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Gene: S1pr1 (sphingosine-1-phosphate receptor 1) Rattus norvegicus
Symbol: S1pr1
Name: sphingosine-1-phosphate receptor 1
RGD ID: 61958
Description: Exhibits G protein-coupled receptor activity and sphingolipid binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of stress fiber assembly; and positive regulation of smooth muscle cell proliferation. Predicted to localize to several cellular components, including external side of plasma membrane; intrinsic component of plasma membrane; and nucleoplasm. Used to study hypertension. Orthologous to human S1PR1 (sphingosine-1-phosphate receptor 1); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
Also known as: Edg1; EDG1 (Edg1); endothelial differentiation G-protein coupled receptor 1; endothelial differentiation sphingolipid G-protein-coupled receptor 1; S1P receptor 1; S1P receptor Edg-1; S1P1; sphingosine 1-phosphate receptor 1; sphingosine 1-phosphate receptor Edg-1
Homo sapiens (human) : S1PR1 (sphingosine-1-phosphate receptor 1)  HGNC  Alliance
Mus musculus (house mouse) : S1pr1 (sphingosine-1-phosphate receptor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : S1pr1 (sphingosine-1-phosphate receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : S1PR1 (sphingosine-1-phosphate receptor 1)
Canis lupus familiaris (dog) : S1PR1 (sphingosine-1-phosphate receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : S1pr1 (sphingosine-1-phosphate receptor 1)
Sus scrofa (pig) : S1PR1 (sphingosine-1-phosphate receptor 1)
Chlorocebus sabaeus (African green monkey) : S1PR1 (sphingosine-1-phosphate receptor 1)
Heterocephalus glaber (naked mole-rat) : S1pr1 (sphingosine-1-phosphate receptor 1)
more info ...
Is Marker For: Strains:   SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc   SHRSP.WKY-(D2Mit21-D2Rat157)/Gcrc  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02218,654,406 - 218,658,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2218,654,554 - 218,658,761 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02236,742,193 - 236,746,400 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42211,851,304 - 211,855,511 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12211,814,057 - 211,818,265 (-)NCBI
Celera2196,132,649 - 196,136,856 (-)NCBICelera
Cytogenetic Map2q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on S1pr1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61958
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.