Symbol:
Defa5
Name:
defensin alpha 5
RGD ID:
727951
Description:
Predicted to enable pore-forming activity and protein homodimerization activity. Predicted to be involved in several processes, including defense response to bacterium; defense response to symbiont; and positive regulation of interleukin-8 production. Predicted to be located in midbody and secretory granule. Predicted to be active in extracellular space. Orthologous to several human genes including DEFA5 (defensin alpha 5); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; acetylsalicylic acid.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
alpha-defensin 5, Paneth cell-specific; Defa; defensin NP-2; defensin NP-2 precursor; defensin, alpha 5, Paneth cell-specific; LOC286995; neutrophil antibiotic peptide NP-1; neutrophil antibiotic peptide NP-2; neutrophil defensin 1; neutrophil defensin 2; ratNP-1; ratNP-2
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
DEFA5 (defensin alpha 5)
HGNC
EggNOG, Ensembl, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Mus musculus (house mouse):
Defa21 (defensin, alpha, 21)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
LOC100991118 (defensin alpha 5)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
LOC103247087 (defensin alpha 5)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
DEFA4 (defensin alpha 4)
HGNC
Ensembl, OrthoDB, Panther, PhylomeDB, Treefam
Homo sapiens (human):
DEFA6 (defensin alpha 6)
HGNC
Ensembl, Panther, PhylomeDB, Treefam
Homo sapiens (human):
DEFA3 (defensin alpha 3)
HGNC
Ensembl, Panther, PhylomeDB, Treefam
Homo sapiens (human):
DEFA1 (defensin alpha 1)
HGNC
EggNOG, Ensembl, Panther, Treefam
Homo sapiens (human):
DEFA1B (defensin alpha 1B)
HGNC
Ensembl, PhylomeDB, Treefam
Homo sapiens (human):
SLC1A4 (solute carrier family 1 member 4)
HGNC
OMA
Alliance orthologs 3
Homo sapiens (human):
DEFA6 (defensin alpha 6)
Alliance
DIOPT (Ensembl Compara|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Homo sapiens (human):
DEFA3 (defensin alpha 3)
Alliance
DIOPT (Ensembl Compara|OrthoInspector|PANTHER)
Homo sapiens (human):
DEFA3 (defensin alpha 3)
Alliance
DIOPT (Ensembl Compara|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Homo sapiens (human):
DEFA5 (defensin alpha 5)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Homo sapiens (human):
DEFA5 (defensin alpha 5)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|SonicParanoid)
Homo sapiens (human):
DEFA1 (defensin alpha 1)
Alliance
DIOPT (Ensembl Compara|OrthoInspector|PANTHER)
Homo sapiens (human):
DEFA1 (defensin alpha 1)
Alliance
DIOPT (Ensembl Compara|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Defa9 (defensin, alpha, 9)
Alliance
DIOPT (Ensembl Compara|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Defa8 (defensin, alpha, 8)
Alliance
DIOPT (Ensembl Compara|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Defa7 (defensin, alpha, 7)
Alliance
DIOPT (Ensembl Compara|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Defa15 (defensin, alpha, 15)
Alliance
DIOPT (Ensembl Compara|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Defa14 (defensin, alpha, 14)
Alliance
DIOPT (Ensembl Compara|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Defa13 (defensin, alpha, 13)
Alliance
DIOPT (Ensembl Compara|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Defa11 (defensin, alpha, 11)
Alliance
DIOPT (Ensembl Compara|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Defa10 (defensin, alpha, 10)
Alliance
DIOPT (Ensembl Compara|PhylomeDB|SonicParanoid)
Homo sapiens (human):
DEFA1B (defensin alpha 1B)
Alliance
DIOPT (Ensembl Compara|OrthoInspector|PANTHER)
Homo sapiens (human):
DEFA1B (defensin alpha 1B)
Alliance
DIOPT (Ensembl Compara|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Related Pseudogenes:
Defa5-ps2
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 16 77,044,994 - 77,047,318 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 16 77,044,994 - 77,047,318 (-) Ensembl GRCr8 mRatBN7.2 16 70,342,530 - 70,344,854 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 16 70,342,530 - 70,344,836 (-) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 16 75,616,245 - 75,618,551 (-) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 16 79,069,107 - 79,071,419 (-) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 16 74,318,539 - 74,320,851 (-) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 16 75,338,050 - 75,340,401 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 16 75,338,052 - 75,340,360 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 16 74,952,566 - 74,954,917 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 16 75,024,375 - 75,026,675 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 16 68,215,238 - 68,217,544 (-) NCBI Celera RGSC_v3.1 16 75,024,639 - 75,026,940 (-) NCBI Cytogenetic Map 16 q12.5 NCBI
JBrowse:
Imported Disease Annotations - ClinVar