Tlr8 (toll-like receptor 8) - Rat Genome Database

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Gene: Tlr8 (toll-like receptor 8) Rattus norvegicus
Analyze
Symbol: Tlr8
Name: toll-like receptor 8
RGD ID: 1590327
Description: Predicted to enable identical protein binding activity; nucleic acid binding activity; and pattern recognition receptor activity. Predicted to be involved in several processes, including cellular response to mechanical stimulus; pattern recognition receptor signaling pathway; and regulation of cytokine production. Predicted to act upstream of or within regulation of protein phosphorylation. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TLR8 (toll like receptor 8); PARTICIPATES IN Toll-like receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC684440; similar to toll-like receptor 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X30,708,714 - 30,733,104 (+)NCBIGRCr8
mRatBN7.2X27,091,780 - 27,116,092 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX27,091,778 - 27,116,549 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX28,164,972 - 28,187,831 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X31,566,484 - 31,589,384 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X27,779,612 - 27,802,461 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X28,539,158 - 28,562,803 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX28,539,158 - 28,562,803 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X28,932,434 - 28,956,373 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX27,503,122 - 27,525,908 (+)NCBICelera
Cytogenetic MapXq13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. TLR4 links podocytes with the innate immune system to mediate glomerular injury. Banas MC, etal., J Am Soc Nephrol. 2008 Apr;19(4):704-13. doi: 10.1681/ASN.2007040395. Epub 2008 Feb 6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression. Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1.
4. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Gene expression of nucleic acid-sensing pattern recognition receptors in children hospitalized for respiratory syncytial virus-associated acute bronchiolitis. Scagnolari C, etal., Clin Vaccine Immunol. 2009 Jun;16(6):816-23. Epub 2009 Apr 22.
10. Mechanistic investigation of immunosuppression in patients with condyloma acuminata. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
Additional References at PubMed
PMID:12032557   PMID:14976262   PMID:16111635   PMID:16123302   PMID:16188996   PMID:16286015   PMID:19593445   PMID:20004021   PMID:23520111   PMID:24091496   PMID:24740015   PMID:24942581  
PMID:25599397   PMID:32815784   PMID:37199563  


Genomics

Comparative Map Data
Tlr8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X30,708,714 - 30,733,104 (+)NCBIGRCr8
mRatBN7.2X27,091,780 - 27,116,092 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX27,091,778 - 27,116,549 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX28,164,972 - 28,187,831 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X31,566,484 - 31,589,384 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X27,779,612 - 27,802,461 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X28,539,158 - 28,562,803 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX28,539,158 - 28,562,803 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X28,932,434 - 28,956,373 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX27,503,122 - 27,525,908 (+)NCBICelera
Cytogenetic MapXq13NCBI
TLR8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X12,906,620 - 12,923,169 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX12,906,620 - 12,923,169 (+)EnsemblGRCh38hg38GRCh38
GRCh37X12,924,739 - 12,941,288 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X12,834,679 - 12,851,209 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX17,038,744 - 17,055,292 (+)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX10,691,356 - 10,708,478 (+)NCBIHuRef
CHM1_1X12,955,183 - 12,971,731 (+)NCBICHM1_1
T2T-CHM13v2.0X12,488,083 - 12,504,631 (+)NCBIT2T-CHM13v2.0
Tlr8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X166,024,119 - 166,047,325 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX166,025,692 - 166,047,325 (-)EnsemblGRCm39 Ensembl
GRCm38X167,241,123 - 167,264,329 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX167,242,696 - 167,264,329 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X163,680,664 - 163,701,720 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X162,580,693 - 162,607,911 (-)NCBIMGSCv36mm8
CeleraX150,416,046 - 150,437,421 (-)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX78.29NCBI
Tlr8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955544303,319 - 306,426 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955544302,027 - 317,110 (-)NCBIChiLan1.0ChiLan1.0
TLR8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X14,690,911 - 14,707,471 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X14,694,577 - 14,711,137 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X5,518,742 - 5,535,304 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X12,808,144 - 12,824,720 (+)NCBIpanpan1.1PanPan1.1panPan2
TLR8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X9,381,159 - 9,399,938 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX9,337,717 - 9,356,229 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X9,333,237 - 9,351,758 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX9,347,575 - 9,351,742 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X9,317,807 - 9,336,322 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X9,357,237 - 9,375,770 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X9,349,380 - 9,367,898 (+)NCBIUU_Cfam_GSD_1.0
Tlr8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X2,638,020 - 2,642,609 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364702,638,014 - 2,641,133 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364702,638,020 - 2,642,201 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX9,597,604 - 9,616,757 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X9,551,284 - 9,616,762 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X10,451,110 - 10,512,940 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TLR8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X11,387,933 - 11,405,056 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX11,400,907 - 11,404,029 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605613,179,722 - 13,196,707 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlr8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248821,240,626 - 1,312,468 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248821,240,519 - 1,247,311 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tlr8
78 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:97
Count of miRNA genes:86
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000073535
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 12 4 9
Low 2 22 51 36 7 36 8 9 8 27 23 2 8
Below cutoff 1 15 5 5 5 1 41 8 9

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001101009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide EF032638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000073535   ⟹   ENSRNOP00000066040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX27,091,778 - 27,116,549 (+)Ensembl
Rnor_6.0 EnsemblX28,539,158 - 28,562,803 (+)Ensembl
RefSeq Acc Id: NM_001101009   ⟹   NP_001094479
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X30,708,726 - 30,731,626 (+)NCBI
mRatBN7.2X27,091,780 - 27,114,679 (+)NCBI
Rnor_6.0X28,539,158 - 28,562,803 (+)NCBI
Rnor_5.0X28,932,434 - 28,956,373 (+)NCBI
CeleraX27,503,122 - 27,525,908 (+)RGD
Sequence:
RefSeq Acc Id: XM_039100074   ⟹   XP_038956002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X30,708,714 - 30,733,104 (+)NCBI
mRatBN7.2X27,091,780 - 27,116,092 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001094479 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956002 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABM92444 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066040
  ENSRNOP00000066040.1
GenBank Protein QQJ43002 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43003 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43004 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43005 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43006 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43007 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43008 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43009 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43010 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43011 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43012 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43013 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43014 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43015 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43016 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43017 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43018 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43019 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43020 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43021 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43022 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43023 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43024 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43025 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43026 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43027 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43028 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43029 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43030 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43031 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43032 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43033 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43034 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43035 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43036 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43037 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43038 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43039 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43040 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43041 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43042 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43043 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43044 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43045 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43046 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43047 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43048 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43049 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43050 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43051 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43052 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43053 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43054 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43055 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43056 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43057 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43058 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43059 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43060 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43061 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43062 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43063 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43064 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43065 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43066 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43067 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43068 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43069 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43070 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43071 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43072 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43073 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43074 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43075 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43076 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43077 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43078 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43079 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43080 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43081 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43082 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43083 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43084 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43085 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43086 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43087 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43088 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43089 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43090 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43091 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43092 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43093 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43094 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43095 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43096 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43097 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43098 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43099 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43100 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43101 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43102 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43103 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43104 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43105 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43106 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43107 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43108 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43109 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43110 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43111 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43112 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43113 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43114 (Get FASTA)   NCBI Sequence Viewer  
  QQJ43115 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001094479   ⟸   NM_001101009
- Peptide Label: precursor
- UniProtKB: A5H300 (UniProtKB/TrEMBL),   A0A8K2AD52 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066040   ⟸   ENSRNOT00000073535
RefSeq Acc Id: XP_038956002   ⟸   XM_039100074
- Peptide Label: isoform X1
- UniProtKB: A5H300 (UniProtKB/TrEMBL),   A0A8K2AD52 (UniProtKB/TrEMBL)
Protein Domains
LRRCT   TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A5H300-F1-model_v2 AlphaFold A5H300 1-1029 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701785
Promoter ID:EPDNEW_R12308
Type:initiation region
Name:Tlr8_1
Description:toll-like receptor 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X28,539,206 - 28,539,266EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590327 AgrOrtholog
BioCyc Gene G2FUF-2659 BioCyc
Ensembl Genes ENSRNOG00000045992 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073535 ENTREZGENE
  ENSRNOT00000073535.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  Toll-Interleukin_rcpt UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
KEGG Report rno:684440 UniProtKB/TrEMBL
NCBI Gene 684440 ENTREZGENE
PANTHER PTHR47410:SF1 UniProtKB/TrEMBL
  TOLL-LIKE RECEPTOR 7-RELATED UniProtKB/TrEMBL
Pfam LRR_1 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
PhenoGen Tlr8 PhenoGen
PROSITE LRR UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000045992 RatGTEx
SMART LRR_SD22 UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
UniProt A0A8K0ZN04_RAT UniProtKB/TrEMBL
  A0A8K0ZNB8_RAT UniProtKB/TrEMBL
  A0A8K0ZQ97_RAT UniProtKB/TrEMBL
  A0A8K2AD52 ENTREZGENE, UniProtKB/TrEMBL
  A5H300 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-02 Tlr8  toll-like receptor 8  LOC684440  similar to toll-like receptor 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC684440  similar to toll-like receptor 8      Symbol and Name status set to provisional 70820 PROVISIONAL