Tmsb4x (thymosin beta 4, X-linked) - Rat Genome Database

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Gene: Tmsb4x (thymosin beta 4, X-linked) Rattus norvegicus
Analyze
Symbol: Tmsb4x
Name: thymosin beta 4, X-linked
RGD ID: 621622
Description: Predicted to have actin monomer binding activity and enzyme binding activity. Involved in osteoblast differentiation. Predicted to localize to cytosol and nucleus. Orthologous to human TMSB4X (thymosin beta 4 X-linked); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: t beta 4; thymosin beta-4; thymosin, beta 4; thymosin, beta 4, X chromosome
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X27,144,677 - 27,146,667 (+)NCBI
Rnor_6.0 EnsemblX28,593,405 - 28,595,395 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X28,593,405 - 28,617,267 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X28,985,080 - 28,987,070 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1559,582,271 - 59,582,388 (-)NCBI
CeleraX27,555,904 - 27,557,894 (+)NCBICelera
Cytogenetic MapXq13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beryllium sulfate  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
CU-O LINKAGE  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
etoposide  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
glucose  (ISO)
griseofulvin  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
methapyrilene  (EXP)
microcystin-LR  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
okadaic acid  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (EXP,ISO)
sodium arsenite  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
troglitazone  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zoledronic acid  (ISO)

References

Additional References at PubMed
PMID:1447300   PMID:1999398   PMID:3670309   PMID:6954532   PMID:12477932   PMID:14657002   PMID:15466884   PMID:15565145   PMID:16189468   PMID:16641100   PMID:17716628   PMID:20809981  
PMID:21106936   PMID:21332672   PMID:21343177   PMID:22046407   PMID:22658674   PMID:23073962   PMID:23807296   PMID:24006456   PMID:24039044   PMID:24828499   PMID:26457369   PMID:27068509  
PMID:29956769   PMID:31054361  


Genomics

Comparative Map Data
Tmsb4x
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X27,144,677 - 27,146,667 (+)NCBI
Rnor_6.0 EnsemblX28,593,405 - 28,595,395 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X28,593,405 - 28,617,267 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X28,985,080 - 28,987,070 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1559,582,271 - 59,582,388 (-)NCBI
CeleraX27,555,904 - 27,557,894 (+)NCBICelera
Cytogenetic MapXq13NCBI
TMSB4X
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX12,975,110 - 12,977,227 (+)EnsemblGRCh38hg38GRCh38
GRCh38X12,975,110 - 12,977,223 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X12,993,229 - 12,995,342 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X12,903,148 - 12,905,267 (+)NCBINCBI36hg18NCBI36
Build 34X12,752,883 - 12,755,002NCBI
CeleraX17,110,896 - 17,113,015 (+)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX10,756,223 - 10,758,343 (+)NCBIHuRef
CHM1_1X13,023,770 - 13,025,890 (+)NCBICHM1_1
Tmsb4x
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X165,990,089 - 165,996,475 (-)NCBIGRCm39mm39
GRCm39 EnsemblX165,990,089 - 165,992,311 (-)Ensembl
GRCm38X167,207,093 - 167,213,479 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX167,207,093 - 167,209,315 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X163,645,026 - 163,647,150 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X144,389,562 - 144,391,688 (-)NCBImm8
MGSCv36X162,551,199 - 162,553,323 (-)NCBImm8
CeleraX150,380,762 - 150,382,939 (-)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX78.28NCBI
Tmsb4x
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955544266,397 - 268,447 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955544266,397 - 268,447 (-)NCBIChiLan1.0ChiLan1.0
TMSB4X
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v0X5,587,242 - 5,589,417 (+)NCBIMhudiblu_PPA_v0panPan3
LOC100683370
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,127,694 - 21,128,346 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,118,894 - 22,119,534 (-)NCBI
ROS_Cfam_1.0121,020,853 - 21,021,492 (-)NCBI
UMICH_Zoey_3.1121,077,166 - 21,077,806 (-)NCBI
UNSW_CanFamBas_1.0120,969,395 - 20,970,035 (-)NCBI
UU_Cfam_GSD_1.0121,240,994 - 21,241,634 (-)NCBI
Tmsb4x
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X2,668,453 - 2,670,610 (+)NCBI
SpeTri2.0NW_0049364702,668,525 - 2,670,611 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMSB4X
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX9,650,179 - 9,651,661 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X9,649,516 - 9,651,662 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X10,549,221 - 10,551,375 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMSB4X
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X11,454,090 - 11,456,268 (+)NCBI
Tmsb4x
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248821,198,099 - 1,200,237 (-)NCBI

Position Markers
TMSB4X  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X27,146,300 - 27,146,518 (+)MAPPER
Rnor_6.0X28,595,029 - 28,595,246NCBIRnor6.0
Rnor_5.0X28,986,704 - 28,986,921UniSTSRnor5.0
CeleraX27,557,528 - 27,557,745UniSTS
Cytogenetic Map5q22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X144092703Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X166260933443848Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X428214049282140Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X595407850954078Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X15688119127888215Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1815335263153352Rat
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2159262344320739Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2159262344468300Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:194
Count of miRNA genes:131
Interacting mature miRNAs:149
Transcripts:ENSRNOT00000071708
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 9 9 23 6 19 6 74 22 34 11
Medium 40 43 35 35 8 11 13 7 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC058137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC084720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC097308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K01334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000071708   ⟹   ENSRNOP00000066062
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX28,593,405 - 28,595,395 (+)Ensembl
RefSeq Acc Id: NM_031136   ⟹   NP_112398
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X27,144,677 - 27,146,667 (+)NCBI
Rnor_6.0X28,593,405 - 28,617,267 (+)NCBI
Rnor_5.0X28,985,080 - 28,987,070 (+)NCBI
CeleraX27,555,904 - 27,557,894 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_112398   ⟸   NM_031136
- UniProtKB: P62329 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066062   ⟸   ENSRNOT00000071708

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701786
Promoter ID:EPDNEW_R12309
Type:single initiation site
Name:Tmsb4x_1
Description:thymosin beta 4, X-linked
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X28,593,397 - 28,593,457EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621622 AgrOrtholog
Ensembl Genes ENSRNOG00000047931 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000066062 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000071708 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.520 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6889807 IMAGE-MGC_LOAD
InterPro Beta-thymosin UniProtKB/Swiss-Prot
  Beta-thymosin_sf UniProtKB/Swiss-Prot
KEGG Report rno:81814 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72784 IMAGE-MGC_LOAD
NCBI Gene 81814 ENTREZGENE
PANTHER PTHR12021 UniProtKB/Swiss-Prot
Pfam Thymosin UniProtKB/Swiss-Prot
PhenoGen Tmsb4x PhenoGen
PIRSF Thymosin_beta UniProtKB/Swiss-Prot
PROSITE THYMOSIN_B4 UniProtKB/Swiss-Prot
SMART THY UniProtKB/Swiss-Prot
UniProt P62329 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P01253 UniProtKB/Swiss-Prot
  P01254 UniProtKB/Swiss-Prot
  Q0P5V6 UniProtKB/Swiss-Prot
  Q63576 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-12-31 Tmsb4x  thymosin beta 4, X-linked  Tmsb4x  thymosin, beta 4, X chromosome  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Tmsb4x  thymosin, beta 4, X chromosome  Tmsb4x  thymosin beta 4, X-linked  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-14 Tmsb4x  thymosin beta 4, X-linked  Tmsb4x  thymosin, beta 4, X chromosome  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Tmsb4x  thymosin, beta 4, X chromosome  Tmsb4x  thymosin, beta 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Tmsb4x  thymosin, beta 4    thymosin beta-4  Name updated 1299863 APPROVED
2002-08-07 Tmsb4x  thymosin beta-4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the beta-thymosin family of actin monomer-sequestering proteins 737835