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Gene: Huwe1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1) Rattus norvegicus

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Symbol:

Huwe1

Name:

HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1

RGD ID:

1561763

Description:

Enables DNA binding activity. Predicted to be involved in several processes, including positive regulation of metabolic process; protein ubiquitination; and regulation of intracellular signal transduction. Located in nucleus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Turner type. Orthologous to human HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A; flutamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

E3 ubiquitin-protein ligase HUWE1; HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase; HECT, UBA and WWE domain-containing protein 1; HECT-type E3 ubiquitin transferase HUWE1; hypothetical protein LOC501546; LOC501546; upstream regulatory element-binding protein 1; URE-B1; URE-binding protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	24,350,708 - 24,480,798 (+)	NCBI		GRCr8
mRatBN7.2	X	20,873,795 - 21,001,378 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	20,873,795 - 21,001,262 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	X	21,474,627 - 21,603,348 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	21,499,934 - 21,598,876 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	21,848,515 - 21,950,709 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	X	23,634,031 - 23,635,008 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	41,269,837 - 41,397,687 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	21,152,936 - 21,282,567 (+)	NCBI		Celera
Cytogenetic Map	X	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Huwe1	Rat	Atkin Syndrome		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: Atkin Flaitz Patil Smith syndrome	ClinVar	PMID:26059843\|PMID:28492532
Huwe1	Rat	autism spectrum disorder		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: Autism spectrum disorder	ClinVar	PMID:25741868\|PMID:28492532
Huwe1	Rat	autistic disorder		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: Autism \| ClinVar Annotator: match by term: Mental retardation, X-linked	ClinVar	PMID:21681106\|PMID:25741868\|PMID:30208311
Huwe1	Rat	blepharophimosis		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: Blepharophimosis	ClinVar	PMID:25741868
Huwe1	Rat	chromosome Xp11.22 duplication syndrome		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: HUWE1-related disorder	ClinVar	PMID:17576681\|PMID:18414213\|PMID:25741868\|PMID:28492532\|PMID:29180823\|PMID:39825153\|PMID:9536098
Huwe1	Rat	Cornelia de Lange syndrome 2		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome	ClinVar	PMID:26386245\|PMID:27334371\|PMID:28166369\|PMID:28492532\|PMID:28548707\|PMID:31334757\|PMID:31602316
Huwe1	Rat	Developmental Disabilities		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: Global developmental delay	ClinVar	PMID:25741868\|PMID:25741905\|PMID:28492532
Huwe1	Rat	genetic disease		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:16700052\|PMID:18414213\|PMID:25644381\|PMID:25741868\|PMID:25741869\|PMID:25985138\|PMID:28492532\|PMID:29180823\|PMID:7708685\|PMID:9153201
Huwe1	Rat	intellectual disability		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: Intellectual disability \| ClinVar Annotator: match by term: intellectual disabilities	ClinVar	PMID:25741868\|PMID:28492532
Huwe1	Rat	intellectual disability		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: Intellectual disability \| ClinVar Annotator: match by term: intellectual disabilities	ClinVar	PMID:25741868\|PMID:28492532\|PMID:29180823\|PMID:30109123
Huwe1	Rat	intellectual disability		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: Intellectual disability \| ClinVar Annotator: match by term: intellectual disabilities	ClinVar	PMID:25741868\|PMID:28492532\|PMID:29180823
Huwe1	Rat	Neurodevelopmental Disorders		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: Neurodevelopmental abnormality	ClinVar
Huwe1	Rat	non-syndromic intellectual disability		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: Non-syndromic intellectual disability	ClinVar	PMID:25741868
Huwe1	Rat	non-syndromic X-linked intellectual disability		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: Non-syndromic X-linked intellectual disability	ClinVar	PMID:18252223\|PMID:19377476\|PMID:25741868\|PMID:28492532\|PMID:29118367
Huwe1	Rat	non-syndromic X-linked intellectual disability 1		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED 1	ClinVar	PMID:26059843\|PMID:28492532
Huwe1	Rat	non-syndromic X-linked intellectual disability 99		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED 99	ClinVar	PMID:25741868
Huwe1	Rat	Say Meyer Syndrome		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: Trigonocephaly, short stature, and retarded psychomotor development	ClinVar	PMID:25741868\|PMID:30797980
Huwe1	Rat	spermatogenic failure 57		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: Male infertility with azoospermia or oligozoospermia due to single gene more ...	ClinVar	PMID:25741868
Huwe1	Rat	syndromic X-linked intellectual disability Lubs type		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: Syndromic X-linked intellectual disability Lubs type	ClinVar	PMID:25741868
Huwe1	Rat	syndromic X-linked intellectual disability Turner type		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: HUWE1-related neurodevelopmental disorder \| ClinVar Annotator: match by term: INTELLECTUAL more ...	ClinVar	PMID:16700052\|PMID:18252223\|PMID:19377476\|PMID:25326635\|PMID:25326637\|PMID:25590979\|PMID:25741868\|PMID:25741869\|PMID:25985138\|PMID:27130160\|PMID:27884935\|PMID:28492532\|PMID:29118367\|PMID:29180823\|PMID:29758562\|PMID:30797980\|PMID:35887114\|PMID:39825153\|PMID:6107045\|PMID:7943042\|PMID:7943044
Huwe1	Rat	X-Linked Intellectual Developmental Disorders		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED	ClinVar	PMID:25741868
Huwe1	Rat	X-linked mental retardation-hypotonic facies syndrome-1		ISO	RGD:1343412	8554872	ClinVar Annotator: match by term: Carpenter-Waziri syndrome	ClinVar	PMID:25741868

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Huwe1	Rat	syndromic X-linked intellectual disability Turner type		ISO	RGD:1343412	11554173	CTD Direct Evidence: marker/mechanism	CTD

Imported Disease Annotations - OMIM

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Huwe1	Rat	syndromic X-linked intellectual disability Turner type		ISO	RGD:1343412	7240710		OMIM

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Huwe1	Rat	(-)-marinopyrrole A	multiple interactions	ISO	RGD:1343412	6480464	[HUWE1 protein co-treated with marinopyrrole A] results in increased ubiquitination of MCL1 protein	CTD	PMID:36346691
Huwe1	Rat	17beta-estradiol	increases expression	ISO	RGD:1557240	6480464	Estradiol results in increased expression of HUWE1 mRNA	CTD	PMID:39298647
Huwe1	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1557240	6480464	Tetrachlorodibenzodioxin affects the expression of HUWE1 mRNA	CTD	PMID:21570461
Huwe1	Rat	2,3,7,8-Tetrachlorodibenzofuran	decreases expression	EXP		6480464	2,3,7,8-tetrachlorodibenzofuran results in decreased expression of HUWE1 mRNA	CTD	PMID:32109520
Huwe1	Rat	2,6-dimethoxyphenol	multiple interactions	ISO	RGD:1343412	6480464	[Furaldehyde co-treated with pyrogallol 1,3-dimethyl ether] results in decreased expression of HUWE1 protein	CTD	PMID:38598786
Huwe1	Rat	2-bromohexadecanoic acid	multiple interactions	ISO	RGD:1343412	6480464	2-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in more ...	CTD	PMID:38195004
Huwe1	Rat	2-hydroxypropanoic acid	increases expression	ISO	RGD:1343412	6480464	Lactic Acid results in increased expression of HUWE1 mRNA	CTD	PMID:30851411
Huwe1	Rat	3,3',4,4'-tetrachlorobiphenyl	multiple interactions	ISO	RGD:1557240	6480464	3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of HUWE1 mRNA]	CTD	PMID:19467301
Huwe1	Rat	3,4-methylenedioxymethamphetamine	decreases expression	ISO	RGD:1557240	6480464	N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of HUWE1 mRNA	CTD	PMID:26251327
Huwe1	Rat	3-isobutyl-1-methyl-7H-xanthine	multiple interactions	ISO	RGD:1343412	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ...	CTD	PMID:28628672
Huwe1	Rat	4,4'-sulfonyldiphenol	multiple interactions	ISO	RGD:1343412	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ...	CTD	PMID:28628672
Huwe1	Rat	4,4'-sulfonyldiphenol	increases expression	ISO	RGD:1343412	6480464	bisphenol S results in increased expression of HUWE1 protein	CTD	PMID:34186270
Huwe1	Rat	4,4'-sulfonyldiphenol	affects expression	ISO	RGD:1343412	6480464	bisphenol S affects the expression of HUWE1 protein	CTD	PMID:31945527
Huwe1	Rat	4,4'-sulfonyldiphenol	decreases expression	ISO	RGD:1557240	6480464	bisphenol S results in decreased expression of HUWE1 mRNA	CTD	PMID:39298647
Huwe1	Rat	4-hydroxyphenyl retinamide	increases expression	ISO	RGD:1557240	6480464	Fenretinide results in increased expression of HUWE1 mRNA	CTD	PMID:28973697
Huwe1	Rat	acrolein	multiple interactions	ISO	RGD:1343412	6480464	[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of more ...	CTD	PMID:32699268
Huwe1	Rat	aflatoxin B1	increases expression	ISO	RGD:1557240	6480464	Aflatoxin B1 results in increased expression of HUWE1 mRNA	CTD	PMID:19770486
Huwe1	Rat	aflatoxin B1	increases methylation	ISO	RGD:1343412	6480464	Aflatoxin B1 results in increased methylation of HUWE1 gene	CTD	PMID:27153756
Huwe1	Rat	Aflatoxin B2 alpha	decreases methylation	ISO	RGD:1343412	6480464	aflatoxin B2 results in decreased methylation of HUWE1 exon	CTD	PMID:30157460
Huwe1	Rat	Aflatoxin B2 alpha	increases methylation	ISO	RGD:1343412	6480464	aflatoxin B2 results in increased methylation of HUWE1 intron	CTD	PMID:30157460
Huwe1	Rat	alpha-pinene	multiple interactions	ISO	RGD:1343412	6480464	[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of more ...	CTD	PMID:32699268
Huwe1	Rat	antirheumatic drug	increases expression	ISO	RGD:1343412	6480464	Antirheumatic Agents results in increased expression of HUWE1 mRNA	CTD	PMID:24449571
Huwe1	Rat	Aroclor 1254	decreases expression	ISO	RGD:1557240	6480464	Chlorodiphenyl (54% Chlorine) results in decreased expression of HUWE1 mRNA	CTD	PMID:23650126
Huwe1	Rat	arsane	multiple interactions	ISO	RGD:1343412	6480464	[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of HUWE1 more ...	CTD	PMID:39836092
Huwe1	Rat	arsenic atom	multiple interactions	ISO	RGD:1343412	6480464	[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of HUWE1 more ...	CTD	PMID:39836092
Huwe1	Rat	arsenite(3-)	multiple interactions	ISO	RGD:1343412	6480464	arsenite inhibits the reaction [G3BP1 protein binds to HUWE1 mRNA]	CTD	PMID:32406909
Huwe1	Rat	arsenous acid	increases expression	ISO	RGD:1343412	6480464	Arsenic Trioxide results in increased expression of HUWE1 mRNA	CTD	PMID:20458559
Huwe1	Rat	atrazine	increases expression	ISO	RGD:1343412	6480464	Atrazine results in increased expression of HUWE1 mRNA	CTD	PMID:22378314
Huwe1	Rat	atrazine	decreases expression	ISO	RGD:1557240	6480464	Atrazine results in decreased expression of HUWE1 mRNA	CTD	PMID:26518232
Huwe1	Rat	benzo[a]pyrene	increases mutagenesis	ISO	RGD:1343412	6480464	Benzo(a)pyrene results in increased mutagenesis of HUWE1 gene	CTD	PMID:25435355
Huwe1	Rat	benzo[a]pyrene	affects methylation	ISO	RGD:1343412	6480464	Benzo(a)pyrene affects the methylation of HUWE1 5' UTR; Benzo(a)pyrene affects the methylation of HUWE1 promoter	CTD	PMID:27901495
Huwe1	Rat	benzo[a]pyrene	increases expression	ISO	RGD:1557240	6480464	Benzo(a)pyrene results in increased expression of HUWE1 mRNA	CTD	PMID:22228805
Huwe1	Rat	benzo[a]pyrene	multiple interactions	ISO	RGD:1557240	6480464	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of HUWE1 mRNA]	CTD	PMID:22228805
Huwe1	Rat	benzo[a]pyrene	increases expression	ISO	RGD:1343412	6480464	Benzo(a)pyrene results in increased expression of HUWE1 mRNA	CTD	PMID:17879257
Huwe1	Rat	benzo[a]pyrene	affects expression	ISO	RGD:1343412	6480464	Benzo(a)pyrene affects the expression of HUWE1 mRNA	CTD	PMID:25690898
Huwe1	Rat	benzo[e]pyrene	decreases methylation	ISO	RGD:1343412	6480464	benzo(e)pyrene results in decreased methylation of HUWE1 exon	CTD	PMID:30157460
Huwe1	Rat	beta-lapachone	increases expression	ISO	RGD:1343412	6480464	beta-lapachone results in increased expression of HUWE1 mRNA	CTD	PMID:38218311
Huwe1	Rat	beta-lapachone	decreases expression	ISO	RGD:1343412	6480464	beta-lapachone results in decreased expression of HUWE1 mRNA	CTD	PMID:38218311
Huwe1	Rat	bis(2-chloroethyl) sulfide	increases phosphorylation	ISO	RGD:1343412	6480464	Mustard Gas results in increased phosphorylation of HUWE1 protein	CTD	PMID:19845377
Huwe1	Rat	bis(2-ethylhexyl) phthalate	decreases expression	ISO	RGD:1557240	6480464	Diethylhexyl Phthalate results in decreased expression of HUWE1 mRNA	CTD	PMID:33754040
Huwe1	Rat	bisphenol A	increases expression	ISO	RGD:1557240	6480464	bisphenol A results in increased expression of HUWE1 mRNA	CTD	PMID:26063408
Huwe1	Rat	bisphenol A	increases expression	ISO	RGD:1343412	6480464	bisphenol A results in increased expression of HUWE1 protein	CTD	PMID:34186270\|PMID:37567409
Huwe1	Rat	bisphenol A	decreases methylation	ISO	RGD:1343412	6480464	bisphenol A results in decreased methylation of HUWE1 gene	CTD	PMID:31601247
Huwe1	Rat	bisphenol A	decreases expression	ISO	RGD:1557240	6480464	bisphenol A results in decreased expression of HUWE1 mRNA	CTD	PMID:33221593
Huwe1	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of HUWE1 mRNA	CTD	PMID:32145629
Huwe1	Rat	bisphenol A	decreases methylation	ISO	RGD:1557240	6480464	bisphenol A results in decreased methylation of HUWE1 promoter	CTD	PMID:27312807
Huwe1	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of HUWE1 mRNA	CTD	PMID:25181051
Huwe1	Rat	Bisphenol A diglycidyl ether	affects splicing	ISO	RGD:1557240	6480464	bisphenol A diglycidyl ether affects the splicing of HUWE1 mRNA	CTD	PMID:36464114
Huwe1	Rat	bisphenol AF	affects splicing	ISO	RGD:1557240	6480464	bisphenol AF affects the splicing of HUWE1 mRNA	CTD	PMID:36464114
Huwe1	Rat	bisphenol AF	increases expression	ISO	RGD:1343412	6480464	bisphenol AF results in increased expression of HUWE1 protein	CTD	PMID:34186270
Huwe1	Rat	bisphenol F	multiple interactions	ISO	RGD:1343412	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ...	CTD	PMID:28628672
Huwe1	Rat	bisphenol F	increases expression	ISO	RGD:1343412	6480464	bisphenol F results in increased expression of HUWE1 protein	CTD	PMID:34186270
Huwe1	Rat	cadmium atom	multiple interactions	ISO	RGD:1343412	6480464	2-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in more ...	CTD	PMID:38195004
Huwe1	Rat	cadmium dichloride	increases expression	ISO	RGD:1343412	6480464	Cadmium Chloride results in increased expression of HUWE1 mRNA	CTD	PMID:38382870
Huwe1	Rat	cadmium dichloride	multiple interactions	ISO	RGD:1343412	6480464	2-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in more ...	CTD	PMID:38195004
Huwe1	Rat	caffeine	affects phosphorylation	ISO	RGD:1343412	6480464	Caffeine affects the phosphorylation of HUWE1 protein	CTD	PMID:35688186
Huwe1	Rat	carbon nanotube	decreases expression	ISO	RGD:1557240	6480464	Nanotubes, Carbon analog results in decreased expression of HUWE1 mRNA	CTD	PMID:25554681
Huwe1	Rat	CGP 52608	multiple interactions	ISO	RGD:1343412	6480464	CGP 52608 promotes the reaction [RORA protein binds to HUWE1 gene]	CTD	PMID:28238834
Huwe1	Rat	chlorpyrifos	increases expression	ISO	RGD:1557240	6480464	Chlorpyrifos results in increased expression of HUWE1 mRNA	CTD	PMID:20350560
Huwe1	Rat	cisplatin	increases phosphorylation	ISO	RGD:1557240	6480464	Cisplatin results in increased phosphorylation of HUWE1 protein	CTD	PMID:22006019
Huwe1	Rat	coumarin	affects phosphorylation	ISO	RGD:1343412	6480464	coumarin affects the phosphorylation of HUWE1 protein	CTD	PMID:35688186
Huwe1	Rat	crocidolite asbestos	decreases expression	ISO	RGD:1557240	6480464	Asbestos, Crocidolite results in decreased expression of HUWE1 mRNA	CTD	PMID:29279043
Huwe1	Rat	dexamethasone	multiple interactions	ISO	RGD:1343412	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ...	CTD	PMID:28628672
Huwe1	Rat	diarsenic trioxide	increases expression	ISO	RGD:1343412	6480464	Arsenic Trioxide results in increased expression of HUWE1 mRNA	CTD	PMID:20458559
Huwe1	Rat	dicrotophos	increases expression	ISO	RGD:1343412	6480464	dicrotophos results in increased expression of HUWE1 mRNA	CTD	PMID:28302478
Huwe1	Rat	doxorubicin	increases expression	ISO	RGD:1343412	6480464	Doxorubicin results in increased expression of HUWE1 mRNA	CTD	PMID:16404146
Huwe1	Rat	enzyme inhibitor	multiple interactions	ISO	RGD:1343412	6480464	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation more ...	CTD	PMID:23301498
Huwe1	Rat	ethanol	affects splicing	ISO	RGD:1557240	6480464	Ethanol affects the splicing of HUWE1 mRNA	CTD	PMID:30319688
Huwe1	Rat	ethanol	increases expression	ISO	RGD:1557240	6480464	Ethanol results in increased expression of HUWE1 mRNA	CTD	PMID:30319688
Huwe1	Rat	flutamide	increases expression	EXP		6480464	Flutamide results in increased expression of HUWE1 mRNA	CTD	PMID:24136188
Huwe1	Rat	FR900359	affects phosphorylation	ISO	RGD:1343412	6480464	FR900359 affects the phosphorylation of HUWE1 protein	CTD	PMID:37730182
Huwe1	Rat	furfural	multiple interactions	ISO	RGD:1343412	6480464	[Furaldehyde co-treated with pyrogallol 1,3-dimethyl ether] results in decreased expression of HUWE1 protein; [Sodium Chloride more ...	CTD	PMID:38598786
Huwe1	Rat	glycochenodeoxycholic acid	multiple interactions	ISO	RGD:1343412	6480464	Glycochenodeoxycholic Acid inhibits the reaction [HUWE1 protein binds to MCL1 protein]	CTD	PMID:21507240
Huwe1	Rat	hexadecanoic acid	increases phosphorylation	ISO	RGD:1343412	6480464	Palmitic Acid results in increased phosphorylation of HUWE1 protein	CTD	PMID:28073184
Huwe1	Rat	indometacin	multiple interactions	ISO	RGD:1343412	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ...	CTD	PMID:28628672
Huwe1	Rat	ivermectin	decreases expression	ISO	RGD:1343412	6480464	Ivermectin results in decreased expression of HUWE1 protein	CTD	PMID:32959892
Huwe1	Rat	lead diacetate	multiple interactions	ISO	RGD:1557240	6480464	[lead acetate results in increased abundance of Lead] which results in decreased methylation of HUWE1 more ...	CTD	PMID:33445541
Huwe1	Rat	lead(0)	multiple interactions	ISO	RGD:1557240	6480464	[lead acetate results in increased abundance of Lead] which results in decreased methylation of HUWE1 more ...	CTD	PMID:33445541
Huwe1	Rat	lipopolysaccharide	increases expression	ISO	RGD:1343412	6480464	Lipopolysaccharides results in increased expression of HUWE1 mRNA	CTD	PMID:35811015
Huwe1	Rat	lipopolysaccharide	multiple interactions	ISO	RGD:1343412	6480464	[NAT10 protein affects the susceptibility to Lipopolysaccharides] which affects the expression of HUWE1 mRNA; [S-(1,2-dichlorovinyl)cysteine more ...	CTD	PMID:35811015\|PMID:35877022
Huwe1	Rat	manganese atom	multiple interactions	ISO	RGD:1343412	6480464	[manganese chloride results in increased abundance of Manganese] which results in decreased expression of HUWE1 more ...	CTD	PMID:39836092
Huwe1	Rat	manganese(0)	multiple interactions	ISO	RGD:1343412	6480464	[manganese chloride results in increased abundance of Manganese] which results in decreased expression of HUWE1 more ...	CTD	PMID:39836092
Huwe1	Rat	manganese(II) chloride	multiple interactions	ISO	RGD:1343412	6480464	[manganese chloride results in increased abundance of Manganese] which results in decreased expression of HUWE1 more ...	CTD	PMID:39836092
Huwe1	Rat	methapyrilene	decreases methylation	ISO	RGD:1343412	6480464	Methapyrilene results in decreased methylation of HUWE1 exon	CTD	PMID:30157460
Huwe1	Rat	ozone	multiple interactions	ISO	RGD:1343412	6480464	[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of more ...	CTD	PMID:32699268
Huwe1	Rat	perfluorooctane-1-sulfonic acid	decreases expression	ISO	RGD:1343412	6480464	perfluorooctane sulfonic acid results in decreased expression of HUWE1 protein	CTD	PMID:24301089
Huwe1	Rat	pirinixic acid	increases expression	ISO	RGD:1557240	6480464	pirinixic acid results in increased expression of HUWE1 mRNA	CTD	PMID:23811191
Huwe1	Rat	rac-lactic acid	increases expression	ISO	RGD:1343412	6480464	Lactic Acid results in increased expression of HUWE1 mRNA	CTD	PMID:30851411
Huwe1	Rat	S-(1,2-dichlorovinyl)-L-cysteine	multiple interactions	ISO	RGD:1343412	6480464	[S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of HUWE1 mRNA	CTD	PMID:35811015
Huwe1	Rat	SB 431542	multiple interactions	ISO	RGD:1343412	6480464	[LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in increased expression of HUWE1 more ...	CTD	PMID:37664457
Huwe1	Rat	silicon dioxide	decreases expression	ISO	RGD:1557240	6480464	Silicon Dioxide analog results in decreased expression of HUWE1 mRNA	CTD	PMID:26263183
Huwe1	Rat	sodium arsenate	increases expression	ISO	RGD:1557240	6480464	sodium arsenate results in increased expression of HUWE1 mRNA	CTD	PMID:21795629
Huwe1	Rat	sodium arsenite	multiple interactions	ISO	RGD:1343412	6480464	[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of HUWE1 more ...	CTD	PMID:33939924\|PMID:39836092
Huwe1	Rat	sodium arsenite	increases expression	ISO	RGD:1557240	6480464	sodium arsenite results in increased expression of HUWE1 mRNA	CTD	PMID:36209798
Huwe1	Rat	sodium chloride	multiple interactions	ISO	RGD:1343412	6480464	[Sodium Chloride co-treated with Furaldehyde] results in decreased expression of HUWE1 protein; [Sodium Chloride co-treated more ...	CTD	PMID:38598786
Huwe1	Rat	tetrachloromethane	increases expression	ISO	RGD:1557240	6480464	Carbon Tetrachloride results in increased expression of HUWE1 mRNA	CTD	PMID:31919559
Huwe1	Rat	thapsigargin	decreases expression	EXP		6480464	Thapsigargin results in decreased expression of HUWE1 protein	CTD	PMID:35544339
Huwe1	Rat	titanium dioxide	increases expression	ISO	RGD:1557240	6480464	titanium dioxide results in increased expression of HUWE1 mRNA	CTD	PMID:23557971\|PMID:29264374
Huwe1	Rat	titanium dioxide	increases methylation	ISO	RGD:1557240	6480464	titanium dioxide results in increased methylation of HUWE1 gene	CTD	PMID:35295148
Huwe1	Rat	titanium dioxide	affects expression	ISO	RGD:1557240	6480464	titanium dioxide affects the expression of HUWE1 mRNA	CTD	PMID:17656681
Huwe1	Rat	triphenyl phosphate	affects expression	ISO	RGD:1343412	6480464	triphenyl phosphate affects the expression of HUWE1 mRNA	CTD	PMID:37042841
Huwe1	Rat	triptonide	decreases expression	ISO	RGD:1557240	6480464	triptonide results in decreased expression of HUWE1 mRNA	CTD	PMID:33045310
Huwe1	Rat	troglitazone	decreases expression	ISO	RGD:1557240	6480464	troglitazone results in decreased expression of HUWE1 mRNA	CTD	PMID:28973697
Huwe1	Rat	trovafloxacin	decreases expression	ISO	RGD:1557240	6480464	trovafloxacin results in decreased expression of HUWE1 mRNA	CTD	PMID:35537566
Huwe1	Rat	tungsten	decreases expression	ISO	RGD:1557240	6480464	Tungsten results in decreased expression of HUWE1 mRNA	CTD	PMID:30912803
Huwe1	Rat	valproic acid	decreases methylation	ISO	RGD:1343412	6480464	Valproic Acid results in decreased methylation of HUWE1 gene	CTD	PMID:29154799

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Huwe1	Rat	base-excision repair	involved_in	ISS	UniProtKB:Q7Z6Z7	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Huwe1	Rat	base-excision repair	involved_in	IBA	PANTHER:PTN002600464\|UniProtKB:Q7Z6Z7	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Huwe1	Rat	base-excision repair	involved_in	ISO	RGD:1343412	1624291	PMID:19713937	RGD	PMID:19713937
Huwe1	Rat	cell differentiation	involved_in	IEA	UniProtKB-KW:KW-0221	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Huwe1	Rat	chromatin remodeling	involved_in	IEA	GO:0140852	1600115	GO_REF:0000108	GOC	GO_REF:0000108
Huwe1	Rat	circadian regulation of gene expression	involved_in	ISO	RGD:1343412	1624291	PMID:20534529	RGD	PMID:20534529
Huwe1	Rat	circadian regulation of gene expression	involved_in	ISO	RGD:1557240	1624291	PMID:20534529	RGD	PMID:20534529
Huwe1	Rat	circadian regulation of gene expression	involved_in	ISS	UniProtKB:Q7TMY8	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Huwe1	Rat	DNA damage response	involved_in	IEA	UniProtKB-KW:KW-0227	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Huwe1	Rat	DNA repair	involved_in	IEA	UniProtKB-KW:KW-0234	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Huwe1	Rat	Golgi organization	involved_in	IBA	PANTHER:PTN007498696\|UniProtKB:Q8IYU2	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Huwe1	Rat	membrane fusion	involved_in	IBA	PANTHER:PTN007498696\|UniProtKB:Q8IYU2	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Huwe1	Rat	negative regulation of mitochondrial fusion	involved_in	ISO	RGD:1343412	1624291	PMID:26214738	RGD	PMID:26214738
Huwe1	Rat	negative regulation of peroxisome proliferator activated receptor signaling pathway	involved_in	ISO	RGD:1557240	1624291	PMID:29331071	RGD	PMID:29331071
Huwe1	Rat	negative regulation of peroxisome proliferator activated receptor signaling pathway	involved_in	ISS	UniProtKB:Q7TMY8	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Huwe1	Rat	positive regulation of canonical NF-kappaB signal transduction	involved_in	ISO	RGD:1343412	1624291	PMID:27746020	RGD	PMID:27746020
Huwe1	Rat	positive regulation of canonical NF-kappaB signal transduction	involved_in	ISS	UniProtKB:Q7Z6Z7	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Huwe1	Rat	positive regulation of protein targeting to mitochondrion	involved_in	ISO	RGD:1343412	9068941	PMID:24270810	ParkinsonsUK-UCL	PMID:24270810
Huwe1	Rat	positive regulation of protein ubiquitination	involved_in	ISS	UniProtKB:Q7TMY8	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Huwe1	Rat	positive regulation of protein ubiquitination	involved_in	ISO	RGD:1557240	1624291	PMID:20534529	RGD	PMID:20534529
Huwe1	Rat	positive regulation of protein ubiquitination	involved_in	ISO	RGD:1343412	1624291	PMID:20534529	RGD	PMID:20534529
Huwe1	Rat	positive regulation of type 2 mitophagy	involved_in	ISO	RGD:1343412	1624291	PMID:30217973	RGD	PMID:30217973
Huwe1	Rat	proteasome-mediated ubiquitin-dependent protein catabolic process	involved_in	ISO	RGD:1557240	1624291	PMID:29331071	RGD	PMID:29331071
Huwe1	Rat	proteasome-mediated ubiquitin-dependent protein catabolic process	involved_in	ISS	UniProtKB:Q7TMY8	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Huwe1	Rat	protein branched polyubiquitination	involved_in	ISS	UniProtKB:Q7Z6Z7	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Huwe1	Rat	protein branched polyubiquitination	involved_in	ISO	RGD:1343412	1624291	PMID:27746020	RGD	PMID:27746020
Huwe1	Rat	protein K48-linked ubiquitination	involved_in	ISS	UniProtKB:Q7Z6Z7	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Huwe1	Rat	protein K48-linked ubiquitination	involved_in	ISO	RGD:1343412	1624291	PMID:27746020	RGD	PMID:27746020
Huwe1	Rat	protein monoubiquitination	involved_in	ISS	UniProtKB:Q7Z6Z7	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Huwe1	Rat	protein monoubiquitination	involved_in	ISO	RGD:1343412	1624291	PMID:19713937	RGD	PMID:19713937
Huwe1	Rat	protein polyubiquitination	involved_in	ISS	UniProtKB:Q7Z6Z7	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Huwe1	Rat	protein polyubiquitination	involved_in	ISO	RGD:1343412	1624291	PMID:15989957	RGD	PMID:15989957
Huwe1	Rat	protein ubiquitination	involved_in	IEA	UniPathway:UPA00143	1600115	GO_REF:0000041	UniProt	GO_REF:0000041
Huwe1	Rat	rhythmic process	involved_in	IEA	UniProtKB-KW:KW-0090	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Huwe1	Rat	ubiquitin-dependent protein catabolic process	involved_in	IBA	FB:FBgn0029006\|MGI:1202301\|MGI:1861728\|MGI:1914144\|MGI:1915747\|MGI:1926884\|MGI:1933754\|MGI:97297\|PANTHER:PTN008515277\|SGD:S000000927\|SGD:S000002865\|UniProtKB:O00308\|UniProtKB:O15033\|UniProtKB:P46934\|UniProtKB:Q5BDP1\|UniProtKB:Q8IYU2\|UniProtKB:Q96J02\|UniProtKB:Q96PU5\|UniProtKB:Q9HAU4\|UniProtKB:Q9HCE7	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Huwe1	Rat	cytoplasm	is_active_in	IBA	FB:FBgn0003557\|FB:FBgn0029006\|FB:FBgn0259174\|FB:FBgn0261931\|MGI:1202301\|MGI:1914144\|MGI:97297\|PANTHER:PTN008515277\|PomBase:SPAC11G7.02\|PomBase:SPAC1805.15c\|SGD:S000000927\|TAIR:locus:2135630\|UniProtKB:O15033\|UniProtKB:P46934\|UniProtKB:Q7Z6Z7\|UniProtKB:Q8IYU2\|UniProtKB:Q96J02\|UniProtKB:Q9HCE7\|WB:WBGene00007009	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Huwe1	Rat	cytoplasm	located_in	IEA	UniProtKB-KW:KW-0963	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Huwe1	Rat	cytoplasm	located_in	IEA	UniProtKB-SubCell:SL-0086	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Huwe1	Rat	cytoplasm	located_in	ISO	RGD:1343412	1624291	PMID:19713937	RGD	PMID:19713937
Huwe1	Rat	cytoplasm	located_in	ISS	UniProtKB:Q7Z6Z7	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Huwe1	Rat	cytosol	located_in	ISO	RGD:1343412\|UniProtKB:Q7Z6Z7-1\|UniProtKB:Q7Z6Z7-3	1624291		RGD	GO_REF:0000052
Huwe1	Rat	Golgi membrane	is_active_in	IBA	PANTHER:PTN007498696\|UniProtKB:Q8IYU2	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Huwe1	Rat	mitochondrion	located_in	IEA	UniProtKB-SubCell:SL-0173	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Huwe1	Rat	mitochondrion	located_in	IEA	UniProtKB-KW:KW-0496	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Huwe1	Rat	nucleoplasm	located_in	ISO	RGD:1343412\|UniProtKB:Q7Z6Z7-1\|UniProtKB:Q7Z6Z7-3	1624291		RGD	GO_REF:0000052
Huwe1	Rat	nucleus	located_in	IEA	UniProtKB-SubCell:SL-0191	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Huwe1	Rat	nucleus	located_in	IEA	UniProtKB-KW:KW-0539	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Huwe1	Rat	nucleus	is_active_in	IBA	FB:FBgn0030674\|PANTHER:PTN000135257\|RGD:1561763\|UniProtKB:Q7Z6Z7\|UniProtKB:Q8IYU2	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Huwe1	Rat	nucleus	located_in	IDA		8554643	PMID:7968380	UniProt

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Huwe1	Rat	DNA binding	enables	IDA		8554643	PMID:7968380	UniProt
Huwe1	Rat	DNA binding	enables	IEA	UniProtKB-KW:KW-0238	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Huwe1	Rat	histone ubiquitin ligase activity	enables	ISO	RGD:1343412	1624291	PMID:15767685	RGD	PMID:15767685
Huwe1	Rat	histone ubiquitin ligase activity	enables	ISS	UniProtKB:Q7Z6Z7	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Huwe1	Rat	protein binding	enables	ISO	RGD:1343412	1624291	UniProtKB:A0A7P0TBJ1\|UniProtKB:P04637\|UniProtKB:P04792\|UniProtKB:P06746\|UniProtKB:P20393\|UniProtKB:Q07820\|UniProtKB:Q13107\|UniProtKB:Q14CZ0\|UniProtKB:Q8N726\|UniProtKB:Q96C12\|UniProtKB:Q9C0C7 PMID:15989956, PMID:19713937, PMID:20023629, PMID:20534529, PMID:21507240, PMID:21522127, PMID:25277244, PMID:26496610, PMID:28169274, PMID:30217973, PMID:33961781, PMID:35776542, PMID:36631436	RGD	PMID:15989956\|PMID:19713937\|PMID:20023629\|PMID:20534529\|PMID:21507240\|PMID:21522127\|PMID:25277244\|PMID:26496610\|PMID:28169274\|PMID:30217973\|PMID:33961781\|PMID:35776542\|PMID:36631436
Huwe1	Rat	protein binding	enables	IPI	UniProtKB:A0A0G2K916,UniProtKB:B2GV38,UniProtKB:B5DFN4,UniProtKB:D3Z941,UniProtKB:D4AA63,UniProtKB:F1M853,UniProtKB:P11250,UniProtKB:P61107,UniProtKB:P62718,UniProtKB:P97612,UniProtKB:Q09167,UniProtKB:Q498M4,UniProtKB:Q5PPJ6,UniProtKB:Q5PPK9,UniProtKB:Q63569,UniProtKB:Q6AYJ7	11344934	PMID:27191843	UniProt
Huwe1	Rat	protein binding	enables	ISO	RGD:1343412,UniProtKB:Q7Z6Z7-2	1624291	UniProtKB:P12830\|UniProtKB:P27797\|UniProtKB:P36957\|UniProtKB:Q8TDX7 PMID:32814053	RGD	PMID:32814053
Huwe1	Rat	transferase activity	enables	IEA	UniProtKB-KW:KW-0808	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Huwe1	Rat	ubiquitin protein ligase activity	enables	ISO	RGD:1557240	1624291	PMID:29331071	RGD	PMID:29331071
Huwe1	Rat	ubiquitin protein ligase activity	enables	ISO	RGD:1343412	1624291	PMID:26214738, PMID:27746020, PMID:30217973	RGD	PMID:26214738\|PMID:27746020\|PMID:30217973
Huwe1	Rat	ubiquitin protein ligase activity	enables	IBA	FB:FBgn0003557\|FB:FBgn0029006\|FB:FBgn0259174\|FB:FBgn0261931\|MGI:1861728\|MGI:1914144\|MGI:1926884\|MGI:1933754\|MGI:97297\|PANTHER:PTN008515277\|PomBase:SPAC11G7.02\|PomBase:SPAC1805.15c\|SGD:S000000927\|UniProtKB:O15033\|UniProtKB:P46934\|UniProtKB:Q7Z6Z7\|UniProtKB:Q96J02\|UniProtKB:Q96PU5\|UniProtKB:Q9HAU4\|UniProtKB:Q9HCE7	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Huwe1	Rat	ubiquitin protein ligase activity	enables	ISS	UniProtKB:Q7TMY8	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Huwe1	Rat	ubiquitin protein ligase activity	enables	ISS	UniProtKB:Q7Z6Z7	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Huwe1	Rat	ubiquitin-protein transferase activity	enables	IEA	InterPro:IPR000569\|InterPro:IPR035983	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Huwe1	Rat	ubiquitin-protein transferase activity	enables	ISO	RGD:1343412	1624291	PMID:15989957, PMID:19713937	RGD	PMID:15989957\|PMID:19713937
Huwe1	Rat	ubiquitin-protein transferase activity	enables	ISS	UniProtKB:Q7Z6Z7	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Huwe1	Rat	ubiquitin-ubiquitin ligase activity	enables	ISO	RGD:1343412	1624291	PMID:27746020	RGD	PMID:27746020

Molecular Pathway Annotations Click to see Annotation Detail View

Imported Annotations - PID (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Huwe1	Rat	p53 signaling pathway		ISO	RGD:1343412	9068941		PID	PID:200206

Disease Annotations Click to see Annotation Detail View

Atkin Syndrome (ISO)

autism spectrum disorder (ISO)

autistic disorder (ISO)

blepharophimosis (ISO)

chromosome Xp11.22 duplication syndrome (ISO)

Cornelia de Lange syndrome 2 (ISO)

Developmental Disabilities (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Neurodevelopmental Disorders (ISO)

non-syndromic intellectual disability (ISO)

non-syndromic X-linked intellectual disability (ISO)

non-syndromic X-linked intellectual disability 1 (ISO)

non-syndromic X-linked intellectual disability 99 (ISO)

Say Meyer Syndrome (ISO)

spermatogenic failure 57 (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

syndromic X-linked intellectual disability Turner type (ISO)

X-Linked Intellectual Developmental Disorders (ISO)

X-linked mental retardation-hypotonic facies syndrome-1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-marinopyrrole A (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,6-dimethoxyphenol (ISO)

2-bromohexadecanoic acid (ISO)

2-hydroxypropanoic acid (ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acrolein (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

alpha-pinene (ISO)

antirheumatic drug (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

beta-lapachone (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol A diglycidyl ether (ISO)

bisphenol AF (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

coumarin (ISO)

crocidolite asbestos (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

flutamide (EXP)

FR900359 (ISO)

furfural (ISO)

glycochenodeoxycholic acid (ISO)

hexadecanoic acid (ISO)

indometacin (ISO)

ivermectin (ISO)

lead diacetate (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methapyrilene (ISO)

ozone (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

rac-lactic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

tetrachloromethane (ISO)

thapsigargin (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

troglitazone (ISO)

trovafloxacin (ISO)

tungsten (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

base-excision repair (IBA,ISO,ISS)

cell differentiation (IEA)

chromatin remodeling (IEA)

circadian regulation of gene expression (ISO,ISS)

DNA damage response (IEA)

DNA repair (IEA)

Golgi organization (IBA)

membrane fusion (IBA)

negative regulation of mitochondrial fusion (ISO)

negative regulation of peroxisome proliferator activated receptor signaling pathway (ISO,ISS)

positive regulation of canonical NF-kappaB signal transduction (ISO,ISS)

positive regulation of protein targeting to mitochondrion (ISO)

positive regulation of protein ubiquitination (ISO,ISS)

positive regulation of type 2 mitophagy (ISO)

proteasome-mediated ubiquitin-dependent protein catabolic process (ISO,ISS)

protein branched polyubiquitination (ISO,ISS)

protein K48-linked ubiquitination (ISO,ISS)

protein monoubiquitination (ISO,ISS)

protein polyubiquitination (ISO,ISS)

protein ubiquitination (IEA)

rhythmic process (IEA)

ubiquitin-dependent protein catabolic process (IBA)

Cellular Component

cytoplasm (IBA,IEA,ISO,ISS)

cytosol (ISO)

Golgi membrane (IBA)

mitochondrion (IEA)

nucleoplasm (ISO)

nucleus (IBA,IDA,IEA)

Molecular Function

DNA binding (IDA,IEA)

histone ubiquitin ligase activity (ISO,ISS)

protein binding (IPI,ISO)

transferase activity (IEA)

ubiquitin protein ligase activity (IBA,ISO,ISS)

ubiquitin-protein transferase activity (IEA,ISO,ISS)

ubiquitin-ubiquitin ligase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

p53 signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Cloning of a DNA binding protein that is a tyrosine kinase substrate and recognizes an upstream initiator-like sequence in the promoter of the preprodynorphin gene.	Gu J, etal., Brain Res Mol Brain Res. 1994 Jul;24(1-4):77-88.
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
8.	The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles.	Topalidou I, etal., PLoS Genet. 2016 May 18;12(5):e1006074. doi: 10.1371/journal.pgen.1006074. eCollection 2016 May.

Additional References at PubMed

PMID:7478539	PMID:15767685	PMID:15989957	PMID:19028597	PMID:19056867	PMID:19713937	PMID:19946888	PMID:20534529	PMID:22658674	PMID:24270810	PMID:26214738	PMID:26698301
PMID:30217973	PMID:30221657

Genomics

Comparative Map Data

Huwe1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	24,350,708 - 24,480,798 (+)	NCBI		GRCr8
mRatBN7.2	X	20,873,795 - 21,001,378 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	20,873,795 - 21,001,262 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	X	21,474,627 - 21,603,348 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	21,499,934 - 21,598,876 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	21,848,515 - 21,950,709 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	X	23,634,031 - 23,635,008 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	41,269,837 - 41,397,687 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	21,152,936 - 21,282,567 (+)	NCBI		Celera
Cytogenetic Map	X	q13	NCBI

HUWE1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	53,532,096 - 53,686,719 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	53,532,096 - 53,686,752 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	53,559,057 - 53,713,664 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	53,576,476 - 53,697,776 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	X	57,390,630 - 57,545,232 (-)	NCBI		Celera
Cytogenetic Map	X	p11.22	NCBI
HuRef	X	50,615,901 - 50,769,910 (-)	NCBI		HuRef
CHM1_1	X	53,550,037 - 53,704,971 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	52,818,443 - 52,973,077 (-)	NCBI		T2T-CHM13v2.0

Huwe1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	150,583,779 - 150,718,413 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	150,583,803 - 150,718,413 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	151,800,785 - 151,935,417 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	151,800,807 - 151,935,417 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	148,237,825 - 148,369,960 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	147,144,043 - 147,275,608 (+)	NCBI		MGSCv36	mm8
Celera	X	132,494,924 - 132,629,529 (-)	NCBI		Celera
Cytogenetic Map	X	F3	NCBI
cM Map	X	68.46	NCBI

Huwe1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955475	551,159 - 671,747 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955475	550,643 - 671,771 (-)	NCBI	ChiLan1.0	ChiLan1.0

HUWE1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	54,931,498 - 55,081,896 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	54,935,098 - 55,085,490 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	45,746,228 - 45,897,250 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	53,855,404 - 54,005,383 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	53,855,404 - 54,005,366 (-)	Ensembl	panpan1.1		panPan2

HUWE1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	45,234,666 - 45,409,641 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	45,234,322 - 45,410,043 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	36,751,409 - 36,836,872 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	45,559,669 - 45,734,540 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	45,559,746 - 45,731,948 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	45,054,717 - 45,229,543 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	45,504,350 - 45,679,158 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	45,571,951 - 45,747,074 (-)	NCBI		UU_Cfam_GSD_1.0

Huwe1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	38,139,253 - 38,283,118 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936751	478,300 - 622,820 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936751	478,978 - 622,818 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HUWE1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	46,281,967 - 46,444,228 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	46,281,958 - 46,444,315 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	51,780,471 - 51,942,782 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HUWE1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	49,661,506 - 49,814,551 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	49,660,790 - 49,808,572 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666086	3,622,912 - 3,777,017 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Huwe1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624909	745,651 - 859,233 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624909	745,141 - 891,421 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Huwe1
277 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	271
Count of miRNA genes:	170
Interacting mature miRNAs:	206
Transcripts:	ENSRNOT00000003882, ENSRNOT00000004064
Prediction methods:	Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1598873	Memor2	Memory QTL 2	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	X	20990947	41052531	Rat
70165	Bp64	Blood pressure QTL 64	5.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	1448129	31706553	Rat
1298071	Edpm12	Estrogen-dependent pituitary mass QTL 12	3.2		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	X	2927898	47927898	Rat
2290375	Gluco34	Glucose level QTL 34	2.75		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	20990947	41203591	Rat
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1	43491017	Rat
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
10755455	Coatc13	Coat color QTL 13		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	4406000	49406000	Rat
631666	Iddm5	Insulin dependent diabetes mellitus QTL 5			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	4494549	49494549	Rat
634325	Bw13	Body weight QTL 13	0		body mass (VT:0001259)	body weight (CMO:0000012)	X	1447972	20991088	Rat
631204	Gluco15	Glucose level QTL 15		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	1623715	22646544	Rat
71116	Niddm16	Non-insulin dependent diabetes mellitus QTL 16	7.81		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	15297802	60297802	Rat

Markers in Region

DXRat8

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	X	24,470,360 - 24,470,521 (+)	Marker Load Pipeline
mRatBN7.2	X	20,990,947 - 20,991,088 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	21,592,623 - 21,592,783	NCBI	Rnor6.0
Rnor_5.0	X	21,859,080 - 21,859,240	UniSTS	Rnor5.0
RGSC_v3.4	X	41,386,788 - 41,387,080	RGD	RGSC3.4
RGSC_v3.4	X	41,386,879 - 41,387,039	UniSTS	RGSC3.4
RGSC_v3.1	X	41,440,348 - 41,440,508	RGD
Celera	X	21,272,130 - 21,272,290	UniSTS
RH 3.4 Map	X	186.31	RGD
RH 3.4 Map	X	186.31	UniSTS
RH 2.0 Map	21	223.4	RGD
SHRSP x BN Map	X	6.8999	RGD
FHH x ACI Map	X	7.93	RGD
Cytogenetic Map	X	q21	UniSTS

AU046935

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	X	24,470,385 - 24,470,626 (+)	Marker Load Pipeline
Rnor_6.0	X	21,592,648 - 21,592,888	NCBI	Rnor6.0
Rnor_5.0	X	21,858,975 - 21,859,215	UniSTS	Rnor5.0
RGSC_v3.4	X	41,386,904 - 41,387,144	UniSTS	RGSC3.4
Celera	X	21,272,155 - 21,272,395	UniSTS
Cytogenetic Map	X	q21	UniSTS

RH142513

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	20,939,081 - 20,939,309 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	21,539,418 - 21,539,645	NCBI	Rnor6.0
Rnor_5.0	X	21,910,974 - 21,911,201	UniSTS	Rnor5.0
RGSC_v3.4	X	41,335,217 - 41,335,444	UniSTS	RGSC3.4
Celera	X	21,220,268 - 21,220,495	UniSTS
Cytogenetic Map	X	q21	UniSTS

AU048657

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	20,910,547 - 20,910,793 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	21,511,228 - 21,511,473	NCBI	Rnor6.0
Rnor_5.0	X	21,939,146 - 21,939,391	UniSTS	Rnor5.0
RGSC_v3.4	X	41,306,598 - 41,306,843	UniSTS	RGSC3.4
Celera	X	21,191,983 - 21,192,228	UniSTS
Cytogenetic Map	X	q21	UniSTS

MARC_15341-15342:1017678837:1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	X	24,470,203 - 24,471,096 (+)	Marker Load Pipeline
Rnor_6.0	X	21,592,466 - 21,593,358	NCBI	Rnor6.0
Rnor_5.0	X	21,858,505 - 21,859,397	UniSTS	Rnor5.0
RGSC_v3.4	X	41,386,722 - 41,387,614	UniSTS	RGSC3.4
Celera	X	21,271,973 - 21,272,865	UniSTS
Cytogenetic Map	X	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001408927	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280197	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280198	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280199	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280201	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280202	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280203	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280204	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280205	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280206	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280207	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280209	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280210	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280211	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280212	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280213	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280214	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280215	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280217	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280218	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280221	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280223	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280224	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280225	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280226	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280227	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280228	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280229	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280230	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280231	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280232	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280233	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280234	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280235	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280237	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280238	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280239	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_576948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001835014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001835015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001835016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001835017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001835018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001835019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001835020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001835021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001835022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001835023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001835024	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001835025	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001835026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001842623	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_589680	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_589682	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC086550	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211870	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000081037 ⟹ ENSRNOP00000069644

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	20,903,082 - 20,996,599 (+)	Ensembl
Rnor_6.0 Ensembl	X	21,499,934 - 21,598,876 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000090890 ⟹ ENSRNOP00000071818

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	20,873,795 - 21,001,262 (+)	Ensembl
Rnor_6.0 Ensembl	X	21,499,934 - 21,539,503 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098599 ⟹ ENSRNOP00000095129

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	20,873,795 - 21,001,262 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109386 ⟹ ENSRNOP00000088915

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	20,873,795 - 21,001,262 (+)	Ensembl

RefSeq Acc Id:

NM_001408927 ⟹ NP_001395856

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,217 - 24,480,798 (+)	NCBI
mRatBN7.2	X	20,873,795 - 21,001,378 (+)	NCBI

RefSeq Acc Id:

XM_063280197 ⟹ XP_063136267

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280198 ⟹ XP_063136268

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,321 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280199 ⟹ XP_063136269

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,350,708 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280200 ⟹ XP_063136270

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280201 ⟹ XP_063136271

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280202 ⟹ XP_063136272

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,321 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280203 ⟹ XP_063136273

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,326 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280204 ⟹ XP_063136274

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,321 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280205 ⟹ XP_063136275

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280206 ⟹ XP_063136276

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280207 ⟹ XP_063136277

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,321 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280208 ⟹ XP_063136278

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,350,708 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280209 ⟹ XP_063136279

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,350,794 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280210 ⟹ XP_063136280

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280211 ⟹ XP_063136281

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280212 ⟹ XP_063136282

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280213 ⟹ XP_063136283

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280214 ⟹ XP_063136284

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280215 ⟹ XP_063136285

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280216 ⟹ XP_063136286

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,321 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280217 ⟹ XP_063136287

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,321 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280218 ⟹ XP_063136288

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,321 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280219 ⟹ XP_063136289

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,326 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280220 ⟹ XP_063136290

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280221 ⟹ XP_063136291

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280222 ⟹ XP_063136292

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,350,708 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280223 ⟹ XP_063136293

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280224 ⟹ XP_063136294

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280225 ⟹ XP_063136295

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280226 ⟹ XP_063136296

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280227 ⟹ XP_063136297

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280228 ⟹ XP_063136298

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280229 ⟹ XP_063136299

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280230 ⟹ XP_063136300

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,321 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280231 ⟹ XP_063136301

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280232 ⟹ XP_063136302

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,350,746 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280233 ⟹ XP_063136303

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,350,708 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280234 ⟹ XP_063136304

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280235 ⟹ XP_063136305

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280236 ⟹ XP_063136306

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280237 ⟹ XP_063136307

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280238 ⟹ XP_063136308

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

RefSeq Acc Id:

XM_063280239 ⟹ XP_063136309

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	24,353,322 - 24,480,794 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001395856	(Get FASTA)	NCBI Sequence Viewer
	XP_063136267	(Get FASTA)	NCBI Sequence Viewer
	XP_063136268	(Get FASTA)	NCBI Sequence Viewer
	XP_063136269	(Get FASTA)	NCBI Sequence Viewer
	XP_063136270	(Get FASTA)	NCBI Sequence Viewer
	XP_063136271	(Get FASTA)	NCBI Sequence Viewer
	XP_063136272	(Get FASTA)	NCBI Sequence Viewer
	XP_063136273	(Get FASTA)	NCBI Sequence Viewer
	XP_063136274	(Get FASTA)	NCBI Sequence Viewer
	XP_063136275	(Get FASTA)	NCBI Sequence Viewer
	XP_063136276	(Get FASTA)	NCBI Sequence Viewer
	XP_063136277	(Get FASTA)	NCBI Sequence Viewer
	XP_063136278	(Get FASTA)	NCBI Sequence Viewer
	XP_063136279	(Get FASTA)	NCBI Sequence Viewer
	XP_063136280	(Get FASTA)	NCBI Sequence Viewer
	XP_063136281	(Get FASTA)	NCBI Sequence Viewer
	XP_063136282	(Get FASTA)	NCBI Sequence Viewer
	XP_063136283	(Get FASTA)	NCBI Sequence Viewer
	XP_063136284	(Get FASTA)	NCBI Sequence Viewer
	XP_063136285	(Get FASTA)	NCBI Sequence Viewer
	XP_063136286	(Get FASTA)	NCBI Sequence Viewer
	XP_063136287	(Get FASTA)	NCBI Sequence Viewer
	XP_063136288	(Get FASTA)	NCBI Sequence Viewer
	XP_063136289	(Get FASTA)	NCBI Sequence Viewer
	XP_063136290	(Get FASTA)	NCBI Sequence Viewer
	XP_063136291	(Get FASTA)	NCBI Sequence Viewer
	XP_063136292	(Get FASTA)	NCBI Sequence Viewer
	XP_063136293	(Get FASTA)	NCBI Sequence Viewer
	XP_063136294	(Get FASTA)	NCBI Sequence Viewer
	XP_063136295	(Get FASTA)	NCBI Sequence Viewer
	XP_063136296	(Get FASTA)	NCBI Sequence Viewer
	XP_063136297	(Get FASTA)	NCBI Sequence Viewer
	XP_063136298	(Get FASTA)	NCBI Sequence Viewer
	XP_063136299	(Get FASTA)	NCBI Sequence Viewer
	XP_063136300	(Get FASTA)	NCBI Sequence Viewer
	XP_063136301	(Get FASTA)	NCBI Sequence Viewer
	XP_063136302	(Get FASTA)	NCBI Sequence Viewer
	XP_063136303	(Get FASTA)	NCBI Sequence Viewer
	XP_063136304	(Get FASTA)	NCBI Sequence Viewer
	XP_063136305	(Get FASTA)	NCBI Sequence Viewer
	XP_063136306	(Get FASTA)	NCBI Sequence Viewer
	XP_063136307	(Get FASTA)	NCBI Sequence Viewer
	XP_063136308	(Get FASTA)	NCBI Sequence Viewer
	XP_063136309	(Get FASTA)	NCBI Sequence Viewer
	XP_576948	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH86550	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000069644
	ENSRNOP00000071818
	ENSRNOP00000088915
	ENSRNOP00000095129
	ENSRNOP00000095129.1
GenBank Protein	P51593	(Get FASTA)	NCBI Sequence Viewer

Ensembl Acc Id:

ENSRNOP00000071818 ⟸ ENSRNOT00000090890

Ensembl Acc Id:

ENSRNOP00000069644 ⟸ ENSRNOT00000081037

Ensembl Acc Id:

ENSRNOP00000095129 ⟸ ENSRNOT00000098599

Ensembl Acc Id:

ENSRNOP00000088915 ⟸ ENSRNOT00000109386

RefSeq Acc Id:	NP_001395856 ⟸ NM_001408927
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL), A0A8I6A634 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136303 ⟸ XM_063280233
- Peptide Label:	isoform X14
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL), A0A8I6A634 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136269 ⟸ XM_063280199
- Peptide Label:	isoform X1
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136292 ⟸ XM_063280222
- Peptide Label:	isoform X6
- UniProtKB:	P51593 (UniProtKB/Swiss-Prot), A0A8I6APS3 (UniProtKB/Swiss-Prot), E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136278 ⟸ XM_063280208
- Peptide Label:	isoform X1
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136302 ⟸ XM_063280232
- Peptide Label:	isoform X14
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL), A0A8I6A634 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136279 ⟸ XM_063280209
- Peptide Label:	isoform X1
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136268 ⟸ XM_063280198
- Peptide Label:	isoform X1
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136286 ⟸ XM_063280216
- Peptide Label:	isoform X6
- UniProtKB:	P51593 (UniProtKB/Swiss-Prot), A0A8I6APS3 (UniProtKB/Swiss-Prot), E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136274 ⟸ XM_063280204
- Peptide Label:	isoform X1
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136287 ⟸ XM_063280217
- Peptide Label:	isoform X6
- UniProtKB:	P51593 (UniProtKB/Swiss-Prot), A0A8I6APS3 (UniProtKB/Swiss-Prot), E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136300 ⟸ XM_063280230
- Peptide Label:	isoform X14
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL), A0A8I6A634 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136277 ⟸ XM_063280207
- Peptide Label:	isoform X1
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136272 ⟸ XM_063280202
- Peptide Label:	isoform X1
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136288 ⟸ XM_063280218
- Peptide Label:	isoform X6
- UniProtKB:	P51593 (UniProtKB/Swiss-Prot), A0A8I6APS3 (UniProtKB/Swiss-Prot), E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136275 ⟸ XM_063280205
- Peptide Label:	isoform X1
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136271 ⟸ XM_063280201
- Peptide Label:	isoform X1
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136285 ⟸ XM_063280215
- Peptide Label:	isoform X6
- UniProtKB:	P51593 (UniProtKB/Swiss-Prot), A0A8I6APS3 (UniProtKB/Swiss-Prot), E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136276 ⟸ XM_063280206
- Peptide Label:	isoform X1
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136291 ⟸ XM_063280221
- Peptide Label:	isoform X6
- UniProtKB:	P51593 (UniProtKB/Swiss-Prot), A0A8I6APS3 (UniProtKB/Swiss-Prot), E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136301 ⟸ XM_063280231
- Peptide Label:	isoform X14
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL), A0A8I6A634 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136270 ⟸ XM_063280200
- Peptide Label:	isoform X1
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136290 ⟸ XM_063280220
- Peptide Label:	isoform X6
- UniProtKB:	P51593 (UniProtKB/Swiss-Prot), A0A8I6APS3 (UniProtKB/Swiss-Prot), E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136298 ⟸ XM_063280228
- Peptide Label:	isoform X12
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136267 ⟸ XM_063280197
- Peptide Label:	isoform X1
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136280 ⟸ XM_063280210
- Peptide Label:	isoform X2
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136295 ⟸ XM_063280225
- Peptide Label:	isoform X9
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136296 ⟸ XM_063280226
- Peptide Label:	isoform X10
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136297 ⟸ XM_063280227
- Peptide Label:	isoform X11
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136305 ⟸ XM_063280235
- Peptide Label:	isoform X16
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136281 ⟸ XM_063280211
- Peptide Label:	isoform X3
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136282 ⟸ XM_063280212
- Peptide Label:	isoform X4
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136283 ⟸ XM_063280213
- Peptide Label:	isoform X5
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136293 ⟸ XM_063280223
- Peptide Label:	isoform X7
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136307 ⟸ XM_063280237
- Peptide Label:	isoform X18
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136294 ⟸ XM_063280224
- Peptide Label:	isoform X8
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136299 ⟸ XM_063280229
- Peptide Label:	isoform X13
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136284 ⟸ XM_063280214
- Peptide Label:	isoform X6
- UniProtKB:	P51593 (UniProtKB/Swiss-Prot), A0A8I6APS3 (UniProtKB/Swiss-Prot), E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136309 ⟸ XM_063280239
- Peptide Label:	isoform X20
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136306 ⟸ XM_063280236
- Peptide Label:	isoform X17
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136304 ⟸ XM_063280234
- Peptide Label:	isoform X15
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136308 ⟸ XM_063280238
- Peptide Label:	isoform X19
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136273 ⟸ XM_063280203
- Peptide Label:	isoform X1
- UniProtKB:	E9PSZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136289 ⟸ XM_063280219
- Peptide Label:	isoform X6
- UniProtKB:	P51593 (UniProtKB/Swiss-Prot), A0A8I6APS3 (UniProtKB/Swiss-Prot), E9PSZ5 (UniProtKB/TrEMBL)

Protein Domains

HECT UBA UIM WWE

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P51593-F1-model_v2	AlphaFold	P51593	1-322	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561763	AgrOrtholog
BioCyc Gene	G2FUF-2727	BioCyc
Ensembl Genes	ENSRNOG00000061262	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000081037	ENTREZGENE
	ENSRNOT00000090890	ENTREZGENE
	ENSRNOT00000098599	ENTREZGENE
	ENSRNOT00000098599.1	UniProtKB/Swiss-Prot
	ENSRNOT00000109386	ENTREZGENE
Gene3D-CATH	3.30.720.50	UniProtKB/Swiss-Prot
	6.10.250.1630	UniProtKB/Swiss-Prot
	DNA helicase RuvA subunit, C-terminal domain	UniProtKB/Swiss-Prot
	Hect, E3 ligase catalytic domain	UniProtKB/Swiss-Prot
	Hect, E3 ligase catalytic domain	UniProtKB/Swiss-Prot
	Hect, E3 ligase catalytic domains	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7302447	IMAGE-MGC_LOAD
InterPro	ARM-type_fold	UniProtKB/Swiss-Prot
	E3_Ub_ligase_DUF908	UniProtKB/Swiss-Prot
	E3_Ub_ligase_DUF913	UniProtKB/Swiss-Prot
	E3_ubiq-protein_ligase	UniProtKB/Swiss-Prot
	HECT_dom	UniProtKB/Swiss-Prot
	Hect_E3_ubiquitin_ligase	UniProtKB/Swiss-Prot
	HUWE1/Rev1_UBM	UniProtKB/Swiss-Prot
	UBA	UniProtKB/Swiss-Prot
	UBA-like_sf	UniProtKB/Swiss-Prot
	UBA_HUWE1	UniProtKB/Swiss-Prot
	WWE-dom	UniProtKB/Swiss-Prot
	WWE_dom_sf	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105964	IMAGE-MGC_LOAD
NCBI Gene	Huwe1	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE HUWE1	UniProtKB/Swiss-Prot
	HECT DOMAIN UBIQUITIN-PROTEIN LIGASE	UniProtKB/Swiss-Prot
Pfam	DUF908	UniProtKB/Swiss-Prot
	DUF913	UniProtKB/Swiss-Prot
	HECT	UniProtKB/Swiss-Prot
	UBA_7	UniProtKB/Swiss-Prot
	UBM	UniProtKB/Swiss-Prot
	WWE	UniProtKB/Swiss-Prot
PhenoGen	Huwe1	PhenoGen
PROSITE	HECT	UniProtKB/Swiss-Prot
	UBA	UniProtKB/Swiss-Prot
	WWE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000061262	RatGTEx
SMART	HECTc	UniProtKB/Swiss-Prot
	UBA	UniProtKB/Swiss-Prot
Superfamily-SCOP	ARM repeat	UniProtKB/Swiss-Prot
	SSF56204	UniProtKB/Swiss-Prot
	UBA-like	UniProtKB/Swiss-Prot
	WWE domain	UniProtKB/Swiss-Prot
UniProt	A0A0G2JVW5_RAT	UniProtKB/TrEMBL
	A0A8I6A634	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6APS3	ENTREZGENE
	E9PSZ5	ENTREZGENE, UniProtKB/TrEMBL
	HUWE1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	A0A8I6APS3	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-04-10	Huwe1	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	Huwe1	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-09	Huwe1	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	LOC501546	hypothetical protein LOC501546	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	LOC501546	hypothetical protein LOC501546			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)