Defa5 (defensin alpha 5) - Rat Genome Database

Name: Defa5
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Defa5 (defensin alpha 5) Rattus norvegicus

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Symbol:

Defa5

Name:

defensin alpha 5

Description:

Predicted to have protein homodimerization activity. Predicted to be involved in several processes, including innate immune response in mucosa; membrane disruption in other organism; and response to bacterium. Predicted to localize to the extracellular space. Orthologous to several human genes including DEFA5 (defensin alpha 5); INTERACTS WITH (RS)-amphetamine; acetylsalicylic acid; acrylamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

alpha-defensin 5, Paneth cell-specific; Defa; defensin NP-2; defensin NP-2 precursor; defensin, alpha 5, Paneth cell-specific; LOC286995; neutrophil antibiotic peptide NP-1; neutrophil antibiotic peptide NP-2; neutrophil defensin 1; neutrophil defensin 2; ratNP-1; ratNP-2

Orthologs:

Homo sapiens (human) : DEFA5 (defensin alpha 5) HGNC Alliance
Mus musculus (house mouse) : Defa17 (defensin, alpha, 17) MGI Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100991118 (defensin-5)

more info ...

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DEFA5 (defensin alpha 5)	HGNC	EggNOG, Ensembl, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Mus musculus (house mouse):	Defa17 (defensin, alpha, 17)	HGNC	OrthoMCL, OMA, Panther, OrthoDB
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100991118 (defensin-5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	DEFA4 (defensin alpha 4)	HGNC	Ensembl, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Homo sapiens (human):	DEFA3 (defensin alpha 3)	HGNC	Ensembl, OrthoDB, Panther, PhylomeDB, Treefam
Homo sapiens (human):	DEFA6 (defensin alpha 6)	HGNC	Ensembl, OMA, Panther, PhylomeDB, Treefam
Homo sapiens (human):	DEFA1B (defensin alpha 1B)	HGNC	Ensembl, OrthoDB, PhylomeDB, Treefam
Homo sapiens (human):	DEFA1 (defensin alpha 1)	HGNC	Ensembl, OrthoDB, Panther, Treefam
Alliance orthologs ³
Homo sapiens (human):	DEFA6 (defensin alpha 6)	Alliance	DIOPT (Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):	DEFA3 (defensin alpha 3)	Alliance	DIOPT (Hieranoid, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):	DEFA5 (defensin alpha 5)	Alliance	DIOPT (HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Homo sapiens (human):	DEFA1B (defensin alpha 1B)	Alliance	DIOPT (Hieranoid, OrthoFinder, PhylomeDB, TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	16	75,338,050 - 75,340,401 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	16	74,952,566 - 74,954,917 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	75,024,375 - 75,026,675 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	16	75,024,639 - 75,026,940 (-)	NCBI
Celera	16	68,215,238 - 68,217,544 (-)	NCBI		Celera
Cytogenetic Map	16	q12.5	NCBI

JBrowse:

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Model

Annotation (Toggle Annotation Detail/Summary View)

Disease Annotations

Gene-Chemical Interaction Annotations

Gene Ontology Annotations

References - curated

References - uncurated

Genomics

Comparative Map Data

QTLs in Region (Rnor_6.0)

miRNA Target Status

Sequence

Nucleotide Sequences

Protein Sequences

Transcriptome

Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Damaging Variants

Additional Information

External Database Links

Nomenclature History

RGD Curation Notes

More on Defa5
	Alliance Gene
	NCBI Gene
	Ensembl Gene
	JBrowse: rn5 rn6
	NCBI Genome Data Viewer

RGD Object Information
RGD ID:	727951
Created:	2003-11-05
Species:	Rattus norvegicus
Last Modified:	2019-08-20
Status:	ACTIVE

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

Functional Annotation unavailable	Annotation Distribution unavailable	Genomic Variants unavailble Genomic Variants unavailable
Functional Annotation	Annotation Distribution	Genomic Variants

Protein-Protein Interactions unavailable	Genome Viewer unavailable	Damaging Variants unavailble Damaging Variants unavailable
Protein-Protein Interactions	Genome Viewer	Damaging Variants

Annotation Comparison unavailable	OLGA unavailable
Annotation Comparison	OLGA	Excel (Download)

Gene Enrichment unavailable	Ortholog Finder unavailable
Gene Enrichment	Ortholog Finder

Imported Annotations - CTD