RGD Reference Report - SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins. - Rat Genome Database

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SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins.

Authors: Borinstein, SC  Hyatt, MA  Sykes, VW  Straub, RE  Lipkowitz, S  Boulter, J  Bogler, O 
Citation: Borinstein SC, etal., Cell Signal 2000 Dec;12(11-12):769-79.
RGD ID: 729812
Pubmed: PMID:11152963   (View Abstract at PubMed)

Expression of the src homology 3 (SH3)-encoding, expressed in tumorigenic astrocytes (SETA) gene is associated with astrocyte transformation in culture and tumors in the adult brain. SETA binds to the apoptosis regulator apoptosis-linked gene 2 (ALG-2) interacting protein 1 (AIP1), and modulates apoptosis in astrocytes. The predicted protein structure of SETA revealed two SH3 domains, while related proteins were reported to have three. Here we report the identification of an additional SH3 domain N-terminal to the previously identified SETA sequence. Yeast two-hybrid screening of a p53(-/-) astrocyte cDNA library with this SH3 domain identified a novel gene, SETA binding protein 1 (SB1), with 55% amino acid identity to the renal tumor antigen, NY-REN-45. In vitro confrontation and co-immunoprecipitation experiments confirmed the binding of SB1 to SETA. Evidence that SETA binds to the CD2 protein, the proto-oncogene c-Cbl, and the signal transduction molecule Grb2, and can dimerize via its C-terminal coiled coil (CC) domain is also presented.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
regulation of apoptotic process  TAS 729812 RGD 

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Cbl  (Cbl proto-oncogene)
Sh3kbp1  (SH3 domain-containing kinase-binding protein 1)

Objects referenced in this article
Gene SHKBP1 SH3KBP1 binding protein 1 Homo sapiens
Gene Cbl Casitas B-lineage lymphoma Mus musculus
Gene Grb2 growth factor receptor bound protein 2 Mus musculus
Gene Sh3kbp1 SH3-domain kinase binding protein 1 Mus musculus
Gene Shkbp1 Sh3kbp1 binding protein 1 Mus musculus

Additional Information