Gluco34 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Gluco34 (Glucose level QTL 34) Rattus norvegicus

Symbol: Gluco34
Name: Glucose level QTL 34
RGD ID: 2290375
Trait: blood glucose amount   (VT:0000188)    
Measurement Type: blood glucose level area under curve (AUC)   (CMO:0000350)    
LOD Score: 2.75
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X24,470,360 - 45,082,063RGD_MAPPER_PIPELINE
mRatBN7.2X20,990,947 - 41,203,591RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0X21,592,623 - 44,468,300RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0X21,859,080 - 44,765,347RGDRnor5.0
RGSC_v3.4X41,386,788 - 62,894,306RGDRGSC3.4
RGSC_v3.1X41,440,348 - 62,947,775RGD
Cross Type: intercross
Strains Crossed: CDR/Ygl CDS/Ygl 
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gluco34RatExperimental Diabetes Mellitus  IAGP 1626640on diabetogenic dietRGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gluco34Ratincreased circulating glucose level  IDA 1626640 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gluco34Ratblood glucose level area under curve (AUC)  IDA 1626640 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gluco34Ratcontrolled copper content diet  IDA 1626640 RGD 
Gluco34Ratcontrolled sucrose content diet  IDA 1626640 RGD 
Gluco34Ratfasting  IDA 1626640 RGD 
Gluco34Ratglucose solution  IDA 1626640 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gluco34Ratoral glucose tolerance test  IDA 1626640 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gluco34RatCDR/Ygl  IEA 1626640 RGD 
Gluco34RatCDS/Ygl  IEA 1626640 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gluco34Ratblood glucose amount  IDA 1626640 RGD 


#
Reference Title
Reference Citation
1. GENDER-SPECIFIC GENETIC DISSECTION OF DIABETES IN A RODENT MODEL IDENTIFIES ICA1 AND NDUFA4 AS MAJOR CANDIDATE GENES. Barkalifa R, etal., Physiol Genomics. 2010 Jun 8.
2. Metabolic and genomic dissection of diabetes in the Cohen rat. Yagil C, etal., Physiol Genomics. 2007 Apr 24;29(2):181-92. Epub 2007 Jan 9.


1 to 20 of 216 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1561763Huwe1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1X2087379521001378Rat
69231Hsd17b10hydroxysteroid (17-beta) dehydrogenase 10X2108914221091603Rat
1359621Ribc1RIB43A domain with coiled-coils 1X2109171721103688Rat
61991Smc1astructural maintenance of chromosomes 1AX2110332321148053Rat
1596452Iqsec2IQ motif and Sec7 domain ArfGEF 2X2125479921337179Rat
1560601Kdm5clysine demethylase 5CX2134545921387045Rat
10045415KantrKANTR integral membrane proteinX2140271721430663Rat
1563283Tspyl2TSPY-like 2X2143947821445208Rat
620748Gpr173G-protein coupled receptor 173X2144626121471119Rat
41187622LOC120099523U2 spliceosomal RNAX2153152621531690Rat
1594343Cldn34aclaudin 34AX2171710121737363Rat
1591324Rab7a-ps1RAB7A, member RAS oncogene family, pseudogene 1X2173840421739267Rat
1591314Samt2l3spermatogenesis associated multipass transmembrane protein 2 like 3X2179846021803412Rat
1565163Shroom2shroom family member 2X2181246921983724Rat
1565799Gpr143G protein-coupled receptor 143X2200291422027720Rat
1590221Samt2l2spermatogenesis associated multipass transmembrane protein 2 like 2X2237669022379601Rat
2318768LOC100362115rCG64250-likeX2239827922416392Rat
1590206Samt2l1spermatogenesis associated multipass transmembrane protein 2 like 1X2243426822437212Rat
2318689LOC100362195hypothetical LOC100362195X2245746622459565Rat
2323576LOC100363019hypothetical LOC100363019X2248170322484017Rat

1 to 20 of 216 rows
1 to 20 of 220 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10272DXWox7211X3170655531706768Ratregion
10692DXWox17203X3103514431035347Ratregion
11167DXWox6144X2697607526976219Ratregion
34148DXMgh8122X2508866425088786Ratregion
34405DXMgh2143X3779773137797874Ratregion
34451DXMgh4117X2180716121807280Ratregion
34559DXMgh12199X3170655331706766Ratregion
33575DXMit5211X4120338041203591Ratregion
36035DXRat13176X3722913437229310Ratregion
36111DXRat8161X2099094720991088Ratregion
36153DXRat10144X3415364634153790Ratregion
36301DXRat9139X2542783025427967Ratregion
35331DXRat25117X3266514332665260Ratregion
36952DXRat11124X4105240741052531Ratregion
36771DXRat12164X3947830739478471Ratregion
39720DXRat86218X3335963333359851Ratregion
39898DXRat111229X3527715835277387Ratregion
39948DXRat110239X3240916332409404Ratregion
39948DXRat110239X3240916332409719Ratregion
38378DXRat36249X2118635021186599Ratregion
1 to 20 of 220 rows

Flank 1: (DXRat8)
Rat AssemblyChrPosition (strand)Source
GRCr8X24,470,360 - 24,470,521 (+)Marker Load Pipeline
mRatBN7.2X20,990,947 - 20,991,088 (+)MAPPER
Rnor_6.0X21,592,623 - 21,592,783NCBI
Rnor_5.0X21,859,080 - 21,859,240UniSTS
RGSC_v3.4X41,386,788 - 41,387,080RGD
RGSC_v3.4X41,386,879 - 41,387,039UniSTS
RGSC_v3.1X41,440,348 - 41,440,508RGD
CeleraX21,272,130 - 21,272,290UniSTS
RH 3.4 MapX186.31UniSTS
RH 3.4 MapX186.31RGD
RH 2.0 Map21223.4RGD
SHRSP x BN MapX6.8999RGD
FHH x ACI MapX7.93RGD
Cytogenetic MapXq21UniSTS
Peak: (DXMit5)
Rat AssemblyChrPosition (strand)Source
GRCr8X45,081,852 - 45,082,063 (+)Marker Load Pipeline
mRatBN7.2X41,203,380 - 41,203,591 (+)MAPPER
Rnor_6.0X44,468,090 - 44,468,300NCBI
Rnor_5.0X44,765,137 - 44,765,347UniSTS
RGSC_v3.4X62,894,095 - 62,894,306RGD
RGSC_v3.4X62,894,096 - 62,894,306UniSTS
RGSC_v3.1X62,947,565 - 62,947,775RGD
CeleraX41,864,292 - 41,864,502UniSTS
RH 3.4 MapX580.3UniSTS
RH 3.4 MapX580.3RGD
SHRSP x BN MapX14.89UniSTS
SHRSP x BN MapX14.89RGD
FHH x ACI MapX16.69RGD
Cytogenetic MapXq22UniSTS
Flank 2: (DXMit5)
Rat AssemblyChrPosition (strand)Source
GRCr8X45,081,852 - 45,082,063 (+)Marker Load Pipeline
mRatBN7.2X41,203,380 - 41,203,591 (+)MAPPER
Rnor_6.0X44,468,090 - 44,468,300NCBI
Rnor_5.0X44,765,137 - 44,765,347UniSTS
RGSC_v3.4X62,894,095 - 62,894,306RGD
RGSC_v3.4X62,894,096 - 62,894,306UniSTS
RGSC_v3.1X62,947,565 - 62,947,775RGD
CeleraX41,864,292 - 41,864,502UniSTS
RH 3.4 MapX580.3UniSTS
RH 3.4 MapX580.3RGD
SHRSP x BN MapX14.89UniSTS
SHRSP x BN MapX14.89RGD
FHH x ACI MapX16.69RGD
Cytogenetic MapXq22UniSTS


1 to 10 of 12 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat

1 to 10 of 12 rows


Note Type Note Reference
qtl_cross_type intercross  
qtl_general the S allele from CDS was responsible for low glucose level whereas the R allele was responsible for high glucose level 1626640
qtl_general software package used: one-way ANOVA and MultiQTL version 2.5 1626640
qtl_general measurement method: rats were fasted overnight and then OGTT was performed 1626640
qtl_general significant cosegregation for blood glucose level was observed but the pattern was opposite to that of Gluco32 and Gluco33 1626640
qtl_general number of animals used: 101 F2 males 1626640
qtl_map this region incorporates 74 known and 24 predicted genes and spans 20 cM 1626640