Sh3kbp1 (SH3 domain-containing kinase-binding protein 1) - Rat Genome Database

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Gene: Sh3kbp1 (SH3 domain-containing kinase-binding protein 1) Rattus norvegicus
Analyze
Symbol: Sh3kbp1
Name: SH3 domain-containing kinase-binding protein 1
RGD ID: 620904
Description: Enables ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including actin filament organization; positive regulation of B cell activation; and regulation of cell shape. Predicted to be located in cell-cell junction and endocytic vesicle. Human ortholog(s) of this gene implicated in immunodeficiency 61. Orthologous to human SH3KBP1 (SH3 domain containing kinase binding protein 1); PARTICIPATES IN endocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CIN85; regulator of ubiquitous kinase; ruk; Seta; SH3 domain-containing adapter protein; SH3-containing, expressed in tumorigenic astrocytes; SH3-domain kinase binding protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X38,686,530 - 39,031,658 (-)NCBIGRCr8
mRatBN7.2X34,877,862 - 35,223,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX34,877,866 - 35,222,747 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX36,015,061 - 36,359,892 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X39,478,687 - 39,823,541 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X34,644,756 - 34,989,581 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X37,790,004 - 38,196,365 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX37,790,586 - 38,196,204 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X38,094,434 - 38,505,289 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X56,075,533 - 56,422,980 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X56,129,005 - 56,476,449 (-)NCBI
CeleraX35,544,608 - 35,884,206 (-)NCBICelera
Cytogenetic MapXq14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
capsaicin  (EXP)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (EXP,ISO)
clozapine  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
gentamycin  (EXP)
glycidyl methacrylate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
isoflurane  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
methyl methanesulfonate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel dichloride  (EXP)
nicotine  (ISO)
oxidopamine  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
permethrin  (EXP)
PhIP  (EXP)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
quercetin  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. SETA: a novel SH3 domain-containing adapter molecule associated with malignancy in astrocytes. Bogler O, etal., Neuro-oncol 2000 Jan;2(1):6-15.
2. SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins. Borinstein SC, etal., Cell Signal 2000 Dec;12(11-12):769-79.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein. Gout I, etal., EMBO J 2000 Aug 1;19(15):4015-25.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Intersectin 1 forms a complex with adaptor protein Ruk/CIN85 in vivo independently of epidermal growth factor stimulation. Nikolaienko O, etal., Cell Signal. 2009 May;21(5):753-9. doi: 10.1016/j.cellsig.2009.01.013. Epub 2009 Jan 8.
9. The adaptor molecule CIN85 regulates Syk tyrosine kinase level by activating the ubiquitin-proteasome degradation pathway. Peruzzi G, etal., J Immunol. 2007 Aug 15;179(4):2089-96.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Identification and characterization of a novel Rho GTPase activating protein implicated in receptor-mediated endocytosis. Sakakibara T, etal., FEBS Lett 2004 May 21;566(1-3):294-300.
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:12135478   PMID:12771190   PMID:15522216   PMID:16177060   PMID:16751601   PMID:20221403   PMID:21830225   PMID:21834987   PMID:23793062   PMID:25468996   PMID:29636373  


Genomics

Comparative Map Data
Sh3kbp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X38,686,530 - 39,031,658 (-)NCBIGRCr8
mRatBN7.2X34,877,862 - 35,223,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX34,877,866 - 35,222,747 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX36,015,061 - 36,359,892 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X39,478,687 - 39,823,541 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X34,644,756 - 34,989,581 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X37,790,004 - 38,196,365 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX37,790,586 - 38,196,204 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X38,094,434 - 38,505,289 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X56,075,533 - 56,422,980 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X56,129,005 - 56,476,449 (-)NCBI
CeleraX35,544,608 - 35,884,206 (-)NCBICelera
Cytogenetic MapXq14NCBI
SH3KBP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X19,533,977 - 19,887,600 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX19,533,977 - 19,887,600 (-)EnsemblGRCh38hg38GRCh38
GRCh37X19,552,095 - 19,905,718 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X19,463,441 - 19,815,640 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X19,313,176 - 19,665,376NCBI
CeleraX23,675,636 - 24,008,177 (-)NCBICelera
Cytogenetic MapXp22.12NCBI
HuRefX17,300,128 - 17,651,187 (-)NCBIHuRef
CHM1_1X19,582,478 - 19,936,208 (-)NCBICHM1_1
T2T-CHM13v2.0X19,116,856 - 19,470,507 (-)NCBIT2T-CHM13v2.0
Sh3kbp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X158,409,888 - 158,758,916 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX158,410,268 - 158,761,065 (+)EnsemblGRCm39 Ensembl
GRCm38X159,626,892 - 159,975,920 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX159,627,272 - 159,978,069 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X156,065,340 - 156,413,849 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X155,052,706 - 155,318,272 (+)NCBIMGSCv36mm8
CeleraX142,872,597 - 143,219,835 (+)NCBICelera
Cytogenetic MapXF4NCBI
cM MapX73.65NCBI
Sh3kbp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555094,960 - 345,012 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555096,157 - 344,930 (-)NCBIChiLan1.0ChiLan1.0
SH3KBP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X21,332,665 - 21,689,981 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X21,336,054 - 21,693,305 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X12,154,789 - 12,511,949 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X19,517,952 - 19,822,925 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX19,517,952 - 19,822,931 (-)Ensemblpanpan1.1panPan2
SH3KBP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X15,482,593 - 15,818,113 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX15,484,680 - 15,817,967 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X15,442,674 - 15,782,235 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX15,441,780 - 15,779,762 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X15,491,286 - 15,830,650 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X15,493,198 - 15,832,564 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X15,560,580 - 15,900,196 (-)NCBIUU_Cfam_GSD_1.0
Sh3kbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X8,541,179 - 8,830,808 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366244,327,031 - 4,615,699 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366244,327,100 - 4,616,724 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SH3KBP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX15,885,069 - 16,224,183 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X15,887,131 - 16,229,212 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X17,136,481 - 17,492,932 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SH3KBP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X17,999,262 - 18,357,003 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX17,999,211 - 18,357,157 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605619,857,065 - 20,214,417 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sh3kbp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248294,329,824 - 4,714,298 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248294,329,959 - 4,714,329 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sh3kbp1
704 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1388
Count of miRNA genes:246
Interacting mature miRNAs:309
Transcripts:ENSRNOT00000006438, ENSRNOT00000006741, ENSRNOT00000058687, ENSRNOT00000058688, ENSRNOT00000074898
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat

Markers in Region
RH18201  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X34,877,938 - 34,878,128 (+)MAPPERmRatBN7.2
Rnor_6.0X37,790,659 - 37,790,848NCBIRnor6.0
Rnor_5.0X38,095,089 - 38,095,278UniSTSRnor5.0
RGSC_v3.4X56,075,610 - 56,075,799UniSTSRGSC3.4
CeleraX35,544,685 - 35,544,874UniSTS
Cytogenetic MapXq21UniSTS
AW530792  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X34,877,514 - 34,877,635 (+)MAPPERmRatBN7.2
Rnor_6.0X37,790,235 - 37,790,355NCBIRnor6.0
Rnor_5.0X38,094,665 - 38,094,785UniSTSRnor5.0
RGSC_v3.4X56,075,186 - 56,075,306UniSTSRGSC3.4
CeleraX35,544,261 - 35,544,381UniSTS
RH 3.4 MapX499.1UniSTS
Cytogenetic MapXq21UniSTS
AU048313  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X35,211,181 - 35,211,310 (+)MAPPERmRatBN7.2
Rnor_6.0X38,185,037 - 38,185,165NCBIRnor6.0
Rnor_5.0X38,494,431 - 38,494,559UniSTSRnor5.0
RGSC_v3.4X56,411,812 - 56,411,940UniSTSRGSC3.4
CeleraX35,873,465 - 35,873,593UniSTS
Cytogenetic MapXq21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 43 22 6 19 6 3 5 74 22 40 11 3
Low 1 35 35 35 5 6 13 1 5
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF131867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF230519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF230520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF255884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF255885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF255886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF255887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF255888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U90261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000006438   ⟹   ENSRNOP00000006438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX34,877,866 - 35,222,747 (-)Ensembl
Rnor_6.0 EnsemblX37,790,586 - 38,196,204 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000006741   ⟹   ENSRNOP00000006741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX34,877,866 - 35,222,747 (-)Ensembl
Rnor_6.0 EnsemblX37,791,483 - 38,196,060 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000074898   ⟹   ENSRNOP00000067100
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX34,877,866 - 35,222,747 (-)Ensembl
Rnor_6.0 EnsemblX37,791,601 - 38,026,774 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095370   ⟹   ENSRNOP00000093532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX34,877,866 - 35,222,747 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096669   ⟹   ENSRNOP00000083463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX34,877,866 - 35,020,429 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113102   ⟹   ENSRNOP00000089759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX34,877,866 - 35,146,767 (-)Ensembl
RefSeq Acc Id: NM_053360   ⟹   NP_445812
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X38,686,530 - 39,031,393 (-)NCBI
mRatBN7.2X34,877,862 - 35,222,747 (-)NCBI
Rnor_6.0X37,790,582 - 38,196,204 (-)NCBI
Rnor_5.0X38,094,434 - 38,505,289 (-)NCBI
RGSC_v3.4X56,075,533 - 56,422,980 (-)RGD
CeleraX35,544,608 - 35,884,206 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256924   ⟹   XP_006256986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X38,686,530 - 38,953,932 (-)NCBI
mRatBN7.2X34,877,862 - 35,145,267 (-)NCBI
Rnor_6.0X37,790,004 - 38,026,891 (-)NCBI
Rnor_5.0X38,094,434 - 38,505,289 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256929   ⟹   XP_006256991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X38,686,530 - 38,953,931 (-)NCBI
mRatBN7.2X34,877,862 - 35,145,264 (-)NCBI
Rnor_6.0X37,790,004 - 38,026,806 (-)NCBI
Rnor_5.0X38,094,434 - 38,505,289 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256930   ⟹   XP_006256992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X38,686,530 - 38,829,093 (-)NCBI
mRatBN7.2X34,877,862 - 35,020,424 (-)NCBI
Rnor_6.0X37,790,004 - 37,932,668 (-)NCBI
Rnor_5.0X38,094,434 - 38,505,289 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256931   ⟹   XP_006256993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X38,686,530 - 39,031,653 (-)NCBI
mRatBN7.2X34,877,862 - 35,223,008 (-)NCBI
Rnor_6.0X37,790,004 - 38,196,365 (-)NCBI
Rnor_5.0X38,094,434 - 38,505,289 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773199   ⟹   XP_008771421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X38,686,530 - 38,719,604 (-)NCBI
mRatBN7.2X34,877,862 - 34,910,937 (-)NCBI
Rnor_6.0X37,790,004 - 37,823,989 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773200   ⟹   XP_008771422
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X38,686,530 - 38,717,815 (-)NCBI
mRatBN7.2X34,877,862 - 34,909,151 (-)NCBI
Rnor_6.0X37,790,004 - 37,822,257 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039100100   ⟹   XP_038956028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X38,686,530 - 39,031,652 (-)NCBI
mRatBN7.2X34,877,862 - 35,223,007 (-)NCBI
RefSeq Acc Id: XM_039100101   ⟹   XP_038956029
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X38,686,530 - 39,031,651 (-)NCBI
mRatBN7.2X34,877,862 - 35,223,006 (-)NCBI
RefSeq Acc Id: XM_039100102   ⟹   XP_038956030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X38,686,530 - 39,031,658 (-)NCBI
mRatBN7.2X34,877,862 - 35,223,013 (-)NCBI
RefSeq Acc Id: XM_039100103   ⟹   XP_038956031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X38,686,530 - 39,031,656 (-)NCBI
mRatBN7.2X34,877,862 - 35,223,012 (-)NCBI
RefSeq Acc Id: XM_039100104   ⟹   XP_038956032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X38,686,530 - 39,031,649 (-)NCBI
mRatBN7.2X34,877,862 - 35,223,005 (-)NCBI
RefSeq Acc Id: XM_063280332   ⟹   XP_063136402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X38,686,530 - 38,953,932 (-)NCBI
RefSeq Acc Id: XM_063280333   ⟹   XP_063136403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X38,686,530 - 38,953,946 (-)NCBI
RefSeq Acc Id: XM_063280334   ⟹   XP_063136404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X38,686,530 - 38,829,077 (-)NCBI
RefSeq Acc Id: XM_063280335   ⟹   XP_063136405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X38,686,530 - 38,719,605 (-)NCBI
RefSeq Acc Id: XM_063280336   ⟹   XP_063136406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X38,686,530 - 38,717,817 (-)NCBI
Protein Sequences
Protein RefSeqs NP_445812 (Get FASTA)   NCBI Sequence Viewer  
  XP_006256986 (Get FASTA)   NCBI Sequence Viewer  
  XP_006256991 (Get FASTA)   NCBI Sequence Viewer  
  XP_006256992 (Get FASTA)   NCBI Sequence Viewer  
  XP_006256993 (Get FASTA)   NCBI Sequence Viewer  
  XP_008771421 (Get FASTA)   NCBI Sequence Viewer  
  XP_008771422 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956028 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956029 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956030 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956031 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956032 (Get FASTA)   NCBI Sequence Viewer  
  XP_063136402 (Get FASTA)   NCBI Sequence Viewer  
  XP_063136403 (Get FASTA)   NCBI Sequence Viewer  
  XP_063136404 (Get FASTA)   NCBI Sequence Viewer  
  XP_063136405 (Get FASTA)   NCBI Sequence Viewer  
  XP_063136406 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF36522 (Get FASTA)   NCBI Sequence Viewer  
  AAF43035 (Get FASTA)   NCBI Sequence Viewer  
  AAF43036 (Get FASTA)   NCBI Sequence Viewer  
  AAH70877 (Get FASTA)   NCBI Sequence Viewer  
  AAK51625 (Get FASTA)   NCBI Sequence Viewer  
  AAK51626 (Get FASTA)   NCBI Sequence Viewer  
  AAK51627 (Get FASTA)   NCBI Sequence Viewer  
  AAK51628 (Get FASTA)   NCBI Sequence Viewer  
  AAK51629 (Get FASTA)   NCBI Sequence Viewer  
  EDL96135 (Get FASTA)   NCBI Sequence Viewer  
  EDL96136 (Get FASTA)   NCBI Sequence Viewer  
  EDL96137 (Get FASTA)   NCBI Sequence Viewer  
  EDL96138 (Get FASTA)   NCBI Sequence Viewer  
  EDL96139 (Get FASTA)   NCBI Sequence Viewer  
  EDL96140 (Get FASTA)   NCBI Sequence Viewer  
  EDL96141 (Get FASTA)   NCBI Sequence Viewer  
  EDL96142 (Get FASTA)   NCBI Sequence Viewer  
  EDL96143 (Get FASTA)   NCBI Sequence Viewer  
  EDL96144 (Get FASTA)   NCBI Sequence Viewer  
  EDL96145 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006438
  ENSRNOP00000006438.5
  ENSRNOP00000006741
  ENSRNOP00000006741.7
  ENSRNOP00000067100
  ENSRNOP00000067100.3
  ENSRNOP00000083463
  ENSRNOP00000083463.1
  ENSRNOP00000089759
  ENSRNOP00000089759.1
  ENSRNOP00000093532
  ENSRNOP00000093532.1
  ENSRNOP00055038745
  ENSRNOP00060026670
  ENSRNOP00065016896
GenBank Protein Q925Q9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445812   ⟸   NM_053360
- UniProtKB: Q6IRL5 (UniProtKB/TrEMBL),   A6IPM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256993   ⟸   XM_006256931
- Peptide Label: isoform X1
- UniProtKB: Q9JKQ1 (UniProtKB/Swiss-Prot),   Q9JKQ0 (UniProtKB/Swiss-Prot),   Q925R3 (UniProtKB/Swiss-Prot),   Q925R2 (UniProtKB/Swiss-Prot),   Q925R1 (UniProtKB/Swiss-Prot),   Q925R0 (UniProtKB/Swiss-Prot),   Q9JLU9 (UniProtKB/Swiss-Prot),   Q925Q9 (UniProtKB/Swiss-Prot),   A6IPL9 (UniProtKB/TrEMBL),   A6IPM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256991   ⟸   XM_006256929
- Peptide Label: isoform X8
- UniProtKB: A0A8I6A8U3 (UniProtKB/TrEMBL),   A6IPM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256986   ⟸   XM_006256924
- Peptide Label: isoform X4
- UniProtKB: A6IPM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256992   ⟸   XM_006256930
- Peptide Label: isoform X11
- UniProtKB: A6IPM3 (UniProtKB/TrEMBL),   A6IPM4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771421   ⟸   XM_008773199
- Peptide Label: isoform X13
- Sequence:
RefSeq Acc Id: XP_008771422   ⟸   XM_008773200
- Peptide Label: isoform X15
- UniProtKB: A6IPM6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006438   ⟸   ENSRNOT00000006438
RefSeq Acc Id: ENSRNOP00000006741   ⟸   ENSRNOT00000006741
RefSeq Acc Id: ENSRNOP00000067100   ⟸   ENSRNOT00000074898
RefSeq Acc Id: XP_038956030   ⟸   XM_039100102
- Peptide Label: isoform X5
- UniProtKB: A6IPM1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956031   ⟸   XM_039100103
- Peptide Label: isoform X7
- UniProtKB: A6IPM1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956028   ⟸   XM_039100100
- Peptide Label: isoform X2
- UniProtKB: M0RBZ7 (UniProtKB/TrEMBL),   A6IPM1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956029   ⟸   XM_039100101
- Peptide Label: isoform X3
- UniProtKB: A0A0H2UHD8 (UniProtKB/TrEMBL),   A6IPM0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956032   ⟸   XM_039100104
- Peptide Label: isoform X9
- UniProtKB: A0A8I6AJT1 (UniProtKB/TrEMBL),   A6IPM0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000083463   ⟸   ENSRNOT00000096669
RefSeq Acc Id: ENSRNOP00000089759   ⟸   ENSRNOT00000113102
RefSeq Acc Id: ENSRNOP00000093532   ⟸   ENSRNOT00000095370
RefSeq Acc Id: XP_063136403   ⟸   XM_063280333
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063136402   ⟸   XM_063280332
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063136404   ⟸   XM_063280334
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063136405   ⟸   XM_063280335
- Peptide Label: isoform X14
RefSeq Acc Id: XP_063136406   ⟸   XM_063280336
- Peptide Label: isoform X15
Protein Domains
SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q925Q9-F1-model_v2 AlphaFold Q925Q9 1-709 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620904 AgrOrtholog
BioCyc Gene G2FUF-2489 BioCyc
Ensembl Genes ENSRNOG00000004322 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055026871 UniProtKB/Swiss-Prot
  ENSRNOG00060018228 UniProtKB/Swiss-Prot
  ENSRNOG00065013202 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006438.7 UniProtKB/TrEMBL
  ENSRNOT00000006741 UniProtKB/TrEMBL
  ENSRNOT00000006741.8 UniProtKB/Swiss-Prot
  ENSRNOT00000074898.3 UniProtKB/TrEMBL
  ENSRNOT00000095370.1 UniProtKB/TrEMBL
  ENSRNOT00000096669.1 UniProtKB/Swiss-Prot
  ENSRNOT00000113102.1 UniProtKB/TrEMBL
  ENSRNOT00055047129 UniProtKB/Swiss-Prot
  ENSRNOT00060032668 UniProtKB/Swiss-Prot
  ENSRNOT00065021818 UniProtKB/Swiss-Prot
Gene3D-CATH SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7096160 IMAGE-MGC_LOAD
InterPro CIN85_SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CIN85_SH3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CIN85_SH3_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91419 IMAGE-MGC_LOAD
NCBI Gene 84357 ENTREZGENE
PANTHER LD44138P UniProtKB/TrEMBL
  PTHR14167:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 DOMAIN-CONTAINING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH3_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sh3kbp1 PhenoGen
PRINTS P67PHOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPECTRNALPHA UniProtKB/TrEMBL
PROSITE SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004322 RatGTEx
  ENSRNOG00055026871 RatGTEx
  ENSRNOG00060018228 RatGTEx
  ENSRNOG00065013202 RatGTEx
SMART SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHD8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A8U3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJT1 ENTREZGENE, UniProtKB/TrEMBL
  A6IPL9 ENTREZGENE, UniProtKB/TrEMBL
  A6IPM0 ENTREZGENE, UniProtKB/TrEMBL
  A6IPM1 ENTREZGENE, UniProtKB/TrEMBL
  A6IPM2 ENTREZGENE, UniProtKB/TrEMBL
  A6IPM3 ENTREZGENE, UniProtKB/TrEMBL
  A6IPM4 ENTREZGENE, UniProtKB/TrEMBL
  A6IPM6 ENTREZGENE, UniProtKB/TrEMBL
  A6IPM8_RAT UniProtKB/TrEMBL
  M0RBZ7 ENTREZGENE, UniProtKB/TrEMBL
  Q6IRL5 ENTREZGENE, UniProtKB/TrEMBL
  Q925Q9 ENTREZGENE
  Q925R0 ENTREZGENE
  Q925R1 ENTREZGENE
  Q925R2 ENTREZGENE
  Q925R3 ENTREZGENE
  Q9JKQ0 ENTREZGENE
  Q9JKQ1 ENTREZGENE
  Q9JLU9 ENTREZGENE
  SH3K1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q925R0 UniProtKB/Swiss-Prot
  Q925R1 UniProtKB/Swiss-Prot
  Q925R2 UniProtKB/Swiss-Prot
  Q925R3 UniProtKB/Swiss-Prot
  Q9JKQ0 UniProtKB/Swiss-Prot
  Q9JKQ1 UniProtKB/Swiss-Prot
  Q9JLU9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Sh3kbp1  SH3 domain-containing kinase-binding protein 1  Sh3kbp1  SH3-domain kinase binding protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Sh3kbp1  SH3-domain kinase binding protein 1      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Sh3kbp1  SH3-domain kinase binding protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in tumorigenic astrocytes 729728