Flt3 (Fms related receptor tyrosine kinase 3) - Rat Genome Database

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Gene: Flt3 (Fms related receptor tyrosine kinase 3) Rattus norvegicus
Analyze
Symbol: Flt3
Name: Fms related receptor tyrosine kinase 3
RGD ID: 61308
Description: Enables nuclear glucocorticoid receptor binding activity. Involved in animal organ regeneration; cellular response to glucocorticoid stimulus; and response to organonitrogen compound. Located in cytosol; nucleus; and plasma membrane. Part of protein-containing complex. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); leukemia (multiple); and prostate cancer. Orthologous to human FLT3 (fms related receptor tyrosine kinase 3); PARTICIPATES IN acute myeloid leukemia pathway; cytokine mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FL cytokine receptor; FMS-like tyrosine kinase 3; fms-related tyrosine kinase 3; LOC304265; receptor-type tyrosine-protein kinase FLT3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2127,623,658 - 7,699,474 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl127,623,930 - 7,699,474 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx128,309,422 - 8,384,638 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0128,932,574 - 9,007,795 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0127,960,581 - 8,035,804 (+)NCBIRnor_WKY
Rnor_6.0129,360,439 - 9,437,004 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,360,672 - 9,436,570 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01211,478,443 - 11,552,730 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4128,193,629 - 8,268,682 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1128,280,429 - 8,290,827 (+)NCBI
Celera129,364,576 - 9,437,757 (+)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEP)
antigen processing and presentation  (ISO)
B cell differentiation  (IBA,ISO)
cell population proliferation  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to glucocorticoid stimulus  (IEP)
cellular response to virus  (ISO)
common myeloid progenitor cell proliferation  (ISO)
cytokine-mediated signaling pathway  (IBA,ISO)
dendritic cell differentiation  (ISO)
dendritic cell homeostasis  (ISO)
hemopoiesis  (ISO)
homeostasis of number of cells within a tissue  (ISO)
leukocyte homeostasis  (ISO)
lymph node development  (ISO)
lymphocyte differentiation  (ISO)
lymphocyte proliferation  (ISO)
lymphoid progenitor cell differentiation  (ISO)
myeloid progenitor cell differentiation  (ISO)
negative regulation of B cell differentiation  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of interferon-alpha production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of kinase activity  (IBA)
positive regulation of multicellular organism growth  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of type II interferon production  (ISO)
post-embryonic development  (ISO)
pro-B cell differentiation  (ISO)
pro-T cell differentiation  (ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
response to organonitrogen compound  (IEP)
spleen development  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia. Abu-Duhier FM, etal., Br J Haematol. 2001 Jun;113(4):983-8.
2. FMS-like tyrosine kinase 3 interacts with the glucocorticoid receptor complex and affects glucocorticoid dependent signaling. Asadi A, etal., Biochem Biophys Res Commun. 2008 Apr 11;368(3):569-74. Epub 2008 Feb 7.
3. Cloning and expression profile of FLT3 gene during progenitor cell-dependent liver regeneration. Aydin IT, etal., J Gastroenterol Hepatol. 2007 Dec;22(12):2181-8.
4. Role of FLT3 in the proliferation and aggressiveness of hepatocellular carcinoma. Aydin MM, etal., Turk J Med Sci. 2016 Feb 17;46(2):572-81. doi: 10.3906/sag-1501-173.
5. Emergence of polyclonal FLT3 tyrosine kinase domain mutations during sequential therapy with sorafenib and sunitinib in FLT3-ITD-positive acute myeloid leukemia. Baker SD, etal., Clin Cancer Res. 2013 Oct 15;19(20):5758-68. doi: 10.1158/1078-0432.CCR-13-1323. Epub 2013 Aug 22.
6. Flt3 ligand antitumor activity in a murine breast cancer model: a comparison with granulocyte-macrophage colony-stimulating factor and a potential mechanism of action. Braun SE, etal., Hum Gene Ther. 1999 Sep 1;10(13):2141-51.
7. Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias. Carow CE, etal., Blood. 1996 Feb 1;87(3):1089-96.
8. Flt3-ligand induces transient tumor regression in an ectopic treatment model of major histocompatibility complex-negative prostate cancer. Ciavarra RP, etal., Cancer Res. 2000 Apr 15;60(8):2081-4.
9. Stability and prognostic influence of FLT3 mutations in paired initial and relapsed AML samples. Cloos J, etal., Leukemia. 2006 Jul;20(7):1217-20. Epub 2006 Apr 27.
10. FLT3-mediated p38-MAPK activation participates in the control of megakaryopoiesis in primary myelofibrosis. Desterke C, etal., Cancer Res. 2011 Apr 15;71(8):2901-15. doi: 10.1158/0008-5472.CAN-10-1731. Epub 2011 Apr 12.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis. Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89
13. FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model. Grundler R, etal., Blood. 2005 Jun 15;105(12):4792-9. Epub 2005 Feb 17.
14. FMS-like tyrosine kinase 3 (FLT3) amplification in patients with metastatic colorectal cancer. Hasegawa H, etal., Cancer Sci. 2021 Jan;112(1):314-322. doi: 10.1111/cas.14693. Epub 2020 Nov 20.
15. Safety and biological activity of repeated doses of recombinant human Flt3 ligand in patients with bone scan-negative hormone-refractory prostate cancer. Higano CS, etal., Clin Cancer Res. 2004 Feb 15;10(4):1219-25.
16. Promoter-associated DNA methylation & expression profiling of genes (FLT 3, EPB41L3 & SFN) in patients with oral squamous cell carcinoma in the Khasi & Jaintia population of Meghalaya, India. Khongsti S, etal., Indian J Med Res. 2019 Dec;150(6):584-591. doi: 10.4103/ijmr.IJMR_620_18.
17. FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia. Lee BH, etal., Cancer Cell. 2007 Oct;12(4):367-80.
18. BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML. Lin WH, etal., Br J Cancer. 2012 Jan 31;106(3):475-81. doi: 10.1038/bjc.2011.564. Epub 2011 Dec 20.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease. Rau R, etal., Exp Hematol. 2014 Feb;42(2):101-13.e5. doi: 10.1016/j.exphem.2013.10.005. Epub 2013 Oct 29.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Comprehensive gene review and curation RGD comprehensive gene curation
27. Effect of Flt3 ligand gene transfer in experimental pancreatic cancer. Ryschich E, etal., Int J Colorectal Dis. 2007 Feb;22(2):215-23. Epub 2006 Mar 10.
28. Orthotopic treatment model of prostate cancer and metastasis in the immunocompetent mouse: efficacy of flt3 ligand immunotherapy. Somers KD, etal., Int J Cancer. 2003 Dec 10;107(5):773-80.
29. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Yamamoto Y, etal., Blood. 2001 Apr 15;97(8):2434-9.
Additional References at PubMed
PMID:7507245   PMID:7621074   PMID:7630197   PMID:7919361   PMID:8183574   PMID:8384358   PMID:9620281   PMID:12387740   PMID:14759363   PMID:16618805   PMID:18245664   PMID:18469816  
PMID:20360400   PMID:20457904   PMID:21228325   PMID:21539498   PMID:21813452   PMID:22674806   PMID:23418353   PMID:23528453  


Genomics

Candidate Gene Status
Flt3 is a candidate Gene for QTL Cia12
Comparative Map Data
Flt3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2127,623,658 - 7,699,474 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl127,623,930 - 7,699,474 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx128,309,422 - 8,384,638 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0128,932,574 - 9,007,795 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0127,960,581 - 8,035,804 (+)NCBIRnor_WKY
Rnor_6.0129,360,439 - 9,437,004 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,360,672 - 9,436,570 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01211,478,443 - 11,552,730 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4128,193,629 - 8,268,682 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1128,280,429 - 8,290,827 (+)NCBI
Celera129,364,576 - 9,437,757 (+)NCBICelera
Cytogenetic Map12p11NCBI
FLT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381328,003,274 - 28,100,576 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1328,003,274 - 28,100,592 (-)EnsemblGRCh38hg38GRCh38
GRCh371328,577,411 - 28,674,713 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361327,475,411 - 27,572,729 (-)NCBINCBI36Build 36hg18NCBI36
Build 341327,475,752 - 27,572,703NCBI
Celera139,652,471 - 9,749,817 (-)NCBICelera
Cytogenetic Map13q12.2NCBI
HuRef139,398,611 - 9,496,033 (-)NCBIHuRef
CHM1_11328,546,018 - 28,643,312 (-)NCBICHM1_1
T2T-CHM13v2.01327,225,623 - 27,323,127 (-)NCBIT2T-CHM13v2.0
Flt3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395147,267,551 - 147,337,299 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5147,267,551 - 147,337,299 (-)EnsemblGRCm39 Ensembl
GRCm385147,330,741 - 147,400,489 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5147,330,741 - 147,400,489 (-)EnsemblGRCm38mm10GRCm38
MGSCv375148,142,317 - 148,212,065 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365147,641,095 - 147,710,644 (-)NCBIMGSCv36mm8
Celera5145,322,183 - 145,394,029 (-)NCBICelera
Cytogenetic Map5G3NCBI
cM Map586.88NCBI
Flt3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554977,357,212 - 7,461,439 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554977,357,533 - 7,441,215 (-)NCBIChiLan1.0ChiLan1.0
FLT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11327,627,178 - 27,694,863 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1327,627,178 - 27,723,940 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0139,283,747 - 9,381,553 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FLT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12511,551,372 - 11,670,891 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2511,581,206 - 11,692,284 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2511,657,250 - 11,733,707 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02511,678,532 - 11,799,840 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2511,678,653 - 11,799,832 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12511,617,543 - 11,693,992 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02511,610,080 - 11,686,320 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02511,653,606 - 11,730,223 (+)NCBIUU_Cfam_GSD_1.0
Flt3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945172,712,952 - 172,782,113 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647223,169,967 - 23,239,178 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl115,370,496 - 5,455,358 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1115,370,475 - 5,455,439 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2114,980,781 - 5,141,022 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FLT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.137,117,579 - 7,222,600 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl37,116,947 - 7,222,849 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605737,168,175 - 37,271,421 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Flt3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477610,435,850 - 10,517,066 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477610,407,083 - 10,516,350 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
RH129712  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2127,699,131 - 7,699,312 (+)MAPPERmRatBN7.2
Rnor_6.0129,436,662 - 9,436,842NCBIRnor6.0
Rnor_5.01211,552,388 - 11,552,568UniSTSRnor5.0
RGSC_v3.4128,268,340 - 8,268,520UniSTSRGSC3.4
Celera129,437,415 - 9,437,595UniSTS
Cytogenetic Map12p11UniSTS
RH143417  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2127,623,655 - 7,623,812 (+)MAPPERmRatBN7.2
Rnor_6.0129,360,166 - 9,360,322NCBIRnor6.0
Rnor_5.01211,478,170 - 11,478,326UniSTSRnor5.0
Celera129,364,302 - 9,364,458UniSTS
Cytogenetic Map12p11UniSTS
BF405485  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2127,692,412 - 7,692,620 (+)MAPPERmRatBN7.2
Rnor_6.0129,429,851 - 9,430,058NCBIRnor6.0
Rnor_5.01211,545,577 - 11,545,784UniSTSRnor5.0
RGSC_v3.4128,261,379 - 8,261,586UniSTSRGSC3.4
Celera129,430,696 - 9,430,903UniSTS
RH 3.4 Map1288.01UniSTS
Cytogenetic Map12p11UniSTS
UniSTS:265488  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2127,681,890 - 7,683,447 (+)MAPPERmRatBN7.2
Rnor_6.0129,419,183 - 9,420,738NCBIRnor6.0
Rnor_5.01211,534,909 - 11,536,464UniSTSRnor5.0
RGSC_v3.4128,250,538 - 8,252,093UniSTSRGSC3.4
Celera129,420,544 - 9,422,099UniSTS
Cytogenetic Map12p11UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)127977298525593Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12390696910373166Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:87
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000061160
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 11 14
Low 3 14 49 33 8 33 30 17 33 11
Below cutoff 27 8 8 8 8 11 24 16 8 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000088957   ⟹   ENSRNOP00000069753
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl127,623,930 - 7,699,474 (+)Ensembl
Rnor_6.0 Ensembl129,360,672 - 9,436,570 (+)Ensembl
RefSeq Acc Id: NM_001100822   ⟹   NP_001094292
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2127,623,930 - 7,699,474 (+)NCBI
Rnor_6.0129,360,439 - 9,437,004 (+)NCBI
Rnor_5.01211,478,443 - 11,552,730 (+)NCBI
RGSC_v3.4128,193,629 - 8,268,682 (+)RGD
Celera129,364,576 - 9,437,757 (+)RGD
Sequence:
RefSeq Acc Id: XM_039089036   ⟹   XP_038944964
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2127,623,658 - 7,699,474 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001094292 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944964 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAM18767 (Get FASTA)   NCBI Sequence Viewer  
  EDL89562 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001094292   ⟸   NM_001100822
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSRNOP00000069753   ⟸   ENSRNOT00000088957
RefSeq Acc Id: XP_038944964   ⟸   XM_039089036
- Peptide Label: isoform X1
Protein Domains
Ig-like   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JW59-F1-model_v2 AlphaFold A0A0G2JW59 1-1002 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61308 AgrOrtholog
BioCyc Gene G2FUF-20118 BioCyc
Ensembl Genes ENSRNOG00000054764 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000069753 ENTREZGENE
  ENSRNOP00000069753.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000088957 ENTREZGENE
  ENSRNOT00000088957.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro FLT3 UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_rcpt_3_CS UniProtKB/TrEMBL
  Tyr_prot_kinase_AS UniProtKB/TrEMBL
NCBI Gene 140635 ENTREZGENE
PANTHER PTHR24416:SF356 UniProtKB/TrEMBL
Pfam PF00047 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PhenoGen Flt3 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_III UniProtKB/TrEMBL
SMART SM00409 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A0A0G2JW59_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-01-03 Flt3  Fms related receptor tyrosine kinase 3  Flt3  fms-related tyrosine kinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Flt3  fms-related tyrosine kinase 3  Flt3  FMS-like tyrosine kinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-04-27 Flt3  FMS-like tyrosine kinase 3  Flt3_predicted  FMS-like tyrosine kinase 3 (predicted)  Data Merged 737654 APPROVED
2005-01-12 Flt3_predicted  FMS-like tyrosine kinase 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-06-10 Flt3  fms-related tyrosine kinase 3      Symbol and Name status set to approved 70585 APPROVED
2001-10-23 Flt3  fms-related tyrosine kinase 3      Name updated 68913 RESERVED