GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Fosl1 | decreases methylation | ISO | FOSL1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in decreased methylation of FOSL1 promoter | PMID:27901495 | Fosl1 | increases expression | ISO | Fosl1 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene metabolite results in increased expression of FOSL1 mRNA; Benzo(a)pyrene results in increased expression of FOSL1 mRNA | PMID:19770486 PMID:20713471 PMID:21569818 PMID:32553695 | Fosl1 | increases expression | ISO | FOSL1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of FOSL1 mRNA | PMID:20106945 PMID:21632981 PMID:22316170 PMID:32234424 PMID:35690182 PMID:35870112 | Fosl1 | increases methylation | ISO | FOSL1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased methylation of FOSL1 3' UTR | PMID:27901495 | Fosl1 | multiple interactions | ISO | Fosl1 (Mus musculus) | 6480464 | CTD | [Benzo(a)pyrene results in increased activity of AHR protein] which results in increased expression of FOSL1 mRNA | PMID:32553695 | |
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