RGD Reference Report - The versican gene and the risk of intracranial aneurysms. - Rat Genome Database

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The versican gene and the risk of intracranial aneurysms.

Authors: Ruigrok, YM  Rinkel, GJ  Wijmenga, C 
Citation: Ruigrok YM, etal., Stroke. 2006 Sep;37(9):2372-4. Epub 2006 Aug 17.
RGD ID: 1598495
Pubmed: PMID:16917090   (View Abstract at PubMed)
DOI: DOI:10.1161/01.STR.0000236499.55301.09   (Journal Full-text)

BACKGROUND AND PURPOSE: The proteoglycan versican is an excellent candidate gene for intracranial aneurysms (IAs) because it plays an important role in extracellular matrix assembly and is localized in a previously implicated locus for IAs on chromosome 5q. METHODS: We analyzed all the common variations using 16-tag single nucleotide polymorphisms (SNPs) and haplotypes in the versican gene using a 2-stage genotyping approach. For stage 1, 16 SNPs were genotyped in 307 cases and 639 controls. For stage 2, the two SNPs yielding the most significant associations (P<0.01) were genotyped in a second independent cohort of 310 cases for confirmation of the associations. RESULTS: In stage 1, we found several SNPs in strong linkage disequilibrium and haplotypes constituting these SNPs associated with IAs in the Dutch population (strongest SNP association for rs173686 with odds ratio=1.34, 95% CI=1.09 to 1.65, P=0.004). In stage 2, we confirmed association for the 2 SNPs with the most significant associations (strongest SNP association for rs173686 with odds ratio=1.36, 95% CI=1.11 to 1.67, P=0.003). CONCLUSIONS: SNPs in strong linkage disequilibrium and haplotypes constituting these SNPs in the versican gene are associated with IAs suggesting that variation in or near the versican gene plays a role in susceptibility to IAs.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
VCANHumanintracranial aneurysm  IAGP DNA:SNP: :rs173686 (human)RGD 
VcanRatintracranial aneurysm  ISOVCAN (Homo sapiens)DNA:SNP: :rs173686 (human)RGD 
VcanMouseintracranial aneurysm  ISOVCAN (Homo sapiens)DNA:SNP: :rs173686 (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Vcan  (versican)

Genes (Mus musculus)
Vcan  (versican)

Genes (Homo sapiens)
VCAN  (versican)


Additional Information