive regulation of programmed cell death  (ISO)
positive regulation of protein localization to nucleus  (IMP)
positive regulation of protein phosphorylation  (IEA,IMP,ISO)
positive regulation of SMAD protein signal transduction  (ISO,ISS)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of store-operated calcium channel activity  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (TAS)
post-embryonic development  (IMP,ISO)
programmed cell death  (ISO)
prostate gland morphogenesis  (IMP)
prostatic bud formation  (IMP)
pulmonary valve morphogenesis  (IMP)
regulation of branching involved in prostate gland morphogenesis  (IMP)
regulation of cartilage development  (IDA)
regulation of cell differentiation  (IGI,ISO)
regulation of cell fate commitment  (ISO,ISS)
regulation of endothelial cell proliferation  (TAS)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of gene expression  (IDA,IMP)
regulation of mesodermal cell differentiation  (IDA,IGI)
regulation of miRNA transcription  (ISO)
regulation of morphogenesis of a branching structure  (IMP)
regulation of odontogenesis of dentin-containing tooth  (IGI)
regulation of protein import into nucleus  (ISO)
regulation of smooth muscle cell differentiation  (IDA,IGI)
regulation of smooth muscle cell proliferation  (IDA)
renal system process  (IMP)
response to estradiol  (ISO)
response to glucocorticoid  (ISO)
response to mechanical stimulus  (ISO)
response to nitric oxide  (ISO)
response to organic cyclic compound  (ISO)
response to retinoic acid  (ISO)
response to testosterone  (ISO)
retina development in camera-type eye  (ISO)
secondary heart field specification  (ISO)
skeletal system development  (IDA,IMP)
smooth muscle cell differentiation  (IDA)
smooth muscle tissue development  (IMP)
specification of animal organ position  (IMP)
telencephalon development  (ISO)
telencephalon regionalization  (IDA,IGI)
tendon cell differentiation  (IMP)
tongue morphogenesis  (ISO)
trachea development  (ISO)
trachea formation  (IMP)
transcription by RNA polymerase II  (IDA)
type B pancreatic cell development  (ISO)
ureter morphogenesis  (IMP)
ureteric bud development  (IDA,IMP,ISO)
vasculature development  (IMP)

Cellular Component
extracellular region  (IDA,TAS)
extracellular space  (IBA,IDA,ISO)
vesicle  (ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal allantois morphology  (IAGP)
abnormal amniotic cavity morphology  (IAGP)
abnormal angiogenesis  (IAGP)
abnormal anterior eye segment morphology  (IAGP)
abnormal aortic arch and aortic arch branch attachment  (IAGP)
abnormal apical ectodermal ridge morphology  (IAGP)
abnormal artery morphology  (IAGP)
abnormal atrioventricular cushion morphology  (IAGP)
abnormal autopod morphology  (IAGP)
abnormal bone marrow cavity morphology  (IAGP)
abnormal bone marrow development  (IAGP)
abnormal bone ossification  (IAGP)
abnormal canal of Schlemm morphology  (IAGP)
abnormal cardiac mesenchyme morphology  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cartilage development  (IAGP)
abnormal caudal vertebrae morphology  (IAGP)
abnormal chorion morphology  (IAGP)
abnormal conotruncal ridge morphology  (IAGP)
abnormal cornea morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal diencephalon morphology  (IAGP)
abnormal digit morphology  (IAGP)
abnormal ear development  (IAGP)
abnormal embryo development  (IEA)
abnormal embryo size  (IEA)
abnormal embryo turning  (IEA)
abnormal embryonic cloaca development  (IAGP)
abnormal endolymphatic duct morphology  (IAGP)
abnormal external female genitalia morphology  (IAGP)
abnormal extraembryonic mesoderm development  (IAGP)
abnormal eye anterior chamber depth  (IEA)
abnormal eye development  (IAGP)
abnormal eye distance/ position  (IAGP)
abnormal eye electrophysiology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal eye size  (IAGP)
abnormal face development  (IAGP)
abnormal fertility/fecundity  (IAGP)
abnormal fibula morphology  (IAGP)
abnormal forebrain development  (IEA)
abnormal forebrain morphology  (IAGP)
abnormal foregut morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal forelimb stylopod morphology  (IAGP)
abnormal forelimb zeugopod morphology  (IAGP)
abnormal frontal bone morphology  (IAGP)
abnormal head mesenchyme morphology  (IAGP)
abnormal heart and great artery attachment  (IAGP)
abnormal heart development  (IAGP)
abnormal heart looping  (IAGP)
abnormal heart morphology  (IEA)
abnormal heart right ventricle morphology  (IAGP)
abnormal heart right ventricle pressure  (IAGP)
abnormal heart ventricle outflow tract morphology  (IAGP)
abnormal hindbrain development  (IEA)
abnormal hindlimb bud morphology  (IAGP)
abnormal hindlimb stylopod morphology  (IAGP)
abnormal hindlimb zeugopod morphology  (IAGP)
abnormal inner ear morphology  (IAGP)
abnormal interdigital cell death  (IAGP)
abnormal interparietal bone morphology  (IAGP)
abnormal iridocorneal angle  (IAGP)
abnormal iris morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal kidney mesenchyme morphology  (IAGP)
abnormal lateral ganglionic eminence morphology  (IAGP)
abnormal lateral plate mesoderm morphology  (IAGP)
abnormal lateral semicircular canal morphology  (IAGP)
abnormal lens induction  (IAGP)
abnormal limb development  (IAGP)
abnormal line of Schwalbe morphology  (IAGP)
abnormal liver bud morphology  (IAGP)
abnormal long bone diaphysis morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal male reproductive system morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal mandibular angle morphology  (IAGP)
abnormal mandibular condyloid process morphology  (IAGP)
abnormal maxilla morphology  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal metanephric mesenchyme morphology  (IAGP)
abnormal midbrain development  (IEA)
abnormal mouth morphology  (IAGP)
abnormal nasal bone morphology  (IAGP)
abnormal nasal cartilage morphology  (IAGP)
abnormal nephrogenic zone morphology  (IAGP)
abnormal neural tube closure  (IEA)
abnormal nose morphology  (IAGP)
abnormal optic disk morphology  (IAGP)
abnormal optic nerve morphology  (IAGP)
abnormal organ of Corti morphology  (IAGP)
abnormal pharyngeal arch artery morphology  (IAGP)
abnormal placement of pupils  (IAGP)
abnormal posterior eye segment morphology  (IAGP)
abnormal posterior primitive streak morphology  (IAGP)
abnormal primitive node morphology  (IAGP)
abnormal prostate gland anterior lobe morphology  (IAGP)
abnormal pulmonary artery morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal/urinary system morphology  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal retina blood vessel pattern  (IAGP)
abnormal retina inner nuclear layer morphology  (IEA)
abnormal retina morphology  (IAGP)
abnormal retina outer nuclear layer morphology  (IEA)
abnormal retina photoreceptor layer morphology  (IAGP)
abnormal rib morphology  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal scala media morphology  (IAGP)
abnormal semicircular canal ampulla morphology  (IAGP)
abnormal semicircular canal morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal sensory neuron innervation pattern  (IAGP)
abnormal skeleton development  (IAGP)
abnormal snout morphology  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal sternum ossification  (IAGP)
abnormal tail morphology  (IAGP)
abnormal temporal bone squamous part morphology  (IAGP)
abnormal thoracic cage morphology  (IAGP)
abnormal truncus arteriosus septation  (IAGP)
abnormal tympanic ring morphology  (IAGP)
abnormal ureter development  (IAGP)
abnormal ureter morphology  (IAGP)
abnormal ureter smooth muscle morphology  (IAGP)
abnormal ureteral orifice morphology  (IAGP)
abnormal ureteric bud elongation  (IAGP)
abnormal ureterovesical junction morphology  (IAGP)
abnormal utricle morphology  (IAGP)
abnormal vascular endothelial cell physiology  (IAGP)
abnormal vascular smooth muscle morphology  (IAGP)
abnormal vertebrae development  (IAGP)
abnormal vertebral arch development  (IAGP)
abnormal vertebral arch morphology  (IAGP)
abnormal vertebral body development  (IAGP)
abnormal vertebral spinous process morphology  (IAGP)
abnormal vestibular saccule morphology  (IAGP)
abnormal vestibulocollic reflex  (IAGP)
abnormal visceral yolk sac mesenchyme morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitreous body morphology  (IAGP)
abnormal Wolffian duct morphology  (IAGP)
absent alisphenoid bone  (IAGP)
absent allantois  (IAGP)
absent frontal bone  (IAGP)
absent lateral semicircular canal  (IAGP)
absent mandible  (IAGP)
absent mandibular angle  (IAGP)
absent mandibular condyloid process  (IAGP)
absent mandibular coronoid process  (IAGP)
absent maxilla  (IAGP)
absent nasal bone  (IAGP)
absent nasal septum  (IAGP)
absent optic nerve  (IAGP)
absent primordial germ cells  (IAGP)
absent Rathke's pouch  (IAGP)
absent Schlemm's canal  (IAGP)
absent semicircular canals  (IAGP)
absent temporal bone squamous part  (IAGP)
absent tongue  (IAGP)
absent trabecular meshwork  (IAGP)
absent tympanic ring  (IAGP)
absent urinary bladder  (IAGP)
absent visceral yolk sac blood islands  (IAGP)
absent vitelline blood vessels  (IAGP)
absent zygomatic bone  (IAGP)
anal stenosis  (IAGP)
anophthalmia  (IAGP)
anterior cortical cataract  (IAGP)
anterior iris synechia  (IAGP)
anterior subcapsular cataract  (IAGP)
aortopulmonary window  (IAGP)
asymmetric rib joints  (IAGP)
atrial septal defect  (IAGP)
bifid ureter  (IAGP)
broad limb buds  (IAGP)
buphthalmos  (IAGP)
cataract  (IAGP)
cervical vertebral fusion  (IAGP)
circling  (IAGP)
cleft palate  (IAGP)
common atrioventricular valve  (IAGP)
complete atrioventricular septal defect  (IAGP)
conotruncal ridge hypoplasia  (IAGP)
cornea opacity  (IAGP)
decreased anxiety-related response  (IEA)
decreased autopod size  (IAGP)
decreased body weight  (IAGP)
decreased cornea thickness  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased hair follicle number  (IAGP)
decreased lateral semicircular canal size  (IAGP)
decreased litter size  (IAGP)
decreased primordial germ cell number  (IAGP)
decreased rib number  (IAGP)
decreased total retina thickness  (IEA)
decreased tympanic ring size  (IAGP)
decreased vestibular hair cell stereocilia number  (IAGP)
delayed bone ossification  (IAGP)
delayed endochondral bone ossification  (IAGP)
delayed hepatic development  (IAGP)
dilated kidney calyx  (IAGP)
dilated ureter  (IAGP)
double outlet right ventricle  (IAGP)
duplex kidney  (IAGP)
ectopic ureter  (IAGP)
ectopic ureteric bud  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality prior to tooth bud stage  (IEA)
embryonic lethality, complete penetrance  (IAGP)
enlarged kidney  (IAGP)
enlarged Meckel's cartilage  (IAGP)
external male genitalia hypoplasia  (IAGP)
eyelids fail to open  (IAGP)
failure of primitive streak formation  (IAGP)
failure of ventral body wall closure  (IAGP)
fused joints  (IAGP)
heart right ventricle hypertrophy  (IAGP)
holoprosencephaly  (IAGP)
hydronephrosis  (IAGP)
hydrops fetalis  (IAGP)
hydroureter  (IAGP)
hyperactivity  (IEA)
hypoplastic trabecular meshwork  (IAGP)
impaired hearing  (IAGP)
impaired osteoblast differentiation  (IAGP)
impaired skin barrier function  (IAGP)
increased circulating glucose level  (IAGP)
increased grip strength  (IEA)
increased metanephric mesenchyme apoptosis  (IAGP)
increased opacity of vitreous body  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
interrupted aortic arch, type b  (IAGP)
iris hypoplasia  (IAGP)
irregularly shaped pupil  (IAGP)
kidney atrophy  (IAGP)
kidney cyst  (IAGP)
kinked tail  (IAGP)
large anterior fontanelle  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lowered ear position  (IAGP)
microphthalmia  (IAGP)
mydriasis  (IAGP)
no abnormal phenotype detected  (IAGP)
ocular hypertension  (IAGP)
omphalocele  (IAGP)
oral atresia  (IAGP)
ostium primum atrial septal defect  (IAGP)
partial atrioventricular septal defect  (IAGP)
pericardial edema  (IAGP)
pericardial effusion  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
perinatal lethality  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
persistence of hyaloid vascular system  (IAGP)
persistent truncus arteriosus  (IAGP)
polycystic kidney  (IAGP)
polydactyly  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
preaxial polydactyly  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
reduced female fertility  (IAGP)
renal hypoplasia  (IAGP)
retina detachment  (IAGP)
retrognathia  (IAGP)
rib fusion  (IAGP)
round head  (IAGP)
semilunar valve hypoplasia  (IAGP)
seminiferous tubule degeneration  (IAGP)
short face  (IAGP)
short frontal bone  (IAGP)
short mandible  (IAGP)
short maxilla  (IAGP)
short nasal bone  (IAGP)
short ribs  (IAGP)
short tail  (IAGP)
single external naris  (IAGP)
single kidney  (IAGP)
sirenomelia  (IAGP)
small alisphenoid bone  (IAGP)
small allantois  (IAGP)
small frontal bone  (IAGP)
small interparietal bone  (IAGP)
small kidney  (IAGP)
small mandibular coronoid process  (IAGP)
small nasal bone  (IAGP)
small temporal bone squamous part  (IAGP)
small testis  (IAGP)
small vertebral body  (IAGP)
small zygomatic bone  (IAGP)
split xiphoid process  (IAGP)
syndactyly  (IAGP)
thick myocardium  (IAGP)
thin retina ganglion layer  (IAGP)
thin retina inner nuclear layer  (IAGP)
thoracic vertebral fusion  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7. Alarmo EL, etal., Breast Cancer Res Treat. 2007 Jun;103(2):239-46. Epub 2006 Sep 21.
2. Preliminary Analysis of the Nonsynonymous Polymorphism rs17563 in BMP4 Gene in Brazilian Population Suggests Protection for Nonsyndromic Cleft Lip and Palate. Araújo TK, etal., Plast Surg Int. 2012;2012:247104. doi: 10.1155/2012/247104. Epub 2012 Nov 27.
3. The role of bone morphogenetic protein 4 in inner ear development and function. Blauwkamp MN, etal., Hear Res. 2007 Mar;225(1-2):71-9. Epub 2006 Dec 28.
4. Dominant-stable beta-catenin expression causes cell fate alterations and Wnt signaling antagonist expression in a murine granulosa cell tumor model. Boerboom D, etal., Cancer Res. 2006 Feb 15;66(4):1964-73.
5. A predicted functional single-nucleotide polymorphism of bone morphogenetic protein-4 gene affects mRNA expression and shows a significant association with cutaneous melanoma in Southern Italian population. Capasso M, etal., J Cancer Res Clin Oncol. 2009 Dec;135(12):1799-807. doi: 10.1007/s00432-009-0628-y. Epub 2009 Jun 26.
6. Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure. Chang B, etal., BMC Genet. 2001;2:18. Epub 2001 Nov 6.
7. Faulty bone morphogenetic protein signaling in esophageal atresia with tracheoesophageal fistula. Crowley AR, etal., J Pediatr Surg. 2006 Jul;41(7):1208-13.
8. Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury. Davies JE, etal., J Biol. 2008 Sep 19;7(7):24. doi: 10.1186/jbiol85.
9. Gene expression pathways induced by axotomy and decentralization of rat superior cervical ganglion neurons. Del Signore A, etal., Eur J Neurosci. 2006 Jan;23(1):65-74.
10. Rare variants in BMP2 and BMP4 found in otosclerosis patients reduce Smad signaling. Ealy M, etal., Otol Neurotol. 2014 Mar;35(3):395-400. doi: 10.1097/MAO.0000000000000244.
11. Bone morphogenetic protein 4 mediates bile duct ligation induced liver fibrosis through activation of Smad1 and ERK1/2 in rat hepatic stellate cells. Fan J, etal., J Cell Physiol. 2006 May;207(2):499-505.
12. The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways. Fukada T, etal., PLoS One. 2008;3(11):e3642. doi: 10.1371/journal.pone.0003642. Epub 2008 Nov 5.
13. Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions. Fuller ML, etal., Ann Neurol. 2007 Sep;62(3):288-300.
14. Association of BMP4 polymorphisms with isolated tooth agenesis in a Chinese Han population: a case-control study. Gong M, etal., Eur Rev Med Pharmacol Sci. 2015 Jun;19(12):2188-94.
15. Expression of bone morphogenetic protein-4 in the cortical lesions of focal cortical dysplasia IIb and the tuberous sclerosis complex. Guo W, etal., J Mol Neurosci. 2013 May;50(1):7-13. doi: 10.1007/s12031-012-9841-2. Epub 2012 Jul 3.
16. Effect of a fibrin-fibronectin sealing system as a carrier for recombinant human bone morphogenetic protein-4 on bone formation in rat calvarial defects. Han DK, etal., J Periodontol. 2005 Dec;76(12):2216-22.
17. Mutation screening of BMP4 and Id2 genes in Chinese patients with congenital ureteropelvic junction obstruction. He JL, etal., Eur J Pediatr. 2012 Mar;171(3):451-6. doi: 10.1007/s00431-011-1561-z. Epub 2011 Sep 17.
18. Changes in homeobox-containing gene expression during ectopic bone formation induced by bone morphogenetic protein. Iimura T, etal., Biochem Biophys Res Commun 1994 Jun 15;201(2):980-7.
19. Prenatal exposure to di-n-butyl phthalate induces anorectal malformations in male rat offspring. Jiang JT, etal., Toxicology. 2011 Dec 18;290(2-3):322-6. doi: 10.1016/j.tox.2011.10.008. Epub 2011 Oct 18.
20. The mutation in Chd7 causes misexpression of Bmp4 and developmental defects in telencephalic midline. Jiang X, etal., Am J Pathol. 2012 Aug;181(2):626-41. doi: 10.1016/j.ajpath.2012.05.006. Epub 2012 May 29.
21. Apoptosis of oral epithelial cells in oral lichen planus caused by upregulation of BMP-4. Kim SG, etal., J Oral Pathol Med. 2006 Jan;35(1):37-45.
22. The expression of molecular mediators in the idiopathic cutaneous calcification and ossification. Kim SY, etal., J Cutan Pathol. 2008 Sep;35(9):826-31. doi: 10.1111/j.1600-0560.2007.00904.x. Epub 2008 Apr 18.
23. Different levels of TIMPs and MMPs in human lateral and medial rectus muscle tissue excised from strabismic patients. Kitada M, etal., Strabismus. 2003 Sep;11(3):145-55.
24. Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells. Kuroda R, etal., Arthritis Rheum. 2006 Feb;54(2):433-42.
25. Expression of bone morphogenetic proteins, the subfamily of the transforming growth factor-beta superfamily, in renal cell carcinoma. Kwak C, etal., J Urol. 2007 Sep;178(3 Pt 1):1062-7. Epub 2007 Jul 20.
26. Evaluation of differentially expressed genes identified in keratoconus. Lee JE, etal., Mol Vis. 2009 Nov 28;15:2480-7.
27. Zhonghua nan ke xue = National journal of andrology Li ZL, etal., Zhonghua Nan Ke Xue. 2006 Feb;12(2):126-8, 132.
28. Association of bone morphogenetic protein 4 gene polymorphisms with nonsyndromic cleft lip with or without cleft palate in Chinese children. Lin JY, etal., DNA Cell Biol. 2008 Nov;27(11):601-5. doi: 10.1089/dna.2008.0777.
29. Sonic hedgehog, BMP4, and Hox genes in the development of anorectal malformations in Ethylenethiourea-exposed fetal rats. Mandhan P, etal., J Pediatr Surg. 2006 Dec;41(12):2041-5.
30. The influence of sex on the chondrogenic potential of muscle-derived stem cells: implications for cartilage regeneration and repair. Matsumoto T, etal., Arthritis Rheum. 2008 Dec;58(12):3809-19. doi: 10.1002/art.24125.
31. Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1. Matsumoto T, etal., Arthritis Rheum. 2009 May;60(5):1390-405. doi: 10.1002/art.24443.
32. T allele at site 6007 of bone morphogenetic protein-4 gene increases genetic susceptibility to ossification of the posterior longitudinal ligament in male Chinese Han population. Meng XL, etal., Chin Med J (Engl). 2010 Sep;123(18):2537-42.
33. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
34. MGDs mouse GO annotations MGD data from the GO Consortium
35. MGD IEA MGD IEA
36. Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cells. Milano F, etal., Gastroenterology. 2007 Jun;132(7):2412-21. Epub 2007 Mar 19.
37. Phenotype characterization and sequence analysis of BMP2 and BMP4 variants in two Mexican families with oligodontia. Mu Y, etal., Genet Mol Res. 2012 Nov 28;11(4):4110-20. doi: 10.4238/2012.September.25.5.
38. Busulfan-induced central polydactyly, syndactyly and cleft hand or foot: a common mechanism of disruption leads to divergent phenotypes. Naruse T, etal., Dev Growth Differ. 2007 Aug;49(6):533-41.
39. Expression of bone morphogenic proteins and receptors at the injured growth plate cartilage in young rats. Ngo TQ, etal., J Histochem Cytochem. 2006 Aug;54(8):945-54. Epub 2006 May 1.
40. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
41. Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk. Paez-Pereda M, etal., Proc Natl Acad Sci U S A 2003 Feb 4;100(3):1034-9.
42. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
43. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
44. Common variations in BMP4 confer genetic susceptibility to sporadic congenital heart disease in a Han Chinese population. Qian B, etal., Pediatr Cardiol. 2014 Dec;35(8):1442-7. doi: 10.1007/s00246-014-0951-1. Epub 2014 Jul 15.
45. Delayed myelination in an intrauterine growth retardation model is mediated by oxidative stress upregulating bone morphogenetic protein 4. Reid MV, etal., J Neuropathol Exp Neurol. 2012 Jul;71(7):640-53. doi: 10.1097/NEN.0b013e31825cfa81.
46. Study of the association between the BMP4 gene and congenital anomalies of the kidney and urinary tract. Reis GS, etal., J Pediatr (Rio J). 2014 Jan-Feb;90(1):58-64. doi: 10.1016/j.jped.2013.06.004. Epub 2013 Oct 13.
47. Mouse MP Annotation Import Pipeline RGD automated import pipeline
48. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
49. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
50. In vivo bone formation in fracture repair induced by direct retroviral-based gene therapy with bone morphogenetic protein-4. Rundle CH, etal., Bone. 2003 Jun;32(6):591-601.
51. Bone morphogenetic proteins prevent bone marrow stromal cell-mediated oligodendroglial differentiation of transplanted adult neural progenitor cells in the injured spinal cord. Sandner B, etal., Stem Cell Res. 2013 Sep;11(2):758-71. doi: 10.1016/j.scr.2013.05.003. Epub 2013 May 16.
52. Tissue remodeling in the acute otitis media mouse model. Sautter NB, etal., Int J Pediatr Otorhinolaryngol. 2011 Nov;75(11):1368-71. doi: 10.1016/j.ijporl.2011.07.026. Epub 2011 Sep 1.
53. Association of bone morphogenetic proteins with otosclerosis. Schrauwen I, etal., J Bone Miner Res. 2008 Apr;23(4):507-16.
54. Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas. Schwartz DR, etal., Cancer Res. 2003 Jun 1;63(11):2913-22.
55. Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva. Shafritz AB, etal., N Engl J Med 1996 Aug 22;335(8):555-61.
56. BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy. Shahid M, etal., Am J Physiol Heart Circ Physiol. 2016 Apr 15;310(8):H984-94. doi: 10.1152/ajpheart.00879.2015. Epub 2016 Feb 12.
57. Structural and functional healing of critical-size segmental bone defects by transduced muscle-derived cells expressing BMP4. Shen HC, etal., J Gene Med. 2004 Sep;6(9):984-91.
58. Bone morphogenetic protein-4 contributes to the down-regulation of Kv4.3 K+ channels in pathological cardiac hypertrophy. Sun B, etal., Biochem Biophys Res Commun. 2013 Jul 12;436(4):591-4. doi: 10.1016/j.bbrc.2013.05.113. Epub 2013 Jun 6.
59. Downregulation of GATA4 and GATA6 in the heart of rats with nitrofen-induced diaphragmatic hernia. Takayasu H, etal., J Pediatr Surg. 2008 Feb;43(2):362-6. doi: 10.1016/j.jpedsurg.2007.10.047.
60. Noggin and BMP4 co-modulate adult hippocampal neurogenesis in the APP(swe)/PS1(DeltaE9) transgenic mouse model of Alzheimer's disease. Tang J, etal., Biochem Biophys Res Commun. 2009 Jul 31;385(3):341-5. doi: 10.1016/j.bbrc.2009.05.067. Epub 2009 May 20.
61. Over-expression of BMP4 inhibits experimental choroidal neovascularization by modulating VEGF and MMP-9. Xu J, etal., Angiogenesis. 2012 Jun;15(2):213-27. doi: 10.1007/s10456-012-9254-4. Epub 2012 Mar 4.
62. Transcriptional regulation of bone morphogenetic protein 4 by tumor necrosis factor and its relationship with age-related macular degeneration. Xu J, etal., FASEB J. 2011 Jul;25(7):2221-33. doi: 10.1096/fj.10-178350. Epub 2011 Mar 16.
63. Expression of bone morphogenetic proteins and rat distal-less homolog genes following rat femoral fracture. Yaoita H, etal., J Bone Miner Metab. 2000;18(2):63-70.
64. Involvement of over-expressed BMP4 in pentylenetetrazol kindling-induced cell proliferation in the dentate gyrus of adult rats. Yin J, etal., Biochem Biophys Res Commun. 2007 Mar 30;355(1):54-60. Epub 2007 Jan 29.
65. Effect of hyperbaric oxygen on neurological recovery of neonatal rats following hypoxic-ischemic brain damage and its underlying mechanism. Yin X, etal., Int J Clin Exp Pathol. 2013;6(1):66-75. Epub 2012 Nov 20.
66. Bone marrow stromal cells upregulate expression of bone morphogenetic proteins 2 and 4, gap junction protein connexin-43 and synaptophysin after stroke in rats. Zhang C, etal., Neuroscience. 2006 Aug 25;141(2):687-95. Epub 2006 May 30.
67. Down-regulation of SHH/BMP4 signalling in human anorectal malformations. Zhang J, etal., J Int Med Res. 2009 Nov-Dec;37(6):1842-50.
68. BMP4 mediates oxidative stress-induced retinal pigment epithelial cell senescence and is overexpressed in age-related macular degeneration. Zhu D, etal., J Biol Chem. 2009 Apr 3;284(14):9529-39. doi: 10.1074/jbc.M809393200. Epub 2009 Jan 21.
Additional References at PubMed
PMID:1346779   PMID:1460021   PMID:1521591   PMID:1893873   PMID:1970330   PMID:2929915   PMID:3201241   PMID:3268409   PMID:7499338   PMID:7543410   PMID:7577436   PMID:7579524  
PMID:7588050   PMID:7589793   PMID:7657163   PMID:7799920   PMID:7811286   PMID:7848824   PMID:7915533   PMID:8055537   PMID:8104708   PMID:8339498   PMID:8358941   PMID:8436293  
PMID:8507180   PMID:8530045   PMID:8647435   PMID:8651889   PMID:8