Tmsb4x (thymosin beta 4, X-linked) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Tmsb4x (thymosin beta 4, X-linked) Rattus norvegicus
Analyze
Symbol: Tmsb4x
Name: thymosin beta 4, X-linked
RGD ID: 621622
Description: Predicted to enable actin monomer binding activity; enzyme binding activity; and protein sequestering activity. Involved in osteoblast differentiation. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Orthologous to human TMSB4X (thymosin beta 4 X-linked); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: t beta 4; thymosin beta-4; thymosin, beta 4; thymosin, beta 4, X chromosome
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X30,761,611 - 30,763,612 (+)NCBIGRCr8
mRatBN7.2X27,144,666 - 27,146,667 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX27,128,610 - 27,146,667 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX28,217,413 - 28,219,416 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X31,619,373 - 31,621,374 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X27,832,051 - 27,834,054 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X28,593,405 - 28,617,267 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX28,593,405 - 28,595,395 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X28,985,080 - 28,987,070 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1559,582,271 - 59,582,388 (-)NCBI
CeleraX27,555,904 - 27,557,894 (+)NCBICelera
Cytogenetic MapXq13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beryllium sulfate  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
chloropicrin  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
CU-O LINKAGE  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
glucose  (ISO)
griseofulvin  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
iron dichloride  (ISO)
isoprenaline  (ISO)
itraconazole  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
microcystin-LR  (ISO)
Muraglitazar  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (EXP,ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
trichloroethene  (EXP)
troglitazone  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytoskeleton  (IEA)
cytosol  (ISO)
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Differential expression of thymosins beta(4) and beta(10) during rat cerebellum postnatal development. Anadon R, etal., Brain Res 2001 Mar 16;894(2):255-65.
2. Thymosin beta 4 is expressed in ROS 17/2.8 osteosarcoma cells in a regulated manner. Atkinson MJ, etal., Mol Endocrinol 1990 Jan;4(1):69-74.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Sequence of a cloned 523-bp cDNA for thymosin beta 4. Goodall GJ, etal., Arch Biochem Biophys 1985 Jan;236(1):445-7.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Cloning and sequence analysis of cDNA for rat spleen thymosin beta 4. Wodnar-Filipowicz A, etal., Proc Natl Acad Sci U S A 1984 Apr;81(8):2295-7.
Additional References at PubMed
PMID:1447300   PMID:1999398   PMID:3670309   PMID:6954532   PMID:12477932   PMID:14657002   PMID:15466884   PMID:15565145   PMID:16189468   PMID:16641100   PMID:17716628   PMID:20809981  
PMID:21106936   PMID:21332672   PMID:21343177   PMID:22046407   PMID:22658674   PMID:23073962   PMID:23807296   PMID:24006456   PMID:24039044   PMID:24828499   PMID:26457369   PMID:27068509  
PMID:29956769   PMID:31054361   PMID:35979771  


Genomics

Comparative Map Data
Tmsb4x
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X30,761,611 - 30,763,612 (+)NCBIGRCr8
mRatBN7.2X27,144,666 - 27,146,667 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX27,128,610 - 27,146,667 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX28,217,413 - 28,219,416 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X31,619,373 - 31,621,374 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X27,832,051 - 27,834,054 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X28,593,405 - 28,617,267 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX28,593,405 - 28,595,395 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X28,985,080 - 28,987,070 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1559,582,271 - 59,582,388 (-)NCBI
CeleraX27,555,904 - 27,557,894 (+)NCBICelera
Cytogenetic MapXq13NCBI
TMSB4X
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X12,975,110 - 12,977,223 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX12,975,110 - 12,977,227 (+)EnsemblGRCh38hg38GRCh38
GRCh37X12,993,229 - 12,995,342 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X12,903,148 - 12,905,267 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X12,752,883 - 12,755,002NCBI
CeleraX17,110,896 - 17,113,015 (+)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX10,756,223 - 10,758,343 (+)NCBIHuRef
CHM1_1X13,023,770 - 13,025,890 (+)NCBICHM1_1
T2T-CHM13v2.0X12,556,537 - 12,558,650 (+)NCBIT2T-CHM13v2.0
Tmsb4x
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X165,990,089 - 165,996,475 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX165,990,089 - 165,992,311 (-)EnsemblGRCm39 Ensembl
GRCm38X167,207,093 - 167,213,479 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX167,207,093 - 167,209,315 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X163,645,026 - 163,647,150 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X144,389,562 - 144,391,688 (-)NCBIMGSCv36mm8
MGSCv36X162,551,199 - 162,553,323 (-)NCBIMGSCv36mm8
CeleraX150,380,762 - 150,382,939 (-)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX78.28NCBI
Tmsb4x
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955544266,397 - 268,447 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955544266,397 - 268,447 (-)NCBIChiLan1.0ChiLan1.0
TMSB4X
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X14,759,411 - 14,761,586 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X14,763,035 - 14,765,252 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X5,587,242 - 5,589,417 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LOC100683370
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,127,694 - 21,128,346 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,118,894 - 22,119,534 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,020,853 - 21,021,492 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1121,077,166 - 21,077,806 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0120,969,395 - 20,970,035 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,240,994 - 21,241,634 (-)NCBIUU_Cfam_GSD_1.0
Tmsb4x
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X2,668,453 - 2,670,610 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364702,668,016 - 2,670,770 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364702,668,525 - 2,670,611 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMSB4X
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX9,650,179 - 9,651,661 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X9,649,516 - 9,651,662 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X10,549,221 - 10,551,375 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMSB4X
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X11,454,090 - 11,456,268 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605613,239,030 - 13,241,256 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmsb4x
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248821,198,099 - 1,200,201 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248821,198,099 - 1,200,237 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmsb4x
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:194
Count of miRNA genes:131
Interacting mature miRNAs:149
Transcripts:ENSRNOT00000071708
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat

Markers in Region
TMSB4X  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X27,146,300 - 27,146,518 (+)MAPPERmRatBN7.2
Rnor_6.0X28,595,029 - 28,595,246NCBIRnor6.0
Rnor_5.0X28,986,704 - 28,986,921UniSTSRnor5.0
CeleraX27,557,528 - 27,557,745UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC058137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC084720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC097308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K01334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000071708   ⟹   ENSRNOP00000066062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX27,128,610 - 27,146,667 (+)Ensembl
Rnor_6.0 EnsemblX28,593,405 - 28,595,395 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102572   ⟹   ENSRNOP00000097796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX27,144,555 - 27,146,667 (+)Ensembl
RefSeq Acc Id: NM_031136   ⟹   NP_112398
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X30,761,611 - 30,763,612 (+)NCBI
mRatBN7.2X27,144,666 - 27,146,667 (+)NCBI
Rnor_6.0X28,593,405 - 28,617,267 (+)NCBI
Rnor_5.0X28,985,080 - 28,987,070 (+)NCBI
CeleraX27,555,904 - 27,557,894 (+)NCBI
Sequence:
RefSeq Acc Id: NP_112398   ⟸   NM_031136
- UniProtKB: Q0P5V6 (UniProtKB/Swiss-Prot),   P62329 (UniProtKB/Swiss-Prot),   M0R7Y9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066062   ⟸   ENSRNOT00000071708
Ensembl Acc Id: ENSRNOP00000097796   ⟸   ENSRNOT00000102572

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62329-F1-model_v2 AlphaFold P62329 1-44 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701786
Promoter ID:EPDNEW_R12309
Type:single initiation site
Name:Tmsb4x_1
Description:thymosin beta 4, X-linked
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X28,593,397 - 28,593,457EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621622 AgrOrtholog
BioCyc Gene G2FUF-2658 BioCyc
Ensembl Genes ENSRNOG00000046598 UniProtKB/TrEMBL
  ENSRNOG00000047931 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071708.3 UniProtKB/TrEMBL
  ENSRNOT00000072548.3 UniProtKB/TrEMBL
  ENSRNOT00000102572.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.520 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6889807 IMAGE-MGC_LOAD
InterPro Beta-thymosin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Beta-thymosin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81814 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72784 IMAGE-MGC_LOAD
NCBI Gene 81814 ENTREZGENE
PANTHER PTHR12021 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYMOSIN BETA UniProtKB/Swiss-Prot
  THYMOSIN BETA UniProtKB/TrEMBL
  THYMOSIN BETA-4 UniProtKB/TrEMBL
Pfam Thymosin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmsb4x PhenoGen
PIRSF Thymosin_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THYMOSIN_B4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046598 RatGTEx
  ENSRNOG00000047931 RatGTEx
SMART THY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AUX5_RAT UniProtKB/TrEMBL
  A0A8L2QYF0_RAT UniProtKB/TrEMBL
  A6K2G3_RAT UniProtKB/TrEMBL
  A6K2G4_RAT UniProtKB/TrEMBL
  M0R7Y9 ENTREZGENE, UniProtKB/TrEMBL
  P62329 ENTREZGENE
  Q0P5V6 ENTREZGENE
  TYB4_RAT UniProtKB/Swiss-Prot
UniProt Secondary P01253 UniProtKB/Swiss-Prot
  P01254 UniProtKB/Swiss-Prot
  Q0P5V6 UniProtKB/Swiss-Prot
  Q63576 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-12-31 Tmsb4x  thymosin beta 4, X-linked  Tmsb4x  thymosin, beta 4, X chromosome  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Tmsb4x  thymosin, beta 4, X chromosome  Tmsb4x  thymosin beta 4, X-linked  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-14 Tmsb4x  thymosin beta 4, X-linked  Tmsb4x  thymosin, beta 4, X chromosome  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Tmsb4x  thymosin, beta 4, X chromosome  Tmsb4x  thymosin, beta 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Tmsb4x  thymosin, beta 4    thymosin beta-4  Name updated 1299863 APPROVED
2002-08-07 Tmsb4x  thymosin beta-4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the beta-thymosin family of actin monomer-sequestering proteins 737835