Gene: Smc1a (structural maintenance of chromosomes 1A) Rattus norvegicus
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Symbol:
Smc1a
Name:
structural maintenance of chromosomes 1A
Description:
Predicted to have chromatin binding activity; mediator complex binding activity; and protein heterodimerization activity. Involved in meiotic cell cycle. Predicted to localize to several cellular components, including the chromosome; cytosol; and nucleus. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 2. Orthologous to human SMC1A (structural maintenance of chromosomes 1A); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,3-dinitrobenzene; 17alpha-ethynylestradiol.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
DXhXs423e; KIAA0178; SB1.8; segregation of mitotic chromosomes-like 1; SMC (segregation of mitotic chromosomes 1)-like 1; SMC (segregation of mitotic chromosomes 1)-like 1 (yeast) ; SMC protein 1A; SMC-1A; SMC-like 1; SMC-like 1 (yeast) ; SMC-protein; Smc1l1; structural maintenance of chromosomes 1 like 1; structural maintenance of chromosomes 1 like 1 (S. cerevisiae); structural maintenance of chromosomes protein 1A
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SMC1A (structural maintenance of chromosomes 1A) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Smc1a (structural maintenance of chromosomes 1A) HGNC
Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Smc1a (structural maintenance of chromosomes 1A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SMC1A (structural maintenance of chromosomes 1A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SMC1A (structural maintenance of chromosomes 1A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Smc1a (structural maintenance of chromosomes 1A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SMC1A (structural maintenance of chromosomes 1A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
SMC1B (structural maintenance of chromosomes 1B) HGNC
OrthoMCL
Alliance orthologs 3
Mus musculus (house mouse):
Smc1a (structural maintenance of chromosomes 1A)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
SMC1A (structural maintenance of chromosomes 1A)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
smc1a (structural maintenance of chromosomes 1A)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
smc1al (structural maintenance of chromosomes 1A, like)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
him-1
Alliance
DIOPT (Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):
SMC1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
SMC1
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 X 21,710,976 - 21,755,708 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 X 21,691,592 - 21,736,383 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 X 41,503,393 - 41,547,830 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 X 41,556,861 - 41,601,299 (+) NCBI Celera X 21,378,634 - 21,423,365 (+) NCBI Celera Cytogenetic Map X q13 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
Atkin Syndrome ISO RGD:737070 8554872 ClinVar Annotator: match by term: Mental retardation, X-linked, nonspecific ClinVar PMID:28492532 autistic disorder ISO RGD:737070 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 Cognitive Dysfunction ISO RGD:737070 8554872 ClinVar Annotator: match by term: Cognitive impairment ClinVar PMID:25741868 Cornelia de Lange syndrome ISO RGD:737070 8554872 ClinVar Annotator: match by OMIM:300590 ClinVar PMID:18414213 Cornelia de Lange syndrome ISO RGD:737070 8554872 ClinVar Annotator: match by term: Cornelia de Lange Syndrome ClinVar PMID:28492532 Cornelia de Lange syndrome ISO RGD:737070 8554872 ClinVar Annotator: match by term: Cornelia de Lange Syndrome ClinVar PMID:18414213 , PMID:28492532 Cornelia de Lange syndrome ISO RGD:737070 8554872 ClinVar Annotator: match by term: Cornelia de Lange Syndrome ClinVar PMID:25741868 Cornelia de Lange syndrome ISO RGD:737070 8554872 ClinVar Annotator: match by term: Cornelia de Lange Syndrome ClinVar PMID:18414213 more ... Cornelia de Lange syndrome ISO RGD:737070 8554872 ClinVar Annotator: match by term: Cornelia de Lange Syndrome ClinVar Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:18414213 Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:26358754 more ... Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:18414213 more ... Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:16604071 more ... Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:17273969 more ... Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:25741868 more ... Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:26467025 , PMID:28492532 Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:16604071 more ... Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:25326635 more ... Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:25741868 , PMID:30158690 Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:24088041 more ... Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:25574841 Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:16604071 , PMID:18996922 Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:25741868 , PMID:28492532 Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:17273969 Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:22106055 Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:17273969 more ... Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:17221863 more ... Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:18414213 more ... Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:25741868 more ... Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:26386245 Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:16604071 Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:25741868 Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:18414213 , PMID:28492532 Cornelia de Lange syndrome 2 ISO RGD:737070 8554872 ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome ClinVar PMID:28492532 Developmental Disabilities ISO RGD:737070 8554872 ClinVar Annotator: match by term: Developmental delay ClinVar PMID:25741868 Dysarthria ISO RGD:737070 8554872 ClinVar Annotator: match by term: Dysarthria ClinVar PMID:25741868 Funnel Chest ISO RGD:737070 8554872 ClinVar Annotator: match by term: Funnel chest ClinVar PMID:25741868 genetic disease ISO RGD:737070 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar genetic disease ISO RGD:737070 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:16604071 more ... genetic disease ISO RGD:737070 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:16604071 more ... genetic disease ISO RGD:737070 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:16604071 more ... Growth Deficiency and Mental Retardation with Facial Dysmorphism ISO RGD:737070 8554872 ClinVar Annotator: match by term: Growth deficiency and mental retardation with facial dysmorphism ClinVar PMID:25574841 Mental Retardation, X-Linked 78 ISO RGD:737070 8554872 ClinVar Annotator: match by term: MENTAL RETARDATION, X-LINKED 78 ClinVar PMID:28492532 Multiple Abnormalities ISO RGD:737070 8554872 ClinVar Annotator: match by term: Multiple congenital anomalies ClinVar paraplegia ISO RGD:737070 8554872 ClinVar Annotator: match by term: Spastic paraplegia ClinVar PMID:25741868 peripheral nervous system disease ISO RGD:737070 8554872 ClinVar Annotator: match by term: Peripheral nerve disease ClinVar PMID:25741868 polyneuropathy ISO RGD:737070 8554872 ClinVar Annotator: match by term: Polyneuropathy ClinVar PMID:25741868 syndromic X-linked intellectual disability Lubs type ISO RGD:737070 8554872 ClinVar Annotator: match by term: MECP2 duplication syndrome ClinVar PMID:25741868 Talipes Cavus ISO RGD:737070 8554872 ClinVar Annotator: match by term: Pes cavus ClinVar PMID:25741868
Imported Annotations - CTD
adenoid cystic carcinoma ISO RGD:737070 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23685749 Cornelia de Lange syndrome ISO RGD:737070 11554173 CTD Direct Evidence: marker/mechanism CTD epilepsy ISO RGD:737070 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29942082 myeloid leukemia ISO RGD:737070 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23955599 Neurodevelopmental Disorders ISO RGD:737070 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29942082 urinary bladder cancer ISO RGD:737070 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24121791
Imported Annotations - OMIM
Cornelia de Lange syndrome 2 ISO RGD:737070 7240710 OMIM
(S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of SMC1A mRNA CTD PMID:25729387 1,3-dinitrobenzene increases expression EXP 6480464 3-dinitrobenzene results in increased expression of SMC1A mRNA CTD PMID:22841810 1-chloro-2,4-dinitrobenzene decreases expression ISO RGD:737070 6480464 Dinitrochlorobenzene results in decreased expression of SMC1A mRNA CTD PMID:17374397 17alpha-ethynylestradiol multiple interactions ISO RGD:62283 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMC1A mRNA CTD PMID:17942748 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of SMC1A mRNA CTD PMID:15576828 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:737070 6480464 Tetrachlorodibenzodioxin results in decreased expression of SMC1A mRNA CTD PMID:17101203 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:62283 6480464 Tetrachlorodibenzodioxin results in increased expression of SMC1A mRNA CTD PMID:15034205 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:62283 6480464 Tetrachlorodibenzodioxin affects the expression of SMC1A mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:62283 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMC1A mRNA, Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SMC1A promoter] CTD PMID:17942748 , PMID:19654925 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of SMC1A mRNA CTD PMID:21346803 2-hydroxypropanoic acid decreases expression ISO RGD:737070 6480464 Lactic Acid results in decreased expression of SMC1A mRNA CTD PMID:30851411 3,4-methylenedioxymethamphetamine increases expression ISO RGD:62283 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of SMC1A mRNA CTD PMID:20188158 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:62283 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of SMC1A mRNA CTD PMID:26251327 4,4'-diaminodiphenylmethane increases expression ISO RGD:62283 6480464 4, 4'-diaminodiphenylmethane results in increased expression of SMC1A mRNA CTD PMID:18648102 4-(ethoxymethylene)-2-phenyloxazol-5-one decreases expression ISO RGD:737070 6480464 Oxazolone results in decreased expression of SMC1A mRNA CTD PMID:17374397 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2, 6-dinitrotoluene affects the expression of SMC1A mRNA CTD PMID:21346803 4-vinylcyclohexene dioxide affects expression ISO RGD:62283 6480464 4-vinyl-1-cyclohexene dioxide affects the expression of SMC1A mRNA CTD PMID:20829426 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of SMC1A mRNA CTD PMID:16483693 arecoline decreases expression ISO RGD:737070 6480464 Arecoline results in decreased expression of SMC1A mRNA CTD PMID:17682004 Aroclor 1254 decreases expression ISO RGD:62283 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of SMC1A mRNA CTD PMID:23650126 benzo[a]pyrene multiple interactions ISO RGD:62283 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of SMC1A mRNA], AHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of SMC1A mRNA] CTD PMID:15034205 , PMID:22228805 benzo[a]pyrene decreases expression ISO RGD:62283 6480464 Benzo(a)pyrene results in decreased expression of SMC1A mRNA CTD PMID:15034205 benzo[a]pyrene increases expression ISO RGD:62283 6480464 Benzo(a)pyrene results in increased expression of SMC1A mRNA CTD PMID:22228805 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:737070 6480464 Diethylhexyl Phthalate results in decreased expression of SMC1A mRNA CTD PMID:31163220 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SMC1A mRNA CTD PMID:25181051 , PMID:27208089 bisphenol A decreases methylation ISO RGD:737070 6480464 bisphenol A results in decreased methylation of SMC1A promoter CTD PMID:30352284 bisphenol A decreases methylation ISO RGD:62283 6480464 bisphenol A results in decreased methylation of SMC1A promoter CTD PMID:27312807 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of SMC1A gene CTD PMID:28505145 bleomycin A2 increases phosphorylation ISO RGD:737070 6480464 Bleomycin results in increased phosphorylation of SMC1A protein CTD PMID:24933654 bortezomib decreases expression ISO RGD:737070 6480464 Bortezomib results in decreased expression of SMC1A mRNA CTD PMID:20977926 busulfan multiple interactions ISO RGD:737070 6480464 [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of SMC1A protein CTD PMID:20933509 butanal decreases expression ISO RGD:737070 6480464 butyraldehyde results in decreased expression of SMC1A mRNA CTD PMID:26079696 Butyl parahydroxybenzoate (TN) increases expression ISO RGD:737070 6480464 butylparaben results in increased expression of SMC1A mRNA CTD PMID:17121429 chromium(6+) multiple interactions ISO RGD:737070 6480464 chromium hexavalent ion promotes the reaction [ATR protein results in increased phosphorylation of SMC1A protein] more ... CTD PMID:16876463 chromium(6+) increases phosphorylation ISO RGD:737070 6480464 chromium hexavalent ion results in increased phosphorylation of SMC1A protein CTD PMID:16876463 chrysene increases expression ISO RGD:62283 6480464 chrysene results in increased expression of SMC1A mRNA CTD PMID:26377693 clofarabine multiple interactions ISO RGD:737070 6480464 [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of SMC1A protein CTD PMID:20933509 cobalt dichloride decreases expression ISO RGD:737070 6480464 cobaltous chloride results in decreased expression of SMC1A mRNA CTD PMID:19320972 , PMID:19376846 coumestrol increases expression ISO RGD:737070 6480464 Coumestrol results in increased expression of SMC1A mRNA CTD PMID:19167446 coumestrol multiple interactions ISO RGD:737070 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 dicrotophos increases expression ISO RGD:737070 6480464 dicrotophos results in increased expression of SMC1A mRNA CTD PMID:28302478 dorsomorphin multiple interactions ISO RGD:737070 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMC1A mRNA CTD PMID:27188386 doxorubicin multiple interactions ISO RGD:737070 6480464 Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of SMC1A protein]], Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of SMC1A protein] CTD PMID:15489221 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of SMC1A mRNA CTD PMID:29391264 Enterolactone multiple interactions ISO RGD:737070 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SMC1A mRNA CTD PMID:19167446 finasteride increases expression EXP 6480464 Finasteride results in increased expression of SMC1A mRNA CTD PMID:24136188 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of SMC1A mRNA CTD PMID:18035473 furan decreases expression EXP 6480464 furan results in decreased expression of SMC1A mRNA CTD PMID:22507866 geldanamycin increases expression ISO RGD:737070 6480464 geldanamycin results in increased expression of SMC1A mRNA CTD PMID:26705709 hydrogen peroxide multiple interactions ISO RGD:737070 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of SMC1A protein] more ... CTD PMID:24933654 hydrogen peroxide increases phosphorylation ISO RGD:737070 6480464 Hydrogen Peroxide results in increased phosphorylation of SMC1A protein CTD PMID:24933654 lead(0) affects expression ISO RGD:737070 6480464 Lead affects the expression of SMC1A mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:737070 6480464 Lead affects the expression of SMC1A mRNA CTD PMID:28903495 linsidomine increases oxidation EXP 6480464 linsidomine results in increased oxidation of SMC1A protein CTD PMID:28086193 lycopene decreases expression ISO RGD:737070 6480464 lycopene results in decreased expression of SMC1A mRNA CTD PMID:16886892 menadione affects expression ISO RGD:737070 6480464 Vitamin K 3 affects the expression of SMC1A mRNA CTD PMID:20044591 menadione affects expression ISO RGD:62283 6480464 Vitamin K 3 affects the expression of SMC1A mRNA CTD PMID:20829426 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of SMC1A mRNA CTD PMID:30467583 methotrexate decreases expression ISO RGD:737070 6480464 Methotrexate results in decreased expression of SMC1A mRNA CTD PMID:25339124 methoxychlor affects expression ISO RGD:62283 6480464 Methoxychlor affects the expression of SMC1A mRNA CTD PMID:20829426 methylparaben increases expression ISO RGD:737070 6480464 methylparaben results in increased expression of SMC1A mRNA CTD PMID:17121429 myristicin decreases expression ISO RGD:737070 6480464 myristicin results in decreased expression of SMC1A mRNA CTD PMID:24792648 N-acetyl-L-cysteine multiple interactions ISO RGD:737070 6480464 Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of SMC1A protein]], Acetylcysteine inhibits the reaction [resveratrol results in increased phosphorylation of SMC1A protein] CTD PMID:15489221 , PMID:24933654 N-methyl-4-phenylpyridinium increases expression ISO RGD:62283 6480464 1-Methyl-4-phenylpyridinium results in increased expression of SMC1A protein CTD PMID:26558463 nickel atom increases expression ISO RGD:737070 6480464 Nickel results in increased expression of SMC1A mRNA CTD PMID:24768652 nickel sulfate decreases expression ISO RGD:737070 6480464 nickel sulfate results in decreased expression of SMC1A mRNA CTD PMID:17374397 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of SMC1A mRNA CTD PMID:25729387 paracetamol decreases expression ISO RGD:737070 6480464 Acetaminophen results in decreased expression of SMC1A mRNA CTD PMID:21420995 paracetamol increases expression ISO RGD:737070 6480464 Acetaminophen results in increased expression of SMC1A mRNA CTD PMID:22230336 paraquat multiple interactions ISO RGD:62283 6480464 [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of SMC1A mRNA CTD PMID:28012437 pentanal decreases expression ISO RGD:737070 6480464 pentanal results in decreased expression of SMC1A mRNA CTD PMID:26079696 perfluorooctane-1-sulfonic acid increases expression EXP 6480464 perfluorooctane sulfonic acid results in increased expression of SMC1A mRNA CTD PMID:18692542 perfluorooctanoic acid decreases expression ISO RGD:737070 6480464 perfluorooctanoic acid results in decreased expression of SMC1A protein CTD PMID:26879310 phenylmercury acetate decreases expression ISO RGD:737070 6480464 Phenylmercuric Acetate results in decreased expression of SMC1A mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:737070 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMC1A mRNA CTD PMID:27188386 pirinixic acid decreases expression ISO RGD:62283 6480464 pirinixic acid results in decreased expression of SMC1A mRNA CTD PMID:17426115 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:62283 6480464 Pregnenolone Carbonitrile results in increased expression of SMC1A mRNA CTD PMID:28903501 propanal decreases expression ISO RGD:737070 6480464 propionaldehyde results in decreased expression of SMC1A mRNA CTD PMID:26079696 quercetin decreases expression ISO RGD:737070 6480464 Quercetin results in decreased expression of SMC1A mRNA CTD PMID:23727915 rac-lactic acid decreases expression ISO RGD:737070 6480464 Lactic Acid results in decreased expression of SMC1A mRNA CTD PMID:30851411 resveratrol multiple interactions ISO RGD:737070 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [resveratrol promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of SMC1A protein]] more ... CTD PMID:19167446 , PMID:24933654 resveratrol increases phosphorylation ISO RGD:737070 6480464 resveratrol results in increased phosphorylation of SMC1A protein CTD PMID:24933654 SB 431542 multiple interactions ISO RGD:737070 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMC1A mRNA CTD PMID:27188386 sulindac decreases expression EXP 6480464 Sulindac results in decreased expression of SMC1A mRNA CTD PMID:24136188 thimerosal decreases expression ISO RGD:737070 6480464 Thimerosal results in decreased expression of SMC1A mRNA CTD PMID:27188386 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of SMC1A mRNA CTD PMID:25729387 torcetrapib increases expression ISO RGD:737070 6480464 torcetrapib results in increased expression of SMC1A mRNA CTD PMID:23228038 Tributyltin oxide increases phosphorylation ISO RGD:62283 6480464 bis(tri-n-butyltin)oxide results in increased phosphorylation of SMC1A protein CTD PMID:22174045 trimellitic anhydride increases expression ISO RGD:62283 6480464 trimellitic anhydride results in increased expression of SMC1A mRNA CTD PMID:19042947 troglitazone decreases expression ISO RGD:62283 6480464 troglitazone results in decreased expression of SMC1A mRNA CTD PMID:28973697 tungsten decreases expression ISO RGD:62283 6480464 Tungsten results in decreased expression of SMC1A mRNA CTD PMID:30912803 tungsten(4+) decreases expression ISO RGD:62283 6480464 Tungsten results in decreased expression of SMC1A mRNA CTD PMID:30912803 valproic acid decreases expression ISO RGD:737070 6480464 Valproic Acid results in decreased expression of SMC1A mRNA CTD PMID:23179753 , PMID:28001369 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of SMC1A mRNA CTD PMID:23034163
Biological Process cell division IEA UniProtKB-KW:KW-0132 1600115 GO_REF:0000037 UniProt GO_REF:0000037 DNA repair IEA UniProtKB-KW:KW-0234 1600115 GO_REF:0000037 UniProt GO_REF:0000037 DNA repair IEA InterPro:IPR029683 1600115 GO_REF:0000002 InterPro GO_REF:0000002 meiotic cell cycle IEA UniProtKB:Q9CU62 , ensembl:ENSMUSP000000446451600115 GO_REF:0000107 Ensembl GO_REF:0000107 meiotic cell cycle IDA 1331378 PMID:10652260 UniProt meiotic cell cycle ISO RGD:62283 1624291 UniProtKB:P70281 (MGI:MGI:2667549 , PMID:12759374) RGD MGI:MGI:2667549 , PMID:12759374 mitotic sister chromatid cohesion IEA InterPro:IPR029683 1600115 GO_REF:0000002 InterPro GO_REF:0000002 regulation of mitotic spindle assembly ISO RGD:737070 1624291 (PMID:11590136) RGD PMID:11590136 regulation of mitotic spindle assembly IEA UniProtKB:Q14683 , ensembl:ENSP000003234211600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to DNA damage checkpoint signaling ISO RGD:737070 1624291 (PMID:11877377) RGD PMID:11877377 response to DNA damage checkpoint signaling ISS UniProtKB:Q14683 1600115 GO_REF:0000024 UniProt GO_REF:0000024 response to DNA damage checkpoint signaling IEA UniProtKB:Q14683 , ensembl:ENSP000003234211600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to radiation ISO RGD:737070 1624291 (PMID:11877377) RGD PMID:11877377 response to radiation ISS UniProtKB:Q14683 1600115 GO_REF:0000024 UniProt GO_REF:0000024 response to radiation IEA UniProtKB:Q14683 , ensembl:ENSP000003234211600115 GO_REF:0000107 Ensembl GO_REF:0000107 sister chromatid cohesion ISO RGD:737070 1624291 (PMID:15917200) RGD PMID:15917200 stem cell population maintenance ISO RGD:62283 1624291 (MGI:MGI:4833901, PMID:20720539) RGD MGI:MGI:4833901 , PMID:20720539 stem cell population maintenance IEA UniProtKB:Q9CU62 , ensembl:ENSMUSP000000446451600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component cohesin complex ISO RGD:737070 1624291 (PMID:11590136), (PMID:22628566) RGD PMID:11590136 , PMID:22628566 cohesin complex ISO RGD:62283 1624291 (MGI:MGI:1340883, PMID:10375619) RGD MGI:MGI:1340883 , PMID:10375619 cytosol IEA UniProtKB:Q14683 , ensembl:ENSP000003234211600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol ISO RGD:737070 1624291 RGD GO_REF:0000052 kinetochore ISO RGD:737070 1624291 (PMID:11682612), (PMID:12199140) RGD PMID:11682612 , PMID:12199140 kinetochore ISS UniProtKB:Q14683 1600115 GO_REF:0000024 UniProt GO_REF:0000024 kinetochore IEA UniProtKB:Q14683 , ensembl:ENSP000003234211600115 GO_REF:0000107 Ensembl GO_REF:0000107 meiotic cohesin complex ISO RGD:737070 1624291 (PMID:21242291) RGD PMID:21242291 meiotic cohesin complex ISS UniProtKB:Q14683 1600115 GO_REF:0000024 UniProt GO_REF:0000024 meiotic cohesin complex ISO RGD:62283 1624291 (MGI:MGI:5050018, PMID:21527826) RGD MGI:MGI:5050018 , PMID:21527826 meiotic cohesin complex IEA UniProtKB:Q9CU62 , ensembl:ENSMUSP000000446451600115 GO_REF:0000107 Ensembl GO_REF:0000107 meiotic cohesin complex IEA UniProtKB:Q14683 , ensembl:ENSP000003234211600115 GO_REF:0000107 Ensembl GO_REF:0000107 mitotic spindle pole ISO RGD:737070 1624291 (PMID:11590136) RGD PMID:11590136 mitotic spindle pole IEA UniProtKB:Q14683 , ensembl:ENSP000003234211600115 GO_REF:0000107 Ensembl GO_REF:0000107 nuclear matrix ISO RGD:737070 1624291 (PMID:11590136) RGD PMID:11590136 nuclear matrix IEA UniProtKB:Q14683 , ensembl:ENSP000003234211600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm ISO RGD:737070 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:Q14683 , ensembl:ENSP000003234211600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus ISO RGD:737070 1624291 (PMID:11076961) RGD PMID:11076961 nucleus ISS UniProtKB:Q14683 1600115 GO_REF:0000024 UniProt GO_REF:0000024 nucleus ISO RGD:62283 1624291 (MGI:MGI:1340883, PMID:10375619) RGD MGI:MGI:1340883 , PMID:10375619 Molecular Function ATP binding IEA UniProtKB-KW:KW-0067 1600115 GO_REF:0000037 UniProt GO_REF:0000037 ATP binding IEA InterPro:IPR010935 , InterPro:IPR036277 1600115 GO_REF:0000002 InterPro GO_REF:0000002 chromatin binding ISO RGD:62283 1624291 (MGI:MGI:4833901 more ... RGD MGI:MGI:4833901 more ... chromatin binding ISS UniProtKB:Q14683 1600115 GO_REF:0000024 UniProt GO_REF:0000024 chromatin binding IEA UniProtKB:Q9CU62 , ensembl:ENSMUSP000000446451600115 GO_REF:0000107 Ensembl GO_REF:0000107 chromatin binding IEA UniProtKB:Q14683 , ensembl:ENSP000003234211600115 GO_REF:0000107 Ensembl GO_REF:0000107 chromatin binding ISO RGD:737070 1624291 (PMID:11076961) RGD PMID:11076961 mediator complex binding ISO RGD:62283 1624291 (MGI:MGI:4833901, PMID:20720539) RGD MGI:MGI:4833901 , PMID:20720539 mediator complex binding IEA UniProtKB:Q9CU62 , ensembl:ENSMUSP000000446451600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein binding ISO RGD:62283 1624291 UniProtKB:Q61550 more ... RGD MGI:MGI:1340883 more ... protein binding ISO RGD:737070 1624291 UniProtKB:O60216 more ... RGD PMID:11076961 more ... protein heterodimerization activity ISO RGD:737070 1624291 UniProtKB:Q9UQE7 (PMID:11590136) RGD PMID:11590136 protein heterodimerization activity IEA UniProtKB:Q14683 , ensembl:ENSP000003234211600115 GO_REF:0000107 Ensembl GO_REF:0000107
Gene-Chemical Interaction Annotations
