Slc16a2 (solute carrier family 16 member 2) - Rat Genome Database

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Gene: Slc16a2 (solute carrier family 16 member 2) Rattus norvegicus
Analyze
Symbol: Slc16a2
Name: solute carrier family 16 member 2 (Ensembl:solute carrier family 16 (monocarboxylic acid transporters), member 2)
RGD ID: 628608
Description: Enables thyroid hormone transmembrane transporter activity. Involved in hormone transport. Located in apical plasma membrane. Human ortholog(s) of this gene implicated in Allan-Herndon-Dudley syndrome and intellectual disability. Orthologous to human SLC16A2 (solute carrier family 16 member 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MCT 8; monocarboxylate transporter 8; solute carrier family 16 (monocarboxylic acid transporters), member 2; solute carrier family 16, member 2 (monocarboxylic acid transporter 8); solute carrier family 16, member 2 (thyroid hormone transporter)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X68,725,365 - 68,848,572 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX68,723,261 - 68,848,771 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX70,234,514 - 70,357,718 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X73,734,753 - 73,857,979 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X71,295,965 - 71,419,167 (-)NCBIRnor_WKY
Rnor_6.0X74,578,600 - 74,706,068 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX74,577,131 - 74,706,214 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X75,380,008 - 75,507,522 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X91,700,554 - 91,825,108 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X91,773,988 - 91,898,541 (-)NCBI
CeleraX70,090,308 - 70,212,743 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bosutinib  (ISO)
bromosulfophthalein  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
desipramine  (ISO)
dieldrin  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fipronil  (ISO)
fluoranthene  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
Heptachlor epoxide  (ISO)
hydralazine  (ISO)
indocyanine green  (ISO)
indole-3-methanol  (EXP)
meclofenamic acid  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (ISO)
O-methyleugenol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phloretin  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium nitrate  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
thiacloprid  (ISO)
thioacetamide  (EXP)
thiophanate-methyl  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IDA,ISO)
membrane  (IBA)
plasma membrane  (IDA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. Friesema EC, etal., J Biol Chem 2003 Oct 10;278(41):40128-35. Epub 2003 Jul 18.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Decreased cellular uptake and metabolism in Allan-Herndon-Dudley syndrome (AHDS) due to a novel mutation in the MCT8 thyroid hormone transporter. Maranduba CM, etal., J Med Genet. 2006 May;43(5):457-60. Epub 2005 Jun 24.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Price NT, etal., Biochem J 1998 Jan 15;329 ( Pt 2):321-8.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier. Roberts LM, etal., Endocrinology. 2008 Dec;149(12):6251-61. doi: 10.1210/en.2008-0378. Epub 2008 Aug 7.
Additional References at PubMed
PMID:22699085   PMID:24248460   PMID:24763672   PMID:25594699   PMID:26426690   PMID:26626087   PMID:31561916  


Genomics

Comparative Map Data
Slc16a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X68,725,365 - 68,848,572 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX68,723,261 - 68,848,771 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX70,234,514 - 70,357,718 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X73,734,753 - 73,857,979 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X71,295,965 - 71,419,167 (-)NCBIRnor_WKY
Rnor_6.0X74,578,600 - 74,706,068 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX74,577,131 - 74,706,214 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X75,380,008 - 75,507,522 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X91,700,554 - 91,825,108 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X91,773,988 - 91,898,541 (-)NCBI
CeleraX70,090,308 - 70,212,743 (-)NCBICelera
Cytogenetic MapXq22NCBI
SLC16A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X74,421,493 - 74,533,916 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX74,421,493 - 74,533,917 (+)EnsemblGRCh38hg38GRCh38
GRCh37X73,641,328 - 73,753,751 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X73,557,810 - 73,670,475 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X73,424,105 - 73,536,772NCBI
CeleraX73,924,511 - 74,037,335 (+)NCBICelera
Cytogenetic MapXq13.2NCBI
HuRefX67,276,476 - 67,388,860 (+)NCBIHuRef
CHM1_1X73,534,235 - 73,646,665 (+)NCBICHM1_1
T2T-CHM13v2.0X72,854,953 - 72,967,553 (+)NCBIT2T-CHM13v2.0
Slc16a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X102,741,020 - 102,865,594 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX102,741,020 - 102,865,589 (-)EnsemblGRCm39 Ensembl
GRCm38X103,697,414 - 103,821,988 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX103,697,414 - 103,821,983 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X100,892,753 - 101,017,327 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X99,900,137 - 100,024,678 (-)NCBIMGSCv36mm8
CeleraX90,599,693 - 90,720,985 (-)NCBICelera
Cytogenetic MapXDNCBI
cM MapX46.29NCBI
Slc16a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955562306,051 - 458,889 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955562305,850 - 455,764 (+)NCBIChiLan1.0ChiLan1.0
SLC16A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X73,791,225 - 73,903,727 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX73,791,200 - 73,903,727 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X63,673,992 - 63,787,011 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SLC16A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X57,845,865 - 57,859,827 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX57,845,488 - 57,857,518 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX48,923,040 - 49,038,924 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X58,957,339 - 59,073,281 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX58,956,340 - 59,073,279 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X56,702,227 - 56,818,129 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X58,281,114 - 58,397,225 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X57,888,714 - 58,004,625 (+)NCBIUU_Cfam_GSD_1.0
Slc16a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X44,037,633 - 44,144,591 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936683803,134 - 910,284 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936683803,186 - 910,143 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC16A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX59,748,745 - 59,861,015 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X59,748,685 - 59,861,018 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X67,805,324 - 67,819,628 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC16A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X64,023,846 - 64,123,428 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX64,023,327 - 64,125,422 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606717,596,931 - 17,696,288 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc16a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248366,455,190 - 6,668,643 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248366,454,988 - 6,670,980 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc16a2
298 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:105
Count of miRNA genes:74
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000040637
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 24 22 22 60 27 25 3
Low 3 43 29 19 13 19 7 10 14 8 13 8 7
Below cutoff 4 6 1 1 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000040637   ⟹   ENSRNOP00000042040
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX68,723,261 - 68,848,771 (-)Ensembl
Rnor_6.0 EnsemblX74,577,131 - 74,706,214 (-)Ensembl
RefSeq Acc Id: NM_147216   ⟹   NP_671749
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X68,725,365 - 68,848,572 (-)NCBI
Rnor_6.0X74,578,600 - 74,706,068 (-)NCBI
Rnor_5.0X75,380,008 - 75,507,522 (-)NCBI
RGSC_v3.4X91,700,554 - 91,825,108 (-)RGD
CeleraX70,090,308 - 70,212,743 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_671749 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAD43059 (Get FASTA)   NCBI Sequence Viewer  
  EDM07171 (Get FASTA)   NCBI Sequence Viewer  
  EDM07172 (Get FASTA)   NCBI Sequence Viewer  
  Q8K1P8 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_671749   ⟸   NM_147216
- UniProtKB: G3V9C2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000042040   ⟸   ENSRNOT00000040637

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K1P8-F1-model_v2 AlphaFold Q8K1P8 1-545 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701893
Promoter ID:EPDNEW_R12417
Type:initiation region
Name:Slc16a2_1
Description:solute carrier family 16 member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X74,706,173 - 74,706,233EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628608 AgrOrtholog
BioCyc Gene G2FUF-2003 BioCyc
Ensembl Genes ENSRNOG00000002832 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000042040 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000040637 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
InterPro MCT8 UniProtKB/Swiss-Prot
  MFS UniProtKB/Swiss-Prot
  MFS_dom UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
KEGG Report rno:259248 UniProtKB/Swiss-Prot
NCBI Gene 259248 ENTREZGENE
PANTHER PTHR11360:SF123 UniProtKB/Swiss-Prot
Pfam MFS_1 UniProtKB/Swiss-Prot
PhenoGen Slc16a2 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
UniProt G3V9C2 ENTREZGENE
  MOT8_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3V9C2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc16a2  solute carrier family 16 member 2  Slc16a2  solute carrier family 16, member 2 (thyroid hormone transporter)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Slc16a2  solute carrier family 16, member 2 (thyroid hormone transporter)  Slc16a2  solute carrier family 16, member 2 (monocarboxylic acid transporter 8)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Slc16a2  solute carrier family 16, member 2 (monocarboxylic acid transporter 8)  Slc16a2  solute carrier family 16 (monocarboxylic acid transporters), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Slc16a2  solute carrier family 16 (monocarboxylic acid transporters), member 2    monocarboxylate transporter 8  Name updated 1299863 APPROVED
2003-02-27 Slc16a2  monocarboxylate transporter 8      Symbol and Name status set to provisional 70820 PROVISIONAL