Vcan (versican) - Rat Genome Database

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Gene: Vcan (versican) Rattus norvegicus
Analyze
Symbol: Vcan
Name: versican
RGD ID: 619940
Description: Predicted to enable protein phosphatase binding activity. Involved in axon regeneration. Located in cell surface and perineuronal net. Is active in synapse. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in intracranial aneurysm. Orthologous to human VCAN (versican); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chondroitin sulfate proteoglycan 2; chondroitin sulfate proteoglycan 2 (versican); chondroitin sulfate proteoglycan core protein 2; Cspg2; GHAP; glial hyaluronate-binding protein; large fibroblast proteoglycan; PG-M; versican core protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8222,497,035 - 22,595,955 (-)NCBIGRCr8
mRatBN7.2220,761,718 - 20,860,637 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl220,761,718 - 20,860,637 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx227,798,986 - 27,898,522 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0225,899,274 - 25,998,816 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0220,683,909 - 20,782,542 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0218,490,102 - 18,587,340 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl218,490,102 - 18,565,842 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0218,363,890 - 18,463,115 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4219,712,629 - 19,801,443 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1219,634,740 - 19,688,742 (-)NCBI
Celera216,903,548 - 17,002,158 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
astemizole  (EXP)
atrazine  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP)
bezafibrate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcitriol  (ISO)
carbamazepine  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
corticosterone  (EXP)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
decabromodiphenyl ether  (EXP,ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ethanol  (ISO)
etoposide  (ISO)
fenoldopam  (EXP)
fenvalerate  (EXP)
furan  (EXP)
gentamycin  (EXP)
hexadecanoic acid  (ISO)
indometacin  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lead(0)  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
loliolide  (ISO)
mitoxantrone  (ISO)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
oleic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
phenylephrine  (EXP)
phenytoin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (EXP,ISO)
rofecoxib  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
tremolite asbestos  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (EXP,ISO)

References

References - curated
# Reference Title Reference Citation
1. Versican is upregulated in CNS injury and is a product of oligodendrocyte lineage cells. Asher RA, etal., J Neurosci 2002 Mar 15;22(6):2225-36.
2. Relative and absolute quantification of postsynaptic density proteome isolated from rat forebrain and cerebellum. Cheng D, etal., Mol Cell Proteomics. 2006 Jun;5(6):1158-70. doi: 10.1074/mcp.D500009-MCP200. Epub 2006 Feb 28.
3. Composition of perineuronal net extracellular matrix in rat brain: a different disaccharide composition for the net-associated proteoglycans. Deepa SS, etal., J Biol Chem. 2006 Jun 30;281(26):17789-800. Epub 2006 Apr 27.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Expression of a chondroitin sulfate proteoglycan, versican (PG-M), during development of rat cornea. Koga T, etal., Curr Eye Res. 2005 Jun;30(6):455-63.
7. Versican/PG-M isoforms in vascular smooth muscle cells. Lemire JM, etal., Arterioscler Thromb Vasc Biol 1999 Jul;19(7):1630-9.
8. Overexpression of the V3 variant of versican alters arterial smooth muscle cell adhesion, migration, and proliferation in vitro. Lemire JM, etal., J Cell Physiol 2002 Jan;190(1):38-45.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Differential regulation of expression of hyaluronan-binding proteoglycans in developing brain: aggrecan, versican, neurocan, and brevican. Milev P, etal., Biochem Biophys Res Commun 1998 Jun 18;247(2):207-12.
11. Erosive vitreoretinopathy and wagner disease are caused by intronic mutations in CSPG2/Versican that result in an imbalance of splice variants. Mukhopadhyay A, etal., Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3565-72.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. The versican gene and the risk of intracranial aneurysms. Ruigrok YM, etal., Stroke. 2006 Sep;37(9):2372-4. Epub 2006 Aug 17.
18. Hormone-regulated expression and localization of versican in the rodent ovary. Russell DL, etal., Endocrinology 2003 Mar;144(3):1020-31.
19. Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue. Tang X, etal., J Neurosci Res 2003 Feb 1;71(3):427-44.
20. Versican is induced in infiltrating monocytes in myocardial infarction. Toeda K, etal., Mol Cell Biochem. 2005 Dec;280(1-2):47-56.
Additional References at PubMed
PMID:9434070   PMID:9758703   PMID:12701107   PMID:14620382   PMID:15464361   PMID:15668231   PMID:16187070   PMID:16200461   PMID:16210410   PMID:16510873   PMID:16545622   PMID:16648628  
PMID:17972319   PMID:18431253   PMID:18616564   PMID:19437549   PMID:20489207   PMID:20551380   PMID:21976490   PMID:23658023   PMID:24006456   PMID:24719328   PMID:25845936   PMID:26152723  
PMID:26395512   PMID:27068509   PMID:27559042   PMID:29476059   PMID:31429356   PMID:32001344  


Genomics

Comparative Map Data
Vcan
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8222,497,035 - 22,595,955 (-)NCBIGRCr8
mRatBN7.2220,761,718 - 20,860,637 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl220,761,718 - 20,860,637 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx227,798,986 - 27,898,522 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0225,899,274 - 25,998,816 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0220,683,909 - 20,782,542 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0218,490,102 - 18,587,340 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl218,490,102 - 18,565,842 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0218,363,890 - 18,463,115 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4219,712,629 - 19,801,443 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1219,634,740 - 19,688,742 (-)NCBI
Celera216,903,548 - 17,002,158 (-)NCBICelera
Cytogenetic Map2q12NCBI
VCAN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38583,471,744 - 83,582,302 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl583,471,618 - 83,582,303 (+)EnsemblGRCh38hg38GRCh38
GRCh37582,767,563 - 82,878,121 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36582,803,339 - 82,912,737 (+)NCBINCBI36Build 36hg18NCBI36
Build 34582,803,338 - 82,912,737NCBI
Celera578,672,557 - 78,783,162 (+)NCBICelera
Cytogenetic Map5q14.2-q14.3NCBI
HuRef577,975,785 - 78,086,373 (+)NCBIHuRef
CHM1_1582,200,193 - 82,311,247 (+)NCBICHM1_1
T2T-CHM13v2.0583,960,520 - 84,071,053 (+)NCBIT2T-CHM13v2.0
Vcan
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391389,803,429 - 89,891,146 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1389,803,431 - 89,890,628 (-)EnsemblGRCm39 Ensembl
GRCm381389,655,309 - 89,743,027 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1389,655,312 - 89,742,509 (-)EnsemblGRCm38mm10GRCm38
MGSCv371389,794,915 - 89,882,117 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361390,129,514 - 90,216,773 (-)NCBIMGSCv36mm8
Celera1393,253,094 - 93,340,280 (-)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1345.5NCBI
Vcan
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541826,967,595 - 27,078,430 (-)NCBIChiLan1.0ChiLan1.0
VCAN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2431,721,703 - 31,832,599 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1529,875,328 - 29,986,197 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0531,699,278 - 31,810,169 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1532,019,709 - 32,130,350 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl532,019,709 - 32,130,351 (-)Ensemblpanpan1.1panPan2
VCAN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1324,127,293 - 24,238,859 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl324,119,181 - 24,239,192 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha325,365,073 - 25,476,286 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0324,026,612 - 24,144,361 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl324,026,612 - 24,144,477 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1323,995,927 - 24,107,068 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0323,956,080 - 24,067,483 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0324,243,468 - 24,354,843 (-)NCBIUU_Cfam_GSD_1.0
Vcan
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213179,937,730 - 180,040,914 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364692,585,134 - 2,688,029 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364692,585,142 - 2,688,029 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VCAN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl291,384,391 - 91,811,208 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1291,682,177 - 91,811,674 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2293,783,322 - 93,895,492 (+)NCBISscrofa10.2Sscrofa10.2susScr3
VCAN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1477,581,627 - 77,692,495 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl477,593,449 - 77,690,616 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604926,489,259 - 26,600,350 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vcan
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247433,635,086 - 3,743,332 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Vcan
687 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1336
Count of miRNA genes:308
Interacting mature miRNAs:399
Transcripts:ENSRNOT00000045532, ENSRNOT00000063821, ENSRNOT00000067456
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
61368Mcs1Mammary carcinoma susceptibility QTL 14.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777223319447Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat

Markers in Region
RH134008  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2q12UniSTS
RH143691  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2220,762,051 - 20,762,170 (+)MAPPERmRatBN7.2
Rnor_6.0218,490,436 - 18,490,554NCBIRnor6.0
Rnor_5.0218,364,224 - 18,364,342UniSTSRnor5.0
RGSC_v3.4219,712,963 - 19,713,081UniSTSRGSC3.4
Celera216,903,882 - 16,904,000UniSTS
Cytogenetic Map2q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 32 6 6 6 1 1 63 21 33 4 1
Low 3 11 37 22 19 22 7 9 11 14 5 7 7
Below cutoff 14 13 13 1 3

Sequence


RefSeq Acc Id: ENSRNOT00000045532   ⟹   ENSRNOP00000045935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl220,761,718 - 20,860,539 (-)Ensembl
Rnor_6.0 Ensembl218,514,668 - 18,565,842 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000063821   ⟹   ENSRNOP00000062961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl220,761,718 - 20,860,539 (-)Ensembl
Rnor_6.0 Ensembl218,490,102 - 18,565,842 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000067456   ⟹   ENSRNOP00000058873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl220,761,718 - 20,860,539 (-)Ensembl
Rnor_6.0 Ensembl218,490,102 - 18,565,842 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000088313   ⟹   ENSRNOP00000074854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl220,761,718 - 20,860,637 (-)Ensembl
Rnor_6.0 Ensembl218,492,018 - 18,531,210 (-)Ensembl
RefSeq Acc Id: NM_001170558   ⟹   NP_001164029
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8222,497,035 - 22,595,857 (-)NCBI
mRatBN7.2220,761,718 - 20,860,539 (-)NCBI
Rnor_6.0218,490,102 - 18,587,242 (-)NCBI
Rnor_5.0218,363,890 - 18,463,115 (-)NCBI
Celera216,903,548 - 17,002,060 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001170559   ⟹   NP_001164030
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8222,497,035 - 22,595,857 (-)NCBI
mRatBN7.2220,761,718 - 20,860,539 (-)NCBI
Rnor_6.0218,490,102 - 18,587,242 (-)NCBI
Rnor_5.0218,363,890 - 18,463,115 (-)NCBI
Celera216,903,548 - 17,002,060 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001170560   ⟹   NP_001164031
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8222,497,035 - 22,595,857 (-)NCBI
mRatBN7.2220,761,718 - 20,860,539 (-)NCBI
Rnor_6.0218,490,102 - 18,587,242 (-)NCBI
Rnor_5.0218,363,890 - 18,463,115 (-)NCBI
Celera216,903,548 - 17,002,060 (-)NCBI
Sequence:
RefSeq Acc Id: NM_053663   ⟹   NP_446115
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8222,497,035 - 22,595,955 (-)NCBI
mRatBN7.2220,761,718 - 20,860,637 (-)NCBI
Rnor_6.0218,490,102 - 18,587,340 (-)NCBI
Rnor_5.0218,363,890 - 18,463,115 (-)NCBI
Celera216,903,548 - 17,002,158 (-)NCBI
Sequence:
RefSeq Acc Id: NP_446115   ⟸   NM_053663
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9R1K4 (UniProtKB/Swiss-Prot),   Q9ERB4 (UniProtKB/Swiss-Prot),   O88564 (UniProtKB/Swiss-Prot),   O08592 (UniProtKB/Swiss-Prot),   A0A0G2K944 (UniProtKB/TrEMBL),   A6I4N2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001164030   ⟸   NM_001170559
- Peptide Label: isoform 4 precursor
- UniProtKB: A6I4N1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001164031   ⟸   NM_001170560
- Peptide Label: isoform 3 precursor
- UniProtKB: D3Z9N6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001164029   ⟸   NM_001170558
- Peptide Label: isoform 1 precursor
- UniProtKB: D4A8Y6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000058873   ⟸   ENSRNOT00000067456
RefSeq Acc Id: ENSRNOP00000045935   ⟸   ENSRNOT00000045532
RefSeq Acc Id: ENSRNOP00000062961   ⟸   ENSRNOT00000063821
RefSeq Acc Id: ENSRNOP00000074854   ⟸   ENSRNOT00000088313
Protein Domains
C-type lectin   EGF-like   Ig-like   Ig-like V-type   Link   Sushi

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619940 AgrOrtholog
BioCyc Gene G2FUF-54903 BioCyc
Ensembl Genes ENSRNOG00000029212 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045532 ENTREZGENE
  ENSRNOT00000045532.7 UniProtKB/TrEMBL
  ENSRNOT00000063821 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000063821.4 UniProtKB/Swiss-Prot
  ENSRNOT00000067456 ENTREZGENE
  ENSRNOT00000067456.5 UniProtKB/TrEMBL
  ENSRNOT00000088313 ENTREZGENE
  ENSRNOT00000088313.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CSPG_CTLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Link_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114122 UniProtKB/Swiss-Prot
NCBI Gene 114122 ENTREZGENE
PANTHER AGGRECAN/VERSICAN PROTEOGLYCAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VERSICAN CORE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Xlink UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Vcan PhenoGen
PRINTS EGFBLOOD UniProtKB/TrEMBL
  LINKMODULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LINK_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LINK_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029212 RatGTEx
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LINK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K944 ENTREZGENE, UniProtKB/TrEMBL
  A6I4N1 ENTREZGENE, UniProtKB/TrEMBL
  A6I4N2 ENTREZGENE, UniProtKB/TrEMBL
  CSPG2_RAT UniProtKB/Swiss-Prot
  D3Z9N6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZFC3_RAT UniProtKB/TrEMBL
  D4A8Y6 ENTREZGENE, UniProtKB/TrEMBL
  O08592 ENTREZGENE
  O88564 ENTREZGENE
  Q9ERB4 ENTREZGENE
  Q9R1K4 ENTREZGENE
UniProt Secondary O08592 UniProtKB/Swiss-Prot
  O88564 UniProtKB/Swiss-Prot
  Q9R1K4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-22 Vcan  versican  Cspg2  chondroitin sulfate proteoglycan 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Cspg2  chondroitin sulfate proteoglycan 2    chondroitin sulfate proteoglycan 2 (versican)  Name updated 1299863 APPROVED
2002-08-07 Cspg2  chondroitin sulfate proteoglycan 2 (versican)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression present in vascular smooth muscle cells (SMCs) 632588
gene_expression localized around newly formed corpora lutea and vasculature immediately after ovulation 1299255
gene_regulation FSH and testosterone increase mRNA expression in ovarian tissue 1299255