Phlpp1 (PH domain and leucine rich repeat protein phosphatase 1) - Rat Genome Database

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Gene: Phlpp1 (PH domain and leucine rich repeat protein phosphatase 1) Rattus norvegicus
Analyze
Symbol: Phlpp1
Name: PH domain and leucine rich repeat protein phosphatase 1
RGD ID: 621308
Description: Enables protein serine/threonine phosphatase activity. Involved in several processes, including hippocampus development; protein dephosphorylation; and regulation of intracellular signal transduction. Located in cytoplasm; nucleus; and plasma membrane. Orthologous to human PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1); PARTICIPATES IN protein kinase C (PKC) signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Circadian Oscillatory Protein (SCOP); PH domain and leucine rich repeat protein phosphatase; PH domain leucine-rich repeat protein phosphatase 1; PH domain leucine-rich repeat-containing protein phosphatase 1; PH domain-containing family E member 1; Phlpp; pleckstrin homology domain containing, family E (with leucine rich repeats) member 1; pleckstrin homology domain-containing family E member 1; pleckstrin homology domain-containing family E protein 1; Plekhe1; SCN circadian oscillatory protein; Scop; suprachiasmatic nucleus circadian oscillatory protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21322,308,532 - 22,530,978 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1322,308,548 - 22,530,977 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1322,628,670 - 22,849,686 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01323,913,452 - 24,134,143 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01322,597,347 - 22,819,856 (+)NCBIRnor_WKY
Rnor_6.01326,145,989 - 26,394,505 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1326,172,243 - 26,394,505 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01331,302,241 - 31,550,366 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41312,315,824 - 12,565,692 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11312,343,187 - 12,565,692 (+)NCBI
Celera1322,176,081 - 22,397,222 (+)NCBICelera
Cytogenetic Map13p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. PHLiPPing the switch on Akt and protein kinase C signaling. Brognard J and Newton AC, Trends Endocrinol Metab. 2008 Aug;19(6):223-30. Epub 2008 May 27.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer. Hellwinkel OJ, etal., BJU Int. 2008 Jun;101(11):1454-60. Epub 2008 Mar 11.
4. PHLPP1 splice variants differentially regulate AKT and PKCalpha signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus. Jackson TC, etal., J Neurochem. 2010 Nov;115(4):941-55. doi: 10.1111/j.1471-4159.2010.06984.x. Epub 2010 Sep 28.
5. Serine/threonine kinase akt activation regulates the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPL. Kanan Y, etal., J Neurochem. 2010 Apr;113(2):477-88. Epub 2010 Jan 20.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus. Shimizu K, etal., FEBS Lett 1999 Sep 24;458(3):363-9.
11. Signaling specificity in the Akt pathway in biology and disease. Toker A and Marmiroli S, Adv Biol Regul. 2014 May;55:28-38. doi: 10.1016/j.jbior.2014.04.001. Epub 2014 Apr 19.
Additional References at PubMed
PMID:12594205   PMID:17386267   PMID:20080691   PMID:20513427   PMID:21498666   PMID:22871113   PMID:24394804   PMID:24530606   PMID:29739983   PMID:29940243   PMID:30407372   PMID:30930055  
PMID:32150791   PMID:32480039   PMID:33164862   PMID:34868398  


Genomics

Comparative Map Data
Phlpp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21322,308,532 - 22,530,978 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1322,308,548 - 22,530,977 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1322,628,670 - 22,849,686 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01323,913,452 - 24,134,143 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01322,597,347 - 22,819,856 (+)NCBIRnor_WKY
Rnor_6.01326,145,989 - 26,394,505 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1326,172,243 - 26,394,505 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01331,302,241 - 31,550,366 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41312,315,824 - 12,565,692 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11312,343,187 - 12,565,692 (+)NCBI
Celera1322,176,081 - 22,397,222 (+)NCBICelera
Cytogenetic Map13p11NCBI
PHLPP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381862,715,541 - 62,980,433 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1862,715,541 - 62,980,433 (+)EnsemblGRCh38hg38GRCh38
GRCh371860,382,774 - 60,647,666 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361858,533,714 - 58,798,646 (+)NCBINCBI36Build 36hg18NCBI36
Build 341858,533,713 - 58,798,646NCBI
Celera1857,100,716 - 57,365,706 (+)NCBICelera
Cytogenetic Map18q21.33NCBI
HuRef1857,092,100 - 57,356,438 (+)NCBIHuRef
CHM1_11860,377,900 - 60,642,909 (+)NCBICHM1_1
T2T-CHM13v2.01862,918,332 - 63,183,249 (+)NCBIT2T-CHM13v2.0
Phlpp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391106,099,599 - 106,321,975 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1106,099,482 - 106,321,980 (+)EnsemblGRCm39 Ensembl
GRCm381106,171,869 - 106,394,245 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1106,171,752 - 106,394,250 (+)EnsemblGRCm38mm10GRCm38
MGSCv371108,068,446 - 108,290,822 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361107,999,416 - 108,221,797 (+)NCBIMGSCv36mm8
Celera1109,020,809 - 109,235,924 (+)NCBICelera
Cytogenetic Map1E2.1NCBI
Phlpp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540246,666,599 - 46,772,387 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540246,563,918 - 46,773,349 (+)NCBIChiLan1.0ChiLan1.0
PHLPP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11859,402,317 - 59,655,858 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01856,084,851 - 56,338,551 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PHLPP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1114,027,741 - 14,234,229 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl114,028,652 - 14,234,229 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha114,993,895 - 15,200,571 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0113,886,534 - 14,093,998 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl113,886,542 - 14,093,809 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1113,923,809 - 14,130,372 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0113,856,460 - 14,063,176 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0114,102,787 - 14,309,607 (-)NCBIUU_Cfam_GSD_1.0
Phlpp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494427,228,741 - 27,444,759 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364972,467,684 - 2,683,799 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364972,467,776 - 2,683,794 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHLPP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1158,642,818 - 158,862,106 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11158,642,810 - 158,863,643 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21176,119,433 - 176,234,909 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PHLPP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11816,786,128 - 17,051,250 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660608,634,577 - 8,901,660 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Phlpp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247928,448,013 - 8,681,053 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247928,448,245 - 8,680,845 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Phlpp1
1134 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:510
Count of miRNA genes:244
Interacting mature miRNAs:287
Transcripts:ENSRNOT00000003840
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317027Aia22Adjuvant induced arthritis QTL 222.29joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)13134266636Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
631672Iddm12Insulin dependent diabetes mellitus QTL 122.20.0032blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)13599466834535351Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2303031Bp326Blood pressure QTL 326arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131176653523001904Rat
2317034Aia9Adjuvant induced arthritis QTL 94.62joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131176653532331607Rat
2317044Aia23Adjuvant induced arthritis QTL 232.3joint integrity trait (VT:0010548)ankle joint diameter (CMO:0002148)131176653532331607Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat

Markers in Region
D13Mco13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21322,525,269 - 22,525,438 (+)MAPPERmRatBN7.2
Rnor_6.01326,388,798 - 26,388,966NCBIRnor6.0
Rnor_5.01331,544,659 - 31,544,827UniSTSRnor5.0
RGSC_v3.41312,559,984 - 12,560,153RGDRGSC3.4
RGSC_v3.41312,559,985 - 12,560,153UniSTSRGSC3.4
RGSC_v3.11312,559,984 - 12,560,153RGD
Celera1322,391,515 - 22,391,683UniSTS
Cytogenetic Map13p13UniSTS
D13Uwm8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21322,284,038 - 22,284,156 (+)MAPPERmRatBN7.2
Rnor_6.01326,147,607 - 26,147,724NCBIRnor6.0
Rnor_5.01331,303,859 - 31,303,976UniSTSRnor5.0
RGSC_v3.41312,317,442 - 12,317,559UniSTSRGSC3.4
Cytogenetic Map13p13UniSTS
RH133278  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,179,481 - 28,179,633 (+)MAPPERmRatBN7.2
mRatBN7.21322,530,758 - 22,530,910 (-)MAPPERmRatBN7.2
mRatBN7.21528,179,481 - 28,179,633 (-)MAPPERmRatBN7.2
mRatBN7.21322,530,758 - 22,530,910 (+)MAPPERmRatBN7.2
Rnor_6.01533,365,714 - 33,365,865NCBIRnor6.0
Rnor_6.01326,394,287 - 26,394,438NCBIRnor6.0
Rnor_5.01537,250,377 - 37,250,528UniSTSRnor5.0
Rnor_5.01331,550,148 - 31,550,299UniSTSRnor5.0
RGSC_v3.41532,797,396 - 32,797,547UniSTSRGSC3.4
RGSC_v3.41312,565,474 - 12,565,625UniSTSRGSC3.4
Celera1322,397,004 - 22,397,155UniSTS
Celera1527,757,734 - 27,757,885UniSTS
Cytogenetic Map13p13UniSTS
AI555189  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21322,338,314 - 22,338,512 (+)MAPPERmRatBN7.2
Rnor_6.01326,201,863 - 26,202,060NCBIRnor6.0
Rnor_5.01331,357,332 - 31,357,529UniSTSRnor5.0
RGSC_v3.41312,372,823 - 12,373,020UniSTSRGSC3.4
Celera1322,205,855 - 22,206,052UniSTS
Cytogenetic Map13p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12 2 2 7 2 74 14 24 11
Low 3 31 55 39 12 39 8 11 21 17 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003840   ⟹   ENSRNOP00000003840
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1322,308,548 - 22,530,977 (+)Ensembl
Rnor_6.0 Ensembl1326,172,243 - 26,394,505 (+)Ensembl
RefSeq Acc Id: NM_021657   ⟹   NP_067689
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21322,308,536 - 22,530,977 (+)NCBI
Rnor_6.01326,145,989 - 26,394,505 (+)NCBI
Rnor_5.01331,302,241 - 31,550,366 (+)NCBI
RGSC_v3.41312,315,824 - 12,565,692 (+)RGD
Celera1322,176,081 - 22,397,222 (+)RGD
Sequence:
RefSeq Acc Id: XM_039091048   ⟹   XP_038946976
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21322,308,532 - 22,530,978 (+)NCBI
Protein Sequences
Protein RefSeqs NP_067689 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946976 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA77767 (Get FASTA)   NCBI Sequence Viewer  
  EDL91741 (Get FASTA)   NCBI Sequence Viewer  
  Q9WTR8 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_067689   ⟸   NM_021657
- Sequence:
RefSeq Acc Id: ENSRNOP00000003840   ⟸   ENSRNOT00000003840
RefSeq Acc Id: XP_038946976   ⟸   XM_039091048
- Peptide Label: isoform X1
- UniProtKB: F1LNC3 (UniProtKB/TrEMBL)
Protein Domains
PH   PPM-type phosphatase   Rhodanese

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WTR8-F1-model_v2 AlphaFold Q9WTR8 1-1696 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698748
Promoter ID:EPDNEW_R9273
Type:single initiation site
Name:Phlpp1_1
Description:PH domain and leucine rich repeat protein phosphatase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01326,172,264 - 26,172,324EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621308 AgrOrtholog
BioCyc Gene G2FUF-18611 BioCyc
Ensembl Genes ENSRNOG00000002821 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000003840 ENTREZGENE
  ENSRNOP00000003840.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003840 ENTREZGENE
  ENSRNOT00000003840.4 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM-type_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM-type_phosphatase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59265 UniProtKB/Swiss-Prot
NCBI Gene 59265 ENTREZGENE
Pfam LRR_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Phlpp1 PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHODANESE_3 UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP2Cc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81606 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1LNC3 ENTREZGENE, UniProtKB/TrEMBL
  PHLP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Phlpp1  PH domain and leucine rich repeat protein phosphatase 1  Phlpp  PH domain and leucine rich repeat protein phosphatase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Phlpp  PH domain and leucine rich repeat protein phosphatase  Plekhe1  pleckstrin homology domain containing, family E (with leucine rich repeats) member 1  Symbol and Name updated 1299863 APPROVED
2004-09-10 Plekhe1  pleckstrin homology domain containing, family E (with leucine rich repeats) member 1  Scop  Circadian Oscillatory Protein (SCOP)  Symbol and Name updated 1299863 APPROVED
2002-08-07 Scop  Circadian Oscillatory Protein (SCOP)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a pleckstrin homology domain, leucine-rich repeats, a protein phosphatase 2C-like domain and a glutamine-rich region 633914
gene_expression mainly expressed in the brain 633914