Gene: Fosl1 (FOS like 1, AP-1 transcription factor subunit) Rattus norvegicus
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Symbol: Fosl1
Name: FOS like 1, AP-1 transcription factor subunit
Description: ENCODES a protein that exhibits DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II proximal promoter sequence-specific DNA binding; INVOLVED IN female pregnancy; learning; negative regulation of cell population proliferation; PARTICIPATES IN Wnt signaling pathway; ASSOCIATED WITH congestive heart failure; renal carcinoma; Reperfusion Injury; FOUND IN cytosol; intracellular membrane-bounded organelle; neuron projection; INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,2,4-trimethylbenzene
AGR Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity; involved in several processes, including female pregnancy, regulation of cellular biosynthetic process, and response to steroid hormone; localizes to several cellular components, including the cytosol, neuron projection, and nucleus; biomarker of congestive heart failure, renal carcinoma, and visual epilepsy; orthologous to human FOSL1 (FOS like 1, AP-1 transcription factor subunit).
Merged Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity; involved in several processes, including female pregnancy, regulation of cellular biosynthetic process, and response to steroid hormone; localizes to several cellular components, including the cytosol, neuron projection, and nucleus; biomarker of congestive heart failure, renal carcinoma, and visual epilepsy; orthologous to human FOSL1 (FOS like 1, AP-1 transcription factor subunit); PARTICIPATES IN Wnt signaling pathway; INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,2,4-trimethylbenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: FOS like 1, AP-1 trancription factor subunit; fos-like antigen 1; fos-related antigen 1; Fra-1
Orthologs:
Homo sapiens (human) : FOSL1 (FOS like 1, AP-1 transcription factor subunit)  HGNC  Alliance
Mus musculus (house mouse) : Fosl1 (fos-like antigen 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fosl1 (FOS like 1, AP-1 transcription factor subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : FOSL1 (FOS like 1, AP-1 transcription factor subunit)
Canis lupus familiaris (dog) : FOSL1 (FOS like 1, AP-1 transcription factor subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fosl1 (FOS like 1, AP-1 transcription factor subunit)
Sus scrofa (pig) : FOSL1 (FOS like 1, AP-1 transcription factor subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01220,826,560 - 220,835,066 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01227,755,887 - 227,764,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41208,090,612 - 208,099,118 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11208,244,064 - 208,252,571 (+)NCBI
Celera1200,290,637 - 200,299,144 (+)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Fosl1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2627
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.