Grpr (gastrin releasing peptide receptor) - Rat Genome Database

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Gene: Grpr (gastrin releasing peptide receptor) Rattus norvegicus
Analyze
Symbol: Grpr
Name: gastrin releasing peptide receptor
RGD ID: 2750
Description: Enables G protein-coupled receptor activity and neuropeptide binding activity. Involved in G protein-coupled receptor signaling pathway; learning or memory; and social behavior. Located in membrane. Orthologous to human GRPR (gastrin releasing peptide receptor); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH ammonium chloride; bisphenol A; bleomycin A2.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Gastrin-releasing peptide receptor; GRP-preferring bombesin receptor; GRP-R
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X30,998,425 - 31,038,442 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX30,998,416 - 31,038,442 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX32,038,434 - 32,078,466 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X35,468,323 - 35,508,331 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X31,669,805 - 31,709,843 (+)NCBIRnor_WKY
Rnor_6.0X32,746,259 - 32,786,266 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX32,745,873 - 32,786,359 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X33,083,317 - 33,123,324 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X51,743,248 - 51,783,255 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X51,796,714 - 51,836,724 (+)NCBI
CeleraX31,324,305 - 31,364,289 (+)NCBICelera
Cytogenetic MapXq14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Gastrin-releasing peptide receptor in rat brain membranes: specific binding and stimulation of phosphoinositide breakdown. Hollingsworth EB Mol Pharmacol. 1989 May;35(5):689-94.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Impairments of social behavior and memory after neonatal gastrin-releasing peptide receptor blockade in rats: Implications for an animal model of neurodevelopmental disorders. Presti-Torres J, etal., Neuropharmacology. 2007 Mar;52(3):724-32. Epub 2006 Nov 13.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Molecular basis for selectivity of high affinity peptide antagonists for the gastrin-releasing peptide receptor. Tokita K, etal., J Biol Chem 2001 Sep 28;276(39):36652-63.
Additional References at PubMed
PMID:1327030   PMID:1655761   PMID:1671171   PMID:11960700   PMID:15140764   PMID:17406984   PMID:19912888   PMID:22429708   PMID:22735756   PMID:26658875   PMID:26855425   PMID:28280205  


Genomics

Comparative Map Data
Grpr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X30,998,425 - 31,038,442 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX30,998,416 - 31,038,442 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX32,038,434 - 32,078,466 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X35,468,323 - 35,508,331 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X31,669,805 - 31,709,843 (+)NCBIRnor_WKY
Rnor_6.0X32,746,259 - 32,786,266 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX32,745,873 - 32,786,359 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X33,083,317 - 33,123,324 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X51,743,248 - 51,783,255 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X51,796,714 - 51,836,724 (+)NCBI
CeleraX31,324,305 - 31,364,289 (+)NCBICelera
Cytogenetic MapXq14NCBI
GRPR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X16,123,565 - 16,153,518 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX16,123,565 - 16,153,518 (+)EnsemblGRCh38hg38GRCh38
GRCh37X16,141,688 - 16,171,641 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X16,051,345 - 16,081,562 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X15,901,335 - 15,930,598NCBI
CeleraX20,259,707 - 20,289,922 (+)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX13,896,945 - 13,927,133 (+)NCBIHuRef
CHM1_1X16,172,364 - 16,202,581 (+)NCBICHM1_1
T2T-CHM13v2.0X15,706,468 - 15,736,420 (+)NCBIT2T-CHM13v2.0
Grpr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X162,296,900 - 162,332,732 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX162,296,900 - 162,332,673 (-)EnsemblGRCm39 Ensembl
GRCm38X163,513,904 - 163,549,736 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX163,513,904 - 163,549,677 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X159,951,836 - 159,987,579 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X158,858,009 - 158,893,752 (-)NCBIMGSCv36mm8
CeleraX146,739,026 - 146,774,660 (-)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX75.63NCBI
Grpr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555192,032,500 - 2,063,292 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555192,032,500 - 2,063,292 (-)NCBIChiLan1.0ChiLan1.0
GRPR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X16,099,778 - 16,131,069 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX16,099,778 - 16,131,069 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X8,744,020 - 8,775,085 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GRPR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X12,344,704 - 12,381,445 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX12,345,318 - 12,380,915 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX12,194,783 - 12,232,039 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X12,305,424 - 12,342,697 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX12,306,033 - 12,342,171 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X12,374,968 - 12,412,213 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X12,361,417 - 12,398,693 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X12,387,955 - 12,425,227 (+)NCBIUU_Cfam_GSD_1.0
Grpr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X5,533,131 - 5,565,860 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364705,533,256 - 5,565,869 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364705,533,256 - 5,565,827 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRPR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX12,659,776 - 12,696,103 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X12,654,059 - 12,711,417 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X13,603,713 - 13,650,148 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRPR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X14,569,771 - 14,599,306 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX14,570,453 - 14,599,258 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605616,425,059 - 16,455,086 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grpr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624829907,371 - 939,779 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624829907,386 - 946,385 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grpr
163 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:29
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000005559
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat

Markers in Region
DXWox17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X31,035,144 - 31,035,347 (+)MAPPERmRatBN7.2
Rnor_6.0X32,782,973 - 32,783,175NCBIRnor6.0
Rnor_5.0X33,120,031 - 33,120,233UniSTSRnor5.0
RGSC_v3.4X51,779,962 - 51,780,164UniSTSRGSC3.4
CeleraX31,360,995 - 31,361,197UniSTS
Cytogenetic MapXq21UniSTS
DXArb10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X30,998,206 - 30,998,396 (+)MAPPERmRatBN7.2
Rnor_6.0X32,746,043 - 32,746,230NCBIRnor6.0
Rnor_5.0X33,083,101 - 33,083,288UniSTSRnor5.0
RGSC_v3.4X51,743,029 - 51,743,219RGDRGSC3.4
RGSC_v3.4X51,743,030 - 51,743,219UniSTSRGSC3.4
RGSC_v3.1X51,796,498 - 51,796,688RGD
CeleraX31,324,089 - 31,324,276UniSTS
FHH x ACI MapX14.5099UniSTS
FHH x ACI MapX14.5099RGD
Cytogenetic MapXq21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3
Low 2 12 1 13 1 3 4 50 17 10 9 3
Below cutoff 1 31 29 24 6 24 5 7 22 18 22 2 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005559   ⟹   ENSRNOP00000005559
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX30,998,416 - 31,038,442 (+)Ensembl
Rnor_6.0 EnsemblX32,745,873 - 32,786,359 (+)Ensembl
RefSeq Acc Id: NM_012706   ⟹   NP_036838
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X30,998,425 - 31,038,442 (+)NCBI
Rnor_6.0X32,746,259 - 32,786,266 (+)NCBI
Rnor_5.0X33,083,317 - 33,123,324 (+)NCBI
RGSC_v3.4X51,743,248 - 51,783,255 (+)RGD
CeleraX31,324,305 - 31,364,289 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036838 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA39988 (Get FASTA)   NCBI Sequence Viewer  
  EDL90503 (Get FASTA)   NCBI Sequence Viewer  
  P52500 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036838   ⟸   NM_012706
- UniProtKB: P52500 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005559   ⟸   ENSRNOT00000005559

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52500-F1-model_v2 AlphaFold P52500 1-384 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2750 AgrOrtholog
BioCyc Gene G2FUF-2556 BioCyc
Ensembl Genes ENSRNOG00000004124 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000005559 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005559 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Bombsn_rcpt-like UniProtKB/Swiss-Prot
  Gastrin_pep_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:24938 UniProtKB/Swiss-Prot
NCBI Gene 24938 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Grpr PhenoGen
PRINTS BOMBESINR UniProtKB/Swiss-Prot
  GASTRINRELPR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
UniProt GRPR_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3V6I7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Grpr  Gastrin-releasing peptide receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the cell membrane 734489
gene_domains Thr(297), Phe(302), and Ser(305) of the fourth EC domain are the critical residues for determining receptor selectivity 734489