Gene: Phlpp1 (PH domain and leucine rich repeat protein phosphatase 1) Rattus norvegicus
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Symbol:
Phlpp1
Name:
PH domain and leucine rich repeat protein phosphatase 1
RGD ID:
621308
Description:
Exhibits protein serine/threonine phosphatase activity. Involved in several processes, including hippocampus development; protein dephosphorylation; and regulation of intracellular signal transduction. Localizes to cytoplasm; nucleus; and plasma membrane. Orthologous to human PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1); PARTICIPATES IN protein kinase C (PKC) signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
Circadian Oscillatory Protein (SCOP); PH domain and leucine rich repeat protein phosphatase; PH domain leucine-rich repeat protein phosphatase 1; PH domain leucine-rich repeat-containing protein phosphatase 1; PH domain-containing family E member 1; Phlpp; pleckstrin homology domain containing, family E (with leucine rich repeats) member 1; pleckstrin homology domain-containing family E member 1; pleckstrin homology domain-containing family E protein 1; Plekhe1; SCN circadian oscillatory protein; Scop; suprachiasmatic nucleus circadian oscillatory protein
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Phlpp1 (PH domain and leucine rich repeat protein phosphatase 1) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Phlpp1 (PH domain and leucine rich repeat protein phosphatase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Phlpp1 (PH domain and leucine rich repeat protein phosphatase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Phlpp1 (PH domain and leucine rich repeat protein phosphatase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Mus musculus (house mouse):
Phlpp1 (PH domain and leucine rich repeat protein phosphatase 1)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Saccharomyces cerevisiae (baker's yeast):
CYR1
Alliance
DIOPT (OrthoInspector|PhylomeDB)
Drosophila melanogaster (fruit fly):
Phlpp
Alliance
DIOPT (Hieranoid|InParanoid|OrthoInspector|PhylomeDB|TreeFam)
Caenorhabditis elegans (roundworm):
phlp-2
Alliance
DIOPT (Hieranoid|InParanoid|OrthoInspector|PhylomeDB|TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information:
Annotation category: partial on reference assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 13 26,145,989 - 26,394,505 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 13 26,172,243 - 26,394,505 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 13 31,302,241 - 31,550,366 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 13 12,315,824 - 12,565,692 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 13 12,343,187 - 12,565,692 (+) NCBI Celera 13 22,176,081 - 22,397,222 (+) NCBI Celera Cytogenetic Map 13 p11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
prostate cancer disease_progression ISO RGD:731281 2301729 mRNA:decreased expression:tumor:lower in high versus low Gleason score tumors (p<0.05 compared to at least one housekeeping gene) (human) RGD
Imported Annotations - ClinVar
chromosome 18q deletion syndrome ISO RGD:731281 8554872 ClinVar Annotator: match by term: CHROMOSOME 18q DELETION SYNDROME ClinVar PMID:25741868
Imported Annotations - CTD
Neoplastic Cell Transformation ISO RGD:731281 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21750348
(S)-nicotine affects response to substance ISO RGD:731281 6480464 PHLPP gene SNP affects the susceptibility to Nicotine CTD PMID:18438686 1,2-dimethylhydrazine decreases expression ISO RGD:1550945 6480464 1, 2-Dimethylhydrazine results in decreased expression of PHLPP1 mRNA CTD PMID:22206623 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of PHLPP mRNA CTD PMID:16079270 17beta-estradiol multiple interactions ISO RGD:731281 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of PHLPP1 mRNA CTD PMID:30165855 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of PHLPP1 mRNA CTD PMID:21215274 , PMID:32109520 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1550945 6480464 Tetrachlorodibenzodioxin results in decreased expression of PHLPP mRNA CTD PMID:21212295 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1550945 6480464 Tetrachlorodibenzodioxin affects the expression of PHLPP mRNA, Tetrachlorodibenzodioxin affects the expression of PHLPP1 mRNA CTD PMID:21570461 , PMID:24680724 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1550945 6480464 [Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased expression of PHLPP mRNA CTD PMID:21212295 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2 more ... CTD PMID:32109520 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of PHLPP mRNA CTD PMID:21346803 acetamide decreases expression EXP 6480464 acetamide results in decreased expression of PHLPP1 mRNA CTD PMID:31881176 aflatoxin B1 decreases expression ISO RGD:1550945 6480464 Aflatoxin B1 results in decreased expression of PHLPP mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation ISO RGD:731281 6480464 Aflatoxin B1 results in decreased methylation of PHLPP1 gene CTD PMID:27153756 aflatoxin B1 affects expression ISO RGD:731281 6480464 Aflatoxin B1 affects the expression of PHLPP protein CTD PMID:20106945 alendronic acid affects expression EXP 6480464 Alendronate affects the expression of PHLPP mRNA CTD PMID:16079270 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PHLPP mRNA CTD PMID:16483693 arsenic trichloride multiple interactions ISO RGD:731281 6480464 [arsenic trichloride results in increased expression of MIR190A] promotes the reaction [[MIR190A binds to PHLPP1 3' UTR] which results in decreased expression of PHLPP1 protein], [arsenic trichloride results in increased expression of MIR190A] which results in decreased expression of PHLPP1 protein CTD PMID:21750348 arsenous acid increases expression ISO RGD:731281 6480464 Arsenic Trioxide results in increased expression of PHLPP1 mRNA CTD PMID:29633893 atrazine affects methylation EXP 6480464 Atrazine affects the methylation of PHLPP1 gene CTD PMID:28931070 benzo[a]pyrene decreases expression ISO RGD:731281 6480464 Benzo(a)pyrene results in decreased expression of PHLPP mRNA, Benzo(a)pyrene results in decreased expression of PHLPP1 mRNA CTD PMID:20064835 more ... benzo[a]pyrene multiple interactions ISO RGD:1550945 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PHLPP1 mRNA, AHR protein affects the reaction [Benzo(a)pyrene affects the expression of PHLPP mRNA] CTD PMID:22228805 , PMID:27858113 benzo[a]pyrene decreases expression ISO RGD:1550945 6480464 Benzo(a)pyrene results in decreased expression of PHLPP mRNA CTD PMID:19770486 , PMID:22228805 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:731281 6480464 7 more ... CTD PMID:20382639 benzo[b]fluoranthene multiple interactions ISO RGD:1550945 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PHLPP1 mRNA CTD PMID:27858113 benzo[e]pyrene decreases methylation ISO RGD:731281 6480464 benzo(e)pyrene results in decreased methylation of PHLPP1 intron CTD PMID:30157460 bisphenol A decreases expression ISO RGD:1550945 6480464 bisphenol A results in decreased expression of PHLPP1 mRNA CTD PMID:26063408 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of PHLPP1 gene CTD PMID:28505145 butanal decreases expression ISO RGD:731281 6480464 butyraldehyde results in decreased expression of PHLPP1 mRNA CTD PMID:26079696 carbon nanotube decreases expression ISO RGD:1550945 6480464 Nanotubes, Carbon results in decreased expression of PHLPP1 mRNA CTD PMID:25554681 chrysene multiple interactions ISO RGD:1550945 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PHLPP1 mRNA CTD PMID:27858113 ciglitazone multiple interactions ISO RGD:731281 6480464 [ciglitazone binds to PPARG protein alternative form] which results in increased expression of PHLPP1 mRNA CTD PMID:16197558 cisplatin multiple interactions ISO RGD:731281 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of PHLPP1 mRNA CTD PMID:27392435 cisplatin decreases expression ISO RGD:731281 6480464 Cisplatin results in decreased expression of PHLPP1 mRNA CTD PMID:27392435 copper(II) sulfate decreases expression ISO RGD:731281 6480464 Copper Sulfate results in decreased expression of PHLPP1 mRNA CTD PMID:19549813 crocidolite asbestos decreases expression ISO RGD:1550945 6480464 Asbestos, Crocidolite results in decreased expression of PHLPP1 mRNA CTD PMID:29279043 cyclosporin A decreases expression ISO RGD:731281 6480464 Cyclosporine results in decreased expression of PHLPP mRNA, Cyclosporine results in decreased expression of PHLPP1 mRNA CTD PMID:20106945 , PMID:25562108 diarsenic trioxide increases expression ISO RGD:731281 6480464 Arsenic Trioxide results in increased expression of PHLPP1 mRNA CTD PMID:29633893 dioxygen multiple interactions ISO RGD:1550945 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of PHLPP1 mRNA CTD PMID:30529165 doxorubicin decreases expression ISO RGD:731281 6480464 Doxorubicin results in decreased expression of PHLPP1 mRNA CTD PMID:29803840 ethanol affects splicing ISO RGD:1550945 6480464 Ethanol affects the splicing of PHLPP1 mRNA CTD PMID:30319688 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of PHLPP mRNA CTD PMID:18035473 folic acid decreases expression ISO RGD:1550945 6480464 Folic Acid results in decreased expression of PHLPP1 mRNA CTD PMID:25629700 lipopolysaccharide multiple interactions ISO RGD:1550945 6480464 [Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased expression of PHLPP mRNA CTD PMID:21212295 methamphetamine affects expression ISO RGD:1550945 6480464 Methamphetamine affects the expression of PHLPP1 mRNA CTD PMID:15950759 methamphetamine increases expression ISO RGD:1550945 6480464 Methamphetamine results in increased expression of PHLPP1 protein CTD PMID:15542705 , PMID:15950759 methapyrilene decreases methylation ISO RGD:731281 6480464 Methapyrilene results in decreased methylation of PHLPP1 intron CTD PMID:30157460 nicotine affects response to substance ISO RGD:731281 6480464 PHLPP gene SNP affects the susceptibility to Nicotine CTD PMID:18438686 PD173074 multiple interactions ISO RGD:1550945 6480464 PD 173074 inhibits the reaction [PHLPP1 gene mutant form results in increased phosphorylation of MAPK1 protein], PD 173074 inhibits the reaction [PHLPP1 gene mutant form results in increased phosphorylation of MAPK3 protein] CTD PMID:25953896 pirinixic acid multiple interactions ISO RGD:731281 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PHLPP mRNA CTD PMID:19710929 potassium dichromate decreases expression ISO RGD:731281 6480464 Potassium Dichromate results in decreased expression of PHLPP1 protein CTD PMID:23718831 raloxifene affects expression EXP 6480464 Raloxifene Hydrochloride affects the expression of PHLPP mRNA CTD PMID:16079270 silicon dioxide increases expression ISO RGD:731281 6480464 Silicon Dioxide results in increased expression of PHLPP1 mRNA CTD PMID:25351596 sunitinib increases expression ISO RGD:731281 6480464 Sunitinib results in increased expression of PHLPP1 mRNA CTD PMID:31533062 tetraphene multiple interactions ISO RGD:1550945 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PHLPP1 mRNA CTD PMID:27858113 tremolite asbestos decreases expression ISO RGD:1550945 6480464 tremolite results in decreased expression of PHLPP1 mRNA CTD PMID:29279043 troglitazone decreases expression ISO RGD:1550945 6480464 troglitazone results in decreased expression of PHLPP1 mRNA CTD PMID:28973697 tungsten decreases expression ISO RGD:1550945 6480464 Tungsten results in decreased expression of PHLPP1 mRNA CTD PMID:30912803 valproic acid increases methylation ISO RGD:731281 6480464 Valproic Acid results in increased methylation of PHLPP1 gene CTD PMID:29154799 valproic acid decreases expression ISO RGD:731281 6480464 Valproic Acid results in decreased expression of PHLPP1 mRNA CTD PMID:28001369
Biological Process apoptotic process IEA UniProtKB-KW:KW-0053 1600115 GO_REF:0000043 UniProt GO_REF:0000043 circadian rhythm IEP 633914 RGD entrainment of circadian clock ISO RGD:1550945 1624291 MGI:MGI:4421807 (MGI:MGI:4420841 , PMID:20080691) RGD MGI:MGI:4420841 , PMID:20080691 entrainment of circadian clock IEA UniProtKB:Q8CHE4 , ensembl:ENSMUSP000000565301600115 GO_REF:0000107 Ensembl GO_REF:0000107 hippocampus development IEP 8693633 RGD negative regulation of ERK1 and ERK2 cascade IMP 8693633 PMID:20819118 UniProt negative regulation of protein kinase B signaling ISO RGD:731281 1624291 (PMID:17386267) RGD PMID:17386267 negative regulation of protein kinase B signaling IEA UniProtKB:O60346 , ensembl:ENSP000002627191600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of protein kinase B signaling IMP 8693633 RGD negative regulation of protein kinase C signaling IMP 8693633 RGD positive regulation of protein kinase B signaling IMP 8693633 PMID:20819118 UniProt positive regulation of protein kinase C signaling IMP 8693633 PMID:20819118 UniProt protein dephosphorylation IDA 5131540 RGD protein dephosphorylation IMP 8693633 RGD regulation of apoptotic process ISO RGD:731281 1624291 (PMID:20513427) RGD PMID:20513427 regulation of apoptotic process IEA UniProtKB:O60346 , ensembl:ENSP000002627191600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of JNK cascade ISO RGD:731281 1624291 (PMID:17386267) RGD PMID:17386267 regulation of JNK cascade IEA UniProtKB:O60346 , ensembl:ENSP000002627191600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of MAPK cascade ISO RGD:731281 1624291 (PMID:24530606) RGD PMID:24530606 regulation of p38MAPK cascade ISO RGD:731281 1624291 (PMID:17386267) RGD PMID:17386267 regulation of p38MAPK cascade IEA UniProtKB:O60346 , ensembl:ENSP000002627191600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of protein phosphorylation IMP 8693633 RGD regulation of T cell anergy IEA UniProtKB:Q8CHE4 , ensembl:ENSMUSP000000565301600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of T cell anergy ISO RGD:1550945 1624291 (MGI:MGI:5013552, PMID:21498666) RGD MGI:MGI:5013552 , PMID:21498666 signal transduction IBA MGI:MGI:1913975 more ... 13792537 PMID:21873635 GO_Central Cellular Component cytoplasm IDA 8693633 RGD cytoplasm IBA MGI:MGI:1913975 more ... 13792537 PMID:21873635 GO_Central cytoplasm IMP 8693633 PMID:20819118 UniProt intracellular membrane-bounded organelle IBA MGI:MGI:1913975 more ... 13792537 PMID:21873635 GO_Central nuclear membrane IDA 8693633 RGD nucleoplasm IDA 8693633 RGD plasma membrane IDA 8693633 PMID:20819118 UniProt plasma membrane IEA UniProtKB-SubCell:SL-0039 1600115 GO_REF:0000044 UniProt GO_REF:0000044 Molecular Function catalytic activity IEA InterPro:IPR001932 1600115 GO_REF:0000002 InterPro GO_REF:0000002 metal ion binding IEA UniProtKB-KW:KW-0479 1600115 GO_REF:0000043 UniProt GO_REF:0000043 protein binding ISO RGD:731281 1624291 UniProtKB:O14745 more ... RGD PMID:18162466 more ... protein serine/threonine phosphatase activity IDA 5131540 RGD protein serine/threonine phosphatase activity IBA PANTHER:PTN002555214 more ... 13792537 PMID:21873635 GO_Central
Gene-Chemical Interaction Annotations
