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Gene: Iqsec2 (IQ motif and Sec7 domain ArfGEF 2) Rattus norvegicus
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Symbol: Iqsec2
Name: IQ motif and Sec7 domain ArfGEF 2
Description: Predicted to have ARF guanyl-nucleotide exchange factor activity. Involved in positive regulation of glutamatergic synaptic transmission and positive regulation of long-term synaptic depression. Predicted to localize to several cellular components, including Schaffer collateral - CA1 synapse; photoreceptor ribbon synapse; and postsynaptic density. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human IQSEC2 (IQ motif and Sec7 domain ArfGEF 2); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; glycidol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IQ motif and Sec7 domain 2; IQ motif and SEC7 domain-containing protein 2; LOC685244; RGD1562109; similar to IQ motif and Sec7 domain 2
Orthologs:
Homo sapiens (human) : IQSEC2 (IQ motif and Sec7 domain ArfGEF 2)  HGNC  Alliance
Mus musculus (house mouse) : Iqsec2 (IQ motif and Sec7 domain 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Iqsec2 (IQ motif and Sec7 domain ArfGEF 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100970467 (IQ motif and Sec7 domain ArfGEF 2)
Canis lupus familiaris (dog) : IQSEC2 (IQ motif and Sec7 domain ArfGEF 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Iqsec2 (IQ motif and Sec7 domain ArfGEF 2)
Sus scrofa (pig) : IQSEC2 (IQ motif and Sec7 domain ArfGEF 2)
Chlorocebus sabaeus (African green monkey) : IQSEC2 (IQ motif and Sec7 domain ArfGEF 2)
Heterocephalus glaber (naked mole-rat) : Iqsec2 (IQ motif and Sec7 domain ArfGEF 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X22,212,137 - 22,293,810 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX22,212,132 - 22,294,402 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X64,286,343 - 64,367,399 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X41,651,275 - 41,733,435 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX21,517,185 - 21,598,702 (+)NCBICelera
Cytogenetic MapXq13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Iqsec2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1596452
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.