Ctsl (cathepsin L) - Rat Genome Database

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Gene: Ctsl (cathepsin L) Rattus norvegicus
Analyze
Symbol: Ctsl
Name: cathepsin L
RGD ID: 2448
Description: Exhibits kininogen binding activity; peptidase activity; and peptide binding activity. Involved in several processes, including autophagic cell death; reproductive structure development; and response to odorant. Localizes to several cellular components, including external side of plasma membrane; microvillus; and perikaryon. Colocalizes with apical part of cell and secretory granule. Used to study hepatocellular carcinoma. Biomarker of several diseases, including brain ischemia; hyperthyroidism; muscular atrophy; otitis media; and pancreatitis. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSV (cathepsin V); PARTICIPATES IN chaperone mediated autophagy pathway; antigen processing and presentation pathway; phagocytosis pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cathepsin L1; CATHL; CatL; CP-2; Ctsl1; cyclic protein 2; major excreted protein; MEP; procathepsin L
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.217764,370 - 770,533 (+)NCBI
Rnor_6.0 Ensembl171,872,848 - 1,879,279 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0171,873,105 - 1,879,266 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0171,861,403 - 1,867,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,288,013 - 6,294,174 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1176,288,015 - 6,294,173 (+)NCBI
Celera171,745,833 - 1,751,993 (-)NCBICelera
RH 3.4 Map1716.0RGD
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-diaminobutyric acid  (ISO)
2-methoxyethanol  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-methyladenine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (ISO)
albendazole  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aloxistatin  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
asperphenamate  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beryllium sulfate  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
buspirone  (EXP)
butan-1-ol  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
CCCP  (ISO)
chloroform  (EXP)
chloroquine  (EXP)
choline  (ISO)
chondroitin sulfate  (ISO)
cimetidine  (EXP)
ciprofibrate  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
ethanol  (ISO)
eugenol  (ISO)
fenamidone  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
genistein  (ISO)
glucose  (ISO)
glyphosate  (ISO)
imiquimod  (ISO)
indoles  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (EXP)
maneb  (ISO)
methotrexate  (EXP)
methoxyacetic acid  (EXP)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naloxone  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirimiphos-methyl  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propiconazole  (ISO)
ranitidine  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (ISO)
teicoplanin  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thapsigargin  (ISO)
theophylline  (EXP)
tioguanine  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
trichloroethene  (EXP,ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Anway MD, etal., Biol Reprod 2004 Mar;70(3):562-9. Epub 2003 Oct 29.
2. Aricha R, etal., FASEB J. 2006 Feb;20(2):374-6. Epub 2005 Dec 19.
3. Biswas N, etal., Endocrinology. 2009 Aug;150(8):3547-57. Epub 2009 Apr 16.
4. Boland B and Campbell V, Neurobiol Aging. 2004 Jan;25(1):83-91.
5. Callegari EA, etal., Reprod Biol Endocrinol. 2005 Jan 11;3:3.
6. Cattaruzza F, etal., Gastroenterology. 2011 Nov;141(5):1864-74.e1-3. Epub 2011 Jul 28.
7. Charron M, etal., Biol Reprod 2003 May;68(5):1649-56. Epub 2002 Nov 27.
8. Chaudhary J, etal., Biol Reprod. 2005 May;72(5):1205-17. Epub 2005 Jan 12.
9. Chung SS, etal., J Androl. 1998 Nov-Dec;19(6):686-703.
10. Clark AK, etal., Arthritis Rheum. 2011 Dec 27. doi: 10.1002/art.34351.
11. Dahlmann B, etal., Biochim Biophys Acta. 1989 May 31;991(2):253-62.
12. Debata PR, etal., Biogerontology. 2007 Feb;8(1):25-30. Epub 2006 Jul 25.
13. Durmaz R, etal., Neurochem Res. 2008 Sep;33(9):1683-91. Epub 2008 Apr 11.
14. Farges MC, etal., Am J Physiol Endocrinol Metab 2002 Feb;282(2):E326-35.
15. Franc MA, etal., Arch Toxicol. 2008 Nov;82(11):809-30. Epub 2008 May 9.
16. Funkelstein L, etal., J Neurochem. 2008 Jul;106(1):384-91. Epub 2008 Jul 1.
17. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. GOA data from the GO Consortium
19. Gordon PV, etal., Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G79-87. Epub 2005 Feb 10.
20. Hilliard LM, etal., Am J Nephrol. 2009;29(5):454-64. Epub 2008 Nov 21.
21. Hsing LC, etal., J Autoimmun. 2009 Aug 5.
22. Huang X, etal., Diabetes. 2003 Sep;52(9):2411-8.
23. Irwin LN and Byers DM, Brain Res. 2012 Dec 13;1489:1-7. doi: 10.1016/j.brainres.2012.10.034. Epub 2012 Oct 26.
24. Ishidoh K, etal., FEBS Lett 1987 Oct 19;223(1):69-73.
25. Johnson EM, etal., J Virol. 2009 Oct;83(19):9630-40. Epub 2009 Jul 29.
26. Jormsjo S, etal., Am J Pathol. 2002 Sep;161(3):939-45.
27. Judge AR, etal., Am J Physiol Cell Physiol. 2007 Jan;292(1):C372-82. Epub 2006 Aug 23.
28. Kaasik A, etal., Eur J Neurosci. 2005 Sep;22(5):1023-31.
29. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
30. Lakowska H, etal., Med Sci Monit. 2001 Nov-Dec;7(6):1193-7.
31. Lang P and Andersson G, Cell Mol Life Sci. 2005 Apr;62(7-8):905-18.
32. Lecker SH, etal., FASEB J. 2004 Jan;18(1):39-51.
33. Lee NP, etal., Apoptosis. 2006 Jul;11(7):1215-29.
34. Li-Korotky HS, etal., Laryngoscope 2004 Jun;114(6):1032-6.
35. Ma J, etal., Neurochem Res. 2007 Feb;32(2):311-20. Epub 2006 Nov 4.
36. Makita Y, etal., J Diabetes Complications. 1998 Nov-Dec;12(6):328-36.
37. Mareninova OA, etal., J Clin Invest. 2009 Nov;119(11):3340-55. doi: 10.1172/JCI38674. Epub 2009 Oct 1.
38. Mayer K, etal., Biol Chem. 2009 May-Jun;390(5-6):471-80.
39. Meachem SJ, etal., J Endocrinol. 2005 Sep;186(3):429-46.
40. Meng W, etal., J Musculoskelet Neuronal Interact. 2001 Dec;2(2):171-6.
41. MGD data from the GO Consortium
42. Moreau T, etal., Eur J Biochem. 1988 Apr 5;173(1):185-90.
43. NCBI rat LocusLink and RefSeq merged data July 26, 2002
44. O'Neal P, etal., J Cell Biochem. 2009 Nov 1;108(4):963-73.
45. Ohashi A, etal., Biochem Biophys Res Commun. 2003 Jun 20;306(1):98-103.
46. Ohshita T and Hiroi Y, Biosci Biotechnol Biochem. 2006 Sep;70(9):2254-61. Epub 2006 Sep 7.
47. Pipeline to import KEGG annotations from KEGG into RGD
48. Provenzano PP, etal., Matrix Biol. 2005 Jan;23(8):543-55. Epub 2004 Dec 1.
49. Qi L and Zhang XD, Acta Biochim Biophys Sin (Shanghai). 2014 Feb;46(2):83-91. doi: 10.1093/abbs/gmt133. Epub 2013 Dec 8.
50. Reiser J, etal., J Biol Chem 2004 Aug 13;279(33):34827-32. Epub 2004 Jun 14.
51. RGD automated data pipeline
52. RGD automated import pipeline for gene-chemical interactions
53. Ryvnyak VV, etal., Bull Exp Biol Med. 2004 Jan;137(1):90-1.
54. Sebzda T, etal., World J Gastroenterol. 2005 Jan 28;11(4):587-92.
55. Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8.
56. Sodha NR, etal., Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H428-34. Epub 2008 Dec 12.
57. Sol-Church K, etal., Biochem Biophys Res Commun 2002 Apr 26;293(1):23-9.
58. Sriraman V and Richards JS, Endocrinology 2004 Feb;145(2):582-91. Epub 2003 Oct 16.
59. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
60. Tang Q, etal., J Mol Med. 2009 Mar;87(3):249-60. Epub 2008 Dec 19.
61. Yeh LA, etal., Bioorg Med Chem Lett. 2005 Feb 15;15(4):1193-6.
Additional References at PubMed
PMID:1482371   PMID:1791830   PMID:1837142   PMID:2599113   PMID:3402618   PMID:7777858   PMID:8811434   PMID:9310336   PMID:10699763   PMID:11023992   PMID:11356678   PMID:12782676  
PMID:12809493   PMID:14511383   PMID:15099520   PMID:15196205   PMID:15255544   PMID:15489334   PMID:17500053   PMID:18060871   PMID:18957203   PMID:19458314   PMID:20043885   PMID:20338168  
PMID:21134415   PMID:21217776   PMID:21326229   PMID:21357272   PMID:21374014   PMID:21383048   PMID:21911934   PMID:22365146   PMID:22952693   PMID:23099040   PMID:23106098   PMID:23376485  
PMID:23533145   PMID:24616078   PMID:25558848   PMID:27818353   PMID:28002813   PMID:28743268   PMID:28835281   PMID:30052474   PMID:31302164   PMID:31444477  


Genomics

Comparative Map Data
Ctsl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.217764,370 - 770,533 (+)NCBI
Rnor_6.0 Ensembl171,872,848 - 1,879,279 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0171,873,105 - 1,879,266 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0171,861,403 - 1,867,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,288,013 - 6,294,174 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1176,288,015 - 6,294,173 (+)NCBI
Celera171,745,833 - 1,751,993 (-)NCBICelera
RH 3.4 Map1716.0RGD
Cytogenetic Map17p14NCBI
CTSL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl987,724,051 - 87,731,469 (+)EnsemblGRCh38hg38GRCh38
GRCh38987,726,119 - 87,731,469 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37990,341,034 - 90,346,384 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36989,530,794 - 89,536,204 (+)NCBINCBI36hg18NCBI36
Build 34987,570,533 - 87,575,862NCBI
Celera960,911,195 - 60,916,605 (+)NCBI
Cytogenetic Map9q21.33NCBI
HuRef960,165,416 - 60,170,826 (+)NCBIHuRef
CHM1_1990,488,740 - 90,494,151 (+)NCBICHM1_1
Ctsl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391364,509,704 - 64,518,586 (-)NCBIGRCm39mm39
GRCm39 Ensembl1364,507,151 - 64,518,704 (-)Ensembl
GRCm381364,361,890 - 64,370,772 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1364,359,337 - 64,370,890 (-)EnsemblGRCm38mm10GRCm38
MGSCv371364,464,522 - 64,471,614 (-)NCBIGRCm37mm9NCBIm37
MGSCv361364,377,945 - 64,385,037 (-)NCBImm8
Celera1366,025,830 - 66,032,878 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1333.26NCBI
CTSL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1986,903,001 - 86,908,303 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl986,903,006 - 86,908,303 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0958,851,899 - 58,857,170 (+)NCBIMhudiblu_PPA_v0panPan3
CTSL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1172,215,774 - 72,219,093 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha172,978,019 - 72,981,188 (-)NCBI
ROS_Cfam_1.0172,520,707 - 72,523,876 (-)NCBI
UMICH_Zoey_3.1172,331,483 - 72,334,652 (-)NCBI
UNSW_CanFamBas_1.0172,097,122 - 72,100,291 (-)NCBI
UU_Cfam_GSD_1.0172,802,852 - 72,806,021 (-)NCBI
Ctsl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947118,687,401 - 118,693,831 (-)NCBI
SpeTri2.0NW_0049366803,047,355 - 3,050,640 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1027,668,264 - 27,674,618 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11027,668,523 - 27,674,705 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21031,907,421 - 31,913,554 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTSL
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11298,347,770 - 98,353,426 (+)NCBI
ChlSab1.1 Ensembl1298,347,800 - 98,353,467 (+)Ensembl
Vero_WHO_p1.0NW_02366603886,669,582 - 86,675,194 (+)NCBI

Position Markers
AA923921  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.217770,607 - 770,794 (-)MAPPER
Rnor_6.0171,872,844 - 1,873,030NCBIRnor6.0
Rnor_5.0171,861,142 - 1,861,328UniSTSRnor5.0
RGSC_v3.4176,294,249 - 6,294,435UniSTSRGSC3.4
Celera171,745,572 - 1,745,758UniSTS
RH 3.4 Map175.6UniSTS
Cytogenetic Map17p14UniSTS
RH94583  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.217770,237 - 770,430 (-)MAPPER
Rnor_6.0171,873,208 - 1,873,400NCBIRnor6.0
Rnor_5.0171,861,506 - 1,861,698UniSTSRnor5.0
RGSC_v3.4176,293,879 - 6,294,071UniSTSRGSC3.4
Celera171,745,936 - 1,746,128UniSTS
RH 3.4 Map1716.0UniSTS
Cytogenetic Map17p14UniSTS
Ctsl  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0171,864,475 - 1,864,872NCBIRnor5.0
RGSC_v3.4176,290,705 - 6,291,101UniSTSRGSC3.4
Cytogenetic Map17p14UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17124787908Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17132230361Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17133303755Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138243814Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17163676140Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17173413148Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17173413148Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)1751977023422380Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1751977036283402Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:224
Count of miRNA genes:159
Interacting mature miRNAs:172
Transcripts:ENSRNOT00000025462
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 19
Medium 3 43 57 41 19 41 8 11 74 16 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025462   ⟹   ENSRNOP00000025462
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl171,872,848 - 1,879,279 (-)Ensembl
RefSeq Acc Id: NM_013156   ⟹   NP_037288
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.217764,370 - 770,533 (+)NCBI
Rnor_6.0171,873,105 - 1,879,266 (-)NCBI
Rnor_5.0171,861,403 - 1,867,564 (-)NCBI
RGSC_v3.4176,288,013 - 6,294,174 (+)RGD
Celera171,745,833 - 1,751,993 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037288   ⟸   NM_013156
- Peptide Label: preproprotein
- UniProtKB: P07154 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025462   ⟸   ENSRNOT00000025462

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700264
Promoter ID:EPDNEW_R10788
Type:multiple initiation site
Name:Ctsl_1
Description:cathepsin L
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0171,879,277 - 1,879,337EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2448 AgrOrtholog
Ensembl Genes ENSRNOG00000018566 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000025462 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025462 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6918389 IMAGE-MGC_LOAD
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Pept_asp_AS UniProtKB/Swiss-Prot
  Pept_cys_AS UniProtKB/Swiss-Prot
  Pept_his_AS UniProtKB/Swiss-Prot
  Peptidase_C1A_C UniProtKB/Swiss-Prot
  Peptidase_C1A_papain-like UniProtKB/Swiss-Prot
  Prot_inhib_I29 UniProtKB/Swiss-Prot
KEGG Report rno:25697 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72924 IMAGE-MGC_LOAD
NCBI Gene 25697 ENTREZGENE
Pfam Inhibitor_I29 UniProtKB/Swiss-Prot
  Peptidase_C1 UniProtKB/Swiss-Prot
PharmGKB CTSL1 RGD
PhenoGen Ctsl PhenoGen
PRINTS PAPAIN UniProtKB/Swiss-Prot
PROSITE THIOL_PROTEASE_ASN UniProtKB/Swiss-Prot
  THIOL_PROTEASE_CYS UniProtKB/Swiss-Prot
  THIOL_PROTEASE_HIS UniProtKB/Swiss-Prot
SMART Inhibitor_I29 UniProtKB/Swiss-Prot
  Pept_C1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot
UniProt CATL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9QV07 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-02-03 Ctsl  cathepsin L  Ctsl1  cathepsin L1  Name and Symbol changed 629549 APPROVED
2008-09-26 Ctsl1  cathepsin L1  Ctsl  cathepsin L  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ctsl  Cathepsin L      Symbol and Name status set to approved 70586 APPROVED