S1pr1 (sphingosine-1-phosphate receptor 1) - Rat Genome Database

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Gene: S1pr1 (sphingosine-1-phosphate receptor 1) Rattus norvegicus
Analyze
Symbol: S1pr1
Name: sphingosine-1-phosphate receptor 1
RGD ID: 61958
Description: Enables G protein-coupled receptor activity and sphingolipid binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of stress fiber assembly; and positive regulation of GTPase activity. Predicted to be located in external side of plasma membrane and nucleoplasm. Predicted to be active in cytoplasm; plasma membrane; and presynapse. Used to study hypertension. Orthologous to human S1PR1 (sphingosine-1-phosphate receptor 1); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Edg1; EDG1 (Edg1); endothelial differentiation G-protein coupled receptor 1; endothelial differentiation sphingolipid G-protein-coupled receptor 1; S1P receptor 1; S1P receptor Edg-1; S1P1; sphingosine 1-phosphate receptor 1; sphingosine 1-phosphate receptor Edg-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc   SHRSP.WKY-(D2Mit21-D2Rat157)/Gcrc  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82206,309,715 - 206,314,070 (-)NCBIGRCr8
mRatBN7.22203,624,752 - 203,629,110 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2203,621,587 - 203,629,681 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2211,288,334 - 211,292,535 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02209,178,280 - 209,182,489 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02203,995,309 - 203,999,518 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02218,654,406 - 218,658,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2218,654,554 - 218,658,761 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02236,742,193 - 236,746,400 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42211,851,304 - 211,855,511 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12211,814,057 - 211,818,265 (-)NCBI
Celera2196,132,649 - 196,136,856 (-)NCBICelera
Cytogenetic Map2q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (EXP)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
7,8-dihydroxycoumarin  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
apigenin  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzbromarone  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP,ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP)
DDE  (ISO)
DDT  (EXP)
diallyl trisulfide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxycycline  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
fentin chloride  (EXP)
fingolimod hydrochloride  (ISO)
flutamide  (EXP)
fonofos  (ISO)
furan  (EXP)
furosemide  (EXP)
gentamycin  (EXP)
glucose  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP)
isoprenaline  (ISO)
kainic acid  (ISO)
L-ethionine  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP)
manganese(II) chloride  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naphthalenes  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
ochratoxin A  (ISO)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
pentane-2,3-dione  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenobarbital  (ISO)
PhIP  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium cyanide  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
scopolamine  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sphingosine 1-phosphate  (EXP,ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney. Awad AS, etal., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1516-24. Epub 2006 Jan 10.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Candidate Genes That Determine Response to Salt in the Stroke-Prone Spontaneously Hypertensive Rat. Congenic Analysis. Graham D, etal., Hypertension. 2007 Oct 15;.
5. Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. Kluk MJ and Hla T, Circ Res. 2001 Sep 14;89(6):496-502.
6. Cloning of the rat edg-1 immediate-early gene: expression pattern suggests diverse functions. Lado DC, etal., Gene 1994 Nov 18;149(2):331-6.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition. Okamoto H, etal., J Biol Chem. 1998 Oct 16;273(42):27104-10.
10. Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. Okamoto H, etal., Mol Cell Biol. 2000 Dec;20(24):9247-61.
11. Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate. Parrill AL, etal., J Biol Chem 2000 Dec 15;275(50):39379-84.
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes. Robert P, etal., J Mol Cell Cardiol 2001 Sep;33(9):1589-606.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. Usui S, etal., J Biol Chem 2004 Mar 26;279(13):12300-11. Epub 2004 Jan 07.
Additional References at PubMed
PMID:11032855   PMID:11214319   PMID:11443127   PMID:11726541   PMID:12477932   PMID:14732704   PMID:15371328   PMID:16314531   PMID:16990586   PMID:18535287   PMID:18836449   PMID:19204730  
PMID:19493165   PMID:20032465   PMID:20729401   PMID:20844107   PMID:21289599   PMID:21605625   PMID:21613209   PMID:21668976   PMID:21719706   PMID:22104144   PMID:22344443   PMID:22445889  
PMID:22805346   PMID:22828274   PMID:23969695   PMID:24851274   PMID:24876379   PMID:25255053   PMID:25348153   PMID:26543024   PMID:27697711   PMID:27881715   PMID:28018679   PMID:28104351  
PMID:28493876   PMID:29266713   PMID:31276786   PMID:31476348   PMID:31802363   PMID:32487716   PMID:32924718   PMID:34296288   PMID:34310896   PMID:34347342   PMID:34516079   PMID:34773542  
PMID:37851113   PMID:37880240  


Genomics

Comparative Map Data
S1pr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82206,309,715 - 206,314,070 (-)NCBIGRCr8
mRatBN7.22203,624,752 - 203,629,110 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2203,621,587 - 203,629,681 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2211,288,334 - 211,292,535 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02209,178,280 - 209,182,489 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02203,995,309 - 203,999,518 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02218,654,406 - 218,658,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2218,654,554 - 218,658,761 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02236,742,193 - 236,746,400 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42211,851,304 - 211,855,511 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12211,814,057 - 211,818,265 (-)NCBI
Celera2196,132,649 - 196,136,856 (-)NCBICelera
Cytogenetic Map2q42NCBI
S1PR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381101,236,899 - 101,242,313 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1101,236,865 - 101,243,713 (+)EnsemblGRCh38hg38GRCh38
GRCh371101,702,455 - 101,707,869 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361101,475,043 - 101,479,662 (+)NCBINCBI36Build 36hg18NCBI36
Build 341101,414,596 - 101,419,094NCBI
Celera199,964,008 - 99,968,779 (+)NCBICelera
Cytogenetic Map1p21.2NCBI
HuRef199,828,430 - 99,833,201 (+)NCBIHuRef
CHM1_11101,818,158 - 101,822,929 (+)NCBICHM1_1
T2T-CHM13v2.01101,085,760 - 101,091,176 (+)NCBIT2T-CHM13v2.0
S1pr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393115,504,082 - 115,508,704 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3115,504,082 - 115,508,721 (-)EnsemblGRCm39 Ensembl
GRCm383115,710,433 - 115,715,055 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3115,710,433 - 115,715,072 (-)EnsemblGRCm38mm10GRCm38
MGSCv373115,413,351 - 115,417,973 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363115,702,443 - 115,707,051 (-)NCBIMGSCv36mm8
Celera3122,144,261 - 122,148,908 (-)NCBICelera
Cytogenetic Map3G1NCBI
cM Map350.0NCBI
S1pr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554355,880,288 - 5,881,436 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554355,880,266 - 5,882,823 (+)NCBIChiLan1.0ChiLan1.0
S1PR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21125,787,394 - 125,793,033 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11124,945,604 - 124,950,317 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01103,893,199 - 103,898,381 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11102,606,608 - 102,611,373 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1102,608,839 - 102,609,987 (+)Ensemblpanpan1.1panPan2
S1PR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1648,897,320 - 48,902,206 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl648,897,449 - 48,900,037 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0649,235,333 - 49,239,909 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1648,928,661 - 48,930,939 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0648,908,285 - 48,910,563 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0649,337,617 - 49,339,895 (-)NCBIUU_Cfam_GSD_1.0
S1pr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058111,439,836 - 111,445,001 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367481,245,538 - 1,250,093 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367481,244,962 - 1,250,093 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
S1PR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4117,064,755 - 117,069,650 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14117,064,632 - 117,069,724 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
S1PR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12032,109,436 - 32,117,015 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2032,110,819 - 32,111,967 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603825,954,820 - 25,959,741 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
S1pr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248574,143,270 - 4,147,877 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248574,143,269 - 4,147,877 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in S1pr1
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:574
Count of miRNA genes:276
Interacting mature miRNAs:340
Transcripts:ENSRNOT00000018318
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat

Markers in Region
RH129877  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22203,624,810 - 203,624,994 (+)MAPPERmRatBN7.2
Rnor_6.02218,654,464 - 218,654,647NCBIRnor6.0
Rnor_5.02236,742,103 - 236,742,286UniSTSRnor5.0
RGSC_v3.42211,851,214 - 211,851,397UniSTSRGSC3.4
Celera2196,132,559 - 196,132,742UniSTS
RH 3.4 Map21451.6UniSTS
Cytogenetic Map2q41UniSTS
EDG1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22203,626,108 - 203,627,168 (+)MAPPERmRatBN7.2
Rnor_6.02218,655,762 - 218,656,821NCBIRnor6.0
Rnor_5.02236,743,401 - 236,744,460UniSTSRnor5.0
RGSC_v3.42211,852,512 - 211,853,571UniSTSRGSC3.4
Celera2196,133,857 - 196,134,916UniSTS
Cytogenetic Map2q41UniSTS


Related Rat Strains
The following Strains have been annotated to S1pr1
SHRSP.WKY-(D2Mit21-D2Rat157)/Gcrc     SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000018318   ⟹   ENSRNOP00000052627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2203,621,587 - 203,629,681 (-)Ensembl
Rnor_6.0 Ensembl2218,654,554 - 218,658,761 (-)Ensembl
RefSeq Acc Id: NM_017301   ⟹   NP_058997
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82206,309,863 - 206,314,070 (-)NCBI
mRatBN7.22203,624,901 - 203,629,110 (-)NCBI
Rnor_6.02218,654,554 - 218,658,761 (-)NCBI
Rnor_5.02236,742,193 - 236,746,400 (-)NCBI
RGSC_v3.42211,851,304 - 211,855,511 (-)RGD
Celera2196,132,649 - 196,136,856 (-)RGD
Sequence:
RefSeq Acc Id: XM_008761459   ⟹   XP_008759681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82206,309,715 - 206,313,936 (-)NCBI
mRatBN7.22203,624,752 - 203,628,956 (-)NCBI
Rnor_6.02218,654,406 - 218,658,694 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_058997 (Get FASTA)   NCBI Sequence Viewer  
  XP_008759681 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA83418 (Get FASTA)   NCBI Sequence Viewer  
  AAH97938 (Get FASTA)   NCBI Sequence Viewer  
  EDL82014 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000052627.1
  ENSRNOP00055001361
  ENSRNOP00060000541
  ENSRNOP00065031535
GenBank Protein P48303 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058997   ⟸   NM_017301
- UniProtKB: Q4V7F6 (UniProtKB/Swiss-Prot),   P48303 (UniProtKB/Swiss-Prot),   A6HV78 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759681   ⟸   XM_008761459
- Peptide Label: isoform X1
- UniProtKB: Q4V7F6 (UniProtKB/Swiss-Prot),   P48303 (UniProtKB/Swiss-Prot),   A6HV78 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000052627   ⟸   ENSRNOT00000018318
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48303-F1-model_v2 AlphaFold P48303 1-383 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691699
Promoter ID:EPDNEW_R2223
Type:single initiation site
Name:S1pr1_1
Description:sphingosine-1-phosphate receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02218,658,781 - 218,658,841EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61958 AgrOrtholog
BioCyc Gene G2FUF-51520 BioCyc
Ensembl Genes ENSRNOG00000013683 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055001051 UniProtKB/Swiss-Prot
  ENSRNOG00060000950 UniProtKB/Swiss-Prot
  ENSRNOG00065022778 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018318.4 UniProtKB/Swiss-Prot
  ENSRNOT00055001746 UniProtKB/Swiss-Prot
  ENSRNOT00060001259 UniProtKB/Swiss-Prot
  ENSRNOT00065038878 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7460011 IMAGE-MGC_LOAD
InterPro EDG1 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S1P_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29733 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:116057 IMAGE-MGC_LOAD
NCBI Gene 29733 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR22750:SF16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen S1pr1 PhenoGen
PRINTS EDG1RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S1PRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013683 RatGTEx
  ENSRNOG00055001051 RatGTEx
  ENSRNOG00060000950 RatGTEx
  ENSRNOG00065022778 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC210588
UniProt A6HV78 ENTREZGENE, UniProtKB/TrEMBL
  P48303 ENTREZGENE
  Q4V7F6 ENTREZGENE
  S1PR1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q4V7F6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-20 S1pr1  sphingosine-1-phosphate receptor 1  Edg1  endothelial differentiation sphingolipid G-protein-coupled receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Edg1  endothelial differentiation sphingolipid G-protein-coupled receptor 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression widely expressed 61573