Fosl1 (FOS like 1, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: Fosl1 (FOS like 1, AP-1 transcription factor subunit) Rattus norvegicus
Analyze
Symbol: Fosl1
Name: FOS like 1, AP-1 transcription factor subunit
RGD ID: 2627
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including response to cAMP; response to hydrogen peroxide; and response to steroid hormone. Located in presynaptic membrane. Biomarker of congestive heart failure; renal carcinoma; and visual epilepsy. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human FOSL1 (FOS like 1, AP-1 transcription factor subunit); PARTICIPATES IN Wnt signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: FOS like 1, AP-1 trancription factor subunit; fos-like antigen 1; fos-related antigen 1; Fra-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21202,754,549 - 202,763,057 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1202,754,529 - 202,764,930 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,106,898 - 211,115,363 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,199,949 - 218,208,463 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01210,890,991 - 210,899,504 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01220,826,560 - 220,835,066 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1220,826,560 - 220,835,066 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,755,887 - 227,764,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41208,090,612 - 208,099,118 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11208,244,064 - 208,252,571 (+)NCBI
Celera1200,290,637 - 200,299,144 (+)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(2E,4E)-hexa-2,4-dienoic acid  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-nitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracene-1,8,9-triol  (ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atazanavir sulfate  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoic acid  (ISO)
beta-carotene  (ISO)
beta-naphthoflavone  (EXP)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Botulinum toxin type A  (ISO)
bromobenzene  (EXP)
bromochloroacetic acid  (EXP)
butan-1-ol  (ISO)
butylated hydroxyanisole  (ISO)
butyric acid  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (ISO)
capsaicin  (EXP)
carbofuran  (EXP)
carbon nanotube  (ISO)
catechol  (ISO)
chenodeoxycholic acid  (ISO)
chloroacetaldehyde  (ISO)
chlorpromazine  (ISO)
cholic acid  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clothianidin  (ISO)
clozapine  (EXP)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
DDT  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dichromium trioxide  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP,ISO)
diphenylcyclopropenone  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
erythrosin B  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
genistein  (EXP)
gentamycin  (EXP)
geraniol  (ISO)
glucose  (ISO)
glutathione  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
graphite  (EXP)
haloperidol  (EXP)
hemin  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ifosfamide  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
iron trichloride  (ISO)
iron(III) nitrilotriacetate  (EXP)
isobutanol  (ISO)
isoprenaline  (EXP,ISO)
itraconazole  (ISO)
ketoconazole  (EXP,ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
manganese(II) chloride  (EXP)
mechlorethamine  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
metacetamol  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
Mezerein  (ISO)
miconazole  (EXP)
Muraglitazar  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalenes  (EXP)
nefazodone  (ISO)
neurotensin  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nimustine  (ISO)
Nodularin  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
olanzapine  (EXP)
organoselenium compound  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
palytoxin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PD 0325901  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perylene  (ISO)
phenacetin  (ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
picrotoxin  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
resveratrol  (ISO)
rimonabant  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
saccharin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
SKF 38393  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
styrene oxide  (ISO)
succimer  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetradecane  (EXP)
Tetramethylthiourea  (ISO)
thioacetamide  (EXP)
tin(II) chloride (anhydrous)  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triacsin C  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
undecane  (EXP)
urethane  (ISO)
valsartan  (ISO)
vincaleukoblastine  (ISO)
withaferin A  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Insidious role of nitric oxide in migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKG-ERK signaling pathways. Babykutty S, etal., Clin Exp Metastasis. 2012 Jun;29(5):471-92. doi: 10.1007/s10585-012-9464-6. Epub 2012 Mar 15.
2. A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers. Bergman MR, etal., Biochem J 2003 Feb 1;369(Pt 3):485-96.
3. Fra-1 promotes growth and survival in RAS-transformed thyroid cells by controlling cyclin A transcription. Casalino L, etal., EMBO J. 2007 Apr 4;26(7):1878-90. Epub 2007 Mar 8.
4. FRA-1 protein overexpression is a feature of hyperplastic and neoplastic breast disorders. Chiappetta G, etal., BMC Cancer. 2007 Jan 25;7:17.
5. fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen. Cohen DR and Curran T, Mol Cell Biol 1988 May;8(5):2063-9.
6. Learning-dependent activation of Fra-1: involvement of ventral hippocampus and SNc/VTA complex in learning and habit formation. Faure A, etal., Brain Res Bull. 2006 Jan 15;68(4):233-48. Epub 2005 Sep 19.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer. Gupta S, etal., Sci Rep. 2015 Nov 19;5:16811. doi: 10.1038/srep16811.
10. Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge. Hansson AC and Fuxe K, Brain Res. 2008 Jun 18;1215:1-10. Epub 2008 Apr 10.
11. H(2)O(2)-induced egr-1, fra-1, and c-jun gene expression is mediated by tyrosine kinase in aortic smooth muscle cells. Jin N, etal., Free Radic Biol Med. 2000 Oct 15;29(8):736-46.
12. Carbetapentane attenuates kainate-induced seizures via sigma-1 receptor modulation. Kim HC, etal., Life Sci. 2001 Jul 13;69(8):915-22.
13. The regulation of inducible nitric oxide synthase gene expression induced by lipopolysaccharide and tumor necrosis factor-alpha in C6 cells: involvement of AP-1 and NFkappaB. Lee JK, etal., Life Sci. 2003 Jun 20;73(5):595-609.
14. A functional SNP rs1892901 in FOSL1 is associated with gastric cancer in Chinese population. Liu W, etal., Sci Rep. 2017 Feb 7;7:41737. doi: 10.1038/srep41737.
15. Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation. Matsuo K, etal., Nat Genet 2000 Feb;24(2):184-7.
16. Differential expression of activator protein-1 transcription factors in pregnant rat myometrium. Mitchell JA and Lye SJ, Biol Reprod. 2002 Jul;67(1):240-6.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Localization of transcription factor AP-1 family proteins in ameloblast nuclei of the rat incisor. Nishikawa S J Histochem Cytochem. 2000 Nov;48(11):1511-20.
19. Fos- and Jun-related transcription factors are involved in the signal transduction pathway of mechanical loading in condylar chondrocytes. Papachristou D, etal., Eur J Orthod. 2006 Feb;28(1):20-6. Epub 2005 Dec 22.
20. Experience-dependent decrease in synaptically localized Fra-1. Paratcha G, etal., Brain Res Mol Brain Res. 2000 May 31;78(1-2):120-30.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. Contribution of REM sleep to Fos and FRA expression in the vestibular nuclei of rat leading to vestibular adaptation during the STS-90 Neurolab Mission. Pompeiano O Arch Ital Biol. 2007 Jan;145(1):55-85.
23. Constitutive activation of transcription factor AP-1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP-1 activity in HeLa cells by curcumin. Prusty BK and Das BC, Int J Cancer. 2005 Mar 1;113(6):951-60.
24. GOA pipeline RGD automated data pipeline
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation. Sharma SC and Richards JS, J Biol Chem. 2000 Oct 27;275(43):33718-28.
27. Overexpression of the immediate early gene fra-1 inhibits proliferation, induces apoptosis, and reduces tumourigenicity of c6 glioma cells. Shirsat NV and Shaikh SA, Exp Cell Res. 2003 Nov 15;291(1):91-100.
28. Overexpression of members of the AP-1 transcriptional factor family from an early stage of renal carcinogenesis and inhibition of cell growth by AP-1 gene antisense oligonucleotides in the Tsc2 gene mutant (Eker) rat model. Urakami S, etal., Biochem Biophys Res Commun. 1997 Dec 8;241(1):24-30.
29. Cardiac gene expression profile in rats with terminal heart failure and cachexia. Wellner M, etal., Physiol Genomics. 2005 Feb 10;20(3):256-67. Epub 2004 Dec 28.
30. The differential molecular mechanisms underlying proenkephalin mRNA expression induced by forskolin and phorbol-12-myristic-13-acetate in primary cultured astrocytes. Won JS and Suh HW, Brain Res Mol Brain Res. 2000 Dec 8;84(1-2):41-51.
31. Overexpression of genes in the CA1 hippocampus region of adult rat following episodes of global ischemia. Yakubov E, etal., Brain Res Mol Brain Res. 2004 Aug 23;127(1-2):10-26.
Additional References at PubMed
PMID:7791782   PMID:9294610   PMID:11044407   PMID:12477932   PMID:12773579   PMID:12839939   PMID:19289495   PMID:20472895   PMID:21673316   PMID:21820506   PMID:21947281   PMID:23027619  
PMID:26149388   PMID:30892941   PMID:34973528   PMID:36634215   PMID:37949219  


Genomics

Comparative Map Data
Fosl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21202,754,549 - 202,763,057 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1202,754,529 - 202,764,930 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,106,898 - 211,115,363 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,199,949 - 218,208,463 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01210,890,991 - 210,899,504 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01220,826,560 - 220,835,066 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1220,826,560 - 220,835,066 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,755,887 - 227,764,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41208,090,612 - 208,099,118 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11208,244,064 - 208,252,571 (+)NCBI
Celera1200,290,637 - 200,299,144 (+)NCBICelera
Cytogenetic Map1q43NCBI
FOSL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,892,049 - 65,900,545 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1165,892,049 - 65,900,573 (-)EnsemblGRCh38hg38GRCh38
GRCh371165,659,520 - 65,668,016 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,416,268 - 65,424,573 (-)NCBINCBI36Build 36hg18NCBI36
Build 341165,416,267 - 65,424,573NCBI
Celera1162,983,599 - 62,991,910 (-)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1161,986,283 - 61,994,593 (-)NCBIHuRef
CHM1_11165,544,106 - 65,552,418 (-)NCBICHM1_1
T2T-CHM13v2.01165,885,111 - 65,893,612 (-)NCBIT2T-CHM13v2.0
Fosl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,497,726 - 5,505,966 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl195,497,575 - 5,505,974 (+)EnsemblGRCm39 Ensembl
GRCm38195,447,698 - 5,455,938 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,447,547 - 5,455,946 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,447,698 - 5,455,938 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,447,698 - 5,455,938 (+)NCBIMGSCv36mm8
Celera195,319,672 - 5,327,911 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.33NCBI
Fosl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542219,423,591 - 19,433,885 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542219,425,741 - 19,431,801 (+)NCBIChiLan1.0ChiLan1.0
FOSL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11168,163,562 - 68,172,119 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01161,252,513 - 61,261,032 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11164,581,841 - 64,589,300 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1164,581,841 - 64,589,304 (-)Ensemblpanpan1.1panPan2
FOSL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11851,366,719 - 51,374,411 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1851,368,352 - 51,373,748 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1849,975,212 - 49,982,921 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01852,404,801 - 52,412,502 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1852,405,480 - 52,411,838 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11851,504,866 - 51,512,571 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01851,079,242 - 51,086,930 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01851,868,548 - 51,876,244 (+)NCBIUU_Cfam_GSD_1.0
Fosl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049477,199,963 - 7,206,564 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365993,642,504 - 3,648,417 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365993,642,504 - 3,649,294 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOSL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl26,430,153 - 6,436,173 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.126,430,158 - 6,436,173 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.225,534,085 - 5,540,201 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FOSL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118,356,263 - 8,365,606 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl18,356,836 - 8,364,918 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038105,645,101 - 105,654,787 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fosl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476720,519,313 - 20,524,554 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476720,519,054 - 20,525,311 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fosl1
23 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:55
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000027891
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1199368955224569684Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 3 25 38 22 19 22 8 11 17 11 31 11 8
Below cutoff 6 13 13 13 39 18 8

Sequence


RefSeq Acc Id: ENSRNOT00000027891   ⟹   ENSRNOP00000027891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1202,754,529 - 202,764,930 (+)Ensembl
Rnor_6.0 Ensembl1220,826,560 - 220,835,066 (+)Ensembl
RefSeq Acc Id: NM_012953   ⟹   NP_037085
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21202,754,549 - 202,763,057 (+)NCBI
Rnor_6.01220,826,560 - 220,835,066 (+)NCBI
Rnor_5.01227,755,887 - 227,764,393 (+)NCBI
RGSC_v3.41208,090,612 - 208,099,118 (+)RGD
Celera1200,290,637 - 200,299,144 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037085 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41171 (Get FASTA)   NCBI Sequence Viewer  
  AAA82045 (Get FASTA)   NCBI Sequence Viewer  
  AAH97342 (Get FASTA)   NCBI Sequence Viewer  
  EDM12489 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027891
  ENSRNOP00000027891.1
  ENSRNOP00055029625
  ENSRNOP00065047683
GenBank Protein P10158 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037085   ⟸   NM_012953
- UniProtKB: Q4V8K7 (UniProtKB/Swiss-Prot),   P10158 (UniProtKB/Swiss-Prot),   A6HZ58 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027891   ⟸   ENSRNOT00000027891
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10158-F1-model_v2 AlphaFold P10158 1-275 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690655
Promoter ID:EPDNEW_R1180
Type:multiple initiation site
Name:Fosl1_2
Description:FOS like 1, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1181  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01220,826,536 - 220,826,596EPDNEW
RGD ID:13690656
Promoter ID:EPDNEW_R1181
Type:single initiation site
Name:Fosl1_1
Description:FOS like 1, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1180  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01220,826,731 - 220,826,791EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2627 AgrOrtholog
BioCyc Gene G2FUF-56681 BioCyc
Ensembl Genes ENSRNOG00000020552 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055021318 UniProtKB/Swiss-Prot
  ENSRNOG00065033700 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027891 ENTREZGENE
  ENSRNOT00000027891.3 UniProtKB/Swiss-Prot
  ENSRNOT00055036436 UniProtKB/Swiss-Prot
  ENSRNOT00065057898 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7459558 IMAGE-MGC_LOAD
InterPro AP-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:114353 IMAGE-MGC_LOAD
NCBI Gene 25445 ENTREZGENE
PANTHER FOS TRANSCRIPTION FACTOR-RELATED UniProtKB/TrEMBL
  FOS-RELATED ANTIGEN 1 UniProtKB/TrEMBL
  PTHR23351 UniProtKB/Swiss-Prot
  PTHR23351:SF6 UniProtKB/Swiss-Prot
Pfam bZIP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fosl1 PhenoGen
PRINTS LEUZIPPRFOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020552 RatGTEx
  ENSRNOG00055021318 RatGTEx
  ENSRNOG00065033700 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Leucine zipper domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6HZ58 ENTREZGENE, UniProtKB/TrEMBL
  FOSL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4V8K7 ENTREZGENE
UniProt Secondary Q4V8K7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-01 Fosl1  FOS like 1, AP-1 transcription factor subunit  Fosl1  FOS like 1, AP-1 trancription factor subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-11 Fosl1  FOS like 1, AP-1 trancription factor subunit  Fosl1  fos-like antigen 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Fosl1  Fos-like antigen 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in serum stimulated fibroblasts 632677
gene_homology amino acid homologous to the Fos gene 632677
gene_regulation exhibits immediate-early transcriptional response to extracellular stimuli 632677