Cltrn (collectrin, amino acid transport regulator)

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Gene: Cltrn (collectrin, amino acid transport regulator) Rattus norvegicus

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Symbol:

Cltrn

Name:

collectrin, amino acid transport regulator

RGD ID:

708489

Description:

Predicted to enable protein homodimerization activity. Predicted to be involved in SNARE complex assembly; positive regulation of L-proline import across plasma membrane; and regulation of transmembrane transporter activity. Predicted to act upstream of with a positive effect on calcium-ion regulated exocytosis and insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in brush border membrane and cytoplasm. Predicted to be active in plasma membrane. Orthologous to human CLTRN (collectrin, amino acid transport regulator); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol 3-benzoate; ammonium chloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

collectrin; kidney-specific membrane protein; MGC93468; NX-17; Nx17; Tmem27; transmembrane protein 27

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	33,993,825 - 34,027,124 (-)	NCBI		GRCr8
mRatBN7.2	X	30,361,967 - 30,395,264 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	30,361,967 - 30,395,349 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	31,394,873 - 31,428,148 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	34,831,861 - 34,865,158 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	31,019,084 - 31,052,359 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	32,118,082 - 32,153,687 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	32,118,054 - 32,153,794 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	32,490,603 - 32,522,780 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	51,118,665 - 51,149,768 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	51,172,133 - 51,203,237 (-)	NCBI
Celera	X	30,705,756 - 30,738,867 (-)	NCBI		Celera
Cytogenetic Map	X	q14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Fanconi anemia (ISO)

hepatocellular carcinoma (ISO)

multiple congenital anomalies-hypotonia-seizures syndrome 2 (ISO)

Neurodevelopmental Disorders (ISO)

Renal Aminoacidurias (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

ureteral obstruction (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

17beta-estradiol 3-benzoate (EXP)

acrylamide (ISO)

actinomycin D (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

beta-lapachone (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

cadmium atom (ISO)

calcitriol (ISO)

camptothecin (ISO)

CGP 52608 (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (EXP,ISO)

coumestrol (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

diazinon (EXP)

diquat (ISO)

dorsomorphin (ISO)

enalapril (EXP)

fulvestrant (ISO)

gentamycin (EXP)

glycidol (EXP)

lead diacetate (EXP)

methapyrilene (ISO)

nickel atom (ISO)

Nutlin-3 (ISO)

panobinostat (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (EXP,ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

propanal (ISO)

quercetin (ISO)

rotenone (EXP)

SB 431542 (ISO)

sodium arsenite (ISO)

trichostatin A (ISO)

triptonide (ISO)

tris(2-butoxyethyl) phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium-ion regulated exocytosis (IEA,ISO)

insulin secretion involved in cellular response to glucose stimulus (IEA,ISO)

positive regulation of amino acid transport (IBA,ISO)

positive regulation of L-proline import across plasma membrane (IEA,ISO)

regulation of transmembrane transporter activity (IEA,ISO)

SNARE complex assembly (IEA,ISO)

Cellular Component

brush border membrane (IEA,ISO)

cytoplasm (IEA,ISO)

plasma membrane (IBA,ISO,ISS)

Molecular Function

protein binding (ISO)

protein homodimerization activity (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
5.	Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys.	Zhang H, etal., J Biol Chem 2001 May 18;276(20):17132-9. Epub 2001 Jan 31.
6.	Screening for genes up-regulated in 5/6 nephrectomized mouse kidney.	Zhang H, etal., Kidney Int 1999 Aug;56(2):549-58.

Additional References at PubMed

PMID:15489334	PMID:16330323	PMID:16330324	PMID:17167413	PMID:18981302	PMID:19056867	PMID:21907142	PMID:22628310	PMID:22701690	PMID:23376485

Genomics

Comparative Map Data

Cltrn
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	33,993,825 - 34,027,124 (-)	NCBI		GRCr8
mRatBN7.2	X	30,361,967 - 30,395,264 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	30,361,967 - 30,395,349 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	31,394,873 - 31,428,148 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	34,831,861 - 34,865,158 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	31,019,084 - 31,052,359 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	32,118,082 - 32,153,687 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	32,118,054 - 32,153,794 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	32,490,603 - 32,522,780 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	51,118,665 - 51,149,768 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	51,172,133 - 51,203,237 (-)	NCBI
Celera	X	30,705,756 - 30,738,867 (-)	NCBI		Celera
Cytogenetic Map	X	q14	NCBI

CLTRN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	15,627,318 - 15,675,644 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	15,627,318 - 15,675,012 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	15,645,441 - 15,682,928 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	15,555,372 - 15,593,075 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	15,405,107 - 15,442,811	NCBI
Celera	X	19,760,931 - 19,798,641 (-)	NCBI		Celera
Cytogenetic Map	X	p22.2	NCBI
HuRef	X	13,399,991 - 13,438,249 (-)	NCBI		HuRef
CHM1_1	X	15,676,401 - 15,714,121 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	15,210,303 - 15,247,770 (-)	NCBI		T2T-CHM13v2.0

Cltrn
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	162,873,183 - 162,901,855 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	162,871,826 - 162,901,856 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	164,090,187 - 164,118,859 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	164,088,830 - 164,118,860 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	160,528,119 - 160,556,791 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	159,434,292 - 159,462,964 (+)	NCBI		MGSCv36	mm8
Celera	X	147,304,655 - 147,333,264 (+)	NCBI		Celera
Cytogenetic Map	X	F5	NCBI
cM Map	X	76.12	NCBI

Cltrn
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955519	2,522,155 - 2,570,972 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955519	2,522,154 - 2,569,722 (+)	NCBI	ChiLan1.0	ChiLan1.0

CLTRN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	17,428,298 - 17,465,905 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	17,431,727 - 17,469,290 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	8,255,666 - 8,293,354 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	15,537,112 - 15,574,842 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	15,535,069 - 15,575,268 (-)	Ensembl	panpan1.1		panPan2

CLTRN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	11,863,479 - 11,908,361 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	11,798,839 - 11,900,594 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	11,770,083 - 11,786,549 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	11,824,506 - 11,859,272 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	11,825,149 - 11,861,692 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	11,887,674 - 11,922,326 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	11,881,588 - 11,916,356 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	11,907,346 - 11,941,809 (-)	NCBI		UU_Cfam_GSD_1.0

Cltrn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	5,040,429 - 5,129,055 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	5,040,795 - 5,124,192 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936470	5,040,831 - 5,124,611 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CLTRN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	12,183,796 - 12,224,964 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	12,183,793 - 12,215,474 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	13,279,802 - 13,292,665 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CLTRN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	14,103,046 - 14,154,936 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	14,102,497 - 14,154,123 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666056	15,936,757 - 15,975,408 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cltrn
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624829	412,532 - 446,938 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624829	412,797 - 447,076 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cltrn
77 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	270
Count of miRNA genes:	185
Interacting mature miRNAs:	206
Transcripts:	ENSRNOT00000005348
Prediction methods:	Microtar, Miranda, Pita, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1598873	Memor2	Memory QTL 2	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	X	20990947	41052531	Rat
70165	Bp64	Blood pressure QTL 64	5.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	1448129	31706553	Rat
1298071	Edpm12	Estrogen-dependent pituitary mass QTL 12	3.2		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	X	2927898	47927898	Rat
2290375	Gluco34	Glucose level QTL 34	2.75		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	20990947	41203591	Rat
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1	43491017	Rat
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
10755455	Coatc13	Coat color QTL 13		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	4406000	49406000	Rat
631666	Iddm5	Insulin dependent diabetes mellitus QTL 5			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	4494549	49494549	Rat
71116	Niddm16	Non-insulin dependent diabetes mellitus QTL 16	7.81		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	15297802	60297802	Rat

Markers in Region

RH131137

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	30,362,011 - 30,362,230 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	32,118,127 - 32,118,345	NCBI	Rnor6.0
Rnor_5.0	X	32,490,648 - 32,490,866	UniSTS	Rnor5.0
RGSC_v3.4	X	51,118,710 - 51,118,928	UniSTS	RGSC3.4
Celera	X	30,705,801 - 30,706,019	UniSTS
RH 3.4 Map	X	423.92	UniSTS
Cytogenetic Map	X	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
1	10	18	75	76	73	51	18	51	4	159	54	61	45	42	22

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_020976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC118872	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF178086	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY665561	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078838	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000005348 ⟹ ENSRNOP00000005348

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	30,361,967 - 30,395,349 (-)	Ensembl
Rnor_6.0 Ensembl	X	32,118,054 - 32,153,794 (-)	Ensembl

RefSeq Acc Id:

NM_020976 ⟹ NP_066125

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	33,993,825 - 34,027,124 (-)	NCBI
mRatBN7.2	X	30,361,967 - 30,395,264 (-)	NCBI
Rnor_6.0	X	32,118,082 - 32,153,687 (-)	NCBI
Rnor_5.0	X	32,490,603 - 32,522,780 (-)	NCBI
RGSC_v3.4	X	51,118,665 - 51,149,768 (-)	RGD
Celera	X	30,705,756 - 30,738,867 (-)	RGD

Sequence:

show sequence

AAAGAATGCTGTGGGCACTCTTTTTCCTGGTGACTACTATTCACGCTGAACTCTGCCGTCCAGA
TGCAGAAAATGCCTTTAAAGTAAGACTTAGCATCAAAGCAGCTCTTGGAGATAAAGCGTATGTC
TGGGACACAGATGAAGAATATCTCTTCAGAGCAATGGTGGCATTCTCCATGAGAAAAGTTCCCA
ACAGAGAAGGAACAGAAATTTCCCACGTCCTGCTTTGCAATGTAACCCAGAGAGTGTCATTTTG
GTTTGTGGTCACAGACCCTTTGAAAAACCATACTTTTCCTGCAGTTGAAGTACAGTCAGCCATA
AGAATGAACAGGAAACGGATCAACAGTGCATTCTTTTTGGATGATCATACTCTGGAATTTTTAA
AAATTCCTTCCACTCTTGCTCCCCCGATGGATCCATCTGTGCCCGTCTGGATTATTGTATTTGG
TGTGATATTTTGCATTGTTACAGTTGCAATTGCACTACTGGTTTTATCCGGAATCCGGCAACGA
AGAAGGAACAAGAAAGGACCACCTGGAGTGGAGGATGCAGAAGACAAGTGTGAAAACATCATCA
CAATTGAAAATGGCATCCCTTGTGATCCCTTGGACATGAAGAGAGGGCACATTAATGATGGCTT
CTTGACAGAGGATGAGCGTCTCACCCCTCTCTGAGAGTTACAGTCTTGTAAGAAAATTTCAAGA
TGCTTGAATGTGATAGACAACAATAGACCACTGAAATCATAAGGAGTTAGTTGGCTTCTCAAAA
TATTCGAGAATTTTCTTTTTGATAACCAAATATGTAAATGTAGTTACACATGTTTGTAGTTACT
GATTTGAGCATCTTTAGAAATTAAGTCAGGGCTATAACTATATTTCATATTTTGAAGACCTAAG
GAAAAATTCTTACCACTGGAGAATGACTATAGCATGGCACAGAAATAATTAAAAATGGATCTTT
TTGAATACTGTTTATATTAGTCTGTACATGATGAAGCAAGGAAAAGTAAACATGAGATGGATGA
AAATGGTAATGGAATTTTATTCTGTTCTCACACAAACAGCTGCTTGTATATTTTATACATATTA
GCCTTTAGTAGGGCAAGAGGATCTTTTTGTTGTTTGCTATTGCAATTTGTTCAAGTCCTATCTA
CGCTGATATAATAAAATTAGGATCATCTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_066125	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG09307	(Get FASTA)	NCBI Sequence Viewer
	AAH78838	(Get FASTA)	NCBI Sequence Viewer
	AAV80218	(Get FASTA)	NCBI Sequence Viewer
	EDL90513	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000005348.4
GenBank Protein	Q9ESG3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_066125 ⟸ NM_020976
- Peptide Label:	precursor
- UniProtKB:	Q9ESG3 (UniProtKB/Swiss-Prot), Q6AYY2 (UniProtKB/Swiss-Prot), A6K2L7 (UniProtKB/TrEMBL), A0A8L2Q282 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLWALFFLVTTIHAELCRPDAENAFKVRLSIKAALGDKAYVWDTDEEYLFRAMVAFSMRKVPNR EGTEISHVLLCNVTQRVSFWFVVTDPLKNHTFPAVEVQSAIRMNRKRINSAFFLDDHTLEFLKI PSTLAPPMDPSVPVWIIVFGVIFCIVTVAIALLVLSGIRQRRRNKKGPPGVEDAEDKCENIITI ENGIPCDPLDMKRGHINDGFLTEDERLTPL hide sequence

Ensembl Acc Id:

ENSRNOP00000005348 ⟸ ENSRNOT00000005348

Protein Domains

Collectrin-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9ESG3-F1-model_v2	AlphaFold	Q9ESG3	1-222	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701798

Promoter ID:

EPDNEW_R12322

Type:

initiation region

Name:

Tmem27_1

Description:

transmembrane protein 27

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	32,153,707 - 32,153,767	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:708489	AgrOrtholog
BioCyc Gene	G2FUF-2581	BioCyc
Ensembl Genes	ENSRNOG00000003960	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005348.6	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7129929	IMAGE-MGC_LOAD
InterPro	Collectrin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Collectrin_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:57395	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93468	IMAGE-MGC_LOAD
NCBI Gene	57395	ENTREZGENE
PANTHER	COLLECTRIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR46884	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Collectrin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Cltrn	PhenoGen
PROSITE	COLLECTRIN_LIKE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000003960	RatGTEx
UniProt	A0A8L2Q282	ENTREZGENE, UniProtKB/TrEMBL
	A6K2L7	ENTREZGENE, UniProtKB/TrEMBL
	CLTRN_RAT	UniProtKB/Swiss-Prot
	Q6AYY2	ENTREZGENE
	Q9ESG3	ENTREZGENE
UniProt Secondary	Q6AYY2	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-01-18	Cltrn	collectrin, amino acid transport regulator	Tmem27	transmembrane protein 27	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Tmem27	transmembrane protein 27		kidney-specific membrane protein	Name updated	1299863	APPROVED
2004-09-10	Tmem27	kidney-specific membrane protein	Nx17		Symbol and Name updated	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD