Slc7a11 (solute carrier family 7 member 11) - Rat Genome Database

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Gene: Slc7a11 (solute carrier family 7 member 11) Rattus norvegicus
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Symbol: Slc7a11
Name: solute carrier family 7 member 11
RGD ID: 1309275
Description: Predicted to enable L-kynurenine transmembrane transporter activity and cystine:glutamate antiporter activity. Involved in lens fiber cell differentiation; response to nicotine; and response to oxidative stress. Predicted to be located in several cellular components, including astrocyte projection; brush border membrane; and cell surface. Orthologous to human SLC7A11 (solute carrier family 7 member 11); INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; (S)-AMPA.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cystine/glutamate transporter; LOC310392; solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11; solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Slc7a11Tn(sb-T2/Bart3)2.266Mcwi
Genetic Models: F344-Slc7a11Tn(sb-T2/Bart3)2.266Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82136,532,912 - 136,668,560 (-)NCBIGRCr8
mRatBN7.22134,382,002 - 134,517,622 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2133,963,107 - 134,517,536 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2141,015,140 - 141,089,464 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02139,127,676 - 139,201,998 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02133,756,818 - 133,831,146 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02139,453,774 - 139,528,479 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2139,453,774 - 139,528,162 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02158,930,294 - 159,004,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42139,241,142 - 139,317,101 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12139,198,359 - 139,266,947 (-)NCBI
Celera2128,949,395 - 129,023,474 (-)NCBICelera
Cytogenetic Map2q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(E)-thiamethoxam  (ISO)
(R)-lipoic acid  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-AMPA  (EXP)
(S)-ropivacaine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
1-nitropyrene  (ISO)
1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-(chloromethyl)pyridine  (ISO)
2-amino-4-methylphenol  (ISO)
2-butoxyethanol  (ISO)
2-deoxy-D-glucose  (ISO)
2-tert-butylhydroquinone  (ISO)
25-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-(indol-3-yl)pyruvic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methyladenine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-methylene-bis-(2-chloroaniline)  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-aminosalicylic acid  (ISO)
4-Carboxyphenylglycine  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
4-phenylbutyric acid  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
7beta-aminocephalosporanic acid  (ISO)
8-Br-cAMP  (ISO)
[6]-Shogaol  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
acyclovir  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
alpidem  (ISO)
amikacin  (ISO)
amiodarone  (ISO)
ammonium hexachloroplatinate  (ISO)
amphetamine  (EXP)
ampicillin  (ISO)
andrographolide  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Augmentin  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
baicalein  (ISO)
belinostat  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzethonium chloride  (ISO)
benzidine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beryllium sulfate  (ISO)
beta-lapachone  (ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
biperiden  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
Bisphenol Z  (ISO)
bromfenac  (ISO)
bromobenzene  (EXP)
busulfan  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
ceftriaxone  (EXP)
celastrol  (ISO)
celecoxib  (ISO)
cetylpyridinium  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
cisplatin  (ISO)
clavulanic acid  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
coumaphos  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (EXP)
DDE  (ISO)
DDT  (ISO)
dehydroepiandrosterone  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
diethyl malate  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
Dihydrocorynantheine  (EXP)
dimethyl fumarate  (ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dimethylarsinic acid  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diphenhydramine  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
doramapimod  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
elesclomol  (ISO)
endosulfan  (EXP,ISO)
enniatin  (ISO)
entacapone  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epichlorohydrin  (ISO)
erastin  (EXP,ISO)
eriodictyol  (ISO)
estriol  (ISO)
estrone  (ISO)
ethambutol  (EXP,ISO)
ethanol  (ISO)
Ethyl acrylate  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
etoposide  (ISO)
eugenol  (ISO)
farnesol  (ISO)
ferrostatin-1  (EXP,ISO)
Fexofenadine hydrochloride  (ISO)
fludrocortisone  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP,ISO)
FR900359  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gedunin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (EXP)
glutathione  (ISO)
glycidol  (EXP)
hexadecanoic acid  (ISO)
hexamethylene diisocyanate  (ISO)
Hirsuteine  (EXP)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hypochlorous acid  (ISO)
ibuprofen  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indoline  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
isoniazide  (EXP)
isoprenaline  (ISO)
ketoconazole  (ISO)
KN-93  (ISO)
L-ascorbic acid  (ISO)
L-cystine  (ISO)
L-glutamic acid  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
levofloxacin  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lumiracoxib  (ISO)
LY294002  (ISO)
malonaldehyde  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
mebendazole  (ISO)
MeIQx  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methyl methacrylate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
motexafin gadolinium  (ISO)
mycophenolic acid  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (EXP)
naphthalene-1,2-diol  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
Nonylphenol  (ISO)
O-methyleugenol  (ISO)
o-xylene  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
oseltamivir  (ISO)
oxybenzone  (EXP)
ozone  (ISO)
p-anisidine  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
para-Cresidine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
penbutolol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pifithrin-alpha hydrobromide  (EXP)
pinostrobin  (ISO)
pioglitazone  (ISO)
piroxicam  (ISO)
polymyxin B2  (ISO)
potassium bromate  (ISO)
potassium dichromate  (EXP,ISO)
prednisolone  (ISO)
procyanidin B1  (EXP)
procyclidine  (ISO)
progesterone  (ISO)
propan-2-ol  (ISO)
propofol  (EXP)
prothioconazole  (ISO)
protriptyline  (ISO)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
rac-1,2-dichloropropane  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
rifampicin  (EXP)
rotenone  (ISO)
Ruscogenin  (ISO)
Rutecarpine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sevoflurane  (EXP)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sinapic acid  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP,ISO)
sodium hypochlorite  (ISO)
solasodine  (ISO)
sorafenib  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tauroursodeoxycholic acid  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thapsigargin  (ISO)
thiamethoxam  (ISO)
thiazoles  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
tienilic acid  (ISO)
titanium dioxide  (EXP,ISO)
tolcapone  (ISO)
toluene  (ISO)
trazodone  (ISO)
triacsin C  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
Trihexyphenidyl  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
Valtratum  (ISO)
vanillin  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
wedelolactone  (ISO)
zafirlukast  (ISO)
zearalenone  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult behavior  (ISO)
amino acid transmembrane transport  (IBA,IEA)
amino acid transport  (IEA)
brain development  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to stress  (ISO)
dipeptide import across plasma membrane  (ISO)
glutathione metabolic process  (ISO)
glutathione transmembrane transport  (ISO)
intracellular glutamate homeostasis  (ISO)
L-cystine transport  (ISO)
L-glutamate import across plasma membrane  (ISO)
L-glutamate transmembrane transport  (ISO)
L-kynurenine transmembrane transport  (ISO)
lens fiber cell differentiation  (IEP)
limb development  (ISO)
lung alveolus development  (ISO)
modulation of chemical synaptic transmission  (ISO)
negative regulation of ferroptosis  (ISO)
neutral amino acid transport  (IEA)
platelet aggregation  (ISO)
regulation of AMPA glutamate receptor clustering  (ISO)
regulation of cell population proliferation  (ISO)
regulation of cellular response to oxidative stress  (ISO)
regulation of cysteine metabolic process  (ISO)
regulation of glutamate metabolic process  (ISO)
regulation of glutathione biosynthetic process  (ISO)
regulation of melanin biosynthetic process  (ISO)
regulation of neutrophil apoptotic process  (ISO)
regulation of protein transport  (ISO)
regulation of synapse organization  (ISO)
response to nicotine  (IEP)
response to oxidative stress  (IEP)
response to redox state  (ISO)
response to toxic substance  (ISO)
striatum development  (ISO)
transmembrane transport  (IEA)
ventricular system development  (ISO)
visual learning  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Expression of the cystine-glutamate exchanger (xc-) in retinal ganglion cells and regulation by nitric oxide and oxidative stress. Dun Y, etal., Cell Tissue Res. 2006 May;324(2):189-202. Epub 2006 Jan 28.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. The role of cystine-glutamate exchange in nicotine dependence in rats and humans. Knackstedt LA, etal., Biol Psychiatry. 2009 May 15;65(10):841-5. Epub 2008 Dec 21.
5. Expression and developmental regulation of the cystine/glutamate exchanger (xc-) in the rat. La Bella V, etal., Neurochem Res. 2007 Jun;32(6):1081-90. Epub 2007 Mar 31.
6. Molecular characterization of the cystine/glutamate exchanger and the excitatory amino acid transporters in the rat lens. Lim J, etal., Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2869-77.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer. Toyoda M, etal., Br J Cancer. 2014 May 13;110(10):2506-13. doi: 10.1038/bjc.2014.178. Epub 2014 Apr 24.
Additional References at PubMed
PMID:8699821   PMID:16037214   PMID:16144837   PMID:16399997   PMID:17035536   PMID:17200146   PMID:17575980   PMID:17963724   PMID:19017641   PMID:21191088   PMID:21490221   PMID:21639880  
PMID:22095285   PMID:23085521   PMID:23192314   PMID:24548853   PMID:24687412   PMID:24866234   PMID:25063885   PMID:25429150   PMID:26851652   PMID:27570548   PMID:29024663   PMID:29038291  
PMID:29045497   PMID:29350434   PMID:29488137   PMID:34259984   PMID:35786456   PMID:36456793   PMID:36929608   PMID:37146710   PMID:37391124   PMID:37603538   PMID:37691947   PMID:37822721  
PMID:38816686   PMID:39354361  


Genomics

Comparative Map Data
Slc7a11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82136,532,912 - 136,668,560 (-)NCBIGRCr8
mRatBN7.22134,382,002 - 134,517,622 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2133,963,107 - 134,517,536 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2141,015,140 - 141,089,464 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02139,127,676 - 139,201,998 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02133,756,818 - 133,831,146 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02139,453,774 - 139,528,479 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2139,453,774 - 139,528,162 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02158,930,294 - 159,004,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42139,241,142 - 139,317,101 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12139,198,359 - 139,266,947 (-)NCBI
Celera2128,949,395 - 129,023,474 (-)NCBICelera
Cytogenetic Map2q26NCBI
SLC7A11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384138,164,097 - 138,312,671 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4138,164,097 - 138,242,349 (-)EnsemblGRCh38hg38GRCh38
GRCh374139,085,251 - 139,163,503 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364139,304,698 - 139,382,953 (-)NCBINCBI36Build 36hg18NCBI36
Build 344139,449,092 - 139,520,828NCBI
Celera4136,424,509 - 136,502,906 (-)NCBICelera
Cytogenetic Map4q28.3NCBI
HuRef4134,820,291 - 134,898,999 (-)NCBIHuRef
CHM1_14139,061,708 - 139,139,961 (-)NCBICHM1_1
T2T-CHM13v2.04141,487,564 - 141,636,430 (-)NCBIT2T-CHM13v2.0
Slc7a11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39350,319,385 - 50,403,947 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl349,846,975 - 50,398,063 (-)EnsemblGRCm39 Ensembl
GRCm38350,364,936 - 50,499,087 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl349,892,526 - 50,443,614 (-)EnsemblGRCm38mm10GRCm38
MGSCv37350,168,858 - 50,247,535 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36350,461,131 - 50,539,808 (-)NCBIMGSCv36mm8
Celera350,149,206 - 50,227,932 (-)NCBICelera
Cytogenetic Map3CNCBI
cM Map321.72NCBI
Slc7a11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554285,237,865 - 5,309,085 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554285,238,460 - 5,309,085 (+)NCBIChiLan1.0ChiLan1.0
SLC7A11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23136,031,904 - 136,178,341 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14136,428,877 - 136,575,218 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04130,529,677 - 130,601,396 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14141,841,526 - 141,919,678 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4141,849,343 - 141,959,849 (-)Ensemblpanpan1.1panPan2
SLC7A11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1194,289,792 - 4,379,060 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl194,289,850 - 4,389,048 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha194,539,704 - 4,608,064 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0194,364,717 - 4,454,499 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl194,264,457 - 4,464,477 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1194,293,544 - 4,361,949 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0194,655,537 - 4,724,650 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0195,019,875 - 5,088,260 (+)NCBIUU_Cfam_GSD_1.0
Slc7a11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530151,740,115 - 51,806,268 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365359,177,143 - 9,242,566 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365359,177,305 - 9,242,743 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC7A11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl888,608,174 - 88,687,250 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1888,608,083 - 88,690,589 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLC7A11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1785,149,810 - 85,225,061 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl785,154,068 - 85,225,144 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603764,647,689 - 64,726,569 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc7a11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477718,546,799 - 18,619,947 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477718,540,006 - 18,619,881 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc7a11
751 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:998
Count of miRNA genes:319
Interacting mature miRNAs:468
Transcripts:ENSRNOT00000014317
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2127447387143657569Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527143657569Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat

Markers in Region
RH135019  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22134,443,162 - 134,443,349 (+)MAPPERmRatBN7.2
Rnor_6.02139,453,895 - 139,454,081NCBIRnor6.0
Rnor_5.02158,930,415 - 158,930,601UniSTSRnor5.0
RGSC_v3.42139,241,263 - 139,241,449UniSTSRGSC3.4
Celera2128,949,516 - 128,949,702UniSTS
RH 3.4 Map2822.8UniSTS
Cytogenetic Map2q26UniSTS


Genetic Models
This gene Slc7a11 is modified in the following models/strains:
F344-Slc7a11Tn(sb-T2/Bart3)2.266Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 36 113 84 83 52 25 52 6 193 83 93 41 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000014317   ⟹   ENSRNOP00000014317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2133,963,107 - 134,517,536 (-)Ensembl
Rnor_6.0 Ensembl2139,453,774 - 139,528,162 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114420   ⟹   ENSRNOP00000091221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2134,447,464 - 134,517,536 (-)Ensembl
RefSeq Acc Id: NM_001107673   ⟹   NP_001101143
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82136,593,952 - 136,668,264 (-)NCBI
mRatBN7.22134,443,042 - 134,517,358 (-)NCBI
Rnor_6.02139,453,774 - 139,528,162 (-)NCBI
Rnor_5.02158,930,294 - 159,004,937 (-)NCBI
RGSC_v3.42139,241,142 - 139,317,101 (-)RGD
Celera2128,949,395 - 129,023,474 (-)RGD
Sequence:
RefSeq Acc Id: XM_039102258   ⟹   XP_038958186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82136,532,915 - 136,668,560 (-)NCBI
mRatBN7.22134,382,005 - 134,517,228 (-)NCBI
RefSeq Acc Id: XM_039102259   ⟹   XP_038958187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82136,601,293 - 136,668,560 (-)NCBI
mRatBN7.22134,451,766 - 134,517,228 (-)NCBI
RefSeq Acc Id: XM_039102260   ⟹   XP_038958188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82136,532,912 - 136,668,533 (-)NCBI
mRatBN7.22134,382,002 - 134,517,622 (-)NCBI
RefSeq Acc Id: XM_063281786   ⟹   XP_063137856
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82136,593,952 - 136,668,533 (-)NCBI
RefSeq Acc Id: NP_001101143   ⟸   NM_001107673
- UniProtKB: D4ADU2 (UniProtKB/TrEMBL),   A0A8I6AB70 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014317   ⟸   ENSRNOT00000014317
RefSeq Acc Id: XP_038958188   ⟸   XM_039102260
- Peptide Label: isoform X3
- UniProtKB: D4ADU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958186   ⟸   XM_039102258
- Peptide Label: isoform X1
- UniProtKB: D4ADU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958187   ⟸   XM_039102259
- Peptide Label: isoform X2
- UniProtKB: D4ADU2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091221   ⟸   ENSRNOT00000114420
RefSeq Acc Id: XP_063137856   ⟸   XM_063281786
- Peptide Label: isoform X4
- UniProtKB: D4ADU2 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADU2-F1-model_v2 AlphaFold D4ADU2 1-502 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309275 AgrOrtholog
BioCyc Gene G2FUF-53144 BioCyc
Ensembl Genes ENSRNOG00000010210 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014317.6 UniProtKB/TrEMBL
  ENSRNOT00000114420 ENTREZGENE
  ENSRNOT00000114420.1 UniProtKB/TrEMBL
  ENSRNOT00000120596 ENTREZGENE
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/TrEMBL
InterPro AA/rel_permease1 UniProtKB/TrEMBL
  AminoAcid_Transporter UniProtKB/TrEMBL
  L_AA_transporter UniProtKB/TrEMBL
KEGG Report rno:310392 UniProtKB/TrEMBL
NCBI Gene 310392 ENTREZGENE
PANTHER AMINO ACID TRANSPORTER UniProtKB/TrEMBL
  CYSTINE/GLUTAMATE TRANSPORTER UniProtKB/TrEMBL
Pfam AA_permease_2 UniProtKB/TrEMBL
PharmGKB SLC7A11 RGD
PhenoGen Slc7a11 PhenoGen
PIRSF AA_transporter UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010210 RatGTEx
UniProt A0A8I6AB70 ENTREZGENE, UniProtKB/TrEMBL
  D4ADU2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Slc7a11  solute carrier family 7 (cationic amino acid transporter, y+ system), member 11   Slc7a11_predicted  solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Slc7a11_predicted  solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 (predicted)      Symbol and Name status set to approved 70820 APPROVED