Acot9 (acyl-CoA thioesterase 9) - Rat Genome Database

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Gene: Acot9 (acyl-CoA thioesterase 9) Rattus norvegicus
Analyze
Symbol: Acot9
Name: acyl-CoA thioesterase 9
RGD ID: 1359188
Description: Predicted to enable acetyl-CoA hydrolase activity and long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process; long-chain fatty acid metabolic process; and short-chain fatty acid metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human ACOT9 (acyl-CoA thioesterase 9); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Acate2; acyl-Coenzyme A thioesterase 2, mitochondrial; acyl-coenzyme A thioesterase 9, mitochondrial; LOC302640; similar to acyl-CoA thioesterase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X43,922,943 - 43,973,311 (-)NCBIGRCr8
mRatBN7.2X40,073,197 - 40,123,573 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX40,064,810 - 40,123,559 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX41,332,153 - 41,371,197 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X44,799,449 - 44,838,500 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X42,484,036 - 42,523,088 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X43,543,069 - 43,592,200 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX43,543,070 - 43,592,200 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X43,846,064 - 43,895,821 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X61,548,318 - 61,600,120 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X61,601,787 - 61,653,589 (-)NCBI
CeleraX40,701,964 - 40,751,523 (-)NCBICelera
Cytogenetic MapXq21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-acetamidofluorene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
acetamide  (EXP)
aconitine  (EXP)
aristolochic acid A  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
choline  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyproconazole  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP,ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
heptanal  (ISO)
hexanal  (ISO)
indole-3-methanol  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nonanal  (ISO)
obeticholic acid  (ISO)
octanal  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
prochloraz  (EXP)
progesterone  (ISO)
propanal  (ISO)
resveratrol  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
streptozocin  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydropalmatine  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10383425   PMID:16103133   PMID:18614015  


Genomics

Comparative Map Data
Acot9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X43,922,943 - 43,973,311 (-)NCBIGRCr8
mRatBN7.2X40,073,197 - 40,123,573 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX40,064,810 - 40,123,559 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX41,332,153 - 41,371,197 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X44,799,449 - 44,838,500 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X42,484,036 - 42,523,088 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X43,543,069 - 43,592,200 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX43,543,070 - 43,592,200 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X43,846,064 - 43,895,821 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X61,548,318 - 61,600,120 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X61,601,787 - 61,653,589 (-)NCBI
CeleraX40,701,964 - 40,751,523 (-)NCBICelera
Cytogenetic MapXq21NCBI
ACOT9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X23,701,055 - 23,743,276 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX23,701,055 - 23,766,475 (-)EnsemblGRCh38hg38GRCh38
GRCh37X23,719,172 - 23,761,393 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X23,631,698 - 23,671,328 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX27,842,554 - 27,882,190 (-)NCBICelera
Cytogenetic MapXp22.11NCBI
HuRefX21,460,810 - 21,501,317 (-)NCBIHuRef
CHM1_1X23,752,695 - 23,792,269 (-)NCBICHM1_1
T2T-CHM13v2.0X23,284,668 - 23,326,884 (-)NCBIT2T-CHM13v2.0
Acot9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X154,045,439 - 154,080,650 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX154,045,439 - 154,080,650 (+)EnsemblGRCm39 Ensembl
GRCm38X155,262,443 - 155,297,654 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX155,262,443 - 155,297,654 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X151,697,043 - 151,732,050 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X150,603,226 - 150,638,364 (+)NCBIMGSCv36mm8
CeleraX138,566,044 - 138,601,000 (+)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX72.38NCBI
Acot9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555094,143,586 - 4,167,128 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555094,143,246 - 4,167,129 (-)NCBIChiLan1.0ChiLan1.0
ACOT9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X25,504,426 - 25,544,539 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X25,503,513 - 25,547,923 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X16,300,116 - 16,365,713 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X23,678,071 - 23,717,092 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX23,676,669 - 23,717,092 (-)Ensemblpanpan1.1panPan2
ACOT9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X19,395,763 - 19,460,945 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX19,395,762 - 19,551,198 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X19,350,059 - 19,415,885 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX19,342,343 - 19,374,457 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X19,389,633 - 19,455,007 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X19,422,682 - 19,488,508 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X19,479,032 - 19,544,221 (-)NCBIUU_Cfam_GSD_1.0
Acot9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X12,323,397 - 12,397,793 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936624795,237 - 836,571 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936624795,272 - 834,441 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACOT9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX19,834,614 - 19,864,660 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X19,835,674 - 19,864,570 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X21,205,864 - 21,234,787 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACOT9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X22,152,651 - 22,190,536 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX22,151,384 - 22,190,505 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605624,048,616 - 24,087,263 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acot9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624897125,348 - 155,621 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624897125,348 - 155,557 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acot9
157 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:35
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000005033
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000005033   ⟹   ENSRNOP00000005033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX40,073,205 - 40,123,559 (-)Ensembl
Rnor_6.0 EnsemblX43,543,070 - 43,592,200 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111580   ⟹   ENSRNOP00000089191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX40,073,198 - 40,116,798 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113538   ⟹   ENSRNOP00000091656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX40,064,810 - 40,123,559 (-)Ensembl
RefSeq Acc Id: NM_001013960   ⟹   NP_001013982
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X43,922,943 - 43,973,205 (-)NCBI
mRatBN7.2X40,073,197 - 40,123,465 (-)NCBI
Rnor_6.0X43,543,069 - 43,592,200 (-)NCBI
Rnor_5.0X43,846,064 - 43,895,821 (-)NCBI
RGSC_v3.4X61,548,318 - 61,600,120 (-)RGD
CeleraX40,701,964 - 40,751,523 (-)RGD
Sequence:
RefSeq Acc Id: XM_039099644   ⟹   XP_038955572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X43,922,943 - 43,973,311 (-)NCBI
mRatBN7.2X40,073,197 - 40,123,573 (-)NCBI
RefSeq Acc Id: XM_039099645   ⟹   XP_038955573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X43,922,943 - 43,973,311 (-)NCBI
mRatBN7.2X40,073,197 - 40,123,573 (-)NCBI
RefSeq Acc Id: NP_001013982   ⟸   NM_001013960
- UniProtKB: Q5U2X8 (UniProtKB/TrEMBL),   F7ETS0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005033   ⟸   ENSRNOT00000005033
RefSeq Acc Id: XP_038955573   ⟸   XM_039099645
- Peptide Label: isoform X1
- UniProtKB: A6IPR3 (UniProtKB/TrEMBL),   F7ETS0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955572   ⟸   XM_039099644
- Peptide Label: isoform X1
- UniProtKB: A6IPR3 (UniProtKB/TrEMBL),   F7ETS0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089191   ⟸   ENSRNOT00000111580
Ensembl Acc Id: ENSRNOP00000091656   ⟸   ENSRNOT00000113538
Protein Domains
HotDog ACOT-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2X8-F1-model_v2 AlphaFold Q5U2X8 1-439 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701818
Promoter ID:EPDNEW_R12342
Type:initiation region
Name:Acot9_1
Description:acyl-CoA thioesterase 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X43,592,272 - 43,592,332EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359188 AgrOrtholog
BioCyc Gene G2FUF-2442 BioCyc
BioCyc Pathway PWY-5148 [acyl-CoA hydrolysis] BioCyc
  PWY-5972 [stearate biosynthesis I (animals)] BioCyc
  PWY-5996 [oleate biosynthesis II (animals and fungi)] BioCyc
  PWY-8042 [acylceramide biosynthesis] BioCyc
  PWY3O-1801 [palmitoleate biosynthesis IV (fungi and animals)] BioCyc
BioCyc Pathway Image PWY-5148 BioCyc
  PWY-5972 BioCyc
  PWY-5996 BioCyc
  PWY-8042 BioCyc
  PWY3O-1801 BioCyc
Ensembl Genes ENSRNOG00000003782 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005033.6 UniProtKB/TrEMBL
  ENSRNOT00000111580.1 UniProtKB/TrEMBL
  ENSRNOT00000113538.1 UniProtKB/TrEMBL
Gene3D-CATH Hotdog Thioesterase UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7126662 IMAGE-MGC_LOAD
InterPro HOTDOG_ACOT UniProtKB/TrEMBL
  HotDog_dom UniProtKB/TrEMBL
KEGG Report rno:302640 UniProtKB/TrEMBL
MGC_CLONE MGC:94122 IMAGE-MGC_LOAD
NCBI Gene 302640 ENTREZGENE
PANTHER ACYL-COA THIOESTERASE UniProtKB/TrEMBL
  ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL UniProtKB/TrEMBL
PhenoGen Acot9 PhenoGen
PROSITE HOTDOG_ACOT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003782 RatGTEx
Superfamily-SCOP SSF54637 UniProtKB/TrEMBL
UniProt A0A8I6A6Q0_RAT UniProtKB/TrEMBL
  A0A8I6AFW7_RAT UniProtKB/TrEMBL
  A6IPR3 ENTREZGENE, UniProtKB/TrEMBL
  F7ETS0 ENTREZGENE, UniProtKB/TrEMBL
  Q5U2X8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-05 Acot9  acyl-CoA thioesterase 9  LOC302640  similar to acyl-CoA thioesterase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 LOC302640  similar to acyl-CoA thioesterase      Symbol and Name status set to provisional 70820 PROVISIONAL