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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2627
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fosl1
Name: FOS like 1, AP-1 transcription factor subunit
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosl1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of FOSL1 mRNAPMID:33387578
Fosl1multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FOSL1 proteinPMID:8625438
Fosl1affects expressionISOFosl1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of FOSL1 mRNAPMID:24058054
Fosl1affects expressionISOFOSL1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of FOSL1 mRNA; Tetrachlorodibenzodioxin affects the expression of FOSL1 proteinPMID:16985168 PMID:22298810
Fosl1increases expressionISOFosl1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of FOSL1 mRNAPMID:18691609 PMID:19770486 PMID:21496263 PMID:32553695
Fosl1increases expressionISOFOSL1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of FOSL1 mRNAPMID:12377990 PMID:20106945 PMID:21496263 PMID:21632981 PMID:23152189 PMID:23625689
Fosl1multiple interactionsISOFosl1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FOSL1 mRNAPMID:17942748
Fosl1multiple interactionsISOFOSL1 (Homo sapiens)6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FOSL1 mRNA]PMID:23625689
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