Nhs (NHS actin remodeling regulator) - Rat Genome Database

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Gene: Nhs (NHS actin remodeling regulator) Rattus norvegicus
Analyze
Symbol: Nhs
Name: NHS actin remodeling regulator
RGD ID: 1561818
Description: Predicted to be involved in cell differentiation and lens development in camera-type eye. Predicted to localize to Golgi apparatus; cell junction; and nuclear body. Human ortholog(s) of this gene implicated in Nance-Horan syndrome and cataract 40. Orthologous to human NHS (NHS actin remodeling regulator); INTERACTS WITH bisphenol A; paracetamol; 17beta-estradiol (ortholog).
Type: protein-coding
RefSeq Status: INFERRED
Also known as: LOC317494; Nance-Horan syndrome (congenital cataracts and dental anomalies); Nance-Horan syndrome (human); Nance-Horan syndrome protein; RGD1561818; similar to Nance-Horan syndrome protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X32,551,974 - 32,892,961 (+)NCBI
Rnor_6.0 EnsemblX34,623,405 - 34,673,742 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X34,312,102 - 34,675,912 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X34,656,286 - 35,018,650 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X53,321,827 - 53,720,326 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX32,845,030 - 33,180,545 (+)NCBICelera
Cytogenetic MapXq14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8282045  


Genomics

Comparative Map Data
Nhs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X32,551,974 - 32,892,961 (+)NCBI
Rnor_6.0 EnsemblX34,623,405 - 34,673,742 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X34,312,102 - 34,675,912 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X34,656,286 - 35,018,650 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X53,321,827 - 53,720,326 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX32,845,030 - 33,180,545 (+)NCBICelera
Cytogenetic MapXq14NCBI
NHS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX17,375,200 - 17,735,994 (+)EnsemblGRCh38hg38GRCh38
GRCh38X17,375,200 - 17,735,994 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X17,393,323 - 17,754,114 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X17,303,464 - 17,664,035 (+)NCBINCBI36hg18NCBI36
Build 34X17,153,199 - 17,513,768NCBI
CeleraX21,515,624 - 21,873,432 (+)NCBI
Cytogenetic MapXp22.2-p22.13NCBI
HuRefX15,153,213 - 15,512,673 (+)NCBIHuRef
CHM1_1X17,424,184 - 17,784,494 (+)NCBICHM1_1
Nhs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X160,616,286 - 160,942,437 (-)NCBIGRCm39mm39
GRCm39 EnsemblX160,616,292 - 160,942,726 (-)Ensembl
GRCm38X161,833,290 - 162,159,441 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX161,833,296 - 162,159,730 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X158,274,200 - 158,597,722 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X157,180,373 - 157,503,895 (-)NCBImm8
CeleraX145,069,096 - 145,393,381 (-)NCBICelera
Cytogenetic MapXF4NCBI
cM MapX74.17NCBI
Nhs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955519599,682 - 918,762 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955519596,216 - 919,352 (-)NCBIChiLan1.0ChiLan1.0
NHS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X17,357,898 - 17,728,178 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX17,358,416 - 17,728,178 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X9,988,584 - 10,359,110 (+)NCBIMhudiblu_PPA_v0panPan3
NHS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X13,487,919 - 13,834,869 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX13,488,515 - 13,831,386 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX13,339,834 - 13,686,761 (+)NCBI
ROS_Cfam_1.0X13,451,227 - 13,798,368 (+)NCBI
UMICH_Zoey_3.1X13,518,311 - 13,864,906 (+)NCBI
UNSW_CanFamBas_1.0X13,504,402 - 13,851,231 (+)NCBI
UU_Cfam_GSD_1.0X13,573,553 - 13,920,854 (+)NCBI
Nhs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X6,887,249 - 6,971,110 (+)NCBI
SpeTri2.0NW_0049364706,632,724 - 6,967,878 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NHS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX13,855,340 - 14,209,664 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X13,854,950 - 14,209,085 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X14,951,338 - 15,302,337 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NHS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X15,803,386 - 16,183,809 (+)NCBI
ChlSab1.1 EnsemblX16,168,609 - 16,183,787 (+)Ensembl
Vero_WHO_p1.0NW_02366605617,683,202 - 18,052,952 (+)NCBI
Nhs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248292,185,410 - 2,520,869 (+)NCBI

Position Markers
DXRat25  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X32,665,143 - 32,665,260 (+)MAPPER
Rnor_6.0X34,424,518 - 34,424,634NCBIRnor6.0
Rnor_5.0X34,768,466 - 34,768,582UniSTSRnor5.0
CeleraX32,956,567 - 32,956,683UniSTS
RH 3.4 MapX474.4UniSTS
RH 3.4 MapX474.4RGD
RH 2.0 Map21361.4RGD
FHH x ACI MapX14.5099RGD
Cytogenetic MapXq21UniSTS
DXGot26  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X32,632,625 - 32,632,857 (+)MAPPER
Rnor_6.0X34,392,155 - 34,392,386NCBIRnor6.0
Rnor_5.0X34,735,954 - 34,736,185UniSTSRnor5.0
RGSC_v3.4X53,457,104 - 53,457,336RGDRGSC3.4
RGSC_v3.4X53,457,105 - 53,457,336UniSTSRGSC3.4
RGSC_v3.1X53,510,574 - 53,510,805RGD
CeleraX32,924,132 - 32,924,363UniSTS
RH 3.4 MapX464.9UniSTS
RH 3.4 MapX464.9RGD
RH 2.0 Map21358.3RGD
Cytogenetic MapXq21UniSTS
AW527792  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X32,718,432 - 32,718,567 (+)MAPPER
Rnor_6.0X34,477,929 - 34,478,063NCBIRnor6.0
Rnor_5.0X34,821,916 - 34,822,050UniSTSRnor5.0
RGSC_v3.4X53,542,979 - 53,543,113UniSTSRGSC3.4
CeleraX33,009,500 - 33,009,634UniSTS
RH 3.4 MapX474.4UniSTS
Cytogenetic MapXq21UniSTS
RH133422  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X32,552,422 - 32,552,609 (+)MAPPER
Rnor_6.0X34,312,689 - 34,312,875NCBIRnor6.0
Rnor_5.0X34,656,540 - 34,656,726UniSTSRnor5.0
RGSC_v3.4X53,320,950 - 53,321,136UniSTSRGSC3.4
CeleraX32,844,153 - 32,844,339UniSTS
RH 3.4 MapX467.1UniSTS
Cytogenetic MapXq21UniSTS
fi17a01.x1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22176,807,742 - 176,807,800 (-)MAPPER
mRatBN7.2X32,555,266 - 32,555,943 (+)MAPPER
Rnor_6.0X34,315,533 - 34,316,209NCBIRnor6.0
Rnor_6.02190,570,717 - 190,570,774NCBIRnor6.0
Rnor_5.02214,303,158 - 214,303,215UniSTSRnor5.0
Rnor_5.0X34,659,384 - 34,660,060UniSTSRnor5.0
RGSC_v3.4X53,323,794 - 53,324,470UniSTSRGSC3.4
RGSC_v3.42183,795,076 - 183,795,133UniSTSRGSC3.4
Celera2173,769,534 - 173,769,591UniSTS
CeleraX32,846,997 - 32,847,673UniSTS
Cytogenetic MapXq21UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X144092703Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X428214049282140Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X595407850954078Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X15688119127888215Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1815335263153352Rat
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2159262344320739Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2159262344468300Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:79
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000041924
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 17 1 6
Low 3 40 16 6 12 6 8 8 57 34 35 10 8
Below cutoff 3 30 24 7 24 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000041924   ⟹   ENSRNOP00000039704
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX34,623,405 - 34,672,940 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091746   ⟹   ENSRNOP00000070291
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX34,630,048 - 34,673,742 (+)Ensembl
RefSeq Acc Id: NM_001191733   ⟹   NP_001178662
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X32,553,300 - 32,889,992 (+)NCBI
Rnor_6.0X34,313,566 - 34,672,940 (+)NCBI
Rnor_5.0X34,656,286 - 35,018,650 (+)NCBI
CeleraX32,845,030 - 33,180,545 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773173   ⟹   XP_008771395
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X32,783,851 - 32,892,961 (+)NCBI
Rnor_6.0X34,569,870 - 34,675,912 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602084   ⟹   XP_017457573
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X32,551,974 - 32,892,961 (+)NCBI
Rnor_6.0X34,312,102 - 34,675,912 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602085   ⟹   XP_017457574
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X32,799,376 - 32,892,961 (+)NCBI
Rnor_6.0X34,589,036 - 34,675,912 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178662 (Get FASTA)   NCBI Sequence Viewer  
  XP_008771395 (Get FASTA)   NCBI Sequence Viewer  
  XP_017457573 (Get FASTA)   NCBI Sequence Viewer  
  XP_017457574 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001178662   ⟸   NM_001191733
- Sequence:
RefSeq Acc Id: XP_008771395   ⟸   XM_008773173
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017457573   ⟸   XM_017602084
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017457574   ⟸   XM_017602085
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000039704   ⟸   ENSRNOT00000041924
RefSeq Acc Id: ENSRNOP00000070291   ⟸   ENSRNOT00000091746

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561818 AgrOrtholog
Ensembl Genes ENSRNOG00000030759 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000039704 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000070291 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041924 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000091746 UniProtKB/TrEMBL
InterPro NHS_fam UniProtKB/TrEMBL
NCBI Gene 317494 ENTREZGENE
Pfam NHS UniProtKB/TrEMBL
PhenoGen Nhs PhenoGen
UniProt A0A0G2JXJ0_RAT UniProtKB/TrEMBL
  F1LU76_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Nhs  NHS actin remodeling regulator  Nhs  Nance-Horan syndrome (congenital cataracts and dental anomalies)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-22 Nhs  Nance-Horan syndrome (congenital cataracts and dental anomalies)  Nhs  Nance-Horan syndrome (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Nhs  Nance-Horan syndrome (human)  RGD1561818_predicted  similar to Nance-Horan syndrome protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561818_predicted  similar to Nance-Horan syndrome protein (predicted)  LOC317494  similar to Nance-Horan syndrome protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC317494  similar to Nance-Horan syndrome protein      Symbol and Name status set to provisional 70820 PROVISIONAL