Huwe1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1) - Rat Genome Database

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Gene: Huwe1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1) Rattus norvegicus
Analyze
Symbol: Huwe1
Name: HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
RGD ID: 1561763
Description: Enables DNA binding activity. Predicted to be involved in several processes, including circadian regulation of gene expression; negative regulation of mitochondrial fusion; and protein ubiquitination. Located in nucleus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Turner type. Orthologous to human HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A; flutamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase HUWE1; HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase; HECT, UBA and WWE domain-containing protein 1; HECT-type E3 ubiquitin transferase HUWE1; hypothetical protein LOC501546; LOC501546; upstream regulatory element-binding protein 1; URE-B1; URE-binding protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X20,873,795 - 21,001,378 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX20,873,795 - 21,001,262 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X21,474,627 - 21,603,348 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX21,499,934 - 21,598,876 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X21,848,515 - 21,950,709 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X23,634,031 - 23,635,008 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X41,269,837 - 41,397,687 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX21,152,936 - 21,282,567 (+)NCBICelera
Cytogenetic MapXq13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO,ISS)
cytosol  (IEA,ISO)
Golgi membrane  (IEA)
mitochondrion  (IEA)
nucleoplasm  (IEA,ISO)
nucleus  (IDA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cloning of a DNA binding protein that is a tyrosine kinase substrate and recognizes an upstream initiator-like sequence in the promoter of the preprodynorphin gene. Gu J, etal., Brain Res Mol Brain Res. 1994 Jul;24(1-4):77-88.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
8. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, etal., PLoS Genet. 2016 May 18;12(5):e1006074. doi: 10.1371/journal.pgen.1006074. eCollection 2016 May.
Additional References at PubMed
PMID:7478539   PMID:15767685   PMID:15989957   PMID:19028597   PMID:19056867   PMID:19713937   PMID:19946888   PMID:20534529   PMID:22658674   PMID:24270810   PMID:26214738   PMID:26698301  
PMID:30217973   PMID:30221657  


Genomics

Comparative Map Data
Huwe1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X20,873,795 - 21,001,378 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX20,873,795 - 21,001,262 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X21,474,627 - 21,603,348 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX21,499,934 - 21,598,876 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X21,848,515 - 21,950,709 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X23,634,031 - 23,635,008 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X41,269,837 - 41,397,687 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX21,152,936 - 21,282,567 (+)NCBICelera
Cytogenetic MapXq13NCBI
HUWE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X53,532,096 - 53,686,719 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX53,532,096 - 53,686,752 (-)EnsemblGRCh38hg38GRCh38
GRCh37X53,559,057 - 53,713,664 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X53,576,476 - 53,697,776 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX57,390,630 - 57,545,232 (-)NCBICelera
Cytogenetic MapXp11.22NCBI
HuRefX50,615,901 - 50,769,910 (-)NCBIHuRef
CHM1_1X53,550,037 - 53,704,971 (-)NCBICHM1_1
T2T-CHM13v2.0X52,818,443 - 52,973,077 (-)NCBIT2T-CHM13v2.0
Huwe1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X150,583,779 - 150,718,413 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX150,583,803 - 150,718,413 (+)EnsemblGRCm39 Ensembl
GRCm38X151,800,785 - 151,935,417 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX151,800,807 - 151,935,417 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X148,237,825 - 148,369,960 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X147,144,043 - 147,275,608 (+)NCBIMGSCv36mm8
CeleraX132,494,924 - 132,629,529 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
Huwe1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955475551,159 - 671,747 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955475550,643 - 671,771 (-)NCBIChiLan1.0ChiLan1.0
HUWE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1X54,935,098 - 55,085,490 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X45,746,228 - 45,897,250 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X53,855,404 - 54,005,383 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX53,855,404 - 54,005,366 (-)Ensemblpanpan1.1panPan2
HUWE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X45,234,666 - 45,409,641 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX45,234,322 - 45,410,043 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX36,751,409 - 36,836,872 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X45,559,669 - 45,734,540 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX45,559,746 - 45,731,948 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X45,054,717 - 45,229,543 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X45,504,350 - 45,679,158 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X45,571,951 - 45,747,074 (-)NCBIUU_Cfam_GSD_1.0
Huwe1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X38,139,253 - 38,283,118 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936751478,300 - 622,820 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936751478,978 - 622,818 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HUWE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX46,281,967 - 46,444,228 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X46,281,958 - 46,444,315 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X51,780,471 - 51,942,782 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HUWE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X49,661,506 - 49,814,551 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX49,660,790 - 49,808,572 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660863,622,912 - 3,777,017 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Huwe1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624909745,651 - 859,233 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624909745,141 - 891,421 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Huwe1
253 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:271
Count of miRNA genes:170
Interacting mature miRNAs:206
Transcripts:ENSRNOT00000003882, ENSRNOT00000004064
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat

Markers in Region
DXRat8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X20,990,947 - 20,991,088 (+)MAPPERmRatBN7.2
Rnor_6.0X21,592,623 - 21,592,783NCBIRnor6.0
Rnor_5.0X21,859,080 - 21,859,240UniSTSRnor5.0
RGSC_v3.4X41,386,879 - 41,387,039UniSTSRGSC3.4
RGSC_v3.4X41,386,788 - 41,387,080RGDRGSC3.4
RGSC_v3.1X41,440,348 - 41,440,508RGD
CeleraX21,272,130 - 21,272,290UniSTS
RH 3.4 MapX186.31UniSTS
RH 3.4 MapX186.31RGD
RH 2.0 Map21223.4RGD
SHRSP x BN MapX6.8999RGD
FHH x ACI MapX7.93RGD
Cytogenetic MapXq21UniSTS
AU046935  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X21,592,648 - 21,592,888NCBIRnor6.0
Rnor_5.0X21,858,975 - 21,859,215UniSTSRnor5.0
RGSC_v3.4X41,386,904 - 41,387,144UniSTSRGSC3.4
CeleraX21,272,155 - 21,272,395UniSTS
Cytogenetic MapXq21UniSTS
RH142513  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X20,939,081 - 20,939,309 (+)MAPPERmRatBN7.2
Rnor_6.0X21,539,418 - 21,539,645NCBIRnor6.0
Rnor_5.0X21,910,974 - 21,911,201UniSTSRnor5.0
RGSC_v3.4X41,335,217 - 41,335,444UniSTSRGSC3.4
CeleraX21,220,268 - 21,220,495UniSTS
Cytogenetic MapXq21UniSTS
AU048657  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X20,910,547 - 20,910,793 (+)MAPPERmRatBN7.2
Rnor_6.0X21,511,228 - 21,511,473NCBIRnor6.0
Rnor_5.0X21,939,146 - 21,939,391UniSTSRnor5.0
RGSC_v3.4X41,306,598 - 41,306,843UniSTSRGSC3.4
CeleraX21,191,983 - 21,192,228UniSTS
Cytogenetic MapXq21UniSTS
MARC_15341-15342:1017678837:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X21,592,466 - 21,593,358NCBIRnor6.0
Rnor_5.0X21,858,505 - 21,859,397UniSTSRnor5.0
RGSC_v3.4X41,386,722 - 41,387,614UniSTSRGSC3.4
CeleraX21,271,973 - 21,272,865UniSTS
Cytogenetic MapXq21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 55 39 19 39 8 11 74 35 40 11 8
Low 1 2 2 2 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001408927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_576948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001835014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001835015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001835016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001835017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001835018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001835019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001835020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001835021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001835022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001835023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001835024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001835025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001835026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001842623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_589680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_589682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC086550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000081037   ⟹   ENSRNOP00000069644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX20,903,082 - 20,996,599 (+)Ensembl
Rnor_6.0 EnsemblX21,499,934 - 21,598,876 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090890   ⟹   ENSRNOP00000071818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX20,873,795 - 21,001,262 (+)Ensembl
Rnor_6.0 EnsemblX21,499,934 - 21,539,503 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098599   ⟹   ENSRNOP00000095129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX20,873,795 - 21,001,262 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109386   ⟹   ENSRNOP00000088915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX20,873,795 - 21,001,262 (+)Ensembl
RefSeq Acc Id: NM_001408927   ⟹   NP_001395856
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X20,873,795 - 21,001,378 (+)NCBI
RefSeq Acc Id: ENSRNOP00000071818   ⟸   ENSRNOT00000090890
RefSeq Acc Id: ENSRNOP00000069644   ⟸   ENSRNOT00000081037
RefSeq Acc Id: ENSRNOP00000095129   ⟸   ENSRNOT00000098599
RefSeq Acc Id: ENSRNOP00000088915   ⟸   ENSRNOT00000109386
RefSeq Acc Id: NP_001395856   ⟸   NM_001408927
- UniProtKB: P51593 (UniProtKB/Swiss-Prot),   A0A8I6APS3 (UniProtKB/Swiss-Prot),   A0A8I6A634 (UniProtKB/TrEMBL)
Protein Domains
HECT   UBA   UIM   WWE

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51593-F1-model_v2 AlphaFold P51593 1-322 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561763 AgrOrtholog
BioCyc Gene G2FUF-2727 BioCyc
Ensembl Genes ENSRNOG00000061262 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055022936 UniProtKB/Swiss-Prot
  ENSRNOG00060026890 UniProtKB/Swiss-Prot
  ENSRNOG00065024729 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000081037.2 UniProtKB/TrEMBL
  ENSRNOT00000090890.2 UniProtKB/TrEMBL
  ENSRNOT00000098599.1 UniProtKB/Swiss-Prot
  ENSRNOT00000109386 ENTREZGENE
  ENSRNOT00000109386.1 UniProtKB/TrEMBL
  ENSRNOT00055040443 UniProtKB/Swiss-Prot
  ENSRNOT00060050142 UniProtKB/Swiss-Prot
  ENSRNOT00065044799 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.720.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.1630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/Swiss-Prot
  Hect, E3 ligase catalytic domain UniProtKB/Swiss-Prot
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7302447 IMAGE-MGC_LOAD
InterPro ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF4414 UniProtKB/TrEMBL
  E3_Ub_ligase_DUF908 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E3_Ub_ligase_DUF913 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HECT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HUWE1/Rev1_UBM UniProtKB/Swiss-Prot
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  UBA_HUWE1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WWE-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WWE_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105964 IMAGE-MGC_LOAD
NCBI Gene Huwe1 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE HUWE1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HECT DOMAIN UBIQUITIN-PROTEIN LIGASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLY [ADP-RIBOSE] POLYMERASE UniProtKB/TrEMBL
  PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP11 UniProtKB/TrEMBL
Pfam DUF4414 UniProtKB/TrEMBL
  DUF908 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF913 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBM UniProtKB/Swiss-Prot
  WWE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Huwe1 PhenoGen
PROSITE HECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WWE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000061262 RatGTEx
  ENSRNOG00055022936 RatGTEx
  ENSRNOG00060026890 RatGTEx
  ENSRNOG00065024729 RatGTEx
SMART HECTc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP ARM repeat UniProtKB/Swiss-Prot
  SSF117839 UniProtKB/TrEMBL
  SSF46934 UniProtKB/TrEMBL
  SSF48371 UniProtKB/TrEMBL
  SSF56204 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA-like UniProtKB/Swiss-Prot
  WWE domain UniProtKB/Swiss-Prot
UniProt A0A0G2JVW5_RAT UniProtKB/TrEMBL
  A0A8I6A634 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APS3 ENTREZGENE
  E9PSZ5_RAT UniProtKB/TrEMBL
  HUWE1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A8I6APS3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Huwe1  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1  Huwe1  HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-09 Huwe1  HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase  LOC501546  hypothetical protein LOC501546  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC501546  hypothetical protein LOC501546      Symbol and Name status set to provisional 70820 PROVISIONAL