Ctsl (cathepsin L) - Rat Genome Database

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Gene: Ctsl (cathepsin L) Rattus norvegicus
Analyze
Symbol: Ctsl
Name: cathepsin L
RGD ID: 2448
Description: Enables kininogen binding activity; peptidase activity; and peptide binding activity. Involved in several processes, including Sertoli cell differentiation; decidualization; and response to odorant. Located in external side of plasma membrane; microvillus; and perikaryon. Colocalizes with apical part of cell and secretory granule. Used to study hepatocellular carcinoma. Biomarker of several diseases, including brain ischemia; hyperthyroidism; muscular atrophy; otitis media; and pancreatitis. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSV (cathepsin V); PARTICIPATES IN chaperone mediated autophagy pathway; antigen processing and presentation pathway; phagocytosis pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cathepsin L1; CATHL; CatL; CP-2; Ctsl1; cyclic protein 2; major excreted protein; MEP; procathepsin L
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.217764,370 - 770,533 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl17764,309 - 770,548 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx17783,032 - 789,194 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0172,325,609 - 2,331,773 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.017780,461 - 786,622 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0171,873,105 - 1,879,266 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl171,872,848 - 1,879,279 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0171,861,403 - 1,867,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,288,013 - 6,294,174 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1176,288,015 - 6,294,173 (+)NCBI
Celera171,745,833 - 1,751,993 (-)NCBICelera
RH 3.4 Map1716.0RGD
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-diaminobutyric acid  (ISO)
2-methoxyethanol  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methyladenine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (ISO)
albendazole  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aloxistatin  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
amphetamine  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asperphenamate  (ISO)
azathioprine  (ISO)
bafilomycin A1  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
berberine  (ISO)
beryllium sulfate  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromobenzene  (EXP)
buspirone  (EXP)
butan-1-ol  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
CCCP  (ISO)
CGP 52608  (ISO)
chloroform  (EXP)
chloroquine  (EXP)
choline  (ISO)
chondroitin sulfate  (ISO)
cimetidine  (EXP)
ciprofibrate  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
ethanol  (ISO)
eugenol  (ISO)
fenamidone  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
imiquimod  (ISO)
indoles  (EXP)
indometacin  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
Liensinine  (ISO)
lipopolysaccharide  (EXP)
maneb  (ISO)
methidathion  (ISO)
methotrexate  (EXP)
methoxyacetic acid  (EXP)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naloxone  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirimiphos-methyl  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propiconazole  (ISO)
ranitidine  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sotorasib  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
teicoplanin  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thapsigargin  (ISO)
theophylline  (EXP)
tioguanine  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
trametinib  (ISO)
trichloroethene  (EXP,ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression and localization of cathepsin k in adult rat sertoli cells. Anway MD, etal., Biol Reprod 2004 Mar;70(3):562-9. Epub 2003 Oct 29.
2. Overexpression of phosphodiesterases in experimental autoimmune myasthenia gravis: suppression of disease by a phosphodiesterase inhibitor. Aricha R, etal., FASEB J. 2006 Feb;20(2):374-6. Epub 2005 Dec 19.
3. Cathepsin L colocalizes with chromogranin a in chromaffin vesicles to generate active peptides. Biswas N, etal., Endocrinology. 2009 Aug;150(8):3547-57. Epub 2009 Apr 16.
4. Abeta-mediated activation of the apoptotic cascade in cultured cortical neurones: a role for cathepsin-L. Boland B and Campbell V, Neurobiol Aging. 2004 Jan;25(1):83-91.
5. PGF2alpha induced differential expression of genes involved in turnover of extracellular matrix in rat decidual cells. Callegari EA, etal., Reprod Biol Endocrinol. 2005 Jan 11;3:3.
6. Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice. Cattaruzza F, etal., Gastroenterology. 2011 Nov;141(5):1864-74.e1-3. Epub 2011 Jul 28.
7. A GC-box within the proximal promoter region of the rat cathepsin L gene activates transcription in Sertoli cells of sexually mature rats. Charron M, etal., Biol Reprod 2003 May;68(5):1649-56. Epub 2002 Nov 27.
8. The helix-loop-helix inhibitor of differentiation (ID) proteins induce post-mitotic terminally differentiated Sertoli cells to re-enter the cell cycle and proliferate. Chaudhary J, etal., Biol Reprod. 2005 May;72(5):1205-17. Epub 2005 Jan 12.
9. Evidence for cross-talk between Sertoli and germ cells using selected cathepsins as markers. Chung SS, etal., J Androl. 1998 Nov-Dec;19(6):686-703.
10. Spinal cathepsin S and fractalkine contribute to chronic pain in collagen induced arthritis. Clark AK, etal., Arthritis Rheum. 2011 Dec 27. doi: 10.1002/art.34351.
11. ATP-activated, high-molecular-mass proteinase-I from rat skeletal muscle is a cysteine proteinase-alpha 1-macroglobulin complex. Dahlmann B, etal., Biochim Biophys Acta. 1989 May 31;991(2):253-62.
12. Altered expression of trefoil factor 3 and cathepsin L gene in rat kidney during aging. Debata PR, etal., Biogerontology. 2007 Feb;8(1):25-30. Epub 2006 Jul 25.
13. The protective effect of dexanabinol (HU-211) on nitric oxide and cysteine protease-mediated neuronal death in focal cerebral ischemia. Durmaz R, etal., Neurochem Res. 2008 Sep;33(9):1683-91. Epub 2008 Apr 11.
14. Increased muscle proteolysis after local trauma mainly reflects macrophage-associated lysosomal proteolysis. Farges MC, etal., Am J Physiol Endocrinol Metab 2002 Feb;282(2):E326-35.
15. Patterns of dioxin-altered mRNA expression in livers of dioxin-sensitive versus dioxin-resistant rats. Franc MA, etal., Arch Toxicol. 2008 Nov;82(11):809-30. Epub 2008 May 9.
16. Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression. Funkelstein L, etal., J Neurochem. 2008 Jul;106(1):384-91. Epub 2008 Jul 1.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. A 14-kDa cathepsin L-derived carboxyl IGFBP-2 fragment is sequestered by cultured rat ileal crypt cells. Gordon PV, etal., Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G79-87. Epub 2005 Feb 10.
20. Hypertension-mediated albuminuria is associated with reduced lysosomal activity in the kidney and the heart. Hilliard LM, etal., Am J Nephrol. 2009;29(5):454-64. Epub 2008 Nov 21.
21. Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse. Hsing LC, etal., J Autoimmun. 2009 Aug 5.
22. Impaired cathepsin L gene expression in skeletal muscle is associated with type 2 diabetes. Huang X, etal., Diabetes. 2003 Sep;52(9):2411-8.
23. Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus. Irwin LN and Byers DM, Brain Res. 2012 Dec 13;1489:1-7. doi: 10.1016/j.brainres.2012.10.034. Epub 2012 Oct 26.
24. Molecular cloning and sequencing of cDNA for rat cathepsin L. Ishidoh K, etal., FEBS Lett 1987 Oct 19;223(1):69-73.
25. Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis. Johnson EM, etal., J Virol. 2009 Oct;83(19):9630-40. Epub 2009 Jul 29.
26. Differential expression of cysteine and aspartic proteases during progression of atherosclerosis in apolipoprotein E-deficient mice. Jormsjo S, etal., Am J Pathol. 2002 Sep;161(3):939-45.
27. Role for IkappaBalpha, but not c-Rel, in skeletal muscle atrophy. Judge AR, etal., Am J Physiol Cell Physiol. 2007 Jan;292(1):C372-82. Epub 2006 Aug 23.
28. Up-regulation of lysosomal cathepsin L and autophagy during neuronal death induced by reduced serum and potassium. Kaasik A, etal., Eur J Neurosci. 2005 Sep;22(5):1023-31.
29. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
30. Changes in the activity of lysosomal enzymes in rat kidneys in the course of acute pancreatitis. Lakowska H, etal., Med Sci Monit. 2001 Nov-Dec;7(6):1193-7.
31. Differential expression of monomeric and proteolytically processed forms of tartrate-resistant acid phosphatase in rat tissues. Lang P and Andersson G, Cell Mol Life Sci. 2005 Apr;62(7-8):905-18.
32. Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. Lecker SH, etal., FASEB J. 2004 Jan;18(1):39-51.
33. Blockage of testicular connexins induced apoptosis in rat seminiferous epithelium. Lee NP, etal., Apoptosis. 2006 Jul;11(7):1215-29.
34. Cathepsin gene expression profile in rat acute pneumococcal otitis media. Li-Korotky HS, etal., Laryngoscope 2004 Jun;114(6):1032-6.
35. Induced expression of cathepsins and cystatin C in a murine model of demyelination. Ma J, etal., Neurochem Res. 2007 Feb;32(2):311-20. Epub 2006 Nov 4.
36. Expression of cysteine proteinases and their inhibitor, cystatin beta, in cultured rat mesangial cells. Makita Y, etal., J Diabetes Complications. 1998 Nov-Dec;12(6):328-36.
37. Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis. Mareninova OA, etal., J Clin Invest. 2009 Nov;119(11):3340-55. doi: 10.1172/JCI38674. Epub 2009 Oct 1.
38. Release of endo-lysosomal cathepsins B, D, and L from IEC6 cells in a cell culture model mimicking intestinal manipulation. Mayer K, etal., Biol Chem. 2009 May-Jun;390(5-6):471-80.
39. Developmentally distinct in vivo effects of FSH on proliferation and apoptosis during testis maturation. Meachem SJ, etal., J Endocrinol. 2005 Sep;186(3):429-46.
40. Localization of cathepsins G and L in spontaneous resorption of intervertebral discs in a rat experimental model. Meng W, etal., J Musculoskelet Neuronal Interact. 2001 Dec;2(2):171-6.
41. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
42. Cysteine-proteinase-inhibiting function of T kininogen and of its proteolytic fragments. Moreau T, etal., Eur J Biochem. 1988 Apr 5;173(1):185-90.
43. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
44. Experimental hyperthyroidism in rats increases the expression of the ubiquitin ligases atrogin-1 and MuRF1 and stimulates multiple proteolytic pathways in skeletal muscle. O'Neal P, etal., J Cell Biochem. 2009 Nov 1;108(4):963-73.
45. New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors. Ohashi A, etal., Biochem Biophys Res Commun. 2003 Jun 20;306(1):98-103.
46. Cathepsin L plays an important role in the lysosomal degradation of L-lactate dehydrogenase. Ohshita T and Hiroi Y, Biosci Biotechnol Biochem. 2006 Sep;70(9):2254-61. Epub 2006 Sep 7.
47. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
48. Intrinsic fibroblast-mediated remodeling of damaged collagenous matrices in vivo. Provenzano PP, etal., Matrix Biol. 2005 Jan;23(8):543-55. Epub 2004 Dec 1.
49. Role of chaperone-mediated autophagy in degrading Huntington's disease-associated huntingtin protein. Qi L and Zhang XD, Acta Biochim Biophys Sin (Shanghai). 2014 Feb;46(2):83-91. doi: 10.1093/abbs/gmt133. Epub 2013 Dec 8.
50. Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin. Reiser J, etal., J Biol Chem 2004 Aug 13;279(33):34827-32. Epub 2004 Jun 14.
51. GOA pipeline RGD automated data pipeline
52. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
53. Electron histochemical localization of cathepsin L in the liver. Ryvnyak VV, etal., Bull Exp Biol Med. 2004 Jan;137(1):90-1.
54. Effect of vitamin E and human placenta cysteine peptidase inhibitor on expression of cathepsins B and L in implanted hepatoma Morris 5123 tumor model in Wistar rats. Sebzda T, etal., World J Gastroenterol. 2005 Jan 28;11(4):587-92.
55. Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis. Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8.
56. Endostatin and angiostatin are increased in diabetic patients with coronary artery disease and associated with impaired coronary collateral formation. Sodha NR, etal., Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H428-34. Epub 2008 Dec 12.
57. Evolution of placentally expressed cathepsins. Sol-Church K, etal., Biochem Biophys Res Commun 2002 Apr 26;293(1):23-9.
58. Cathepsin L gene expression and promoter activation in rodent granulosa cells. Sriraman V and Richards JS, Endocrinology 2004 Feb;145(2):582-91. Epub 2003 Oct 16.
59. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
60. Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling. Tang Q, etal., J Mol Med. 2009 Mar;87(3):249-60. Epub 2008 Dec 19.
61. Effects of a verbenachalcone derivative on neurite outgrowth, inhibition of caspase induction and gene expression. Yeh LA, etal., Bioorg Med Chem Lett. 2005 Feb 15;15(4):1193-6.
Additional References at PubMed
PMID:1482371   PMID:1791830   PMID:1837142   PMID:2599113   PMID:3402618   PMID:7777858   PMID:8811434   PMID:9310336   PMID:10699763   PMID:11023992   PMID:11356678   PMID:12782676  
PMID:12809493   PMID:14511383   PMID:15099520   PMID:15196205   PMID:15255544   PMID:15489334   PMID:17500053   PMID:18060871   PMID:18957203   PMID:19458314   PMID:20043885   PMID:20338168  
PMID:21134415   PMID:21217776   PMID:21326229   PMID:21357272   PMID:21374014   PMID:21383048   PMID:21911934   PMID:22365146   PMID:22952693   PMID:23099040   PMID:23106098   PMID:23376485  
PMID:23533145   PMID:24616078   PMID:25558848   PMID:27818353   PMID:28002813   PMID:28743268   PMID:28835281   PMID:30052474   PMID:31302164   PMID:31444477  


Genomics

Comparative Map Data
Ctsl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.217764,370 - 770,533 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl17764,309 - 770,548 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx17783,032 - 789,194 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0172,325,609 - 2,331,773 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.017780,461 - 786,622 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0171,873,105 - 1,879,266 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl171,872,848 - 1,879,279 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0171,861,403 - 1,867,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,288,013 - 6,294,174 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1176,288,015 - 6,294,173 (+)NCBI
Celera171,745,833 - 1,751,993 (-)NCBICelera
RH 3.4 Map1716.0RGD
Cytogenetic Map17p14NCBI
CTSL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38987,726,119 - 87,731,469 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl987,724,051 - 87,731,469 (+)EnsemblGRCh38hg38GRCh38
GRCh37990,341,034 - 90,346,384 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36989,530,794 - 89,536,204 (+)NCBINCBI36Build 36hg18NCBI36
Build 34987,570,533 - 87,575,862NCBI
Celera960,911,195 - 60,916,605 (+)NCBICelera
Cytogenetic Map9q21.33NCBI
HuRef960,165,416 - 60,170,826 (+)NCBIHuRef
CHM1_1990,488,740 - 90,494,151 (+)NCBICHM1_1
T2T-CHM13v2.0999,879,735 - 99,885,089 (+)NCBIT2T-CHM13v2.0
Ctsl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391364,509,704 - 64,518,586 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1364,507,151 - 64,518,704 (-)EnsemblGRCm39 Ensembl
GRCm381364,361,890 - 64,370,772 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1364,359,337 - 64,370,890 (-)EnsemblGRCm38mm10GRCm38
MGSCv371364,464,522 - 64,471,614 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361364,377,945 - 64,385,037 (-)NCBIMGSCv36mm8
Celera1366,025,830 - 66,032,878 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1333.26NCBI
LOC100987260
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1951,696,841 - 51,702,165 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0958,851,899 - 58,857,170 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1986,903,001 - 86,908,303 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl986,903,006 - 86,908,303 (+)Ensemblpanpan1.1panPan2
CTSL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1172,215,774 - 72,219,093 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha172,978,019 - 72,981,188 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0172,520,707 - 72,523,876 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl172,520,707 - 72,523,900 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1172,331,483 - 72,334,652 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0172,097,122 - 72,100,291 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0172,802,852 - 72,806,021 (-)NCBIUU_Cfam_GSD_1.0
Ctsl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947118,687,401 - 118,693,831 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366803,047,355 - 3,050,640 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1027,668,264 - 27,674,618 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11027,668,523 - 27,674,705 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21031,907,421 - 31,913,554 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTSL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11298,347,770 - 98,353,426 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1298,347,800 - 98,353,467 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603886,669,582 - 86,675,194 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ctsl
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:224
Count of miRNA genes:159
Interacting mature miRNAs:172
Transcripts:ENSRNOT00000025462
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat

Markers in Region
AA923921  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.217770,607 - 770,794 (-)MAPPERmRatBN7.2
Rnor_6.0171,872,844 - 1,873,030NCBIRnor6.0
Rnor_5.0171,861,142 - 1,861,328UniSTSRnor5.0
RGSC_v3.4176,294,249 - 6,294,435UniSTSRGSC3.4
Celera171,745,572 - 1,745,758UniSTS
RH 3.4 Map175.6UniSTS
Cytogenetic Map17p14UniSTS
RH94583  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.217770,237 - 770,430 (-)MAPPERmRatBN7.2
Rnor_6.0171,873,208 - 1,873,400NCBIRnor6.0
Rnor_5.0171,861,506 - 1,861,698UniSTSRnor5.0
RGSC_v3.4176,293,879 - 6,294,071UniSTSRGSC3.4
Celera171,745,936 - 1,746,128UniSTS
RH 3.4 Map1716.0UniSTS
Cytogenetic Map17p14UniSTS
Ctsl  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0171,864,475 - 1,864,872NCBIRnor5.0
RGSC_v3.4176,290,705 - 6,291,101UniSTSRGSC3.4
Cytogenetic Map17p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 19
Medium 3 43 57 41 19 41 8 11 74 16 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025462   ⟹   ENSRNOP00000025462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl17764,309 - 770,548 (+)Ensembl
Rnor_6.0 Ensembl171,872,848 - 1,879,279 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111570   ⟹   ENSRNOP00000093716
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl17764,309 - 770,548 (+)Ensembl
RefSeq Acc Id: NM_013156   ⟹   NP_037288
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.217764,370 - 770,533 (+)NCBI
Rnor_6.0171,873,105 - 1,879,266 (-)NCBI
Rnor_5.0171,861,403 - 1,867,564 (-)NCBI
RGSC_v3.4176,288,013 - 6,294,174 (+)RGD
Celera171,745,833 - 1,751,993 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_037288   ⟸   NM_013156
- Peptide Label: preproprotein
- UniProtKB: Q9QV07 (UniProtKB/Swiss-Prot),   P07154 (UniProtKB/Swiss-Prot),   I2FHN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025462   ⟸   ENSRNOT00000025462
RefSeq Acc Id: ENSRNOP00000093716   ⟸   ENSRNOT00000111570
Protein Domains
Cathepsin propeptide inhibitor   Peptidase C1A papain C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07154-F1-model_v2 AlphaFold P07154 1-334 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700264
Promoter ID:EPDNEW_R10788
Type:multiple initiation site
Name:Ctsl_1
Description:cathepsin L
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0171,879,277 - 1,879,337EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2448 AgrOrtholog
BioCyc Gene G2FUF-10545 BioCyc
Ensembl Genes ENSRNOG00000018566 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025462 ENTREZGENE
  ENSRNOT00000025462.7 UniProtKB/TrEMBL
  ENSRNOT00000111570.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.2250 UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6918389 IMAGE-MGC_LOAD
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_papain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_inhib_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25697 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72924 IMAGE-MGC_LOAD
NCBI Gene 25697 ENTREZGENE
PANTHER CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROCATHEPSIN L UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CTSL1 RGD
PhenoGen Ctsl PhenoGen
PRINTS PAPAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018566 RatGTEx
SMART Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AKK6_RAT UniProtKB/TrEMBL
  A0A8L2QDP6_RAT UniProtKB/TrEMBL
  A6KQE4_RAT UniProtKB/TrEMBL
  CATL1_RAT UniProtKB/Swiss-Prot
  I2FHN3 ENTREZGENE, UniProtKB/TrEMBL
  P07154 ENTREZGENE
  Q9QV07 ENTREZGENE
UniProt Secondary Q9QV07 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-02-03 Ctsl  cathepsin L  Ctsl1  cathepsin L1  Name and Symbol changed 629549 APPROVED
2008-09-26 Ctsl1  cathepsin L1  Ctsl  cathepsin L  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ctsl  Cathepsin L      Symbol and Name status set to approved 70586 APPROVED