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Gene: Flt3 (fms-related tyrosine kinase 3) Rattus norvegicus
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Symbol: Flt3
Name: fms-related tyrosine kinase 3
Description: Exhibits glucocorticoid receptor binding activity. Involved in animal organ regeneration; cellular response to glucocorticoid stimulus; and response to organonitrogen compound. Localizes to several cellular components, including the cytosol; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia; precursor lymphoblastic lymphoma/leukemia; and prostate cancer. Orthologous to human FLT3 (fms related tyrosine kinase 3); PARTICIPATES IN acute myeloid leukemia pathway; cytokine mediated signaling pathway; INTERACTS WITH (RS)-amphetamine; 2-acetamidofluorene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FL cytokine receptor; FMS-like tyrosine kinase 3; LOC304265; receptor-type tyrosine-protein kinase FLT3
Orthologs:
Homo sapiens (human) : FLT3 (fms related tyrosine kinase 3)  HGNC  Alliance
Mus musculus (house mouse) : Flt3 (FMS-like tyrosine kinase 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Flt3 (fms related tyrosine kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : FLT3 (fms related tyrosine kinase 3)
Canis lupus familiaris (dog) : FLT3 (fms related tyrosine kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Flt3 (fms related tyrosine kinase 3)
Sus scrofa (pig) : FLT3 (fms related tyrosine kinase 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0129,360,439 - 9,437,004 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01211,478,443 - 11,552,730 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4128,193,629 - 8,268,682 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1128,280,429 - 8,290,827 (+)NCBI
Celera129,364,576 - 9,437,757 (+)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Flt3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61308
Created: 2001-01-05
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.