Cnksr2 (connector enhancer of kinase suppressor of Ras 2) - Rat Genome Database

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Gene: Cnksr2 (connector enhancer of kinase suppressor of Ras 2) Rattus norvegicus
Analyze
Symbol: Cnksr2
Name: connector enhancer of kinase suppressor of Ras 2
RGD ID: 708454
Description: Enables identical protein binding activity. Involved in postsynapse organization. Located in several cellular components, including neuronal cell body; postsynaptic density; and postsynaptic membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in syndromic X-linked mental retardation Hough type. Orthologous to human CNKSR2 (connector enhancer of kinase suppressor of Ras 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CNK homolog protein 2; CNK2; connector enhancer of KSR 2; LOC59322; maguin; maguin-1; maguin-2; membrane-associated guanylate kinase-interacting protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X36,908,135 - 37,148,337 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX36,907,850 - 37,150,555 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX38,074,046 - 38,335,201 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X41,541,236 - 41,802,393 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X39,225,951 - 39,487,110 (+)NCBIRnor_WKY
Rnor_6.0X39,711,001 - 39,953,860 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX39,711,201 - 39,951,847 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X40,021,056 - 40,261,531 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X58,198,352 - 58,440,335 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X58,251,535 - 58,484,403 (+)NCBI
CeleraX37,542,061 - 37,781,985 (+)NCBICelera
Cytogenetic MapXq21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Synaptic localization of membrane-associated guanylate kinase-interacting protein mediated by the pleckstrin homology domain. Iida J, etal., Eur J Neurosci 2002 May;15(9):1493-8.
2. The CNK2 scaffold interacts with vilse and modulates Rac cycling during spine morphogenesis in hippocampal neurons. Lim J, etal., Curr Biol. 2014 Mar 31;24(7):786-92. doi: 10.1016/j.cub.2014.02.036. Epub 2014 Mar 20.
3. Densin-180, a synaptic protein, links to PSD-95 through its direct interaction with MAGUIN-1. Ohtakara K, etal., Genes Cells. 2002 Nov;7(11):1149-60.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. MAGUIN, a novel neuronal membrane-associated guanylate kinase-interacting protein. Yao I, etal., J Biol Chem 1999 Apr 23;274(17):11889-96.
Additional References at PubMed
PMID:14597674   PMID:17114649   PMID:19056867   PMID:22871113   PMID:29476059   PMID:30053369   PMID:32235845  


Genomics

Comparative Map Data
Cnksr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X36,908,135 - 37,148,337 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX36,907,850 - 37,150,555 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX38,074,046 - 38,335,201 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X41,541,236 - 41,802,393 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X39,225,951 - 39,487,110 (+)NCBIRnor_WKY
Rnor_6.0X39,711,001 - 39,953,860 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX39,711,201 - 39,951,847 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X40,021,056 - 40,261,531 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X58,198,352 - 58,440,335 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X58,251,535 - 58,484,403 (+)NCBI
CeleraX37,542,061 - 37,781,985 (+)NCBICelera
Cytogenetic MapXq21NCBI
CNKSR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X21,374,418 - 21,654,689 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX21,372,801 - 21,654,695 (+)EnsemblGRCh38hg38GRCh38
GRCh37X21,392,536 - 21,672,807 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X21,302,901 - 21,580,700 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X21,152,636 - 21,430,436NCBI
CeleraX25,513,670 - 25,793,712 (+)NCBICelera
Cytogenetic MapXp22.12NCBI
HuRefX19,116,680 - 19,415,186 (+)NCBIHuRef
CHM1_1X21,422,963 - 21,703,230 (+)NCBICHM1_1
T2T-CHM13v2.0X20,957,756 - 21,238,011 (+)NCBIT2T-CHM13v2.0
Cnksr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X156,604,426 - 156,827,454 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX156,604,432 - 156,826,290 (-)EnsemblGRCm39 Ensembl
GRCm38X157,821,430 - 158,044,458 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX157,821,436 - 158,043,294 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X154,259,505 - 154,481,042 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X153,165,678 - 153,387,215 (-)NCBIMGSCv36mm8
CeleraX141,071,875 - 141,293,833 (-)NCBICelera
Cytogenetic MapXF4NCBI
Cnksr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555091,758,803 - 1,985,511 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555091,758,803 - 1,977,776 (+)NCBIChiLan1.0ChiLan1.0
CNKSR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X21,360,089 - 21,640,819 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX21,360,095 - 21,640,819 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X14,004,393 - 14,285,027 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CNKSR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X17,187,742 - 17,464,526 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX17,187,742 - 17,463,102 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X17,146,603 - 17,424,099 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX17,146,103 - 17,424,094 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X17,181,511 - 17,458,370 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X17,203,159 - 17,480,091 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X17,263,244 - 17,539,996 (+)NCBIUU_Cfam_GSD_1.0
Cnksr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X10,168,415 - 10,430,695 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366242,727,208 - 2,989,653 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNKSR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX17,561,260 - 17,838,493 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X17,561,114 - 17,838,034 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X18,898,868 - 19,131,561 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CNKSR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X19,837,495 - 20,119,396 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX19,891,949 - 20,117,574 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605621,694,514 - 21,984,321 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnksr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248296,286,259 - 6,556,757 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248296,286,716 - 6,556,757 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
RH140438  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X37,138,957 - 37,139,116 (+)MAPPERmRatBN7.2
Rnor_6.0X39,942,271 - 39,942,429NCBIRnor6.0
Rnor_5.0X40,252,153 - 40,252,311UniSTSRnor5.0
RGSC_v3.4X58,430,956 - 58,431,114UniSTSRGSC3.4
CeleraX37,772,606 - 37,772,764UniSTS
RH 3.4 MapX526.1UniSTS
Cytogenetic MapXq21UniSTS
CNKSR2_4601  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X37,148,146 - 37,148,675 (+)MAPPERmRatBN7.2
Rnor_6.0X39,951,459 - 39,951,987NCBIRnor6.0
Rnor_5.0X40,261,341 - 40,261,869UniSTSRnor5.0
RGSC_v3.4X58,440,145 - 58,440,673UniSTSRGSC3.4
CeleraX37,781,795 - 37,782,323UniSTS
Cytogenetic MapXq21UniSTS
RH15676  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X37,138,758 - 37,138,948 (+)MAPPERmRatBN7.2
Rnor_6.0X39,942,072 - 39,942,261NCBIRnor6.0
Rnor_5.0X40,251,954 - 40,252,143UniSTSRnor5.0
RGSC_v3.4X58,430,757 - 58,430,946UniSTSRGSC3.4
CeleraX37,772,407 - 37,772,596UniSTS
Cytogenetic MapXq21UniSTS
UniSTS:224320  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X37,137,655 - 37,137,816 (+)MAPPERmRatBN7.2
Rnor_6.0X39,940,969 - 39,941,129NCBIRnor6.0
Rnor_5.0X40,250,851 - 40,251,011UniSTSRnor5.0
RGSC_v3.4X58,429,654 - 58,429,814UniSTSRGSC3.4
CeleraX37,771,304 - 37,771,464UniSTS
Cytogenetic MapXq21UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:99
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000009802
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 56 1
Low 10 16 6 2 6 8 8 18 17 35 11 8
Below cutoff 3 33 12 6 15 6 3 17 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009802   ⟹   ENSRNOP00000009802
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX36,907,850 - 37,150,555 (+)Ensembl
Rnor_6.0 EnsemblX39,711,255 - 39,951,847 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080512   ⟹   ENSRNOP00000071915
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX36,908,135 - 37,139,231 (+)Ensembl
Rnor_6.0 EnsemblX39,711,201 - 39,942,544 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095688   ⟹   ENSRNOP00000084300
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX36,907,850 - 37,150,555 (+)Ensembl
RefSeq Acc Id: NM_001113366   ⟹   NP_001106837
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X36,908,135 - 37,148,337 (+)NCBI
Rnor_6.0X39,711,201 - 39,951,649 (+)NCBI
Rnor_5.0X40,021,056 - 40,261,531 (+)NCBI
RGSC_v3.4X58,198,352 - 58,440,335 (+)RGD
CeleraX37,542,061 - 37,781,985 (+)RGD
Sequence:
RefSeq Acc Id: NM_021686   ⟹   NP_067718
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X36,908,135 - 37,139,231 (+)NCBI
Rnor_6.0X39,711,201 - 39,942,544 (+)NCBI
Rnor_5.0X40,021,056 - 40,261,531 (+)NCBI
RGSC_v3.4X58,198,352 - 58,440,335 (+)RGD
CeleraX37,542,061 - 37,772,879 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773224   ⟹   XP_008771446
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X36,908,308 - 37,148,337 (+)NCBI
Rnor_6.0X39,711,001 - 39,953,860 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602144   ⟹   XP_017457633
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X36,908,308 - 37,148,337 (+)NCBI
Rnor_6.0X39,711,002 - 39,953,860 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039100001   ⟹   XP_038955929
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X36,908,308 - 37,148,337 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_067718   ⟸   NM_021686
- Peptide Label: isoform 2
- UniProtKB: Q9Z1T4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001106837   ⟸   NM_001113366
- Peptide Label: isoform 1
- UniProtKB: Q9R093 (UniProtKB/Swiss-Prot),   Q9Z1T4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008771446   ⟸   XM_008773224
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017457633   ⟸   XM_017602144
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000071915   ⟸   ENSRNOT00000080512
RefSeq Acc Id: ENSRNOP00000009802   ⟸   ENSRNOT00000009802
RefSeq Acc Id: XP_038955929   ⟸   XM_039100001
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000084300   ⟸   ENSRNOT00000095688
Protein Domains
CRIC   DUF1170   PDZ   PH   SAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1T4-F1-model_v2 AlphaFold Q9Z1T4 1-1032 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701813
Promoter ID:EPDNEW_R12337
Type:single initiation site
Name:Cnksr2_1
Description:connector enhancer of kinase suppressor of Ras 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X39,711,330 - 39,711,390EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
X 58410780 58410781 C T snv FHL/EurMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708454 AgrOrtholog
BioCyc Gene G2FUF-2472 BioCyc
Ensembl Genes ENSRNOG00000007014 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000009802 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000071915 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000084300 ENTREZGENE
  ENSRNOP00000084300.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009802 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000080512 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000095688 ENTREZGENE
  ENSRNOT00000095688.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CNK2/3_dom UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  CRIC_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59322 UniProtKB/Swiss-Prot
NCBI Gene 59322 ENTREZGENE
Pfam CRIC_ras_sig UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cnksr2 PhenoGen
PROSITE CRIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PDZ UniProtKB/Swiss-Prot
  SAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47769 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A0Z8_RAT UniProtKB/TrEMBL
  CNKR2_RAT UniProtKB/Swiss-Prot
  Q9R093 ENTREZGENE
  Q9Z1T4 ENTREZGENE
UniProt Secondary Q9R093 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Cnksr2  connector enhancer of kinase suppressor of Ras 2    membrane-associated guanylate kinase-interacting protein  Name updated 1299863 APPROVED
2004-09-10 Cnksr2  membrane-associated guanylate kinase-interacting protein  LOC59322    Symbol and Name updated 1299863 APPROVED