Cxcl1 (C-X-C motif chemokine ligand 1) - Rat Genome Database

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Gene: Cxcl1 (C-X-C motif chemokine ligand 1) Rattus norvegicus
Symbol: Cxcl1
Name: C-X-C motif chemokine ligand 1
RGD ID: 619869
Description: Enables chemokine activity. Involved in several processes, including neutrophil chemotaxis; positive regulation of monoatomic ion transport; and response to amphetamine. Located in extracellular space. Biomarker of several diseases, including acute necrotizing pancreatitis; lung disease (multiple); prostatitis; severe acute respiratory syndrome; and status epilepticus. Orthologous to several human genes including CXCL1 (C-X-C motif chemokine ligand 1); PARTICIPATES IN interleukin-23 signaling pathway; chemokine mediated signaling pathway; NOD-like receptor signaling pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (R,R,R)-alpha-tocopherol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-X-C motif chemokine 1; chemokine (C-X-C motif) ligand 1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); CINC-1; cytokine-induced neutrophil chemoattractant 1; Gro; Gro1; growth-regulated alpha protein; platelet-derived growth factor-inducible protein KC
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21417,193,364 - 17,195,143 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,193,365 - 17,195,215 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,194,186 - 17,195,964 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,513,114 - 18,514,892 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,205,210 - 17,206,989 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,743,678 - 18,745,457 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,743,685 - 18,745,457 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,653,032 - 18,654,811 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,690,339 - 18,692,118 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,690,338 - 18,692,118 (-)NCBI
Celera1416,570,160 - 16,571,939 (-)NCBICelera
RH 3.4 Map14215.0RGD
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute necrotizing pancreatitis  (IEP)
Alcoholic Liver Diseases  (IEP)
allergic disease  (ISO)
Animal Hepatitis  (IEP)
aspiration pneumonia  (IEP)
asthma  (ISO)
autoimmune hepatitis  (ISO)
bacterial pneumonia  (IEP,ISO)
Brain Injuries  (IEP)
Bronchial Hyperreactivity  (ISO)
bronchopulmonary dysplasia  (IEP)
Burns  (IEP)
Chemical and Drug Induced Liver Injury  (ISO)
chronic obstructive pulmonary disease  (ISO)
common cold  (ISO)
cystic fibrosis  (ISO)
dilated cardiomyopathy  (IEP)
Endotoxemia  (ISO)
Enteritis  (IEP)
esophageal cancer  (IEP)
Experimental Arthritis  (IEP)
Experimental Liver Cirrhosis  (ISO)
Femoral Fractures  (IEP)
genetic disease  (ISO)
Hemorrhage  (IEP)
Hemorrhagic Shock  (IEP,ISO)
Human Influenza  (ISO)
hyperhomocysteinemia  (ISO)
Inflammation  (IDA,IEP)
juvenile rheumatoid arthritis  (ISO)
Legionnaires' disease  (ISO)
Liver Neoplasms  (ISO)
Liver Reperfusion Injury  (IDA,ISO)
lung disease  (IEP,ISO)
Myocardial Reperfusion Injury  (IMP)
Nasal Polyps  (ISO)
plague  (ISO)
pleurisy  (ISO)
Pneumococcal Meningitis  (IEP)
Pneumococcal Pneumonia  (ISO)
pneumonia  (IEP,ISO)
prostatitis  (IEP)
pulmonary emphysema  (ISO)
Reperfusion Injury  (IEP,ISO)
respiratory allergy  (ISO)
respiratory syncytial virus infectious disease  (ISO)
severe acute respiratory syndrome  (IEP)
Spinal Cord Injuries  (IEP)
status epilepticus  (IEP)
Stroke  (IEP)
Subarachnoid Hemorrhage  (IEP)
Ventricular Dysfunction, Right  (IEP)
viral pneumonia  (IEP)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,2-dichlorobenzene  (EXP)
1,3-benzothiazole-2-thiol  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-tert-butylhydroquinone  (ISO)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-Nitrofluoranthene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
Actein  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amosite asbestos  (EXP)
amphibole asbestos  (EXP)
amphotericin B  (ISO)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (ISO)
apocynin  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
asbestos  (ISO)
atrazine  (ISO)
Bardoxolone methyl  (ISO)
Belnacasan  (EXP)
benazepril  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
budesonide  (EXP)
butanal  (ISO)
butane-2,3-dione  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
candesartan  (EXP)
cannabidiol  (ISO)
carbon nanotube  (EXP,ISO)
carmustine  (ISO)
cefaloridine  (EXP)
chloropicrin  (ISO)
chondroitin sulfate  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clozapine  (EXP,ISO)
cobalt atom  (EXP)
cobalt dichloride  (ISO)
cobalt(2+) sulfate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
curcumin  (ISO)
cyanuric chloride  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
diisopropyl fluorophosphate  (EXP)
dinitrogen  (ISO)
diuron  (EXP)
divanadium pentaoxide  (EXP)
doramapimod  (ISO)
doxorubicin  (ISO)
edaravone  (EXP)
elemental selenium  (ISO)
emodin  (EXP)
endosulfan  (EXP)
ethanol  (EXP)
eugenol  (ISO)
famotidine  (EXP)
ferric oxide  (ISO)
fluticasone  (ISO)
formaldehyde  (ISO)
fulvestrant  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
gadolinium trichloride  (EXP)
gemcitabine  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glutathione  (EXP)
gossypol  (ISO)
graphite  (EXP)
halothane  (EXP)
heparan sulfate  (ISO)
hexachlorobenzene  (EXP)
Hexadimethrine bromide  (EXP)
hydrogen chloride  (EXP)
hydrogen peroxide  (ISO)
hydroxychloroquine  (ISO)
idelalisib  (ISO)
indometacin  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
isoflurane  (EXP)
isotretinoin  (ISO)
ketorolac  (EXP)
L-ascorbic acid  (EXP)
lansoprazole  (EXP)
lidocaine  (EXP)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP)
manganese(II) chloride  (EXP)
mesalamine  (ISO)
metformin  (EXP)
methadone  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
metyrapone  (EXP)
microcystin-LR  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
morphine  (EXP)
Muraglitazar  (EXP)
muramyl dipeptide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodimethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalenes  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
o-anisidine  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PD 0325901  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
perfluorobutyric acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
Phytolaccoside E  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
poly(I:C)  (EXP)
potassium chromate  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
propanal  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quartz  (EXP)
ranitidine  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
ritonavir  (ISO)
rofecoxib  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 203580  (EXP,ISO)
SCH-351591  (EXP)
SCH772984  (EXP)
selenium atom  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
spironolactone  (EXP)
streptozocin  (EXP)
sulfapyridine  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
tamoxifen  (EXP)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
tetradecane  (EXP)
thioacetamide  (EXP)
Tiron  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimethyltin  (EXP)
troglitazone  (ISO)
tropisetron  (EXP)
tungsten  (EXP)
tunicamycin  (ISO)
undecane  (EXP)
ursodeoxycholic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
wortmannin  (EXP)
zaragozic acid A  (EXP)
zinc acetate  (ISO)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc protoporphyrin  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Neutrophil chemokines and their role in IL-18-mediated increase in neutrophil O2- production and intestinal edema following alcohol intoxication and burn injury. Akhtar S, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G340-7. Epub 2009 Jun 4.
2. Impaired interleukin-8 chemokine secretion by staphylococcus aureus-activated epithelium and T-cell chemotaxis in cystic fibrosis. Al Alam D, etal., Am J Respir Cell Mol Biol. 2010 Jun;42(6):644-50. Epub 2009 Jul 13.
3. Role of cytokine-induced neutrophil chemoattractant-2 (CINC-2) alpha in a rat model of chronic bronchopulmonary infections with Pseudomonas aeruginosa. Amano H, etal., Cytokine. 2000 Nov;12(11):1662-8.
4. Splenectomy exacerbates lung injury after ischemic acute kidney injury in mice. Andres-Hernando A, etal., Am J Physiol Renal Physiol. 2011 Oct;301(4):F907-16. Epub 2011 Jun 15.
5. A kinetic study of the cytokine/chemokines levels and disruption of blood-brain barrier in infant rats after pneumococcal meningitis. Barichello T, etal., J Neuroimmunol. 2011 Apr;233(1-2):12-7. Epub 2010 Nov 24.
6. CINC-1 is an acute-phase protein induced by focal brain injury causing leukocyte mobilization and liver injury. Campbell SJ, etal., FASEB J 2003 Jun;17(9):1168-70.
7. Ischemia-reperfusion of rat myocardium activates nuclear factor-KappaB and induces neutrophil infiltration via lipopolysaccharide-induced CXC chemokine. Chandrasekar B, etal., Circulation. 2001 May 8;103(18):2296-302.
8. Titanium dioxide nanoparticles induce emphysema-like lung injury in mice. Chen HW, etal., FASEB J. 2006 Nov;20(13):2393-5. Epub 2006 Oct 5.
9. Interferon-beta attenuates lung inflammation following experimental subarachnoid hemorrhage. Cobelens PM, etal., Crit Care. 2010;14(4):R157. Epub 2010 Aug 23.
10. The ratio of ELR+ to ELR- CXC chemokines affects the lung and liver injury following hepatic ischemia/ reperfusion in the rat. Colletti LM, etal., Hepatology. 2000 Feb;31(2):435-45.
11. Chemokine receptor CXCR2 mediates bacterial clearance rather than neutrophil recruitment in a murine model of pneumonic plague. Eisele NA, etal., Am J Pathol. 2011 Mar;178(3):1190-200.
12. Impairment of leukocyte trafficking in a murine pleuritis model by IL-4 and IL-10. Fine JS, etal., Inflammation. 2003 Aug;27(4):161-74.
13. The molecular phenotype of severe asthma in children. Fitzpatrick AM, etal., J Allergy Clin Immunol. 2010 Apr;125(4):851-857.e18.
14. Rat respiratory coronavirus infection: replication in airway and alveolar epithelial cells and the innate immune response. Funk CJ, etal., J Gen Virol. 2009 Dec;90(Pt 12):2956-64. Epub 2009 Sep 9.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Characterization of the inflammatory response during acute and post-acute phases after severe burn. Gauglitz GG, etal., Shock. 2008 Nov;30(5):503-7.
17. Folic acid treatment reduces chemokine release from peripheral blood mononuclear cells in hyperhomocysteinemic subjects. Holven KB, etal., Arterioscler Thromb Vasc Biol. 2002 Apr 1;22(4):699-703.
18. Pulmonary contusion primes systemic innate immunity responses. Hoth JJ, etal., J Trauma. 2009 Jul;67(1):14-21; discussion 21-2.
19. Rat KC cDNA cloning and mRNA expression in lung macrophages and fibroblasts. Huang S, etal., Biochem Biophys Res Commun 1992 Apr 30;184(2):922-9.
20. Increased expression of the chemokines CXCL1 and MIP-1alpha by resident brain cells precedes neutrophil infiltration in the brain following prolonged soman-induced status epilepticus in rats. Johnson EA, etal., J Neuroinflammation. 2011 May 2;8:41.
21. Attenuation of warm ischemia-reperfusion injury in the liver by bucillamine through decreased neutrophil activation and Bax/Bcl-2 modulation. Junnarkar SP, etal., J Gastroenterol Hepatol. 2010 Dec;25(12):1891-9. doi: 10.1111/j.1440-1746.2010.06312.x.
22. Pharmacological inhibition of p110δ subunit of PI3K confers protection against experimental leishmaniasis. Khadem F, etal., J Antimicrob Chemother. 2017 Feb;72(2):467-477. doi: 10.1093/jac/dkw448. Epub 2016 Dec 20.
23. Protection against sepsis-induced lung injury by selective inhibition of protein kinase C-delta (delta-PKC). Kilpatrick LE, etal., J Leukoc Biol. 2011 Jan;89(1):3-10. Epub 2010 Aug 19.
24. Macrophage-dependent regulation of neutrophil mobilization and chemotaxis during development of sterile peritonitis in the rat. Knudsen E, etal., Eur J Haematol 2002 Nov-Dec;69(5-6):284-96.
25. Structure of the gene encoding rat neutrophil chemo-attractant Gro. Konishi K, etal., Gene 1993 Apr 30;126(2):285-6.
26. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
27. Live and heat-killed Lactobacillus rhamnosus GG: effects on proinflammatory and anti-inflammatory cytokines/chemokines in gastrostomy-fed infant rats. Li N, etal., Pediatr Res. 2009 Aug;66(2):203-7.
28. Early combined treatment with sildenafil and adipose-derived mesenchymal stem cells preserves heart function in rat dilated cardiomyopathy. Lin YC, etal., J Transl Med. 2010 Sep 26;8:88.
29. The migration of T cells in response to influenza virus is altered in neonatal mice. Lines JL, etal., J Immunol. 2010 Sep 1;185(5):2980-8. Epub 2010 Jul 23.
30. Ondansetron attenuates hepatic injury via p38 MAPK-dependent pathway in a rat haemorrhagic shock model. Liu FC, etal., Resuscitation. 2011 Mar;82(3):335-40. Epub 2010 Dec 18.
31. Low intensity laser therapy (LILT) in vivo acts on the neutrophils recruitment and chemokines/cytokines levels in a model of acute pulmonary inflammation induced by aerosol of lipopolysaccharide from Escherichia coli in rat. Mafra de Lima F, etal., J Photochem Photobiol B. 2010 Dec 2;101(3):271-8. Epub 2010 Jul 27.
32. Single-dose gamma-irradiation induces up-regulation of chemokine gene expression and recruitment of granulocytes into the portal area but not into other regions of rat hepatic tissue. Malik IA, etal., Am J Pathol. 2010 Apr;176(4):1801-15. Epub 2010 Feb 25.
33. CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation. Marcos V, etal., Nat Med. 2010 Sep;16(9):1018-23. Epub 2010 Sep 5.
34. Selective chemokine mRNA accumulation in the rat spinal cord after contusion injury. McTigue DM, etal., J Neurosci Res. 1998 Aug 1;53(3):368-76.
35. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
36. Activation of nuclear factor kappa B and cytokine imbalance in experimental alcoholic liver disease in the rat. Nanji AA, etal., Hepatology. 1999 Oct;30(4):934-43.
37. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
38. Mechanisms of acute inflammatory lung injury induced by abdominal sepsis. Neumann B, etal., Int Immunol. 1999 Feb;11(2):217-27.
39. Cyclooxygenase inhibition in ventilator-induced lung injury. Niitsu T, etal., Anesth Analg. 2011 Jan;112(1):143-9. Epub 2010 Nov 3.
40. Mast cells are involved in the pathogenesis of indomethacin-induced rat enteritis. Okayama T, etal., J Gastroenterol. 2009;44 Suppl 19:35-9. Epub 2009 Jan 16.
41. Microarray analysis of distinct gene transcription profiles in non-eosinophilic chronic sinusitis with nasal polyps. Payne SC, etal., Am J Rhinol. 2008 Nov-Dec;22(6):568-81.
42. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
43. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
44. Superimposed gastric aspiration increases the severity of inflammation and permeability injury in a rat model of lung contusion. Raghavendran K, etal., J Surg Res. 2009 Aug;155(2):273-82. Epub 2008 Sep 16.
45. Preliminary investigation of a mice model of Klebsiella pneumoniae subsp. ozaenae induced pneumonia. Renois F, etal., Microbes Infect. 2011 Jun 30.
46. GOA pipeline RGD automated data pipeline
47. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
48. A rat model of picornavirus-induced airway infection and inflammation. Rosenthal LA, etal., Virol J. 2009 Aug 11;6:122.
49. The murine neutrophil-chemoattractant chemokines LIX, KC, and MIP-2 have distinct induction kinetics, tissue distributions, and tissue-specific sensitivities to glucocorticoid regulation in endotoxemia. Rovai LE, etal., J Leukoc Biol. 1998 Oct;64(4):494-502.
50. Effects of aliskiren on stroke in rats expressing human renin and angiotensinogen genes. Schmerbach K, etal., PLoS One. 2010 Nov 29;5(11):e15052.
51. Increased cytokine response of rhinovirus-infected airway epithelial cells in chronic obstructive pulmonary disease. Schneider D, etal., Am J Respir Crit Care Med. 2010 Aug 1;182(3):332-40. Epub 2010 Apr 15.
52. Correlation of measurable serum markers of inflammation with lung levels following bilateral femur fracture in a rat model. Sears BW, etal., J Inflamm Res. 2010 Aug 1;2010(3):105-114.
53. Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation. Sharma AK, etal., Respir Res. 2009 Jun 26;10:58.
54. Hepatic interferon regulatory factor 8 expression mediates liver ischemia/reperfusion injury in mice. Shi G, etal., Biochem Pharmacol. 2021 Oct;192:114728. doi: 10.1016/j.bcp.2021.114728. Epub 2021 Aug 13.
55. Differential changes in the concentrations of cytokine-induced neutrophil chemoattractant (CINC)-1 and CINC-2 in exudate during rat lipopolysaccharide-induced inflammation. Shibata F, etal., Cytokine. 1996 Mar;8(3):222-6.
56. Identification of a common receptor for three types of rat cytokine-induced neutrophil chemoattractants (CINCs). Shibata F, etal., Cytokine. 2000 Sep;12(9):1368-73.
57. Induction of pro- and anti-inflammatory molecules in a mouse model of pneumococcal pneumonia after influenza. Smith MW, etal., Comp Med. 2007 Feb;57(1):82-9.
58. The evolving systemic and local biomarker milieu at different stages of disease progression in rat collagen-induced arthritis. Stolina M, etal., Biomarkers. 2008 Nov;13(7):692-712.
59. Multiple berry types prevent N-nitrosomethylbenzylamine-induced esophageal cancer in rats. Stoner GD, etal., Pharm Res. 2010 Jun;27(6):1138-45. Epub 2010 Mar 16.
60. Effect of a phytotherapeutic agent, Eviprostat(R), on prostatic and urinary cytokines/chemokines in a rat model of nonbacterial prostatitis. Sugimoto M, etal., Prostate. 2011 Mar 1;71(4):438-44. doi: 10.1002/pros.21299. Epub 2010 Oct 28.
61. The role of the choroid plexus in neutrophil invasion after traumatic brain injury. Szmydynger-Chodobska J, etal., J Cereb Blood Flow Metab. 2009 Sep;29(9):1503-16. Epub 2009 May 27.
62. Chemokine-dependent neutrophil recruitment in a murine model of Legionella pneumonia: potential role of neutrophils as immunoregulatory cells. Tateda K, etal., Infect Immun. 2001 Apr;69(4):2017-24.
63. Acute exposure of mice to high-dose ultrafine carbon black decreases susceptibility to pneumococcal pneumonia. Tellabati A, etal., Part Fibre Toxicol. 2010 Oct 19;7:30.
64. Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature. Thomas M, etal., Synapse. 2009 Oct;63(10):881-94.
65. Dietary (n-3) polyunsaturated fatty acids affect the kinetics of pro- and antiinflammatory responses in mice with Pseudomonas aeruginosa lung infection. Tiesset H, etal., J Nutr. 2009 Jan;139(1):82-9. Epub 2008 Dec 3.
66. Respiratory syncytial virus (RSV) RNA loads in peripheral blood correlates with disease severity in mice. Torres JP, etal., Respir Res. 2010 Sep 15;11:125.
67. The differences of eosinophil- and neutrophil-related inflammation in elderly allergic and non-allergic chronic obstructive pulmonary disease. Tsai JJ, etal., J Asthma. 2010 Nov;47(9):1040-4.
68. The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury. Uchida Y, etal., Transplantation. 2010 May 15;89(9):1050-6.
69. Role of the Fas/FasL system in a model of RSV infection in mechanically ventilated mice. van den Berg E, etal., Am J Physiol Lung Cell Mol Physiol. 2011 Jul 8.
70. The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons. Wang JG, etal., Mol Pain. 2008 Sep 24;4:38.
71. [Anti-inflammatory effects of erythropoietin on hyperoxia-induced bronchopulmonary dysplasia in newborn rats]. Wang XL and Xue XD, Zhonghua Er Ke Za Zhi. 2009 Jun;47(6):446-51.
72. Proinflammatory events in right ventricular damage during pulmonary embolism: effects of treatment with ketorolac in rats. Watts JA, etal., J Cardiovasc Pharmacol. 2009 Sep;54(3):246-52.
73. [Effects of N-acetylcysteine on mRNA expression of monocyte chemotactic protein and macrophage inflammatory protein 2 in acute necrotizing pancreatitis: experiment with rats] Xu CF, etal., Zhonghua Yi Xue Za Zhi. 2008 Mar 11;88(10):711-5.
74. NF-kappaB mediated enhancement of potassium currents by the chemokine CXCL1/growth related oncogene in small diameter rat sensory neurons. Yang RH, etal., Mol Pain. 2009 May 28;5:26.
75. Akt pathway is required for oestrogen-mediated attenuation of lung injury in a rodent model of cerulein-induced acute pancreatitis. Yang SJ, etal., Injury. 2011 Jul;42(7):638-42. Epub 2010 Aug 14.
76. Role of Akt-dependent up-regulation of hemeoxygenase-1 in resveratrol-mediated attenuation of hepatic injury after trauma hemorrhage. Yu HP, etal., Surgery. 2010 Jul;148(1):103-9. Epub 2010 Feb 1.
77. Mechanisms of dexamethasone-mediated chemokine down-regulation in mild and severe acute pancreatitis. Yubero S, etal., Biochim Biophys Acta. 2009 Dec;1792(12):1205-11. Epub 2009 Oct 7.
Additional References at PubMed
PMID:1415488   PMID:2684956   PMID:7957925   PMID:8607872   PMID:9192722   PMID:9504410   PMID:10725737   PMID:10915734   PMID:12055258   PMID:12517731   PMID:12824006   PMID:12829448  
PMID:12949249   PMID:14617513   PMID:15942680   PMID:16271365   PMID:16522746   PMID:16618742   PMID:16637227   PMID:16818791   PMID:16942465   PMID:17164575   PMID:17166735   PMID:17632282  
PMID:17666044   PMID:17702850   PMID:17959522   PMID:18559975   PMID:18683011   PMID:18694739   PMID:20003523   PMID:20180411   PMID:20226088   PMID:20602290   PMID:21030786   PMID:21418993  
PMID:21905265   PMID:22466126   PMID:22554866   PMID:23460747   PMID:23892723   PMID:24006456   PMID:24280128   PMID:24464584   PMID:25084278   PMID:25383568   PMID:26724371   PMID:27672274  
PMID:28300348   PMID:28820395   PMID:29117499   PMID:30349936   PMID:30397790   PMID:31422522   PMID:31665717   PMID:31722447   PMID:31887360   PMID:32119843   PMID:32802846   PMID:33109545  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21417,193,364 - 17,195,143 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,193,365 - 17,195,215 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,194,186 - 17,195,964 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,513,114 - 18,514,892 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,205,210 - 17,206,989 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,743,678 - 18,745,457 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,743,685 - 18,745,457 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,653,032 - 18,654,811 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,690,339 - 18,692,118 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,690,338 - 18,692,118 (-)NCBI
Celera1416,570,160 - 16,571,939 (-)NCBICelera
RH 3.4 Map14215.0RGD
Cytogenetic Map14p22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38473,869,393 - 73,871,308 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl473,869,393 - 73,871,308 (+)EnsemblGRCh38hg38GRCh38
GRCh37474,735,110 - 74,737,025 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36474,953,973 - 74,955,817 (+)NCBINCBI36Build 36hg18NCBI36
Build 34475,100,143 - 75,101,988NCBI
Celera472,095,237 - 72,097,087 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,546,248 - 70,548,158 (+)NCBIHuRef
CHM1_1474,771,032 - 74,772,942 (+)NCBICHM1_1
T2T-CHM13v2.0477,213,030 - 77,214,945 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39591,039,104 - 91,040,980 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl591,039,100 - 91,040,974 (+)EnsemblGRCm39 Ensembl
GRCm38590,891,245 - 90,893,121 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,891,241 - 90,893,115 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,320,271 - 91,322,147 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36591,966,510 - 91,968,315 (+)NCBIMGSCv36mm8
Celera589,035,565 - 89,037,441 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1456,382,200 - 56,384,184 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0450,325,248 - 50,327,165 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1456,157,626 - 56,159,522 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl456,153,899 - 56,159,474 (-)Ensemblpanpan1.1panPan2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1722,327,041 - 22,329,405 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl722,569,355 - 22,569,900 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
ChlSab1.1 Ensembl722,327,508 - 22,328,959 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666084462,274 - 464,225 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Variants in Cxcl1
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:60
Interacting mature miRNAs:71
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21417,193,616 - 17,193,797 (+)MAPPERmRatBN7.2
Rnor_6.01418,743,931 - 18,744,111NCBIRnor6.0
Rnor_5.01418,653,285 - 18,653,465UniSTSRnor5.0
RGSC_v3.41418,690,592 - 18,690,772UniSTSRGSC3.4
Celera1416,570,413 - 16,570,593UniSTS
RH 3.4 Map14215.0UniSTS
Cytogenetic Map14p22UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 10
Low 23 45 37 18 37 1 2 15 26 1 1
Below cutoff 3 14 12 4 1 4 7 8 35 19 14 7


RefSeq Acc Id: ENSRNOT00000003778   ⟹   ENSRNOP00000003778
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1417,193,365 - 17,195,215 (-)Ensembl
Rnor_6.0 Ensembl1418,743,685 - 18,745,457 (-)Ensembl
RefSeq Acc Id: NM_030845   ⟹   NP_110472
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21417,193,364 - 17,195,143 (-)NCBI
Rnor_6.01418,743,678 - 18,745,457 (-)NCBI
Rnor_5.01418,653,032 - 18,654,811 (-)NCBI
RGSC_v3.41418,690,339 - 18,692,118 (-)RGD
Celera1416,570,160 - 16,571,939 (-)RGD
Protein Sequences
Protein RefSeqs NP_110472 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42053 (Get FASTA)   NCBI Sequence Viewer  
  BAA02008 (Get FASTA)   NCBI Sequence Viewer  
  BAA02009 (Get FASTA)   NCBI Sequence Viewer  
  EDL88575 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003778
GenBank Protein P14095 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_110472   ⟸   NM_030845
- Peptide Label: precursor
- UniProtKB: P14095 (UniProtKB/Swiss-Prot),   G3V6C6 (UniProtKB/TrEMBL),   A6KKD5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003778   ⟸   ENSRNOT00000003778
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14095-F1-model_v2 AlphaFold P14095 1-96 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699226
Promoter ID:EPDNEW_R9750
Type:single initiation site
Description:C-X-C motif chemokine ligand 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01418,745,473 - 18,745,533EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619869 AgrOrtholog
BioCyc Gene G2FUF-16211 BioCyc
Ensembl Genes ENSRNOG00000002802 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003778 ENTREZGENE
  ENSRNOT00000003778.4 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chemokine_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CXC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CXC_Chemokine_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81503 UniProtKB/Swiss-Prot
  PTHR10179 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cxcl1 PhenoGen
RatGTEx ENSRNOG00000002802 RatGTEx
SMART SCY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-21 Cxcl1  C-X-C motif chemokine ligand 1  Cxcl1  chemokine (C-X-C motif) ligand 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-09 Cxcl1  chemokine (C-X-C motif) ligand 1  Cxcl1  chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Cxcl1  chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)  Cxcl1  chemokine (C-X-C motif) ligand 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cxcl1  chemokine (C-X-C motif) ligand 1  Gro1  gro  Symbol and Name updated 1299863 APPROVED
2002-08-07 Gro1  gro      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression is induced in response to injury 632968