Amelx (amelogenin, X-linked) - Rat Genome Database

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Gene: Amelx (amelogenin, X-linked) Rattus norvegicus
Analyze
Symbol: Amelx
Name: amelogenin, X-linked
RGD ID: 2107
Description: Enables identical protein binding activity. A structural constituent of tooth enamel. Involved in response to calcium ion; response to nutrient; and response to xenobiotic stimulus. Located in endocytic vesicle. Biomarker of autosomal dominant hypocalcemia. Human ortholog(s) of this gene implicated in amelogenesis imperfecta and amelogenesis imperfecta type 1E. Orthologous to human AMELX (amelogenin X-linked) and AMELY (amelogenin Y-linked); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Amel; amelogenin; amelogenin X chromosome; amelogenin, X isoform; leucine-rich amelogenin peptide; LRAP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X28,648,803 - 28,660,099 (+)NCBIGRCr8
mRatBN7.2X25,076,362 - 25,087,660 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX25,076,362 - 25,087,660 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX26,080,937 - 26,092,217 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X29,502,009 - 29,513,289 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X25,735,122 - 25,746,420 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X26,439,197 - 26,450,495 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX26,439,197 - 26,450,495 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X26,843,989 - 26,855,287 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X45,763,451 - 45,769,374 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X45,816,919 - 45,822,842 (+)NCBI
CeleraX25,496,279 - 25,507,557 (+)NCBICelera
Cytogenetic MapXq13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and DNA sequence of rat amelogenin and a comparative analysis of mammalian amelogenin protein sequence divergence. Bonass WA, etal., Biochem Biophys Res Commun 1994 Jan 28;198(2):755-63.
2. Intracellular nanosphere subunit assembly as revealed by amelogenin molecular cross-linking studies. Brookes SJ, etal., Eur J Oral Sci. 2006 May;114 Suppl 1:280-4; discussion 285-6, 382.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Amelogenin-deficient mice display an amelogenesis imperfecta phenotype. Gibson CW, etal., J Biol Chem 2001 Aug 24;276(34):31871-5. Epub 2001 Jun 13.
5. Molecular basis and consequences of a deletion in the amelogenin gene, analyzed by capture PCR. Lagerstrom-Fermer M, etal., Genomics 1993 Jul;17(1):89-92.
6. Alternative splicing of amelogenin mRNA from rat incisor ameloblasts. Li R, etal., J Dent Res 1995 Dec;74(12):1880-5.
7. Immunocytochemical study of amelogenin deposition during the early odontogenesis of molars in alendronate-treated newborn rats. Massa LF, etal., J Histochem Cytochem. 2006 Jun;54(6):713-25. Epub 2006 Feb 6.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Internalization of amelogenin by dendritic cells of the papillary layer during transition and early maturation stages. Nishikawa S and Sasaki F, Histochem Cell Biol. 1999 Oct;112(4):301-5.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Expression of amelogenin in odontoblasts. Papagerakis P, etal., Bone. 2003 Mar;32(3):228-40.
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Changes in amelogenesis in the rat incisor following short-term hypocalcaemia. Yamaguti PM, etal., Arch Oral Biol. 2005 Feb;50(2):185-8.
Additional References at PubMed
PMID:1483698   PMID:1734713   PMID:1916828   PMID:2509010   PMID:7948026   PMID:9041053   PMID:11852235   PMID:16293627   PMID:16674683   PMID:16674693   PMID:18281204   PMID:18757743  
PMID:19086270   PMID:20044581   PMID:20304108   PMID:20387077   PMID:20404336   PMID:21653221   PMID:23896516  


Genomics

Comparative Map Data
Amelx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X28,648,803 - 28,660,099 (+)NCBIGRCr8
mRatBN7.2X25,076,362 - 25,087,660 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX25,076,362 - 25,087,660 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX26,080,937 - 26,092,217 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X29,502,009 - 29,513,289 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X25,735,122 - 25,746,420 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X26,439,197 - 26,450,495 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX26,439,197 - 26,450,495 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X26,843,989 - 26,855,287 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X45,763,451 - 45,769,374 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X45,816,919 - 45,822,842 (+)NCBI
CeleraX25,496,279 - 25,507,557 (+)NCBICelera
Cytogenetic MapXq13NCBI
AMELX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X11,293,413 - 11,309,588 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX11,293,413 - 11,300,761 (+)EnsemblGRCh38hg38GRCh38
GRCh37X11,311,533 - 11,318,881 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X11,221,454 - 11,228,802 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX15,438,990 - 15,446,338 (+)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX9,091,155 - 9,098,355 (+)NCBIHuRef
CHM1_1X11,342,001 - 11,349,349 (+)NCBICHM1_1
T2T-CHM13v2.0X10,875,912 - 10,892,087 (+)NCBIT2T-CHM13v2.0
Amelx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X167,959,110 - 167,970,205 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX167,959,110 - 167,970,196 (-)EnsemblGRCm39 Ensembl
GRCm38X169,176,114 - 169,187,209 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX169,176,114 - 169,187,200 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X165,614,046 - 165,625,141 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X164,524,127 - 164,531,314 (-)NCBIMGSCv36mm8
CeleraX152,339,918 - 152,351,218 (-)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX78.95NCBI
Amelx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555441,969,216 - 1,979,063 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555441,974,889 - 1,979,063 (-)NCBIChiLan1.0ChiLan1.0
AMELY
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2Y43,791,359 - 44,000,131 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1Y2,926,868 - 3,135,641 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X3,898,819 - 3,930,686 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X11,214,103 - 11,221,443 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX11,214,103 - 11,221,443 (+)Ensemblpanpan1.1panPan2
AMELX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X7,822,513 - 7,828,692 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX7,822,859 - 7,830,351 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX7,779,650 - 7,787,144 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X7,776,327 - 7,783,824 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX7,776,321 - 7,783,816 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X7,759,322 - 7,766,816 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X7,795,375 - 7,802,872 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X7,790,231 - 7,797,728 (+)NCBIUU_Cfam_GSD_1.0
Amelx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X1,168,483 - 1,174,166 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364701,169,906 - 1,179,604 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364701,169,906 - 1,174,166 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMELX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX8,055,782 - 8,063,449 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X8,055,246 - 8,063,457 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X8,669,948 - 8,677,620 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AMELX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X9,927,740 - 9,934,104 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX9,741,594 - 9,745,776 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
ChlSab1.1 EnsemblX9,741,594 - 9,745,776 (+)NCBIChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605611,535,786 - 11,539,980 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Amelx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248823,072,313 - 3,082,505 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248823,072,970 - 3,083,832 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Amelx
28 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:89
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000005328, ENSRNOT00000052176
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 10 8 10 8 8 9 6 8 6 10 8
Below cutoff 1 8 16 2 8 2 1 21 2 3 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001271073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU168858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U01245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U07054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U51195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U60562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U60563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U60564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U67130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000005328   ⟹   ENSRNOP00000005328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX25,077,763 - 25,081,877 (+)Ensembl
Rnor_6.0 EnsemblX26,440,598 - 26,445,191 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000052176   ⟹   ENSRNOP00000048382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX25,076,362 - 25,087,660 (+)Ensembl
Rnor_6.0 EnsemblX26,439,197 - 26,450,495 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078843   ⟹   ENSRNOP00000069787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX25,076,362 - 25,083,664 (+)Ensembl
Rnor_6.0 EnsemblX26,439,197 - 26,446,499 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087268   ⟹   ENSRNOP00000068556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX25,076,362 - 25,087,660 (+)Ensembl
Rnor_6.0 EnsemblX26,439,197 - 26,450,495 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087293   ⟹   ENSRNOP00000075671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX26,440,584 - 26,446,499 (+)Ensembl
RefSeq Acc Id: NM_001271073   ⟹   NP_001258002
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X28,648,803 - 28,660,099 (+)NCBI
mRatBN7.2X25,076,362 - 25,087,660 (+)NCBI
Rnor_6.0X26,439,197 - 26,450,495 (+)NCBI
Rnor_5.0X26,843,989 - 26,855,287 (+)NCBI
CeleraX25,496,279 - 25,507,557 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271074   ⟹   NP_001258003
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X28,648,803 - 28,660,099 (+)NCBI
mRatBN7.2X25,076,362 - 25,087,660 (+)NCBI
Rnor_6.0X26,439,197 - 26,450,495 (+)NCBI
Rnor_5.0X26,843,989 - 26,855,287 (+)NCBI
CeleraX25,496,279 - 25,507,557 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271075   ⟹   NP_001258004
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X28,648,803 - 28,660,099 (+)NCBI
mRatBN7.2X25,076,362 - 25,087,660 (+)NCBI
Rnor_6.0X26,439,197 - 26,450,495 (+)NCBI
Rnor_5.0X26,843,989 - 26,855,287 (+)NCBI
CeleraX25,496,279 - 25,507,557 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271076   ⟹   NP_001258005
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X28,648,803 - 28,660,099 (+)NCBI
mRatBN7.2X25,076,362 - 25,087,660 (+)NCBI
Rnor_6.0X26,439,197 - 26,450,495 (+)NCBI
Rnor_5.0X26,843,989 - 26,855,287 (+)NCBI
CeleraX25,496,279 - 25,507,557 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271077   ⟹   NP_001258006
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X28,648,803 - 28,656,111 (+)NCBI
mRatBN7.2X25,076,362 - 25,083,672 (+)NCBI
Rnor_6.0X26,439,197 - 26,446,507 (+)NCBI
Rnor_5.0X26,843,989 - 26,855,287 (+)NCBI
CeleraX25,496,279 - 25,503,569 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271078   ⟹   NP_001258007
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X28,648,803 - 28,656,111 (+)NCBI
mRatBN7.2X25,076,362 - 25,083,672 (+)NCBI
Rnor_6.0X26,439,197 - 26,446,507 (+)NCBI
Rnor_5.0X26,843,989 - 26,855,287 (+)NCBI
CeleraX25,496,279 - 25,503,569 (+)NCBI
Sequence:
RefSeq Acc Id: NM_019154   ⟹   NP_062027
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X28,648,803 - 28,656,111 (+)NCBI
mRatBN7.2X25,076,362 - 25,083,672 (+)NCBI
Rnor_6.0X26,440,584 - 26,446,507 (+)NCBI
Rnor_5.0X26,843,989 - 26,855,287 (+)NCBI
RGSC_v3.4X45,763,451 - 45,769,374 (+)RGD
CeleraX25,497,666 - 25,503,569 (+)NCBI
Sequence:
RefSeq Acc Id: NP_062027   ⟸   NM_019154
- Peptide Label: isoform 5 precursor
- UniProtKB: Q63640 (UniProtKB/Swiss-Prot),   Q62945 (UniProtKB/Swiss-Prot),   Q78E56 (UniProtKB/Swiss-Prot),   P63278 (UniProtKB/Swiss-Prot),   A6K2F1 (UniProtKB/TrEMBL),   A0A8L2UHN6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258003   ⟸   NM_001271074
- Peptide Label: isoform 1 precursor
- UniProtKB: A6K2E8 (UniProtKB/TrEMBL),   A0A8L2UHN6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258002   ⟸   NM_001271073
- Peptide Label: isoform 2 precursor
- UniProtKB: A6K2E9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258004   ⟸   NM_001271075
- Peptide Label: isoform 3 precursor
- UniProtKB: Q63642 (UniProtKB/TrEMBL),   A6K2F0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258005   ⟸   NM_001271076
- Peptide Label: isoform 4 precursor
- UniProtKB: A0A0G2JT37 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258006   ⟸   NM_001271077
- Peptide Label: isoform 6 precursor
- UniProtKB: A6K2F2 (UniProtKB/TrEMBL),   A0A8L2UHN6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258007   ⟸   NM_001271078
- Peptide Label: isoform 7 precursor
- UniProtKB: A6K2F3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075671   ⟸   ENSRNOT00000087293
RefSeq Acc Id: ENSRNOP00000068556   ⟸   ENSRNOT00000087268
RefSeq Acc Id: ENSRNOP00000005328   ⟸   ENSRNOT00000005328
RefSeq Acc Id: ENSRNOP00000069787   ⟸   ENSRNOT00000078843
RefSeq Acc Id: ENSRNOP00000048382   ⟸   ENSRNOT00000052176

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63278-F1-model_v2 AlphaFold P63278 1-210 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2107 AgrOrtholog
BioCyc Gene G2FUF-2677 BioCyc
Ensembl Genes ENSRNOG00000003965 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055022760 UniProtKB/Swiss-Prot
  ENSRNOG00060020934 UniProtKB/Swiss-Prot
  ENSRNOG00065023602 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005328.7 UniProtKB/TrEMBL
  ENSRNOT00000052176 ENTREZGENE
  ENSRNOT00000052176.5 UniProtKB/Swiss-Prot
  ENSRNOT00000078843 ENTREZGENE
  ENSRNOT00000078843.2 UniProtKB/Swiss-Prot
  ENSRNOT00000087268 ENTREZGENE
  ENSRNOT00000087268.2 UniProtKB/TrEMBL
  ENSRNOT00055039093 UniProtKB/Swiss-Prot
  ENSRNOT00060036301 UniProtKB/Swiss-Prot
  ENSRNOT00065040413 UniProtKB/Swiss-Prot
InterPro Amelogenin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29160 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29160 ENTREZGENE
PANTHER AMELOGENIN, Y ISOFORM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46794 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Amelogenin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Amelx PhenoGen
PRINTS AMELOGENIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003965 RatGTEx
  ENSRNOG00055022760 RatGTEx
  ENSRNOG00060020934 RatGTEx
  ENSRNOG00065023602 RatGTEx
SMART Amelogenin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JT37 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UHN6 ENTREZGENE, UniProtKB/TrEMBL
  A6K2E8 ENTREZGENE, UniProtKB/TrEMBL
  A6K2E9 ENTREZGENE, UniProtKB/TrEMBL
  A6K2F0 ENTREZGENE, UniProtKB/TrEMBL
  A6K2F1 ENTREZGENE, UniProtKB/TrEMBL
  A6K2F2 ENTREZGENE, UniProtKB/TrEMBL
  A6K2F3 ENTREZGENE, UniProtKB/TrEMBL
  AMELX_RAT UniProtKB/Swiss-Prot
  B2BY38_RAT UniProtKB/TrEMBL
  P63278 ENTREZGENE
  Q62945 ENTREZGENE
  Q63640 ENTREZGENE
  Q63641_RAT UniProtKB/TrEMBL
  Q63642 ENTREZGENE, UniProtKB/TrEMBL
  Q78E56 ENTREZGENE
UniProt Secondary P45559 UniProtKB/Swiss-Prot
  Q62945 UniProtKB/Swiss-Prot
  Q63640 UniProtKB/Swiss-Prot
  Q78E56 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-01-06 Amelx  amelogenin, X-linked  Amelx  amelogenin X chromosome  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-03-01 Amelx  amelogenin X chromosome  Amel  amelogenin  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-06-10 Amel  amelogenin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function structural component of the enamel matrix 632201
gene_process may play a role in mineralization 632201