Gene: S1pr1 (sphingosine-1-phosphate receptor 1) Rattus norvegicus
Symbol: S1pr1
Name: sphingosine-1-phosphate receptor 1
Description: ENCODES a protein that exhibits G-protein coupled receptor activity; sphingolipid binding; G-protein coupled receptor binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; endothelial cell differentiation; G-protein coupled receptor signaling pathway; PARTICIPATES IN G protein mediated signaling pathway via Galphai family; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH cardiac hypertrophy; ASSOCIATED WITH Cardiomegaly; Carcinoma (ortholog); Liver Cirrhosis, Experimental (ortholog); FOUND IN external side of plasma membrane (ortholog); intracellular membrane-bounded organelle (ortholog); intrinsic component of plasma membrane (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate
Type: protein-coding
Also known as: Edg1; EDG1 (Edg1); endothelial differentiation G-protein coupled receptor 1; endothelial differentiation sphingolipid G-protein-coupled receptor 1; S1P receptor 1; S1P receptor Edg-1; S1P1; sphingosine 1-phosphate receptor 1; sphingosine 1-phosphate receptor Edg-1
Homo sapiens (human) : S1PR1 (sphingosine-1-phosphate receptor 1)  HGNC  Alliance
Mus musculus (house mouse) : S1pr1 (sphingosine-1-phosphate receptor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : S1pr1 (sphingosine-1-phosphate receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : S1PR1 (sphingosine-1-phosphate receptor 1)
Canis lupus familiaris (dog) : S1PR1 (sphingosine-1-phosphate receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : S1pr1 (sphingosine-1-phosphate receptor 1)
more info ...
Is Marker For: Strains:   SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc   SHRSP.WKY-(D2Mit21-D2Rat157)/Gcrc  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02218,654,406 - 218,658,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02236,742,193 - 236,746,400 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42211,851,304 - 211,855,511 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12211,814,057 - 211,818,265 (-)NCBI
Celera2196,132,649 - 196,136,856 (-)NCBICelera
Cytogenetic Map2q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on S1pr1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61958
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2018-02-06
Status: ACTIVE